pituitrin and Asthma

Topics: Affective Symptoms; Animals; Asthma; Caffeine; Calcitonin; Calcium; Catecholamines; Circadian Rhythm; Cyclic AMP; Cyclic GMP; Dermatitis, Atopic; Diabetes Insipidus; Glucagon; Growth Hormone; Humans; Hypercalcemia; Hyperparathyroidism; Hypocalcemia; Hypoparathyroidism; Insulin; Organ Specificity; Parathyroid Hormone; Psoriasis; Vasopressins

Topics: Addison Disease; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Asthma; Corticotropin-Releasing Hormone; Facial Paralysis; Glucocorticoids; Granulomatosis with Polyangiitis; Hepatitis; Humans; Hypothalamus; Melanocyte-Stimulating Hormones; Myasthenia Gravis; Pituitary Gland; Pulmonary Edema; Retroperitoneal Fibrosis; Shock, Septic; Vasopressins

Two comparable groups of asthmatics each with 10 patients were treated during 2 years at scheduled intervals with either natural or synthetic ACTH up to a total dose of 2000-95-- IU. All patients had previously been given the natural but never the synthetic hormone. Intradermal tests with natural and synthetic ACTH were performed before treatment and after 1, 12 and 24 months. Serum samples were also taken on these occasions and analysed for antibodies against ACTH, vasopressin and porcine gamma-globulin. No sign of clinical allergy to ACTH was noted in any of the patients during the 2-year period. The incidence of intradermal reactions against natural ACTH was high at the onset of treatment but was not increased by treatment with either synthetic or natural ACTH, while the reactivity rate against synthetic ACTH was increased after both types of treatment. The incidence of IgE reactions against synthetic ACTH at the 20 U/ml level was significantly increased after 12 months' treatment with either natural or synthetic hormone. A high incidence of low-titered agglutinating antibodies against natural or synthetic ACTH was demonstrated before treatment in both the groups, but no significant change in incidence or mean titre against natural or synthetic ACTH or porcine gamma-globulin was noted during treatment with the natural or the synthetic preparation. A few patients, however, did display an increased agglutinating titre against ACTH after 12 months' treatment. Rather unexpectedly, most sera reacting with ACTH were found to react also with vasopressin and a significant increase of the incidence of these reactions and of the titres occurred during the treatment with synthetic as well as with natural ACTH. Two cases have been examined in detail, one because of a fulminant shock after synthetic ACTH and the other because of very high antibody titres without clinical symptoms of ACTH allergy.

Topics: Adrenocorticotropic Hormone; Adult; Aged; Antibodies; Antibody Formation; Antigen-Antibody Reactions; Asthma; Cosyntropin; Female; Humans; Immunoglobulin G; Immunoglobulin M; Intradermal Tests; Male; Middle Aged; Vasopressins

Present study was performed to examine whether ADH was implicated in psychological stress asthma and to explore the underlying molecular mechanism.. We not only examined ADH levels in the cerebrospinal fluid (CSF) via radioimmunoassay, but also measured ADH receptor (ADHR) expression in airway-related vagal preganglionic neurons (AVPNs) through real-time PCR in all experimental mice. Western blotting was performed to evaluate the relationship between ADH and PKA/PKC in psychological stress asthma. Finally, the role of PKA/PKC in psychological stress asthma was analyzed.. Marked asthma exacerbations were noted owing to significantly elevated levels of ADH and ADHR after psychological stress induction as compared to OVA alone (asthma group). ADHR antagonists (SR-49095 or SR-121463A) dramatically lowered higher protein levels of PKAα and PKCα induced by psychological stress as compared to OVA alone, suggesting the correlation between ADH and PKA/PKC in psychological stress asthma. KT-5720 (PKA inhibitor) and Go-7874 (PKC inhibitor) further directly revealed the involvement of PKA/PKC in psychological stress asthma. Some notable changes were also noted after employing PKA and PKC inhibitors in psychological stress asthma, including reduced asthmatic inflammation (lower eosinophil peroxidase (EPO) activity, myeloperoxidase (MPO) activity, immunoglobulin E (IgE) level, and histamine release), substantial decrements in inflammatory cell counts (eosinophils and lymphocytes), and decreased cytokine secretion (IL-6, IL-10, and IFN-γ), indicating the involvement of PKA/PKC in asthma exacerbations induced by psychological stress.. Our results strongly suggested that ADH participated in psychological stress-induced asthma exacerbations via PKA/PKC signal pathway in AVPNs.

Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Asthma; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cytokines; Disease Models, Animal; Eosinophils; Female; Mice; Mice, Inbred BALB C; Morpholines; Neurons; Ovalbumin; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Receptors, Vasopressin; Signal Transduction; Spiro Compounds; Stress, Psychological; Vasopressins

The treatment of status asthmaticus is one of the most important factors in controlling the patient with asthma attacks. We have studied hormone changes in status asthmaticus and considered what is the best treatment in the asthma attack condition in children. Antidiuretic hormone (ADH), renin activity, and aldosterone activity are elevated in severe asthma attack conditions, and these high levels are correlated with high levels in Wood's clinical score. It is theoretical that patients with dehydration and respiratory failure show such elevation in hormones, and it is well known that under such conditions beta 2-stimulant enhances renin production. From our study, it is concluded that beta 2-stimulant subcutaneous injection must be considered in status asthmaticus. In children, aminophylline i.v. drip therapy may be one of the best treatments in status asthmaticus.

Topics: Adolescent; Aldosterone; Aminophylline; Asthma; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Male; Renin; Status Asthmaticus; Vasopressins

Topics: 11-Hydroxycorticosteroids; Adolescent; Asthma; Child; Child, Preschool; Female; Fluid Therapy; Humans; Male; Osmolar Concentration; Renin-Angiotensin System; Status Asthmaticus; Vasopressins

Topics: Adolescent; Age Factors; Asthma; Blood Urea Nitrogen; Child; Child, Preschool; Female; Fluid Therapy; Humans; Infant; Male; Osmotic Pressure; Vasopressins

The plasma antidiuretic hormone concentrations in eight asthmatic children were measured at the onset of an acute severe attack and were repeated 24 h later. Conventional therapy and maintenance fluid intake resulted in a significant fall in antidiuretic hormone concentrations without abnormal changes in other biochemical indicators of dehydration.

Topics: Albuterol; Aminophylline; Asthma; Child; Child, Preschool; Female; Fluid Therapy; Humans; Male; Oxygen Inhalation Therapy; Vasopressins

Plasma antidiuretic hormone concentrations were measured in a group of children with acute asthma and in a control group. Very high levels of antidiuretic hormone were found in the asthmatic group. There were no changes in other biochemical indices. If overproduction of antidiuretic hormone is sustained then fluid administration to children with severe acute asthma is potentially dangerous.

Topics: Acute Disease; Asthma; Child; Child, Preschool; Female; Humans; Infant; Male; Osmolar Concentration; Sodium; Vasopressins

Topics: Administration, Intranasal; Adult; Arginine Vasopressin; Asthma; Deamino Arginine Vasopressin; Diabetes Insipidus; Drug Hypersensitivity; Humans; Male; Pulmonary Fibrosis; Vasopressins

Topics: Acute Disease; Albuterol; Asthma; Female; Humans; Inappropriate ADH Syndrome; Middle Aged; Vasopressins

The prevalence of antibodies against synthetic ACTH preparations and porcine gamma globulin was investigated in 29 asthmatic patients, in 28 rheumatic patients, and in 63 normal subjects of both sexes. Agglutinating antibodies were examined by a passive haemagglutination test and IgE antibodies by a radio-immuno assay. The incidence of agglutinating reactions against Synacthén and porcine gamma globulin was significantly higher in the asthmatic and rheumatic groups than in the group of normal subjects. Titres were generally low, attaining supposedly pathological levels (larger than or equal to 1/200) in about 10 per cent of the asthmatic patients and in 20-40 per cent of the rheumatic patients. In asthmatic patients, the incidence of ACTH specific IgE was higher than that in the normal group. This difference was not statistically significant in patients on routine treatment but it became satistically significant after ACTH booster treatment. In rheumatic patients the incidence of IgE antibodies against ACTH was insignificantly lower than that in the normal group. The incidence of agglutinating antibodies against vasopressin in asthmatic and rheumatic patients was also increased as compared with that in normal subjects and the titres were positively correlated to those against ACTH.

