pirinixic acid has been researched along with Cholestasis in 2 studies
pirinixic acid: structure
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "WY-14,643 treatment induced hepatomegaly in wild type (WT) mice that was also accompanied by induction of the expression of cyclins D1, D3, A2, and B1 and Cdc2 as well as inhibition of Wee 1." | 1.35 | Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis. ( Gyamfi, MA; Wan, YJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trottier, J | 1 |
| Perreault, M | 1 |
| Rudkowska, I | 1 |
| Levy, C | 1 |
| Dallaire-Theroux, A | 1 |
| Verreault, M | 1 |
| Caron, P | 1 |
| Staels, B | 1 |
| Vohl, MC | 1 |
| Straka, RJ | 1 |
| Barbier, O | 1 |
| Gyamfi, MA | 1 |
| Wan, YJ | 1 |
1 trial available for pirinixic acid and Cholestasis
| Article | Year |
|---|---|
Profiling serum bile acid glucuronides in humans: gender divergences, genetic determinants, and response to fenofibrate.
Topics: Bile Acids and Salts; Cholestasis; Female; Fenofibrate; Gene Expression Regulation; Glucuronides; Gl | 2013 |
1 other study available for pirinixic acid and Cholestasis
| Article | Year |
|---|---|
Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis.
Topics: Animals; Bile Acids and Salts; Cell Proliferation; Cholestasis; Cholesterol 7-alpha-Hydroxylase; Cyt | 2009 |