pirinixic acid has been researched along with Enlarged Liver in 14 studies
pirinixic acid: structure
| Excerpt | Relevance | Reference |
|---|---|---|
| "PPARα activation induces hepatomegaly and plays an important role in liver regeneration, but the underlying mechanisms remain unclear." | 1.72 | YAP-TEAD mediates PPAR α-induced hepatomegaly and liver regeneration in mice. ( Bi, H; Fan, S; Gao, Y; Gonzalez, FJ; Huang, M; Jiang, Y; Li, H; Qu, A; Tian, J; Wang, R; Xie, G; Yagai, T; Yang, X; Yao, X; Zhu, S, 2022) |
| " To evaluate the effects of PFHxS and PFNA, male wild-type and Pparα-null mice were dosed by oral gavage with PFHxS (3 or 10mg/kg/day), PFNA (1 or 3mg/kg/day), or vehicle for 7days, and liver gene expression was evaluated by full-genome microarrays." | 1.46 | PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling. ( Abbott, B; Corton, JC; Das, KP; Lau, C; Rooney, J; Rosen, MB, 2017) |
| "WY-14,643 treatment induced hepatomegaly in wild type (WT) mice that was also accompanied by induction of the expression of cyclins D1, D3, A2, and B1 and Cdc2 as well as inhibition of Wee 1." | 1.35 | Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis. ( Gyamfi, MA; Wan, YJ, 2009) |
| "Fumonisin B1 (FB1) is a rodent liver carcinogen and suspected human carcinogen." | 1.33 | Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha. ( Anderson, SP; Bacon, CW; Corton, JC; Dunn, C; Liu, J; Miller, JD; Owen, JR; Riley, RT; Voss, KA, 2006) |
| "Gemfibrozil is a widely used hypolipidemic drug in humans that causes peroxisome proliferation and hepatocarcinogenesis in rodents." | 1.29 | Gemfibrozil-induced peroxisome proliferation and hepatomegaly in male F344 rats. ( Cattley, RC; Miller, RT; Sausen, PJ; Teets, VJ; Voss, KS, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, J | 1 |
| Yang, X | 2 |
| Zhang, YF | 1 |
| Tian, JN | 1 |
| Fan, SC | 1 |
| Gao, Y | 2 |
| Li, HL | 1 |
| Cai, CH | 1 |
| Huang, M | 2 |
| Bi, HC | 1 |
| Fan, S | 1 |
| Qu, A | 2 |
| Jiang, Y | 1 |
| Li, H | 1 |
| Xie, G | 1 |
| Yao, X | 1 |
| Zhu, S | 1 |
| Yagai, T | 1 |
| Tian, J | 1 |
| Wang, R | 1 |
| Gonzalez, FJ | 2 |
| Bi, H | 1 |
| Rosen, MB | 1 |
| Das, KP | 1 |
| Rooney, J | 1 |
| Abbott, B | 1 |
| Lau, C | 1 |
| Corton, JC | 2 |
| Faiola, B | 1 |
| Falls, JG | 1 |
| Peterson, RA | 1 |
| Bordelon, NR | 1 |
| Brodie, TA | 1 |
| Cummings, CA | 1 |
| Romach, EH | 1 |
| Miller, RT | 2 |
| Gyamfi, MA | 1 |
| Wan, YJ | 2 |
| Shah, YM | 1 |
| Matsubara, T | 1 |
| Yang, Q | 1 |
| Fidaleo, M | 1 |
| Arnauld, S | 1 |
| Clémencet, MC | 1 |
| Chevillard, G | 1 |
| Royer, MC | 1 |
| De Bruycker, M | 1 |
| Wanders, RJ | 1 |
| Athias, A | 1 |
| Gresti, J | 1 |
| Clouet, P | 1 |
| Degrace, P | 1 |
| Kersten, S | 1 |
| Espeel, M | 1 |
| Latruffe, N | 1 |
| Nicolas-Francès, V | 1 |
| Mandard, S | 1 |
| Youssef, JA | 1 |
| Bouziane, M | 1 |
| Badr, MZ | 1 |
| Voss, KA | 1 |
| Liu, J | 1 |
| Anderson, SP | 1 |
| Dunn, C | 1 |
| Miller, JD | 1 |
| Owen, JR | 1 |
| Riley, RT | 1 |
| Bacon, CW | 1 |
| Plant, KE | 1 |
| Everett, DM | 1 |
| Gordon Gibson, G | 1 |
| Lyon, J | 1 |
| Plant, NJ | 1 |
| Sausen, PJ | 1 |
| Teets, VJ | 1 |
