pitavastatin has been researched along with Cognitive-Dysfunction* in 1 studies
1 other study(ies) available for pitavastatin and Cognitive-Dysfunction
| Article | Year |
|---|---|
Intranasally administered pitavastatin ameliorates pentylenetetrazol-induced neuroinflammation, oxidative stress and cognitive dysfunction.
The present study aimed to evaluate the neuroprotective potential of intranasally administered pitavastatin in the PTZ-induced kindling model.. Comparative in-silico study showed docking score of -4.56 and -2.86 against GABA. Our findings suggest that the intranasally administered pitavastatin is potential therapeutic approach to managing PTZ-induced kindling and associated comorbid conditions via its antioxidant, anti-inflammatory, and anticonvulsant potential. Further, pitavastatin can modulate GABA Topics: Administration, Intranasal; Animals; Behavior, Animal; Cognitive Dysfunction; Convulsants; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Mice; Neuroprotective Agents; Oxidative Stress; Pentylenetetrazole; Quinolines; Seizures | 2018 |