piroximone has been researched along with Heart Failure in 26 studies
*Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (69.23) | 18.7374 |
| 1990's | 8 (30.77) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bobowski, G; Bristol, JA; Burke, SE; Evans, DB; Newton, RS; Sircar, I; Steffen, RP; Weishaar, RE | 1 |
| Alvarez, R; Bruno, JJ; Stephenson, RA; Strosberg, AM; Venuti, MC | 1 |
| Erhardt, PW | 1 |
| Cohn, JN; Levine, TB; Petein, M | 2 |
| Bussmann, WD; Grohe, G; Klittich, P; Kneissl, GD; Scholz, M; Winkelmann, BW | 1 |
| Baumann, PC; Follath, F; Gallino, A; Ha, HR; Maggiorini, M; Meyer, BJ | 1 |
| Bernadet, P; Besse, P; Coste, P; Dos Santos, P; Durrieu-Jais, C | 1 |
| Castaigne, A; Dubois-Randé, JL; Estagnasie, P; Habbal, R; Lellouche, D; Saal, JP | 1 |
| Albo, C; Benvenuti, C; Castaigne, A; Deleuze, P; Dubois-Randé, JL; Habbal, R; Lellouche, D; Loisance, D; Saal, JP | 1 |
| Thormann, J | 1 |
| Baumann, G; Cremer, G; Joder-Ohlenbusch, AM; Ningel, K; Vieweg, J | 1 |
| Baumann, G; Cremer, G; Ningel, K | 1 |
| Braunwald, E; Colucci, WS; Wright, RF | 1 |
| Burkart, F; Cottier, C; Emmenegger, H; Follath, F; Kiowski, W; Pfisterer, M | 1 |
| Davis, F; Kremser, C; Nemanich, JW; Rajfer, SI; Rossen, JD; Shurman, AJ | 1 |
| Crawford, MH; Kennedy, GT; Miller, WE; O'Rourke, RA; Ruberg, SJ | 1 |
| Hess, ML; Wood, MA | 1 |
| Janicki, JS; Maskin, CS; Weber, KT | 1 |
| Dhainaut, JF | 1 |
| Goto, T; Nunoki, K; Satoh, K; Taira, N | 1 |
| Chatterjee, K; Daly, PA; Kereiakes, D; Modin, G; Simonton, CA | 1 |
| Jain, MC; Janicki, JS; Weber, KT | 1 |
| Axelrod, RJ; Botvinick, EH; Chatterjee, K; Dae, M; De Marco, T | 1 |
| Bache, RJ; Cohn, JN; Heppner, B; Petein, M; Pierpont, GL | 1 |
| Cornyn, J; Loge, D; Massie, BM; Podolin, RA; Topic, N | 1 |
4 review(s) available for piroximone and Heart Failure
| Article | Year |
|---|---|
In search of the digitalis replacement.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Cardiotonic Agents; Cyclic AMP; Digitalis Glycosides; Heart Failure; Humans; Myocardial Contraction; Receptors, Adrenergic, beta; Structure-Activity Relationship | 1987 |
New positive inotropic agents in the treatment of congestive heart failure. Mechanisms of action and recent clinical developments. 2.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Administration, Oral; Aminopyridines; Amrinone; Cardiotonic Agents; Coenzymes; Enoximone; Heart; Heart Failure; Hemodynamics; Humans; Imidazoles; Injections, Intravenous; Milrinone; Nifedipine; Oxyfedrine; Phosphodiesterase Inhibitors; Pyridazines; Pyridones; Quinazolines; Ubiquinone | 1986 |
Long-term oral therapy of congestive heart failure with phosphodiesterase inhibitors.
Topics: Administration, Oral; Amrinone; Enoximone; Heart Failure; Humans; Imidazoles; Milrinone; Phosphodiesterase Inhibitors; Pyridones | 1989 |
Effects of new inotropic agents on exercise performance.
Topics: Adrenergic beta-Agonists; Aminopyridines; Amrinone; Cardiac Output; Cardiotonic Agents; Chronic Disease; Enoximone; Heart Failure; Humans; Imidazoles; Milrinone; Muscles; Oxygen; Oxygen Consumption; Physical Exertion; Pulmonary Wedge Pressure; Pyridones; Time Factors | 1986 |
7 trial(s) available for piroximone and Heart Failure
| Article | Year |
|---|---|
[Acute hemodynamic effects of piroximone i.v. in patients with severe heart failure].
