pituitrin and Adrenal-Gland-Diseases

Topics: Adrenal Gland Diseases; Adrenal Glands; Adrenalectomy; Cushing Syndrome; Dexamethasone; Diagnosis, Differential; Humans; Hydrocortisone; Hyperaldosteronism; Hypertension; Hypokalemia; Kidney; Obesity; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System; Vasopressins

Topics: Adrenal Gland Diseases; Diabetes Insipidus; Diabetic Nephropathies; Diagnosis, Differential; Diuresis; Glomerular Filtration Rate; Humans; Hypercalcemia; Hyponatremia; Kidney; Kidney Concentrating Ability; Kidney Diseases; Natriuresis; Osmolar Concentration; Urologic Diseases; Vasopressins; Water-Electrolyte Balance

Topics: Adrenal Gland Diseases; Central Nervous System Diseases; Diagnosis, Differential; Humans; Hyponatremia; Hypothalamus; Vasopressins; Water Intoxication

Topics: Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Child; Dwarfism, Pituitary; Endocrine System Diseases; Humans; Metabolism, Inborn Errors; Mixed Function Oxygenases; Pedigree; Pituitary Hormones, Anterior; Thyroid Diseases; Thyroid Hormones; Vasopressins

Topics: Acromegaly; Adolescent; Adrenal Gland Diseases; Adult; Animals; Calcitonin; Corticotropin-Releasing Hormone; Enkephalins; Female; Gastrointestinal Hormones; Growth Hormone-Releasing Hormone; Humans; Hypothalamic Hormones; Male; Middle Aged; Nerve Tissue Proteins; Neurotransmitter Agents; Pancreas; Pituitary Hormone-Releasing Hormones; Secretin; Somatostatin; Vasopressins

Topics: Adrenal Gland Diseases; Adrenal Glands; Age Factors; Aged; Brain Edema; Female; Humans; Hyponatremia; Iatrogenic Disease; Kidney; Liver Cirrhosis; Male; Sodium; Vasopressins; Water-Electrolyte Imbalance

Plasma ACTH (normal value: 0.16 plus or minus mU/100 ml) was measured in 116 patients with Cushing's syndrome, using a bioassay including dynamic tests and sequential determinations. In 10 patients with adrenal tumors ACTH levels were nondetectable (ND) or low, and usually nonstimulatable. In 10 patients with ectopic ACTH secretion high levels (0.42 plus or minus 0.07 mU/100 ml) were measured. The extracts of 6 tumors yielded an ACTH-like substance. Forty-three patients with Cushing's disease (without pituitary tumor) had, before treatment, a mean ACTH level of 0.18 plus or minus 0.01 mU/100 ml, accompanied by high levels of plasma cortisol (32.1 plus or minus 1.9 mug/100 ml). Irregular nycthemeral variations occurred. ACTH rose to 0.30 mU/100 ml after incomplete adrenalectomy (20 patients) and to 1.14 mU/100 ml after total adrenalectomy (21 patients). Dexamethasone (8 mg per day) suppressed ACTH levels. Metyrapone induced a normal ACTH rise, but at abnormal times. Lysine-vasopressin (LVP) induced an ACTH mean relative increase of 120% before, and of 140% after adrenalectomy (i.e., within the normal range). Six nonadrenalectomized patients with pituitary tumors showed similar abnormalities of ACTH regulation. However, the ACTH rise after LVP was above 500%. When pituitary tumors occurred after adrenalectomy (12 patients) the mean basal ACTH level was 18 mU/100 ml. Dexamethasone induced a 90% decrease, and LVP a 416% increase in ACTH levels. In 6 patients with nodular adrenal hyperplasia, ACTH was undetectable before treatment. After adrenalectomy, ACTH rose to 0.4 mU/100 ml (11 patients) and the increase after LVP was 90%. Five additional patients developed pituitary tumors. These data confirm the abnormalities of ACTH feedback regulation in Cushing's disease. However, even when pituitary tumors occur, ACTH levels can be altered by metyrapone, dexamethasone and LVP. This last test is of particular interest for the detection of pituitary tumors. The follow-up pattern of treated nodular adrenal hyperplasia appears to be very similar to that of Cushing's disease.

