pirinixic acid has been researched along with Body Weight in 33 studies
pirinixic acid: structure
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Co-treatment of rotenone and WY-14,643 (group IV) decreased focal DNA synthesis and mitosis and increased the incidence of apoptotic hepatocytes." | 1.30 | Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone. ( Ayoubi, SA; Isenberg, JS; Klaunig, JE; Kolaja, KL; Watkins, JB, 1997) |
| "Methapyrilene (MPH) was a widely used antihistamine until it was found to produce hepatocellular carcinoma and cholangiocarcinoma in Fischer 344 rats." | 1.29 | The hepatocarcinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13-week feed study. ( Anderson, NL; Cunningham, ML; Pippin, LL; Wenk, ML, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.03) | 18.7374 |
| 1990's | 13 (39.39) | 18.2507 |
| 2000's | 15 (45.45) | 29.6817 |
| 2010's | 4 (12.12) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Porcelli, L | 1 |
| Gilardi, F | 1 |
| Laghezza, A | 1 |
| Piemontese, L | 1 |
| Mitro, N | 1 |
| Azzariti, A | 1 |
| Altieri, F | 1 |
| Cervoni, L | 1 |
| Fracchiolla, G | 1 |
| Giudici, M | 1 |
| Guerrini, U | 1 |
| Lavecchia, A | 1 |
| Montanari, R | 1 |
| Di Giovanni, C | 1 |
| Paradiso, A | 1 |
| Pochetti, G | 1 |
| Simone, GM | 1 |
| Tortorella, P | 1 |
| Crestani, M | 1 |
| Loiodice, F | 1 |
| Pirat, C | 1 |
| Dacquet, C | 1 |
| Leclerc, V | 1 |
| Hennuyer, N | 1 |
| Beucher-Gaudin, M | 1 |
| Zanirato, G | 1 |
| Géant, A | 1 |
| Staels, B | 2 |
| Ktorza, A | 1 |
| Farce, A | 1 |
| Caignard, DH | 1 |
| Berthelot, P | 1 |
| Lebegue, N | 1 |
| Ericsson, A | 1 |
| Turner, N | 1 |
| Hansson, GI | 1 |
| Wallenius, K | 1 |
| Oakes, ND | 1 |
| Bulhak, AA | 1 |
| Jung, C | 1 |
| Ostenson, CG | 1 |
| Lundberg, JO | 1 |
| Sjöquist, PO | 1 |
| Pernow, J | 1 |
| Foreman, JE | 1 |
| Chang, SC | 1 |
| Ehresman, DJ | 1 |
| Butenhoff, JL | 1 |
| Anderson, CR | 1 |
| Palkar, PS | 1 |
| Kang, BH | 1 |
| Gonzalez, FJ | 2 |
| Peters, JM | 2 |
| Gutgesell, A | 1 |
| Wen, G | 1 |
| König, B | 1 |
| Koch, A | 1 |
| Spielmann, J | 1 |
| Stangl, GI | 1 |
| Eder, K | 1 |
| Ringseis, R | 1 |
| Wölkart, G | 1 |
| Schrammel, A | 1 |
| Dörffel, K | 1 |
| Haemmerle, G | 1 |
| Zechner, R | 1 |
| Mayer, B | 1 |
| Cappon, GD | 1 |
| Liu, RC | 1 |
| Frame, SR | 2 |
| Hurtt, ME | 2 |
| Mally, A | 1 |
| Chipman, JK | 1 |
| Li, S | 1 |
| Wu, P | 1 |
| Yarlagadda, P | 1 |
| Vadjunec, NM | 1 |
| Proia, AD | 1 |
| Harris, RA | 1 |
| Portilla, D | 1 |
| Guzmán, M | 1 |
| Lo Verme, J | 1 |
| Fu, J | 2 |
| Oveisi, F | 2 |
| Blázquez, C | 1 |
| Piomelli, D | 2 |
| Gaetani, S | 1 |
| Lin, E | 1 |
| Murray, AJ | 1 |
| Panagia, M | 1 |
| Hauton, D | 1 |
| Gibbons, GF | 1 |
| Clarke, K | 1 |
| Shimakura, J | 1 |
| Terada, T | 1 |
| Saito, H | 1 |
| Katsura, T | 1 |
| Inui, K | 1 |
| Woods, CG | 1 |
| Burns, AM | 1 |
| Bradford, BU | 1 |
| Ross, PK | 1 |
| Kosyk, O | 1 |
| Swenberg, JA | 1 |
| Cunningham, ML | 2 |
| Rusyn, I | 1 |
| Pippin, LL | 1 |
| Anderson, NL | 1 |
| Wenk, ML | 1 |
| Cattley, RC | 5 |
| Glover, SE | 1 |
| Bojes, HK | 1 |
| Sausen, PJ | 1 |
| Keller, BJ | 1 |
| Thurman, RG | 3 |
| Isenberg, JS | 1 |
| Kolaja, KL | 1 |
| Ayoubi, SA | 1 |
| Watkins, JB | 1 |
| Klaunig, JE | 1 |
| Rose, ML | 2 |
| Germolec, D | 1 |
| Arteel, GE | 1 |
| Schoonhoven, R | 1 |
