pirinixic acid has been researched along with Experimental Hepatoma in 46 studies
pirinixic acid: structure
| Excerpt | Relevance | Reference |
|---|---|---|
| " Following chronic treatment, altered hepatic foci and adenomas were classified as: small-cell, heterogeneous basophilic lesions (spontaneous or tetrachlorodibenzo-p-dioxin-induced); large-cell, homogeneous basophilic lesions (WY-14,643-induced); acidophilic lesions (phenobarbital- or chlordane-induced)." | 3.70 | Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice. ( Anderson, SP; Cattley, RC; Christensen, JG; Corton, JC; Fox, TR; Goldsworthy, TL; Gonzales, AJ; Healy, LN; Malarkey, DE; Romach, EH, 1999) |
| "Hepatocellular adenomas were increased in W-37 (11/20 rats and 0." | 1.29 | Biological potential of basophilic hepatocellular foci and hepatic adenoma induced by the peroxisome proliferator, Wy-14,643. ( Marsman, DS; Popp, JA, 1994) |
| "In ciprofibrate-treated animals 52% and 75% of AA were negative for GST-P and GGT, respectively, and 16% was positive for both the enzymes." | 1.27 | Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione S-transferase and gamma-glutamyltranspeptidase. ( Ito, N; Rao, MS; Reddy, JK; Subbarao, V; Tatematsu, M, 1986) |
| "Altered areas (AA), neoplastic nodules (NN) and hepatocellular carcinomas (HCC) induced by chronic administration of ciprofibrate and Wy-14,643 were examined for iron accumulation after systemic iron overload." | 1.27 | Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats. ( Rao, MS; Reddy, JK; Subbarao, V, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (19.57) | 18.7374 |
| 1990's | 23 (50.00) | 18.2507 |
| 2000's | 12 (26.09) | 29.6817 |
| 2010's | 2 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qu, A | 1 |
| Jiang, C | 1 |
| Cai, Y | 1 |
| Kim, JH | 1 |
| Tanaka, N | 1 |
| Ward, JM | 1 |
| Shah, YM | 1 |
| Gonzalez, FJ | 4 |
| Cho, WS | 1 |
| Jeong, J | 1 |
| Choi, M | 1 |
| Park, SN | 1 |
| Han, BS | 1 |
| Son, WC | 1 |
| Youssef, JA | 1 |
| Bouziane, M | 1 |
| Badr, MZ | 1 |
| Iida, M | 1 |
| Anna, CH | 1 |
| Hartis, J | 1 |
| Bruno, M | 1 |
| Wetmore, B | 1 |
| Dubin, JR | 1 |
| Sieber, S | 1 |
| Bennett, L | 1 |
| Cunningham, ML | 1 |
| Paules, RS | 1 |
| Tomer, KB | 1 |
| Houle, CD | 1 |
| Merrick, AB | 1 |
| Sills, RC | 1 |
| Devereux, TR | 1 |
| Moennikes, O | 1 |
| Stahl, S | 1 |
| Bannasch, P | 1 |
| Buchmann, A | 1 |
| Schwarz, M | 2 |
| Suga, T | 5 |
| Glauert, HP | 1 |
| Eyigor, A | 1 |
| Tharappel, JC | 1 |
| Cooper, S | 1 |
| Lee, EY | 1 |
| Spear, BT | 1 |
| Trapp, C | 1 |
| Epe, B | 1 |
| Rao, MS | 5 |
| Lalwani, ND | 3 |
| Scarpelli, DG | 2 |
| Reddy, JK | 7 |
| Reddy, MK | 1 |
| Qureshi, SA | 1 |
| Marsman, DS | 6 |
| Popp, JA | 9 |
| Miller, RT | 4 |
| Cattley, RC | 14 |
| Lyght, O | 1 |
| Hayashi, F | 1 |
| Tamura, H | 4 |
| Yamada, J | 1 |
| Kasai, H | 1 |
| Green, S | 2 |
| Issemann, I | 1 |
| Tugwood, JD | 1 |
| Prince, RA | 1 |
| Aldridge, TC | 1 |
| Hanausek, M | 1 |
| Sherman, U | 1 |
| Mirowski, M | 1 |
| Adams, AK | 1 |
| Walaszek, Z | 1 |
| Lake, BG | 1 |
| Evans, JG | 1 |
| Cunninghame, ME | 1 |
| Price, RJ | 1 |
| Kato, M | 1 |
| Teets, VJ | 1 |
| Voss, KS | 1 |
| Wahli, W | 1 |
| Ledwith, BJ | 1 |
| Manam, S | 1 |
| Troilo, P | 1 |
| Joslyn, DJ | 1 |
| Galloway, SM | 1 |
| Nichols, WW | 1 |
| Glover, SE | 1 |
| Stewart, WS | 1 |
| Corton, JC | 5 |