Topics: Adrenal Gland Diseases; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Biological Assay; Cushing Syndrome; Dexamethasone; Hormones, Ectopic; Humans; Hydrocortisone; Hyperplasia; Metyrapone; Pituitary Function Tests; Pituitary Gland; Pituitary Gland, Anterior; Pituitary Neoplasms; Rats; Vasopressins

Topics: Adrenal Gland Diseases; Circadian Rhythm; Glucocorticoids; Humans; Insulin; Lysine; Pyrogens; Stress, Physiological; Vasopressins

Topics: Adrenal Gland Diseases; Endocrine System Diseases; Erythrocytes; Female; Gastrins; Gynecomastia; Hormones, Ectopic; Humans; Hypercalcemia; Hyperplasia; Hyperthyroidism; Hypoglycemia; Male; Malignant Carcinoid Syndrome; Metabolic Diseases; Neoplasms; Neurologic Manifestations; Polycythemia; Prognosis; Puberty, Precocious; Vasopressins

Topics: Addison Disease; Adolescent; Adrenal Gland Diseases; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Aged; Child; Cushing Syndrome; Dexamethasone; Female; Fluorometry; Humans; Hydrocortisone; Hyperplasia; Hypopituitarism; Hypothalamo-Hypophyseal System; Injections, Intramuscular; Lysine; Male; Metyrapone; Middle Aged; Pituitary Neoplasms; Pituitary-Adrenal Function Tests; Vasopressins

Topics: Adrenal Gland Diseases; Humans; Hypophysectomy; Hypothalamo-Hypophyseal System; Lysine; Pituitary Diseases; Pituitary-Adrenal Function Tests; Pituitary-Adrenal System; Vasopressins

Topics: 17-Hydroxycorticosteroids; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Circadian Rhythm; Cushing Syndrome; Dexamethasone; Humans; Hydrocortisone; Hyperplasia; Insulin; Metyrapone; Pituitary-Adrenal Function Tests; Pyrogens; Vasopressins

Topics: Adrenal Gland Diseases; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Biological Assay; Brain Neoplasms; Bronchial Neoplasms; Central Nervous System Diseases; Child; Edema; Endocrine System Diseases; Glioblastoma; Humans; Male; Osmolar Concentration; Pituitary Diseases; Renin; Sodium Chloride; Vasopressins

Topics: 17-Hydroxycorticosteroids; Adrenal Gland Diseases; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Arginine; Corticotropin-Releasing Hormone; Cushing Syndrome; Female; Humans; Hypothalamo-Hypophyseal System; Insulin; Lysine; Male; Metyrapone; Middle Aged; Pituitary Gland; Pituitary-Adrenal Function Tests; Pyrogens; Stimulation, Chemical; Vasopressins

Topics: Adolescent; Adrenal Gland Diseases; Adult; Child; Child, Preschool; Dexamethasone; Female; Glucocorticoids; Humans; Infant; Male; Methods; Middle Aged; Prednisolone; Radiometry; Resins, Plant; Thyroid Gland; Tritium; Vasopressins

Topics: Adrenal Gland Diseases; Humans; Hydrocortisone; Vasopressins

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Glands; Adrenocorticotropic Hormone; Dexamethasone; Diagnosis, Differential; Humans; Methods; Vasopressins

Topics: Adolescent; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Adult; Blood; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Insulin; Lysine; Male; Middle Aged; Pituitary Diseases; Pituitary Function Tests; Pituitary-Adrenal Function Tests; Vasopressins

Topics: Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Atrophy; Hypertrophy; Hypophysectomy; Kidney; Liver; Pituitary-Adrenal Function Tests; Postoperative Complications; Rats; Stomach; Thymus Gland; Vasopressins