pirfenidone has been researched along with Innate Inflammatory Response in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (23.08) | 29.6817 |
| 2010's | 9 (34.62) | 24.3611 |
| 2020's | 11 (42.31) | 2.80 |
| Authors | Studies |
|---|---|
| Edwards, BS; Graves, SW; Saunders, MJ; Sklar, LA; Zhu, J | 1 |
| Armendariz-Borunda, J; Galicia-Moreno, M; Lucano-Landeros, S; Miranda-Roblero, HO; Monroy-Ramirez, HC; Sandoval-Rodriguez, A; Santos, A; Silva-Gomez, JA | 1 |
| Chen, F; Huo, J; Li, S; Meng, Y; Tang, Q; Tian, L; Wang, W; Yang, Q | 1 |
| Al-Karmalawy, AA; Antar, SA; Saleh, MA | 1 |
| Zhang, Z; Zhao, J | 1 |
| Abdelmoneim, AM; Alanazi, MM; Baioumy, B; El-Shafey, RS; Elshazly, AME; Faruk, EM; Hussein, AYA; Mersal, EA; Mogahed, MM; Morsi, AA | 1 |
| Ale, T; Kehinde, V; Lavik, E; Liu, S; Wang, HC | 1 |
| Ferrara, F; Granata, G; La Porta, R; Pelliccia, C; Vitiello, A | 1 |
| Evani, SJ; Karna, SLR; Leung, KP; Seshu, J | 1 |
| Chen, Y; He, X; Li, H; Liu, X; Luo, L; Ma, Y; Zeng, Z; Zhan, Z | 1 |
| Hamidi, SH; Kadamboor Veethil, S | 1 |
| Cao, ZJ; Dai, HP; Han, ZF; Li, BC; Li, ZG; Liu, Y; Pang, JL; Qi, XM; Song, MY; Wang, C; Wang, J; Yang, PR; Zhang, XR; Zhang, Z | 1 |
| Cai, L; Coleman, JA; Durack, JC; Erinjeri, JP; Gu, Y; Maybody, M; Solomon, SB; Srimathveeravalli, G; Ueshima, E; Yarmohammadi, H; Zhu, YS | 1 |
| Dorati, R; Fourcaudot, AB; Leung, KP; Medina, JL; Sebastian, EA | 1 |
| Pata, YS; Türkmen, E | 1 |
| Heukels, P; Kool, M; Moor, CC; von der Thüsen, JH; Wijsenbeek, MS | 1 |
| Basir, Z; Chen, G; Lu, Y; Myers, CR; Oshima, K; Qi, X; Stoner, G; Thomas, JP; Tsai, S; Yin, N | 1 |
| Calik, E; Guvenal, T; Hasdemir, PS; Koltan, SO; Koyuncu, FM; Ozbilgin, K; Ozkut, M; Uner, MA | 1 |
| Furuke, S; Hata, KI; Ikeda, K; Itoh, M; Komiya, C; Miyachi, Y; Mori, K; Nakabayashi, K; Ochi, K; Ogawa, Y; Shiba, K; Shimazu, N; Suganami, T; Tanaka, M; Tsuchiya, K; Yamaguchi, S | 1 |
| Choi, JS; Jung, KI; Kim, HK; Shin, SY | 1 |
| Fukuda, T; Kurasawa, K | 1 |
| Bratt, JM; Decile, KC; Giri, SN; Grewal, H; Mansoor, JK; Margolin, SB; Pinkerton, KE; Schelegle, ES; Walby, WF | 1 |
| Chen, XY; Wang, F; Wen, T; Wu, H | 1 |
| Giri, SN; Margolin, SB | 1 |
| Giri, SN; Hyde, DM; Iyer, SN | 1 |
| Millar, AB; Poole, AR; Thickett, DR | 1 |
7 review(s) available for pirfenidone and Innate Inflammatory Response
| Article | Year |
|---|---|
Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti-SARS-CoV-2.
Topics: Angiotensins; Anti-Inflammatory Agents; Antioxidants; Collagen Type I; COVID-19 Drug Treatment; Fibrosis; Humans; Inflammation; Interleukin-1beta; Platelet-Derived Growth Factor; Pyridones; SARS-CoV-2; Transforming Growth Factor beta1; Transforming Growth Factors; Tumor Necrosis Factor-alpha | 2022 |
Effective therapy of pirfenidone in a patient with idiopathic retroperitoneal fibrosis: report of a case.
