Page last updated: 2024-11-02

pirenzepine and Zollinger-Ellison Syndrome

pirenzepine has been researched along with Zollinger-Ellison Syndrome in 6 studies

Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.

Zollinger-Ellison Syndrome: A syndrome that is characterized by the triad of severe PEPTIC ULCER, hypersecretion of GASTRIC ACID, and GASTRIN-producing tumors of the PANCREAS or other tissue (GASTRINOMA). This syndrome may be sporadic or be associated with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1.

Research Excerpts

ExcerptRelevanceReference
"The inhibitory effect of omeprazole, a benzimidazole derivative, on gastric acid secretion was investigated in seven patients with Zollinger-Ellison syndrome resistant to treatment with large doses of histamine H2-receptor antagonists administered alone or in combination with pirenzepine."7.67Effectiveness of omeprazole in seven patients with Zollinger-Ellison syndrome resistant to histamine H2-receptor antagonists. ( Bader, JP; Cortot, A; Delchier, JC; Goldfain, D; Isal, JP; Mignon, M; Soule, JC; Travers, B, 1986)
"Pirenzepine is a 'selective' antimuscarinic agent which, unlike classic anticholinergic agents, inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions."6.37Pirenzepine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in peptic ulcer disease and other allied diseases. ( Brogden, RN; Carmine, AA, 1985)
"The inhibitory effect of omeprazole, a benzimidazole derivative, on gastric acid secretion was investigated in seven patients with Zollinger-Ellison syndrome resistant to treatment with large doses of histamine H2-receptor antagonists administered alone or in combination with pirenzepine."3.67Effectiveness of omeprazole in seven patients with Zollinger-Ellison syndrome resistant to histamine H2-receptor antagonists. ( Bader, JP; Cortot, A; Delchier, JC; Goldfain, D; Isal, JP; Mignon, M; Soule, JC; Travers, B, 1986)
"Pirenzepine is a 'selective' antimuscarinic agent which, unlike classic anticholinergic agents, inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions."2.37Pirenzepine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in peptic ulcer disease and other allied diseases. ( Brogden, RN; Carmine, AA, 1985)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19906 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
de Gara, CJ1
Gledhill, T1
Hunt, RH1
de la Pierre, M1
Aricò, S1
Capussotti, L1
Dellepiane, M1
Marucci, M1
Gandini, G1
Imarisio, P1
Delchier, JC1
Soule, JC1
Mignon, M1
Goldfain, D1
Cortot, A1
Travers, B1
Isal, JP1
Bader, JP1
Ryss, ES1
Cavina, E1
Pagliai, EF1
Goletti, O1
Chiarugi, M1
Chirico, A1
Carmine, AA1
Brogden, RN1

Reviews

2 reviews available for pirenzepine and Zollinger-Ellison Syndrome

ArticleYear
[Current locally acting agents in the treatment of peptic ulcer].
    Klinicheskaia meditsina, 1986, Volume: 64, Issue:8

    Topics: Antacids; Anti-Ulcer Agents; Antidepressive Agents, Tricyclic; Carbonic Anhydrase Inhibitors; Histam

1986
Pirenzepine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in peptic ulcer disease and other allied diseases.
    Drugs, 1985, Volume: 30, Issue:2

    Topics: Benzodiazepinones; Dialysis; Dyspepsia; Gastric Acid; Gastrins; Gastrointestinal Hormones; Humans; I

1985

Other Studies

4 other studies available for pirenzepine and Zollinger-Ellison Syndrome

ArticleYear
Cimetidine versus ranitidine for refractory Zollinger-Ellison syndrome.
    Canadian Medical Association journal, 1984, Mar-01, Volume: 130, Issue:5

    Topics: Benzodiazepinones; Cimetidine; Drug Therapy, Combination; Humans; Pirenzepine; Ranitidine; Zollinger

1984
[Description of a case of Zollinger-Ellison syndrome].
    Minerva medica, 1984, May-07, Volume: 75, Issue:19

    Topics: Benzodiazepinones; Body Weight; Cimetidine; Diarrhea; Female; Gastrectomy; Gastric Acid; Humans; Mid

1984
Effectiveness of omeprazole in seven patients with Zollinger-Ellison syndrome resistant to histamine H2-receptor antagonists.
    Digestive diseases and sciences, 1986, Volume: 31, Issue:7

    Topics: Adult; Anti-Ulcer Agents; Benzimidazoles; Benzodiazepinones; Cimetidine; Drug Resistance; Drug Thera

1986
Pylorus preserving pancreatoduodenectomy for gastrinoma. A case report.
    The Italian journal of surgical sciences, 1986, Volume: 16, Issue:4

    Topics: Adult; Drug Therapy, Combination; Duodenum; Female; Gastrins; Humans; Pancreas; Pirenzepine; Ranitid

1986