| Roberts, RA | 1 |
| Motoki, Y | 2 |
| Morita, R | 1 |
| Watanabe, T | 3 |
| Peters, JM | 3 |
| Motojima, K | 1 |
| Passilly, P | 1 |
| Latruffe, N | 1 |
| Rose, ML | 2 |
| Rivera, CA | 1 |
| Bradford, BU | 1 |
| Graves, LM | 1 |
| Schoonhoven, R | 1 |
| Swenberg, JA | 1 |
| Thurman, RG | 2 |
| Swanson, C | 1 |
| Moreno, ES | 1 |
| Merritt, A | 1 |
| Bocos, C | 1 |
| Christensen, JG | 1 |
| Romach, EH | 1 |
| Healy, LN | 1 |
| Gonzales, AJ | 1 |
| Anderson, SP | 2 |
| Malarkey, DE | 1 |
| Fox, TR | 1 |
| Goldsworthy, TL | 2 |
| Dunn, C | 1 |
| Wong, V | 1 |
| Li, X | 1 |
| Rockett, JC | 1 |
| Swales, KE | 1 |
| Esdaile, DJ | 1 |
| Gibson, GG | 1 |
| Tobin, KA | 1 |
| Steineger, HH | 1 |
| Alberti, S | 1 |
| Spydevold, O | 1 |
| Auwerx, J | 1 |
| Gustafsson, JA | 1 |
| Nebb, HI | 1 |
| Wada, N | 1 |
| Zhang, H | 1 |
| Unrin, H | 1 |
| Kiss, A | 1 |
| Ortiz-Aguayo, R | 1 |
| Sharp, R | 1 |
| Merlino, G | 1 |
| Thorgeirsson, SS | 1 |
| Eacho, PI | 1 |
| Lanier, TL | 1 |
| Brodhecker, CA | 1 |
| Giometti, CS | 1 |
| Taylor, J | 1 |
| Gemmell, MA | 1 |
| Tollaksen, SL | 1 |
| Nemali, MR | 1 |
| Usuda, N | 1 |
| Makino, T | 1 |
| Pitot, HC | 1 |
| Tatematsu, M | 1 |
| Subbarao, V | 2 |
| Ito, N | 1 |
| Conway, JG | 2 |
| Tomaszewski, KE | 1 |
| Olson, MJ | 1 |
4 reviews available for pirinixic acid and Experimental Hepatoma
| Article | Year |
|---|---|
Hepatocarcinogenesis by peroxisome proliferators.
Topics: Administration, Oral; Animals; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Liv | 2004 |
Delineating peroxisome proliferator action to improve human risk assessment.
Topics: Acyl-CoA Oxidase; Animals; Base Sequence; Clofibrate; Cloning, Molecular; Diethylhexyl Phthalate; DN | 1994 |
Peroxisome proliferator-activated receptors: finding the orphan a home.
Topics: Acyl-CoA Oxidase; Animals; Base Sequence; Carcinogens; Clofibrate; Cytochrome P-450 Enzyme System; F | 1994 |
Non-genotoxic hepatocarcinogenesis: suppression of apoptosis by peroxisome proliferators.
Topics: Animals; Anticholesteremic Agents; Apoptosis; Calcium; Cyproterone Acetate; DNA; DNA Fragmentation; | 1996 |
42 other studies available for pirinixic acid and Experimental Hepatoma
| Article | Year |
|---|---|
Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.
Topics: Animals; Cell Proliferation; Fatty Acids; Gene Knockout Techniques; Genes, myc; Hepatocytes; Liver N | 2014 |
26-Week carcinogenicity study of di-isodecyl phthalate by dietary administration to CB6F1-rasH2 transgenic mice.
Topics: Adenoma, Liver Cell; Administration, Oral; Animals; Carcinogenicity Tests; Carcinogens; Clofibrate; | 2011 |
Age-dependent effects of nongenotoxic hepatocarcinogens on liver apoptosis in vivo.
Topics: Aging; Animals; Apoptosis; Carcinogens; Cell Count; Cholesterol; Clofibrate; Hepatocytes; Hepatomega | 2003 |
Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643.
Topics: Animals; Base Sequence; Carcinogens; DNA Primers; Gene Expression Regulation, Neoplastic; Liver Neop | 2003 |
WY-14,643-mediated promotion of hepatocarcinogenesis in connexin32-wild-type and connexin32-null mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Connexins; Gap Junction beta-1 Protein; Liver Neoplasms, Exp | 2003 |
Inhibition of hepatocarcinogenesis by the deletion of the p50 subunit of NF-kappaB in mice administered the peroxisome proliferator Wy-14,643.