Topics: Glucocorticoids; Humans; Inflammation; Male; Middle Aged; Pyridones; Retroperitoneal Fibrosis | 2023 |
The added value of pirfenidone to fight inflammation and fibrotic state induced by SARS-CoV-2 : Anti-inflammatory and anti-fibrotic therapy could solve the lung complications of the infection?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Betacoronavirus; Coronavirus Infections; COVID-19; Drug Therapy, Combination; Humans; Inflammation; Interleukin-1; Interleukin-6; Pandemics; Pneumonia, Viral; Pulmonary Fibrosis; Pyridones; SARS-CoV-2 | 2020 |
Role of pirfenidone in TGF-β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection: a theoretical perspective.
Topics: Anti-Inflammatory Agents, Non-Steroidal; COVID-19; COVID-19 Drug Treatment; Humans; Inflammation; Lung Injury; Pyridones; SARS-CoV-2; Signal Transduction; Transforming Growth Factor beta | 2021 |
Inflammation and immunity in IPF pathogenesis and treatment.
Topics: Adaptive Immunity; Anti-Inflammatory Agents; Clinical Trials as Topic; Extracellular Matrix; Fibroblasts; Fibrosis; Humans; Idiopathic Pulmonary Fibrosis; Immunity, Innate; Indoles; Inflammation; Protein Kinase Inhibitors; Pyridones | 2019 |
[Interstitial pneumonia].
Topics: Apoptosis; Chemokines; Cytokines; Fibrosis; Humans; Immunosuppressive Agents; Inflammation; Interferon-gamma; Lung Diseases, Interstitial; Lung Transplantation; Macrophages; Pyridones; Respiratory Function Tests; Th1 Cells; Th2 Cells; Tomography, X-Ray Computed | 2005 |
The balance between collagen synthesis and degradation in diffuse lung disease.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Biomarkers; Collagen; Disease Models, Animal; Humans; Inflammation; Interferon-gamma; Lung Diseases, Interstitial; Pulmonary Fibrosis; Pyridones | 2001 |
1 trial(s) available for pirfenidone and Innate Inflammatory Response
| Article | Year |
|---|---|
Effects of topical application of pirfenidone ointment on thermoplasty-induced acute lameness in a double-blind and acute and chronic lameness of musculoskeletal origin in an open multi-centered field trial in horses.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Edema; Female; Forelimb; Horse Diseases; Horses; Hot Temperature; Inflammation; Lameness, Animal; Male; Ointments; Pyridones | 2005 |
18 other study(ies) available for pirfenidone and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Inflammation; Kinetics; Microspheres; Peptide Hydrolases; Peptides; Reproducibility of Results; Temperature | 2010 |
Hepatocarcinogenesis Prevention by Pirfenidone Is PPARγ Mediated and Involves Modification of Nuclear NF-kB p65/p50 Ratio.
Topics: Animals; Anti-Inflammatory Agents; Carcinogenesis; Carcinoma, Hepatocellular; Fibrosis; Inflammation; Liver Neoplasms; Male; NF-kappa B; NF-kappa B p50 Subunit; Phosphorylation; PPAR gamma; Pyridones; Rats; Rats, Inbred F344; Signal Transduction; Transcription Factor RelA; Transforming Growth Factor beta1 | 2021 |
The antifibrotic effect of pheretima protein is mediated by the TGF-β1/Smad2/3 pathway and attenuates inflammation in bleomycin-induced idiopathic pulmonary fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Bleomycin; Disease Models, Animal; Freeze Drying; Idiopathic Pulmonary Fibrosis; Inflammation; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Oligochaeta; Proteins; Pyridones; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2022 |
Modeling the Effects of Cypermethrin Toxicity on Ovalbumin-Induced Allergic Pneumonitis Rats: Macrophage Phenotype Differentiation and p38/STAT6 Signaling Are Candidate Targets of Pirfenidone Treatment.
Topics: Alveolitis, Extrinsic Allergic; Animals; Asthma; Dexamethasone; Inflammation; Macrophages; Male; Ovalbumin; p38 Mitogen-Activated Protein Kinases; Phenotype; Pneumonia; Rats; Rats, Wistar | 2023 |
Polyester Nanoparticles and Polyurethane Nanocapsules Deliver Pirfenidone To Reduce Fibrosis and Scarring.
Topics: Cicatrix; Humans; Inflammation; Nanocapsules; Nanoparticles; Polyesters; Polylactic Acid-Polyglycolic Acid Copolymer; Polyurethanes | 2023 |
Pirfenidone regulates LPS mediated activation of neutrophils.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemotaxis; Cytokines; Humans; Inflammation; Lipopolysaccharides; Neutrophil Activation; Neutrophils; Phagocytosis; Pyridones; Signal Transduction | 2020 |
Pirfenidone mediates cigarette smoke extract induced inflammation and oxidative stress in vitro and in vivo.