| Goldsworthy, TL | 3 |
| Goldsworthy, SM | 1 |
| Sprankle, CS | 1 |
| Butterworth, BE | 2 |
| Dunn, C | 1 |
| Wong, V | 1 |
| Li, X | 1 |
| Lawrence, JW | 1 |
| Wollenberg, GK | 1 |
| Frank, JD | 1 |
| DeLuca, JG | 1 |
| Young, ME | 1 |
| Goodwin, GW | 1 |
| Ying, J | 1 |
| Guthrie, P | 1 |
| Wilson, CR | 1 |
| Laws, FA | 1 |
| Taegtmeyer, H | 1 |
| Akiyama, TE | 1 |
| Nicol, CJ | 1 |
| Fievet, C | 1 |
| Ward, JM | 1 |
| Auwerx, J | 1 |
| Lee, SS | 1 |
| Hamano, T | 1 |
| Kobayashi, K | 1 |
| Sakairi, T | 1 |
| Hayashi, M | 1 |
| Mutai, M | 1 |
| Biegel, LB | 1 |
| Applegate, M | 1 |
| O'Connor, JC | 1 |
| Cook, JC | 1 |
| Watanabe, T | 1 |
| Okawa, S | 1 |
| Itoga, H | 1 |
| Imanaka, T | 1 |
| Suga, T | 1 |
| Marsman, DS | 4 |
| Popp, JA | 4 |
| Wada, N | 1 |
| Eldridge, SR | 1 |
| Tilbury, LF | 1 |
| Conway, JG | 1 |
33 other studies available for pirinixic acid and Body Weight
| Article | Year |
|---|---|
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.
Topics: Adipocytes; Animals; Antineoplastic Agents; Benzoxazoles; Body Weight; Calorimetry; Cell Differentia | 2012 |
Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression.
Topics: Animals; Body Weight; Caloric Restriction; Cells, Cultured; Chlorocebus aethiops; COS Cells; Dose-Re | 2017 |
Pharmacological PPARα activation markedly alters plasma turnover of the amino acids glycine, serine and arginine in the rat.
Topics: Animals; Arginase; Arginine; Body Weight; Calorimetry, Indirect; Glycine; Liver; Male; Nitrogen; PPA | 2014 |
PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway.
Topics: Androstadienes; Animals; Blood Glucose; Body Weight; Cardiotonic Agents; Diabetes Mellitus, Type 2; | 2009 |
Differential hepatic effects of perfluorobutyrate mediated by mouse and human PPAR-alpha.
Topics: Alanine Transaminase; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Fluorocarbons; H | 2009 |
Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells.
Topics: Animals; Base Sequence; Body Weight; Carnitine Acyltransferases; Carnitine O-Palmitoyltransferase; C | 2009 |
Cardiac dysfunction in adipose triglyceride lipase deficiency: treatment with a PPARα agonist.
Topics: Animals; Anticholesteremic Agents; Body Weight; Female; Heart; Heart Rate; In Vitro Techniques; Lipa | 2012 |
Effects of the rat hepatic peroxisome proliferator, Wyeth 14,643, on the lactating goat.
Topics: Animals; Animals, Newborn; Body Weight; Estradiol; Female; Goats; Lactation; Lipids; Microbodies; Mi | 2002 |
Non-genotoxic carcinogens: early effects on gap junctions, cell proliferation and apoptosis in the rat.
Topics: Animals; Apoptosis; Body Weight; Carcinogens; Cell Division; Connexin 26; Connexins; Dose-Response R | 2002 |
PPAR alpha ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity.
Topics: Acute Kidney Injury; Acyl-CoA Dehydrogenase; Animals; Body Weight; Cisplatin; Fatty Acids; Isoenzyme | 2004 |
Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha).
Topics: Adipose Tissue; Animals; Body Weight; Cell Nucleus; Cells, Cultured; Dose-Response Relationship, Dru | 2004 |
Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats.
Topics: Animals; Body Weight; Butyrates; CD36 Antigens; Cholesterol; Coenzyme A Ligases; Eating; Endocannabi | 2005 |
Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levels.