Topics: Adult; Aged; Cardiac Catheterization; Cardiac Output; Cardiomyopathy, Dilated; Cardiotonic Agents; Coronary Disease; Dose-Response Relationship, Drug; Electrocardiography, Ambulatory; Female; Heart Failure; Hemodynamics; Humans; Imidazoles; Infusions, Intravenous; Male; Middle Aged; Single-Blind Method; Thermodilution | 1995 |
Effects of piroximone on the right ventricular function in severe heart failure patients.
Topics: Adult; Aged; Cardiotonic Agents; Dose-Response Relationship, Drug; Epoprostenol; Female; Heart Failure; Hemodynamics; Humans; Imidazoles; Least-Squares Analysis; Male; Middle Aged; Myocardial Contraction; Phosphodiesterase Inhibitors; Ventricular Function, Right | 1994 |
Additive haemodynamic effects of piroximone and prostacyclin in severe chronic heart failure.
Topics: Adult; Aged; Cardiotonic Agents; Drug Synergism; Drug Therapy, Combination; Epoprostenol; Female; Heart; Heart Failure; Heart Rate; Hemodynamics; Humans; Imidazoles; Male; Middle Aged; Pulmonary Circulation; Vascular Resistance | 1994 |
Piroximone, dobutamine and nitroprusside: comparative effects on haemodynamics in patients with congestive heart failure.
Topics: Adult; Aged; Analysis of Variance; Cardiotonic Agents; Dobutamine; Female; Heart Failure; Hemodynamics; Humans; Imidazoles; Male; Middle Aged; Nitroprusside; Random Allocation | 1991 |
Long-term treatment with piroximone in patients with chronic heart failure.
Topics: Adult; Aged; Analysis of Variance; Arrhythmias, Cardiac; Cardiotonic Agents; Electrocardiography; Exercise; Female; Follow-Up Studies; Heart Failure; Hemodynamics; Humans; Imidazoles; Male; Middle Aged; Multivariate Analysis | 1990 |
Piroximone (MDL 19,205) in the treatment of unstable and stable chronic cardiac failure.
Topics: Administration, Oral; Cardiotonic Agents; Chronic Disease; Clinical Trials as Topic; Exercise Test; Heart Failure; Hemodynamics; Humans; Imidazoles; Infusions, Intravenous; Thermodilution; Time Factors | 1987 |
Persistent hemodynamic effects without long-term clinical benefits in response to oral piroximone (MDL 19,205) in patients with congestive heart failure.
Topics: Administration, Oral; Adult; Aged; Cardiotonic Agents; Clinical Trials as Topic; Female; Heart Failure; Hemodynamics; Humans; Imidazoles; Male; Middle Aged; Norepinephrine; Physical Exertion; Renin; Time Factors | 1986 |
15 other study(ies) available for piroximone and Heart Failure
| Article | Year |
|---|---|
Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for t
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiotonic Agents; Dogs; Female; Fibrinolytic Agents; Heart Failure; Humans; Imidazoles; Male; Myocardial Contraction; Platelet Aggregation; Pyridazines; Structure-Activity Relationship; Vasodilator Agents | 1989 |
Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blood Platelets; Cardiotonic Agents; Dogs; Drug Evaluation; Heart Failure; Humans; Myocardium; Platelet Aggregation; Quinazolines; Structure-Activity Relationship | 1988 |
Hemodynamic effects of a new inotropic agent, piroximone (MDL 19205), in patients with chronic heart failure.
Topics: Adult; Blood Pressure; Dobutamine; Heart Failure; Heart Rate; Hemodynamics; Humans; Imidazoles; Male; Middle Aged; Myocardial Contraction; Pulmonary Artery; Pulmonary Wedge Pressure; Stimulation, Chemical; Vascular Resistance | 1984 |
Hemodynamic effects and concentration-effect relationship of a graded infusion of piroximone in patients with severe heart failure.
