pitavastatin and Bone-Neoplasms

Bone is a frequent site of metastasis from breast cancer, and a desirable drug could suppress tumor growth as well as metastasis-linked bone loss. Currently, no drug is able to cure breast cancer-associated bone metastasis. In this study, we focused on statins that are known to inhibit cholesterol production and act as antitumor agents. After an initial potency screening of 7 U.S. Food and Drug Administration-approved statins, we examined pitavastatin as a drug candidate for inhibiting tumor and tumor-induced bone loss.

Topics: Animals; Bone Neoplasms; Breast Neoplasms; Cell Line; Cell Line, Tumor; Down-Regulation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Mevalonic Acid; Mice; Mice, Inbred BALB C; Osteoblasts; Quinolines; RAW 264.7 Cells; Volatile Organic Compounds