pituitrin and Adenovirus-Infections--Human

Four children aged between 7 and 19 months with severe bronchopneumonia due to adenovirus type 7, proved by virology and/or serology developed severe hyponatraemia. One of them is reported in detail: it was possible to estimate plasma ADH levels and thereby prove the existence of reversible hypersecretion of the hormone. Whilst the syndrome of hyponatraemia with inappropriate secretion of ADH has not yet been reported in association with severe pneumonia in the child, it is known in adults. The limits of the syndrome and its physiopathology are discussed. It may be due either to vagal stimulation as a result of a fall in left aressure, or to central involvement. Therapeutic implications of the problem are emphasized.

Topics: Adenoviridae Infections; Adenovirus Infections, Human; Diuresis; Hormones, Ectopic; Humans; Hyponatremia; Hypothalamo-Hypophyseal System; Infant; Lung; Male; Pituitary Gland, Posterior; Vagus Nerve; Vasopressins