Topics: Adult; Aged; Cardiotonic Agents; Dose-Response Relationship, Drug; Heart Failure; Hemodynamics; Humans; Imidazoles; Infusions, Intravenous; Male; Middle Aged; Water-Electrolyte Balance | 1993 |
[Continuous monitoring of cardiac output by analysis of the pulse contour].
Topics: Cardiac Output; Cardiotonic Agents; Female; Heart Failure; Humans; Imidazoles; Male; Middle Aged; Monitoring, Physiologic; Pulse; Systole; Thermodilution; Ventricular Function, Left | 1994 |
The influence of clinical intervention on pressure-volume relationships--the conductance (volume) technique.
Topics: Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Catheterization; Cardiac Pacing, Artificial; Cardiac Volume; Computer Graphics; Coronary Angiography; Coronary Disease; Enoximone; Heart Failure; Humans; Imidazoles; Myocardial Contraction; Myocardial Ischemia; Phosphodiesterase Inhibitors; Stroke Volume; Ventricular Function, Left | 1992 |
Acute hemodynamic effects of MDL 19205 in mild congestive heart failure.
Topics: Cardiotonic Agents; Heart Failure; Hemodynamics; Humans; Imidazoles; Injections, Intravenous; Male; Myocardial Contraction | 1987 |
Effects of long-term therapy with oral piroximone on resting hemodynamics, peak aerobic capacity, and the anaerobic threshold in patients with heart failure.
Topics: Administration, Oral; Adult; Aerobiosis; Aged; Anaerobiosis; Cardiotonic Agents; Exercise Test; Female; Heart Failure; Hemodynamics; Humans; Imidazoles; Injections, Intravenous; Male; Middle Aged; Time Factors | 1987 |
Hemodynamic effects of a constant intravenous infusion of piroximone in patients with severe congestive heart failure.
Topics: Aged; Cardiotonic Agents; Heart Failure; Hemodynamics; Humans; Imidazoles; Infusions, Intravenous; Male; Middle Aged | 1988 |
[Use of new inotropic agents in the treatment of acute cardiac failure].
Topics: Adrenergic Agonists; Amrinone; Calcium Channel Blockers; Cardiotonic Agents; Dobutamine; Dopamine; Enoximone; Heart Failure; Humans; Imidazoles; Milrinone; Myocardial Contraction; Pyridones | 1988 |
Amelioration of heart failure by MDL 17043 and MDL 19205, novel positive inotropic drugs, in dog heart-lung preparations.
Topics: Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Dogs; Dose-Response Relationship, Drug; Enoximone; Female; Heart Conduction System; Heart Failure; Heart Rate; Hemodynamics; Imidazoles; Male | 1985 |
Survival in severe left ventricular failure treated with the new nonglycosidic, nonsympathomimetic oral inotropic agents.
Topics: Administration, Oral; Aged; Anti-Arrhythmia Agents; Cardiotonic Agents; Death, Sudden; Drug Evaluation; Enoximone; Female; Heart Failure; Humans; Imidazoles; Male; Middle Aged; Milrinone; Pyridones; Quinazolines; Retrospective Studies; Time Factors | 1987 |
Hemodynamic and clinical evaluation of piroximone, a new inotrope-vasodilator agent, in severe congestive heart failure.
Topics: Aged; Aged, 80 and over; Cardiotonic Agents; Female; Follow-Up Studies; Heart; Heart Failure; Heart Ventricles; Hemodynamics; Humans; Imidazoles; Male; Middle Aged; Vasodilator Agents | 1987 |
Hemodynamic and regional blood flow response to piroximone (MDL 19,205) in dogs with congestive heart failure: a comparison with dobutamine.
Topics: Animals; Coronary Circulation; Dobutamine; Dogs; Heart Failure; Heart Rate; Hemodynamics; Imidazoles; Regional Blood Flow | 1987 |
Combined hemodynamic and scintigraphic assessment of piroximone (MDL 19,205) and comparison with dobutamine and nitroprusside.
Topics: Adult; Aged; Dobutamine; Drug Administration Schedule; Ferricyanides; Heart Failure; Hemodynamics; Humans; Imidazoles; Male; Middle Aged; Nitroprusside; Radionuclide Imaging | 1987 |