pirinixic acid has been researched along with Acute Liver Injury, Drug-Induced in 11 studies
pirinixic acid: structure
| Excerpt | Relevance | Reference |
|---|---|---|
| " To evaluate the effects of PFHxS and PFNA, male wild-type and Pparα-null mice were dosed by oral gavage with PFHxS (3 or 10mg/kg/day), PFNA (1 or 3mg/kg/day), or vehicle for 7days, and liver gene expression was evaluated by full-genome microarrays." | 1.46 | PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling. ( Abbott, B; Corton, JC; Das, KP; Lau, C; Rooney, J; Rosen, MB, 2017) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Rosen, MB | 1 |
| Das, KP | 1 |
| Rooney, J | 1 |
| Abbott, B | 1 |
| Lau, C | 1 |
| Corton, JC | 1 |
| Fang, ZZ | 1 |
| Tanaka, N | 1 |
| Lu, D | 1 |
| Jiang, CT | 1 |
| Zhang, WH | 1 |
| Zhang, C | 1 |
| Du, Z | 1 |
| Fu, ZW | 1 |
| Gao, P | 1 |
| Cao, YF | 1 |
| Sun, HZ | 1 |
| Zhu, ZT | 1 |
| Cai, Y | 1 |
| Krausz, KW | 2 |
| Yao, Z | 1 |
| Gonzalez, FJ | 4 |
| Foreman, JE | 1 |
| Chang, SC | 1 |
| Ehresman, DJ | 1 |
| Butenhoff, JL | 1 |
| Anderson, CR | 1 |
| Palkar, PS | 1 |
| Kang, BH | 1 |
| Peters, JM | 1 |
| Patterson, AD | 1 |
| Shah, YM | 2 |
| Matsubara, T | 1 |
| O'Brien, PJ | 1 |
| Slaughter, MR | 1 |
| Polley, SR | 1 |
| Kramer, K | 1 |
| Amacher, DE | 1 |
| Adler, R | 1 |
| Herath, A | 1 |
| Townsend, RR | 1 |
| Wada, N | 1 |
| Marsman, DS | 1 |
| Popp, JA | 1 |
1 review available for pirinixic acid and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators.
Topics: Animals; Cell Proliferation; Chemical and Drug Induced Liver Injury; DNA-Binding Proteins; Gene Expr | 2008 |
10 other studies available for pirinixic acid and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling.
Topics: Animals; Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Computational Biology; Co | 2017 |
Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; I | 2017 |
Differential hepatic effects of perfluorobutyrate mediated by mouse and human PPAR-alpha.
Topics: Alanine Transaminase; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Fluorocarbons; H | 2009 |
Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity.
Topics: Acetaminophen; Analysis of Variance; Animals; Blotting, Western; Chemical and Drug Induced Liver Inj | 2012 |
Advantages of glutamate dehydrogenase as a blood biomarker of acute hepatic injury in rats.
Topics: Acute Disease; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Biomarkers; Chemical and | 2002 |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
Topics: 1-Naphthylisothiocyanate; Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2005 |
Dose-related effects of the hepatocarcinogen, Wy-14,643, on peroxisomes and cell replication.
Topics: Animals; Autoradiography; Body Weight; Carcinogens; Carnitine O-Acetyltransferase; Cell Division; Ch | 1992 |