Topics: Animals; Body Weight; Carrier Proteins; Diabetes Mellitus, Experimental; Epoxy Compounds; Fatty Acid | 2005 |
Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor alpha.
Topics: Acyl-CoA Oxidase; Animals; Blood Glucose; Body Weight; Caco-2 Cells; Cells, Cultured; Fasting; Fatty | 2006 |
WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase.
Topics: Acyl-CoA Oxidase; Animals; Apoptosis; Body Weight; Caspase 8; Caspase 9; Cell Cycle Proteins; Cell P | 2007 |
The hepatocarcinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13-week feed study.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Cell Division; Dose-Response Relationship, | 1995 |
Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to carcinogenesis and nuclear localization.
Topics: Animals; Body Weight; Carcinogens; Cell Nucleus; Clofibric Acid; Diethylhexyl Phthalate; DNA; Guanos | 1993 |
Paradoxical increase in peroxisomal cyanide-insensitive respiration following dietary exposure to WY-14,643 in the perfused liver.
Topics: Animals; Anticholesteremic Agents; Body Weight; Fasting; Liver; Male; Methanol; Microbodies; Mitocho | 1996 |
Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone.
Topics: Adenoma; Animals; Apoptosis; Body Weight; Bromodeoxyuridine; Carcinogens; Diethylnitrosamine; DNA; L | 1997 |
Dietary glycine prevents increases in hepatocyte proliferation caused by the peroxisome proliferator WY-14,643.
Topics: Animals; Body Weight; Carcinogens; Cell Division; Glycine; Liver; Male; Microbodies; Pyrimidines; Ra | 1997 |
Expression of myc, fos and Ha-ras associated with chemically induced cell proliferation in the rat liver.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carcinogens; Cell Division; | 1994 |
Dietary glycine prevents the development of liver tumors caused by the peroxisome proliferator WY-14,643.
Topics: Animals; Body Weight; Cell Division; Diet; Glycine; Liver Neoplasms, Experimental; Male; Organ Size; | 1999 |
Dexamethasone selectively inhibits WY14,643-induced cell proliferation and not peroxisome proliferation in mice.
Topics: Acyl-CoA Oxidase; Animals; Anti-Inflammatory Agents; Apolipoprotein C-III; Apolipoproteins C; Body W | 2001 |
Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids.
Topics: Animals; Aorta; Blood Pressure; Body Weight; Carboxy-Lyases; Chromans; Constriction; Diabetes Mellit | 2001 |
Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines.
Topics: Animals; Body Weight; Cholesterol; Female; Lipid Metabolism; Liver; Male; Mice; Mice, Congenic; Mice | 2001 |
Peroxisome proliferator-activated receptor alpha (PPAR alpha) agonist, WY-14,643, increased transcription of myosin light chain-2 in cardiomyocytes.
Topics: Animals; Body Weight; Cardiac Myosins; Cell Line; Clofibrate; Diethylhexyl Phthalate; Dose-Response | 2001 |
Comparison of the effects of Wyeth-14,643 in Crl:CD BR and Fisher-344 rats.
Topics: Animals; Anticholesteremic Agents; Body Weight; Leydig Cells; Liver; Male; Microbodies; Organ Size; | 1992 |
Involvement of calmodulin- and protein kinase C-related mechanism in an induction process of peroxisomal fatty acid oxidation-related enzymes by hypolipidemic peroxisome proliferators.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bezafibrate; Body Weight; Calmodulin; Catala | 1992 |
Contrasting hepatocytic peroxisome proliferation, lipofuscin accumulation and cell turnover for the hepatocarcinogens Wy-14,643 and clofibric acid.
Topics: Animals; Body Weight; Carcinogenicity Tests; Cell Death; Cell Division; Clofibric Acid; DNA, Neoplas | 1992 |
Dose-related effects of the hepatocarcinogen, Wy-14,643, on peroxisomes and cell replication.
Topics: Animals; Autoradiography; Body Weight; Carcinogens; Carnitine O-Acetyltransferase; Cell Division; Ch | 1992 |
Age-related susceptibility to the carcinogenic effect of the peroxisome proliferator WY-14,643 in rat liver.
Topics: Aging; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; DNA; Liver; Liver Neoplasms, Ex | 1991 |
Measurement of chemically induced cell proliferation in rodent liver and kidney: a comparison of 5-bromo-2'-deoxyuridine and [3H]thymidine administered by injection or osmotic pump.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Bromodeoxyuridine; Carcinog | 1990 |
Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats.
Topics: Animals; Body Weight; Cell Division; Diethylhexyl Phthalate; DNA; DNA Replication; Eating; Liver; Li | 1988 |