Topics: A549 Cells; Animals; Anti-Inflammatory Agents; Cigarette Smoking; Cytokines; Humans; Inflammation; Inflammation Mediators; Lung; Male; Mice; Mice, Inbred BALB C; Oxidative Stress; Plant Extracts; Pyridones; Reactive Oxygen Species; Respiratory Mucosa; Signal Transduction | 2021 |
Pirfenidone ameliorates silica-induced lung inflammation and fibrosis in mice by inhibiting the secretion of interleukin-17A.
Topics: Animals; Disease Models, Animal; Fibrosis; Inflammation; Interleukin-17; Janus Kinases; Lung; Mice; Mice, Inbred C57BL; Pneumonia; Pyridones; Signal Transduction; Silicon Dioxide; STAT Transcription Factors | 2022 |
Pirfenidone inhibits cryoablation induced local macrophage infiltration along with its associated TGFb1 expression and serum cytokine level in a mouse model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Movement; Cryosurgery; Female; Inflammation; Interleukin-6; Macrophages; Mice; Mice, Inbred BALB C; Muscles; Pyridones; Random Allocation; Transforming Growth Factor beta1 | 2018 |
Pirfenidone Ointment Modulates the Burn Wound Bed in C57BL/6 Mice by Suppressing Inflammatory Responses.
Topics: Actins; Animals; Burns; Cicatrix; Cytokines; Hydroxyproline; Inflammation; Mice; Mice, Inbred C57BL; Pyridones | 2019 |
Prevention of tracheal stenosis with pirfenidone after tracheotomy: An experimental study.
Topics: Animals; Fibrosis; Immunohistochemistry; Inflammation; Interleukin-1beta; Pyridones; Rats; Rats, Sprague-Dawley; Tracheal Stenosis; Tracheotomy; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2019 |
p38γ MAPK is required for inflammation-associated colon tumorigenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinogenesis; Colonic Neoplasms; Cytokines; Enzyme Activation; Humans; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mitogen-Activated Protein Kinase 12; Neoplasm Transplantation; Pyridones; Signal Transduction; Tumor Cells, Cultured | 2016 |
Effect of Pirfenidone on Vascular Proliferation, Inflammation and Fibrosis in an Abdominal Adhesion Rat Model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Female; Inflammation; Injections, Intraperitoneal; Interleukin-17; Neovascularization, Pathologic; Peritoneum; Postoperative Complications; Pyridones; Rats; Rats, Wistar; Tissue Adhesions; Transforming Growth Factor beta; Treatment Outcome; Uterus | 2017 |
Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis.
Topics: Animals; Apoptosis; Caspase 3; Caspase 8; Cells, Cultured; Diet, Western; Disease Models, Animal; Feeding Behavior; Hepatocytes; Humans; Inflammation; Liver; Liver Cirrhosis; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Pyridones; Receptor, Melanocortin, Type 4; Tumor Necrosis Factor-alpha; Up-Regulation | 2017 |
Effects of an anti-transforming growth factor-β agent (pirfenidone) on strabismus surgery in rabbits.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Follow-Up Studies; Inflammation; Oculomotor Muscles; Postoperative Complications; Pyridones; Rabbits; Strabismus; Transforming Growth Factor beta; Wound Healing | 2012 |
Influence of pirfenidone on airway hyperresponsiveness and inflammation in a Brown-Norway rat model of asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchial Provocation Tests; Collagen; Disease Models, Animal; Inflammation; Lung; Male; Mucins; Muscle, Smooth; Ovalbumin; Pyridones; Random Allocation; Rats; Rats, Inbred BN; Respiratory Mucosa; Transforming Growth Factor beta | 2007 |
Protective effects of pirfenidone on D-galactosamine and lipopolysaccharide-induced acute hepatotoxicity in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Galactosamine; Inflammation; Lipid Peroxidation; Lipopolysaccharides; Liver; Liver Diseases; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Pyridones; Rats; Rats, Sprague-Dawley; Severity of Illness Index | 2008 |
Anti-inflammatory effect of pirfenidone in the bleomycin-hamster model of lung inflammation.
Topics: Administration, Oral; Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bleomycin; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cricetinae; Inflammation; Macrophages, Alveolar; Male; Mesocricetus; Neutrophil Infiltration; Pulmonary Fibrosis; Pyridones; Transforming Growth Factor beta | 2000 |