Topics: Acyl-CoA Oxidase; Adenoma, Liver Cell; Animals; Apoptosis; Carcinogens; Cell Proliferation; Diethyln | 2006 |
The peroxisome proliferator WY-14,643 promotes hepatocarcinogenesis caused by endogenously generated oxidative DNA base modifications in repair-deficient Csbm/m/Ogg1-/- mice.
Topics: Animals; Cocarcinogenesis; DNA Damage; DNA Glycosylases; DNA Repair; DNA Repair Enzymes; Guanine; Li | 2007 |
The absence of gamma-glutamyl transpeptidase activity in putative preneoplastic lesions and in hepatocellular carcinomas induced in rats by the hypolipidemic peroxisome proliferator Wy-14,643.
Topics: Acyltransferases; Animals; Anticholesteremic Agents; Hyperplasia; Liver; Liver Neoplasms, Experiment | 1982 |
Development of hepatocellular carcinomas and increased peroxisomal fatty acid beta-oxidation in rats fed [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid (Wy-14,643) in the semipurified diet.
Topics: Animals; Diet; Fatty Acids; Hydrogen Peroxide; Hypolipidemic Agents; Liver Neoplasms, Experimental; | 1981 |
Biological potential of basophilic hepatocellular foci and hepatic adenoma induced by the peroxisome proliferator, Wy-14,643.
Topics: Adenoma, Liver Cell; Adenosine Triphosphatases; Animals; Carcinogens; Cell Division; Liver; Liver Ne | 1994 |
TGF alpha differentially expressed in liver foci induced by diethylnitrosamine initiation and peroxisome proliferator promotion.
Topics: Animals; Carcinogens; Cell Division; Diethylnitrosamine; ErbB Receptors; Growth Substances; Liver; L | 1995 |
Characteristics of the hepatocarcinogenesis caused by dehydroepiandrosterone, a peroxisome proliferator, in male F-344 rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogens; Dehydroepiandrosterone; Deoxyguanosine; Diethylhe | 1994 |
Induction of a 65-kDa tumor-associated protein in altered hepatic foci of rats fed the peroxisome proliferator Wy-14,643.
Topics: Animals; Gene Expression Regulation; Hyperplasia; Lipofuscin; Liver; Liver Neoplasms, Experimental; | 1994 |
Comparison of the hepatic effects of nafenopin and WY-14,643 on peroxisome proliferation and cell replication in the rat and Syrian hamster.
Topics: Animals; Carcinogens; Cell Division; Cricetinae; DNA Replication; Fatty Acids; Liver; Liver Neoplasm | 1993 |
Initiator-specific promotion of hepatocarcinogenesis by WY-14,643 and clofibrate.
Topics: 2-Acetylaminofluorene; Animals; Clofibrate; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; | 1994 |
Activation of immediate-early gene expression by peroxisome proliferators in vitro.
Topics: 3T3 Cells; Animals; Carcinogens; Diethylhexyl Phthalate; DNA Damage; Gene Expression Regulation; Gen | 1993 |
Effect on the expression of c-met, c-myc and PPAR-alpha in liver and liver tumors from rats chronically exposed to the hepatocarcinogenic peroxisome proliferator WY-14,643.
Topics: Animals; Carcinogens; Cell Division; Gene Expression; Genes, myc; Liver; Liver Neoplasms, Experiment | 1996 |
Decreased hepatocyte growth factor level by Wy-14,643, non-genotoxic hepatocarcinogen in F-344 rats.
Topics: Animals; Carcinogens; Hepatocyte Growth Factor; Kidney; Liver Neoplasms, Experimental; Lung; Male; P | 1997 |
Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643.
Topics: Animals; Carcinogens; DNA; Liver; Liver Neoplasms, Experimental; Male; Mice; Microbodies; Pyrimidine | 1997 |
Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner.
Topics: Adipates; Adipose Tissue; Animals; Base Sequence; CD36 Antigens; Clofibrate; Diethylhexyl Phthalate; | 1998 |
Kupffer cell oxidant production is central to the mechanism of peroxisome proliferators.
Topics: Animals; Calcium Signaling; Cell Division; Cell Transformation, Neoplastic; Diet; Diethylhexyl Phtha | 1999 |
Alteration of protein kinase C isoform-specific expression during rat hepatocarcinogenesis after exposure to the peroxisome proliferator WY-14,643.
Topics: Adenoma; Animals; Carcinogens; Chloroform; Liver Neoplasms, Experimental; Male; Neoplasm Proteins; P | 1999 |
Cloning genes responsive to a hepatocarcinogenic peroxisome proliferator chemical reveals novel targets of regulation.
