pirenzepine has been researched along with Sialorrhea in 5 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Sialorrhea: Increased salivary flow.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypersalivation is known as a frequent, disturbing, and socially stigmatizing side effect of therapy with the atypical antipsychotic clozapine." | 2.71 | Reduction of clozapine-induced hypersalivation by pirenzepine is safe. ( Fritze, J; Hiemke, C; Schneider, B; Weber, B; Weigmann, H, 2004) |
| "Pirenzepine is reported to counteract hypersalivation by its selective antagonistic activity on the M4-muscarinic receptor, which is stimulated by clozapine." | 2.70 | Therapeutic effect of pirenzepine for clozapine-induced hypersalivation: a randomized, double-blind, placebo-controlled, cross-over study. ( Bai, YM; Chen, JY; Lin, CC; Liu, WC, 2001) |
| "Sialorrhea is often treated with anticholinergic agents, but they can have undesirable side effects such as drowsiness, sedation, and constipation." | 1.51 | Sialorrhea Successfully Treated by the Combined Use of Selective M1 and M3 Muscarinic Acetylcholine Receptor Antagonists. ( Nonaka, M; Yamamura, Y, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamamura, Y | 1 |
| Nonaka, M | 1 |
| Schneider, B | 1 |
| Weigmann, H | 1 |
| Hiemke, C | 1 |
| Weber, B | 1 |
| Fritze, J | 2 |
| Elliger, T | 1 |
| Perkins, DO | 1 |
| McClure, RK | 1 |
| Bai, YM | 1 |
| Lin, CC | 1 |
| Chen, JY | 1 |
| Liu, WC | 1 |
2 trials available for pirenzepine and Sialorrhea
| Article | Year |
|---|---|
Reduction of clozapine-induced hypersalivation by pirenzepine is safe.
Topics: Adult; Antipsychotic Agents; Chromatography, High Pressure Liquid; Clozapine; Cross-Over Studies; Do | 2004 |
Therapeutic effect of pirenzepine for clozapine-induced hypersalivation: a randomized, double-blind, placebo-controlled, cross-over study.
Topics: Adult; Antipsychotic Agents; Clozapine; Cross-Over Studies; Double-Blind Method; Humans; Muscarinic | 2001 |
3 other studies available for pirenzepine and Sialorrhea
| Article | Year |
|---|---|
Sialorrhea Successfully Treated by the Combined Use of Selective M1 and M3 Muscarinic Acetylcholine Receptor Antagonists.
Topics: Animals; Drug Therapy, Combination; Humans; Male; Mice, Knockout; Middle Aged; Muscarinic Antagonist | 2019 |
Pirenzepine for clozapine-induced hypersalivation.
Topics: Antipsychotic Agents; Clozapine; Humans; Muscarinic Antagonists; Pirenzepine; Sialorrhea | 1995 |
Hypersalivation coincident with olanzapine treatment.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Female; Humans; Olanzapine; Pirenzepine; Schizophrenia | 1998 |