piritrexim has been researched along with Opportunistic Infections in 5 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Queener, SF | 1 |
| Borotz, SE; Carter, RL; Hosmer, CA; Johnson, CA; Krauth, CA; Pfefferkorn, ER; Piper, JR; Queener, SF | 1 |
| Adair, OO; Gangjee, A; Queener, SF | 1 |
| Forsch, RA; Inderlied, CB; Queener, SF; Rosowsky, A; Sibley, CH | 1 |
| Agrawal, VK; Khadikar, PV; Sohgaura, R | 1 |
1 review(s) available for piritrexim and Opportunistic Infections
| Article | Year |
|---|---|
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.
Topics: Animals; Drug Design; Humans; Immunosuppression Therapy; Molecular Structure; Opportunistic Infections; Pneumonia, Pneumocystis; Structure-Activity Relationship | 1995 |
4 other study(ies) available for piritrexim and Opportunistic Infections
| Article | Year |
|---|---|
Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
Topics: Animals; Anti-Infective Agents; Folic Acid Antagonists; Opportunistic Infections; Pneumocystis; Pneumonia, Pneumocystis; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma; Toxoplasmosis; Trimetrexate | 1996 |
Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cricetinae; Drug Screening Assays, Antitumor; Female; Folic Acid Antagonists; Humans; Mice; Mice, Inbred BALB C; Opportunistic Infections; Pneumocystis carinii; Pyridines; Pyrimidines; Rats; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma; Toxoplasmosis | 2003 |
New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.
Topics: AIDS-Related Opportunistic Infections; Animals; Folic Acid Antagonists; Humans; Inhibitory Concentration 50; Liver; Microbial Sensitivity Tests; Mycobacterium avium; Opportunistic Infections; Pneumocystis carinii; Pyrimidines; Rats; Recombinant Proteins; Species Specificity; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma | 2004 |
QSAR studies on biological activity of piritrexim analogues against pc DHFR.
Topics: Alcohol Oxidoreductases; Antineoplastic Agents; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Opportunistic Infections; Pneumocystis; Pyrimidines; Quantitative Structure-Activity Relationship; Regression Analysis | 2002 |