Topics: Adrenocorticotropic Hormone; Adult; Aged; Antibodies; Antibody Specificity; Asthma; Female; Hemadsorption Inhibition Tests; Hemagglutination Tests; Humans; Immunoelectrophoresis; Immunoglobulin E; Male; Middle Aged; Radioallergosorbent Test; Radioimmunoassay; Rheumatic Diseases; Vasopressins

Elevated plasma antidiuretic hormone (ADH) levels were noted in seven patients with status asthmaticus during the acute illness. These values returned to normal with resolution of the disease. The mechanism of this release is not completely understood but is consistent with the hypothesis that bronchospasm leads to decreased pulmonary blood flow, decreased volume return to the left atrium, and stimulation of the atrial volume receptors regulating ADH release. Planning for fluid therapy in patients with status asthmaticus should take into account a high probability of increased plasma ADH concentration during the acute illness. Water intoxication as well as hypoxia and hypercarbia should be considered as a possible cause of an altered state of consciousness associated with status asthmaticus.

Topics: Acute Disease; Adolescent; Adult; Asthma; Child; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Vasopressins

Topics: Asthma; Drug Hypersensitivity; Female; Humans; Respiratory Hypersensitivity; Rhinitis; Vasopressins

Topics: Aldosterone; Asthma; Calcium; Chlorides; Circadian Rhythm; Female; Humans; Hydrocortisone; Hydrogen-Ion Concentration; Kidney Tubules; Middle Aged; Phosphates; Potassium; Prednisone; Sodium; Urination Disorders; Vasopressins; Water; Water-Electrolyte Balance

Topics: Adrenocorticotropic Hormone; Adult; Aged; Arthritis, Rheumatoid; Asthma; Dexamethasone; Female; Humans; Hydrocortisone; Injections, Intramuscular; Injections, Intravenous; Male; Methods; Middle Aged; Pituitary-Adrenal Function Tests; Time Factors; Vasopressins

Topics: Adrenal Cortex Hormones; Aerosols; Anesthetics, Local; Anti-Bacterial Agents; Antitubercular Agents; Asthma; Bronchitis; Bronchodilator Agents; Catalogs, Drug as Topic; Cresols; Detergents; Drug Prescriptions; Ephedrine; Epinephrine; Germany, East; Humans; Isoproterenol; Mineral Waters; Papaverine; Parasympatholytics; Respiratory Therapy; Respiratory Tract Diseases; Solvents; Sympathomimetics; Terpenes; Theophylline; Tuberculosis, Pulmonary; Vasopressins

Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Arthritis, Rheumatoid; Asthma; Blood; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; In Vitro Techniques; Injections, Intramuscular; Male; Metyrapone; Middle Aged; Pituitary Function Tests; Pituitary-Adrenal Function Tests; Urine; Vasopressins

Topics: Acetylcholine; Amino Alcohols; Antipyrine; Aprotinin; Arginine Vasopressin; Asthma; Carisoprodol; Cholinergic Antagonists; Deanol; Enzyme Inhibitors; Guinea Pigs; Pharmacology; Phenylbutazone; Vasopressins

Topics: Amino Alcohols; Antipyrine; Aprotinin; Arginine Vasopressin; Asthma; Carisoprodol; Deanol; Enzyme Inhibitors; Guinea Pigs; Histamine; Pharmacology; Phenylbutazone; Research; Serotonin; Serotonin Antagonists; Vasopressins

Topics: Adrenocorticotropic Hormone; Anesthetics; Asthma; Autonomic Nerve Block; Eczema; Endocrinology; Humans; Hypersensitivity; Hypothalamus; Lidocaine; Male; Migraine Disorders; Pituitary-Adrenal Function Tests; Research; Reticular Formation; Stellate Ganglion; Sympathectomy; Urticaria; Vasomotor System; Vasopressins

Topics: Arginine Vasopressin; Asthma; Caffeine; Humans; Procaine; Vasopressins