pirinixic acid has been researched along with Liver Neoplasms in 25 studies
pirinixic acid: structure
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Glutathione S-transferase placental (GST-P)-negative hepatocellular altered foci (HAF), hepatocellular adenoma (HCA), and hepatocellular carcinoma (HCC) were generated by two initiation-promotion models with N-nitrosodiethylamine (NDEN) and peroxisome proliferators, Wy-14,643 and clofibrate." | 3.72 | alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers. ( Fukushima, S; Kikuchi, K; Kushida, M; Mikami, N; Morimura, K; Oeda, K; Okuno, Y; Ozaki, K; Saito, K; Sukata, T; Sumida, K; Uwagawa, S, 2004) |
| "Co-treatment of rotenone and WY-14,643 (group IV) decreased focal DNA synthesis and mitosis and increased the incidence of apoptotic hepatocytes." | 1.30 | Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone. ( Ayoubi, SA; Isenberg, JS; Klaunig, JE; Kolaja, KL; Watkins, JB, 1997) |
| " Thus, in contrast to the non-mutagenicity of peroxisome proliferators in short-term assays, chronic administration of these compounds led to DNA alterations that were detectable by 32P-postlabeling assay." | 1.28 | Induction of rat liver DNA alterations by chronic administration of peroxisome proliferators as detected by 32P-postlabeling. ( Danna, TF; Randerath, E; Randerath, K; Rao, MS; Reddy, JK; Reddy, R, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.00) | 18.7374 |
| 1990's | 9 (36.00) | 18.2507 |
| 2000's | 12 (48.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fracchiolla, G | 1 |
| Lavecchia, A | 1 |
| Laghezza, A | 1 |
| Piemontese, L | 1 |
| Trisolini, R | 1 |
| Carbonara, G | 1 |
| Tortorella, P | 1 |
| Novellino, E | 1 |
| Loiodice, F | 1 |
| König, B | 1 |
| Koch, A | 1 |
| Spielmann, J | 1 |
| Hilgenfeld, C | 1 |
| Hirche, F | 1 |
| Stangl, GI | 1 |
| Eder, K | 1 |
| Martínez de Ubago, M | 1 |
| García-Oya, I | 1 |
| Pérez-Pérez, A | 1 |
| Canfrán-Duque, A | 1 |
| Quintana-Portillo, R | 1 |
| Rodríguez de Fonseca, F | 1 |
| González-Yanes, C | 1 |
| Sánchez-Margalet, V | 1 |
| Fischer, JG | 1 |
| Glauert, HP | 1 |
| Yin, T | 1 |
| Sweeney-Reeves, ML | 1 |
| Larmonier, N | 1 |
| Black, MC | 1 |
| Hironaka, K | 1 |
| Factor, VM | 1 |
| Calvisi, DF | 1 |
| Conner, EA | 1 |
| Thorgeirsson, SS | 1 |
| Sukata, T | 1 |
| Uwagawa, S | 1 |
| Ozaki, K | 1 |
| Sumida, K | 1 |
| Kikuchi, K | 1 |
| Kushida, M | 1 |
| Saito, K | 1 |
| Morimura, K | 3 |
| Oeda, K | 1 |
| Okuno, Y | 1 |
| Mikami, N | 1 |
| Fukushima, S | 1 |
| Cheung, C | 1 |
| Ward, JM | 1 |
| Reddy, JK | 5 |
| Gonzalez, FJ | 3 |
| Shah, YM | 1 |
| Yang, Q | 1 |
| Tanabe, T | 1 |
| Takagi, M | 1 |
| Muzio, G | 1 |
| Maggiora, M | 1 |
| Oraldi, M | 1 |
| Trombetta, A | 1 |
| Canuto, RA | 1 |
| Rao, MS | 3 |
| Lalwani, ND | 1 |
| Vu-Dac, N | 1 |
| Schoonjans, K | 1 |
| Kosykh, V | 1 |
| Dallongeville, J | 2 |
| Fruchart, JC | 2 |
| Staels, B | 2 |