Topics: Animals; Base Sequence; Cloning, Molecular; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; | 1998 |
Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice.
Topics: Adenoma; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Carcinogens; Carcinoma; Carr | 1999 |
Dietary glycine prevents the development of liver tumors caused by the peroxisome proliferator WY-14,643.
Topics: Animals; Body Weight; Cell Division; Diet; Glycine; Liver Neoplasms, Experimental; Male; Organ Size; | 1999 |
Apoptosis, mitosis and cyclophilin-40 expression in regressing peroxisome proliferator-induced adenomas.
Topics: Adenoma; Animals; Apoptosis; Carrier Proteins; Cyclophilins; Liver; Liver Neoplasms, Experimental; M | 2000 |
Use of suppression-PCR subtractive hybridisation to identify genes that demonstrate altered expression in male rat and guinea pig livers following exposure to Wy-14,643, a peroxisome proliferator and non-genotoxic hepatocarcinogen.
Topics: Animals; Carcinogens; Cloning, Molecular; DNA; DNA Primers; Gene Expression Regulation; Guinea Pigs; | 2000 |
Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha.
Topics: alpha-Linolenic Acid; Animals; Cells, Cultured; Cholesterol; Dietary Fats; DNA-Binding Proteins; Fas | 2000 |
Involvement of hepatocyte growth factor on hepatocarcinogenesis induced by peroxisome proliferators.
Topics: Animals; Dose-Response Relationship, Drug; Drug Antagonism; Gene Expression Regulation, Neoplastic; | 2000 |
Phosphorylation of 13 kDa nuclear protein in hepatocarcinomas induced by peroxisome proliferators.
Topics: Animals; Liver Neoplasms, Experimental; Male; Nuclear Proteins; Peroxisome Proliferators; Phosphoryl | 2000 |
Evidence that reduction of hepatocyte growth factor (HGF) is not required for peroxisome proliferator-induced hepatocyte proliferation.
Topics: Animals; Carcinogens; Cell Division; Hepatocyte Growth Factor; Hepatocytes; Humans; Liver Neoplasms, | 2001 |
Enhancement by Wy-14,643, a hepatic peroxisome proliferator, of diethylnitrosamine-initiated hepatic tumorigenesis in the rat.
Topics: Acetates; Animals; Cell Division; Clofibrate; Diethylnitrosamine; Drug Synergism; Liver; Liver Neopl | 1978 |
Contrasting hepatocytic peroxisome proliferation, lipofuscin accumulation and cell turnover for the hepatocarcinogens Wy-14,643 and clofibric acid.
Topics: Animals; Body Weight; Carcinogenicity Tests; Cell Death; Cell Division; Clofibric Acid; DNA, Neoplas | 1992 |
Age-related susceptibility to the carcinogenic effect of the peroxisome proliferator WY-14,643 in rat liver.
Topics: Aging; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; DNA; Liver; Liver Neoplasms, Ex | 1991 |
Hepatocellular DNA synthesis in rats given peroxisome proliferating agents: comparison of WY-14,643 to clofibric acid, nafenopin and LY171883.
Topics: Acetophenones; Animals; Bromodeoxyuridine; Clofibric Acid; DNA Replication; Immunohistochemistry; Li | 1991 |
Quantitative changes in sets of proteins as markers of biological response.
Topics: Animals; Biomarkers; Carcinogens; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Electrophoresi | 1991 |
Lack of expression of glutathione-S-transferase P, gamma-glutamyl transpeptidase, and alpha-fetoprotein messenger RNAs in liver tumors induced by peroxisome proliferators.
Topics: alpha-Fetoproteins; Animals; Cell Division; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; | 1988 |
Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver.
Topics: Adenosine Triphosphatases; Animals; Anticholesteremic Agents; Carcinogens; Diethylnitrosamine; gamma | 1989 |
Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione S-transferase and gamma-glutamyltranspeptidase.
Topics: Animals; Cell Division; Clofibric Acid; Fibric Acids; gamma-Glutamyltransferase; Glutathione Transfe | 1986 |
Relationship of oxidative damage to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and Wy-14,643.
Topics: Animals; Anticholesteremic Agents; Cell Division; Diethylhexyl Phthalate; Enzyme Induction; Hydrogen | 1989 |
Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats.
Topics: Animals; Body Weight; Cell Division; Diethylhexyl Phthalate; DNA; DNA Replication; Eating; Liver; Li | 1988 |
Increased resistance of peroxisome proliferator-induced hepatic lesions to iron overload in rats.
Topics: Animals; Cell Division; Clofibrate; Clofibric Acid; Fibric Acids; Iron; Liver; Liver Neoplasms, Expe | 1986 |