| Voss, KS | 1 |
| Cattley, RC | 1 |
| Choudhury, AI | 1 |
| Chahal, S | 1 |
| Bell, AR | 1 |
| Tomlinson, SR | 1 |
| Roberts, RA | 1 |
| Salter, AM | 1 |
| Bell, DR | 1 |
| Cai, Y | 1 |
| Konishi, T | 1 |
| Han, G | 1 |
| Campwala, KH | 1 |
| French, SW | 1 |
| Smith, PF | 1 |
| O'Brien, KA | 1 |
| Keenan, KP | 1 |
14 other studies available for pirinixic acid and Enlarged Liver
| Article | Year |
|---|---|
Peroxisome proliferator-activated receptor α agonist induces mouse hepatomegaly through the spatial hepatocyte enlargement and proliferation.
Topics: Animals; Cell Proliferation; Hepatocytes; Hepatomegaly; Hypertrophy; Liver; Mice; Mice, Knockout; PP | 2023 |
YAP-TEAD mediates PPAR α-induced hepatomegaly and liver regeneration in mice.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Gene Expression Regulation; Gene Knockdown Tech | 2022 |
PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling.
Topics: Animals; Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Computational Biology; Co | 2017 |
PPAR alpha, more than PPAR delta, mediates the hepatic and skeletal muscle alterations induced by the PPAR agonist GW0742.
Topics: Animals; Dose-Response Relationship, Drug; Hepatomegaly; Liver; Male; Mice; Mice, Inbred C57BL; Mice | 2008 |
Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis.
Topics: Animals; Bile Acids and Salts; Cell Proliferation; Cholestasis; Cholesterol 7-alpha-Hydroxylase; Cyt | 2009 |
PPARalpha-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells.
Topics: Animals; Cell Cycle; Cell Proliferation; DNA Damage; DNA Repair; Gene Expression; Gene Expression Pr | 2010 |
A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver.
Topics: Acetyl-CoA C-Acyltransferase; Animals; Cholesterol; Gene Deletion; Gene Expression Regulation; Hepat | 2011 |
Age-dependent effects of nongenotoxic hepatocarcinogens on liver apoptosis in vivo.
Topics: Aging; Animals; Apoptosis; Carcinogens; Cell Count; Cholesterol; Clofibrate; Hepatocytes; Hepatomega | 2003 |
Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha.
Topics: Administration, Oral; Animals; Apoptosis; Carcinogens, Environmental; Cell Proliferation; Culture Me | 2006 |
Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth.
Topics: Active Transport, Cell Nucleus; alpha Karyopherins; Animals; Cell Proliferation; Cyproterone Acetate | 2006 |
Gemfibrozil-induced peroxisome proliferation and hepatomegaly in male F344 rats.
Topics: Animals; Cell Division; Gemfibrozil; Hepatomegaly; Humans; Hypolipidemic Agents; Male; Microbodies; | 1995 |
Species differences in peroxisome proliferation; mechanisms and relevance.
Topics: Animals; Cell Line; Clofenapate; Cricetinae; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; | 2000 |
The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.
Topics: Androstanols; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Cytochrome P45 | 2002 |
Evaluation of bromodeoxyuridine labeling in hepatomegaly produced by peroxisomal proliferation or P-450 induction in rodents.
Topics: Animals; Anticholesteremic Agents; Bromodeoxyuridine; Cell Division; Cytochrome P-450 Enzyme System; | 1991 |