| Auwerx, J | 1 |
| Cunningham, ML | 1 |
| Elwell, MR | 1 |
| Matthews, HB | 1 |
| Roberts, RA | 1 |
| Isenberg, JS | 1 |
| Kolaja, KL | 1 |
| Ayoubi, SA | 1 |
| Watkins, JB | 1 |
| Klaunig, JE | 1 |
| Hayashi, F | 1 |
| Motoki, Y | 1 |
| Tamura, H | 1 |
| Watanabe, T | 1 |
| Ogura, T | 1 |
| Esumi, H | 1 |
| Suga, T | 1 |
| Peters, JM | 1 |
| Aoyama, T | 1 |
| Cattley, RC | 4 |
| Nobumitsu, U | 1 |
| Hashimoto, T | 1 |
| Clavey, V | 1 |
| Copin, C | 1 |
| Mariotte, MC | 1 |
| Baugé, E | 1 |
| Chinetti, G | 1 |
| Fruchart, J | 1 |
| Anderson, SP | 1 |
| Corton, JC | 1 |
| Kaplanski, C | 1 |
| Pauley, CJ | 1 |
| Griffiths, TG | 1 |
| Kawabata, TT | 1 |
| Ledwith, BJ | 1 |
| Rose, ML | 1 |
| Rusyn, I | 1 |
| Bojes, HK | 1 |
| Belyea, J | 1 |
| Thurman, RG | 1 |
| Biegel, LB | 1 |
| Hurtt, ME | 1 |
| Frame, SR | 1 |
| O'Connor, JC | 1 |
| Cook, JC | 1 |
| Randerath, E | 1 |
| Randerath, K | 1 |
| Reddy, R | 1 |
| Danna, TF | 1 |
| Marsman, DS | 1 |
| Popp, JA | 1 |
| Gupta, RC | 1 |
| Goel, SK | 1 |
| Earley, K | 1 |
| Singh, B | 1 |
2 reviews available for pirinixic acid and Liver Neoplasms
| Article | Year |
|---|---|
Non-genotoxic hepatocarcinogenesis: suppression of apoptosis by peroxisome proliferators.
Topics: Animals; Anticholesteremic Agents; Apoptosis; Calcium; Cyproterone Acetate; DNA; DNA Fragmentation; | 1996 |
Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation.
Topics: Animals; Cell Division; Enzyme Activation; Glycine; Humans; Kupffer Cells; Liver; Liver Neoplasms; N | 2000 |
1 trial available for pirinixic acid and Liver Neoplasms
| Article | Year |
|---|---|
Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Apolipoprotein A-II; Apolipoproteins E; Base Sequence; Cells | 1995 |
22 other studies available for pirinixic acid and Liver Neoplasms
| Article | Year |
|---|---|
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity.
Topics: Binding Sites; Cell Line, Tumor; Computer Simulation; Hepatoblastoma; Humans; Liver Neoplasms; Model | 2008 |
Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Fatty Acid Synthases; Glycerol-3-Pho | 2009 |
Oleoylethanolamide, a natural ligand for PPAR-alpha, inhibits insulin receptor signalling in HTC rat hepatoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Dose-Response Relationship, Drug; Endocannabinoids; E | 2009 |
Moderate iron overload enhances lipid peroxidation in livers of rats, but does not affect NF-kappaB activation induced by the peroxisome proliferator, Wy-14,643.
Topics: Animals; DNA; DNA Damage; Iron Overload; Iron, Dietary; Lipid Peroxidation; Liver; Liver Neoplasms; | 2002 |
Dysregulation of DNA repair pathways in a transforming growth factor alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis.
Topics: Animals; Disease Models, Animal; DNA Damage; DNA Repair; Gene Expression Regulation; Genes, myc; Hep | 2003 |
alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers.
