pirinixic acid has been researched along with Injury, Myocardial Reperfusion in 9 studies
pirinixic acid: structure
| Excerpt | Relevance | Reference |
|---|---|---|
| " Langendorff-perfused hearts of rats pretreated with the selective PPAR-α agonist WY-14643 (WY, pirinixic acid; 3 mg·(kg body mass)·day(-1); 5 days) were subjected to 30 min ischaemia - 2 h reperfusion with or without the phosphatidylinositol 3-kinase (PI3K)-Akt inhibitor wortmannin for the evaluation of functional (left ventricular developed pressure, LVDP) recovery, infarct size (IS), and reperfusion-induced arrhythmias." | 3.78 | PPAR-alpha activation as a preconditioning-like intervention in rats in vivo confers myocardial protection against acute ischaemia-reperfusion injury: involvement of PI3K-Akt. ( Adameová, A; Barlaka, E; Carnická, S; Galatou, E; Kelly, T; Khandelwal, VK; Lazou, A; Ledvényiová, V; Nemčeková, M; Ravingerová, T, 2012) |
| "During reperfusion, the incidence of arrhythmia was higher in the control group compared with the WY-14643 group (9/10 versus 3/10, P<0." | 1.43 | Protective Effect of Peroxisome Proliferator-Activated Receptor α Activation against Cardiac Ischemia-Reperfusion Injury Is Related to Upregulation of Uncoupling Protein-3. ( Kim, HJ; Kim, JW; Kwak, YL; Lee, H; Song, JW, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barlaka, E | 3 |
| Ledvényiová, V | 4 |
| Galatou, E | 3 |
| Ferko, M | 2 |
| Čarnická, S | 4 |
| Ravingerová, T | 4 |
| Lazou, A | 3 |
| Nemčeková, M | 3 |
| Muráriková, M | 1 |
| Chytilová, A | 1 |
| Mandíková, P | 1 |
| Adameová, A | 2 |
| Kolář, F | 1 |
| Song, JW | 1 |
| Kim, HJ | 1 |
| Lee, H | 1 |
| Kim, JW | 1 |
| Kwak, YL | 1 |
| Bulhak, AA | 2 |
| Jung, C | 1 |
| Ostenson, CG | 1 |
| Lundberg, JO | 1 |
| Sjöquist, PO | 2 |
| Pernow, J | 2 |
| Kelly, T | 1 |
| Khandelwal, VK | 1 |
| Xu, CB | 1 |
| Edvinsson, L | 1 |
| Yeh, CH | 1 |
| Chen, TP | 1 |
| Lee, CH | 1 |
| Wu, YC | 1 |
| Lin, YM | 1 |
| Lin, PJ | 1 |
| Wayman, NS | 1 |
| Hattori, Y | 1 |
| McDonald, MC | 1 |
| Mota-Filipe, H | 1 |
| Cuzzocrea, S | 1 |
| Pisano, B | 1 |
| Chatterjee, PK | 1 |
| Thiemermann, C | 1 |
9 other studies available for pirinixic acid and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Delayed cardioprotective effects of WY-14643 are associated with inhibition of MMP-2 and modulation of Bcl-2 family proteins through PPAR-α activation in rat hearts subjected to global ischaemia-reperfusion.
Topics: Animals; Heart Function Tests; In Vitro Techniques; Male; Matrix Metalloproteinase 2; Matrix Metallo | 2013 |
Treatment of rats with hypolipidemic compound pirinixic acid protects their hearts against ischemic injury: are mitochondrial K(ATP) channels and reactive oxygen species involved?
Topics: Animals; Cardiotonic Agents; Cytoprotection; Disease Models, Animal; Hypolipidemic Agents; Lipid Per | 2013 |
Upregulation of genes involved in cardiac metabolism enhances myocardial resistance to ischemia/reperfusion in the rat heart.
Topics: Animals; Male; Myocardial Reperfusion Injury; Myocardium; PPAR alpha; Pyrimidines; Rats; Rats, Wista | 2013 |
Protective Effect of Peroxisome Proliferator-Activated Receptor α Activation against Cardiac Ischemia-Reperfusion Injury Is Related to Upregulation of Uncoupling Protein-3.
Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Cell Hypoxia; Cell Line; Cell Survival; Coronary | 2016 |
PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway.
Topics: Androstadienes; Animals; Blood Glucose; Body Weight; Cardiotonic Agents; Diabetes Mellitus, Type 2; | 2009 |
PPAR-alpha activation as a preconditioning-like intervention in rats in vivo confers myocardial protection against acute ischaemia-reperfusion injury: involvement of PI3K-Akt.
Topics: Androstadienes; Animals; Arrhythmias, Cardiac; Chymases; Disease Models, Animal; Male; Myocardial In | 2012 |
Protection against myocardial ischaemia/reperfusion injury by PPAR-alpha activation is related to production of nitric oxide and endothelin-1.
Topics: Animals; Blood Pressure; Endothelin-1; Enzyme Inhibitors; Heart Rate; Immunoblotting; Male; Myocardi | 2006 |
Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators.
Topics: Animals; Apoptosis; Cardiopulmonary Bypass; Caspase 3; Caspases; Cell Adhesion Molecules; Cytokines; | 2006 |
Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size.
Topics: Adult; Animals; Cardiotonic Agents; Cell Adhesion Molecules; Cell Line; Cells, Cultured; Chemokine C | 2002 |