pirenzepine has been researched along with Zollinger-Ellison Syndrome in 6 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Zollinger-Ellison Syndrome: A syndrome that is characterized by the triad of severe PEPTIC ULCER, hypersecretion of GASTRIC ACID, and GASTRIN-producing tumors of the PANCREAS or other tissue (GASTRINOMA). This syndrome may be sporadic or be associated with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The inhibitory effect of omeprazole, a benzimidazole derivative, on gastric acid secretion was investigated in seven patients with Zollinger-Ellison syndrome resistant to treatment with large doses of histamine H2-receptor antagonists administered alone or in combination with pirenzepine." | 7.67 | Effectiveness of omeprazole in seven patients with Zollinger-Ellison syndrome resistant to histamine H2-receptor antagonists. ( Bader, JP; Cortot, A; Delchier, JC; Goldfain, D; Isal, JP; Mignon, M; Soule, JC; Travers, B, 1986) |
| "Pirenzepine is a 'selective' antimuscarinic agent which, unlike classic anticholinergic agents, inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions." | 6.37 | Pirenzepine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in peptic ulcer disease and other allied diseases. ( Brogden, RN; Carmine, AA, 1985) |
| "The inhibitory effect of omeprazole, a benzimidazole derivative, on gastric acid secretion was investigated in seven patients with Zollinger-Ellison syndrome resistant to treatment with large doses of histamine H2-receptor antagonists administered alone or in combination with pirenzepine." | 3.67 | Effectiveness of omeprazole in seven patients with Zollinger-Ellison syndrome resistant to histamine H2-receptor antagonists. ( Bader, JP; Cortot, A; Delchier, JC; Goldfain, D; Isal, JP; Mignon, M; Soule, JC; Travers, B, 1986) |
| "Pirenzepine is a 'selective' antimuscarinic agent which, unlike classic anticholinergic agents, inhibits gastric acid secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular and urinary functions." | 2.37 | Pirenzepine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in peptic ulcer disease and other allied diseases. ( Brogden, RN; Carmine, AA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Gara, CJ | 1 |
| Gledhill, T | 1 |
| Hunt, RH | 1 |
| de la Pierre, M | 1 |
| Aricò, S | 1 |
| Capussotti, L | 1 |
| Dellepiane, M | 1 |
| Marucci, M | 1 |
| Gandini, G | 1 |
| Imarisio, P | 1 |
| Delchier, JC | 1 |
| Soule, JC | 1 |
| Mignon, M | 1 |
| Goldfain, D | 1 |
| Cortot, A | 1 |
| Travers, B | 1 |
| Isal, JP | 1 |
| Bader, JP | 1 |
| Ryss, ES | 1 |
| Cavina, E | 1 |
| Pagliai, EF | 1 |
| Goletti, O | 1 |
| Chiarugi, M | 1 |
| Chirico, A | 1 |
| Carmine, AA | 1 |
| Brogden, RN | 1 |
2 reviews available for pirenzepine and Zollinger-Ellison Syndrome
| Article | Year |
|---|---|
[Current locally acting agents in the treatment of peptic ulcer].
Topics: Antacids; Anti-Ulcer Agents; Antidepressive Agents, Tricyclic; Carbonic Anhydrase Inhibitors; Histam | 1986 |
Pirenzepine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in peptic ulcer disease and other allied diseases.
Topics: Benzodiazepinones; Dialysis; Dyspepsia; Gastric Acid; Gastrins; Gastrointestinal Hormones; Humans; I | 1985 |
4 other studies available for pirenzepine and Zollinger-Ellison Syndrome
| Article | Year |
|---|---|
Cimetidine versus ranitidine for refractory Zollinger-Ellison syndrome.
Topics: Benzodiazepinones; Cimetidine; Drug Therapy, Combination; Humans; Pirenzepine; Ranitidine; Zollinger | 1984 |
[Description of a case of Zollinger-Ellison syndrome].
Topics: Benzodiazepinones; Body Weight; Cimetidine; Diarrhea; Female; Gastrectomy; Gastric Acid; Humans; Mid | 1984 |
Effectiveness of omeprazole in seven patients with Zollinger-Ellison syndrome resistant to histamine H2-receptor antagonists.
Topics: Adult; Anti-Ulcer Agents; Benzimidazoles; Benzodiazepinones; Cimetidine; Drug Resistance; Drug Thera | 1986 |
Pylorus preserving pancreatoduodenectomy for gastrinoma. A case report.
Topics: Adult; Drug Therapy, Combination; Duodenum; Female; Gastrins; Humans; Pancreas; Pirenzepine; Ranitid | 1986 |