Topics: Adenoma; Alkylating Agents; alpha-Macroglobulins; Animals; Anticholesteremic Agents; Biomarkers, Tum | 2004 |
Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis.
Topics: Animals; Carcinogens; Cell Line; Cell Proliferation; Genetic Predisposition to Disease; Humans; Live | 2006 |
Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Gene Expression Profiling; | 2007 |
PPARalpha and PP2A are involved in the proapoptotic effect of conjugated linoleic acid on human hepatoma cell line SK-HEP-1.
Topics: Antineoplastic Agents; Apoptosis; Base Sequence; bcl-2 Homologous Antagonist-Killer Protein; bcl-Ass | 2007 |
Sequential histologic study of rat liver during peroxisome proliferator [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]-acetic acid (Wy-14,643)-induced carcinogenesis.
Topics: Animals; Anticholesteremic Agents; Carcinogens; Hyperplasia; Liver; Liver Neoplasms; Male; Microbodi | 1984 |
Relationship of carcinogenicity and cellular proliferation induced by mutagenic noncarcinogens vs carcinogens. III. Organophosphate pesticides vs tris(2,3-dibromopropyl)phosphate.
Topics: Animals; Cell Division; DNA Damage; Insecticides; Kidney; Kidney Neoplasms; Liver; Liver Neoplasms; | 1994 |
Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone.
Topics: Adenoma; Animals; Apoptosis; Body Weight; Bromodeoxyuridine; Carcinogens; Diethylnitrosamine; DNA; L | 1997 |
Induction of hepatic poly(ADP-ribose) polymerase by peroxisome proliferators, non-genotoxic hepatocarcinogens.
Topics: Administration, Oral; Animals; Carcinogens; Diethylhexyl Phthalate; Enzyme Induction; Liver; Liver N | 1998 |
Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver.
Topics: Acyl-CoA Oxidase; Animals; Cell Cycle; Cyclin-Dependent Kinases; Liver Neoplasms; Male; Mice; Oxidor | 1998 |
Cell culture conditions determine apolipoprotein CIII secretion and regulation by fibrates in human hepatoma HepG2 cells.
Topics: Animals; Anticholesteremic Agents; Apolipoprotein C-III; Apolipoproteins; Apolipoproteins C; Blood; | 1999 |
Hepatic expression of acute-phase protein genes during carcinogenesis induced by peroxisome proliferators.
Topics: Adenoma; Animals; Diethylhexyl Phthalate; Diethylnitrosamine; Gene Expression Regulation, Neoplastic | 1999 |
Differentiation of rat oval cells after activation of peroxisome proliferator-activated receptor alpha43.
Topics: Animals; Cell Differentiation; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Liver; Liver | 2000 |
Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats.
Topics: Adenocarcinoma; Animals; Caprylates; Carcinogenicity Tests; Carcinogens; Cell Division; Diet; Estrad | 2001 |
Enhancement by Wy-14,643, a hepatic peroxisome proliferator, of diethylnitrosamine-initiated hepatic tumorigenesis in the rat.
Topics: Acetates; Animals; Cell Division; Clofibrate; Diethylnitrosamine; Drug Synergism; Liver; Liver Neopl | 1978 |
Induction of rat liver DNA alterations by chronic administration of peroxisome proliferators as detected by 32P-postlabeling.
Topics: Affinity Labels; Animals; Clofibric Acid; DNA Damage; DNA, Neoplasm; Fibric Acids; Hypolipidemic Age | 1991 |
Failure of the peroxisome proliferator WY-14,643 to initiate growth-selectable foci in rat liver.
Topics: Animals; Carcinogens; Hepatectomy; Hydrogen Peroxide; Liver Neoplasms; Male; Microbodies; Oxidoreduc | 1989 |
32P-postlabeling analysis of peroxisome proliferator-DNA adduct formation in rat liver in vivo and hepatocytes in vitro.
Topics: Animals; Anticholesteremic Agents; Carcinogens; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; | 1985 |