pirenzepine has been researched along with Seizures in 15 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have used the pilocarpine-induced seizure model in mice and i." | 5.29 | Assessment of the muscarinic receptor subtypes involved in pilocarpine-induced seizures in mice. ( Deirmengiant, C; Maslanski, JA; Patelt, J; Powelt, R, 1994) |
| " Clozapine is the second-generation antipsychotic most frequently associated with seizures, with risperidone appearing to confer a relatively low risk." | 4.82 | Antipsychotic medication and seizures: a review. ( Hedges, D; Jeppson, K; Whitehead, P, 2003) |
| "To report a case of seizures in a patient who started receiving olanzapine, and to review seizure risk associated with antipsychotic use." | 3.70 | Seizure associated with olanzapine. ( Crismon, ML; Dorson, PG; Lee, JW, 1999) |
| "Most traditional neuroleptics have a narrow therapeutic-to-toxic index, and thus, the novel antipsychotics are the result of a search to substantially widen the distance between the dose that treats psychosis and the one that produces adverse effects." | 2.40 | The relationship of pharmacology to side effects. ( Casey, DE, 1997) |
| " Considerable progress has been made in improving the motor side effect profile with the advent of clozapine and risperidone." | 2.39 | Side effect profiles of new antipsychotic agents. ( Casey, DE, 1996) |
| "A 27-year-old white woman was observed to have a seizure while receiving a stable dosage of olanzapine 15 mg/d, with the addition of quetiapine 100 mg in the evening 1 day before the occurrence of the seizure." | 1.31 | New-onset seizure associated with quetiapine and olanzapine. ( Hedges, DW; Jeppson, KG, 2002) |
| "We have used the pilocarpine-induced seizure model in mice and i." | 1.29 | Assessment of the muscarinic receptor subtypes involved in pilocarpine-induced seizures in mice. ( Deirmengiant, C; Maslanski, JA; Patelt, J; Powelt, R, 1994) |
| "After that rabbits developed clonic convulsions." | 1.28 | Effect of intracerebral injection of pirenzepine on electroencephalography and convulsions in conscious rabbits. ( Jiang, YX; Peng, JZ, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Bonelli, RM | 1 |
| Hedges, D | 1 |
| Jeppson, K | 1 |
| Whitehead, P | 1 |
| Ushizima, M | 2 |
| Amano, N | 1 |
| Potier, S | 1 |
| Sénécal, J | 1 |
| Chabot, JG | 1 |
| Psarropoulou, C | 1 |
| Descarries, L | 1 |
| Maslanski, JA | 1 |
| Powelt, R | 1 |
| Deirmengiant, C | 1 |
| Patelt, J | 1 |
| Casey, DE | 2 |
| Lee, JW | 1 |
| Crismon, ML | 1 |
| Dorson, PG | 1 |
| Deshauer, D | 1 |
| Albuquerque, J | 1 |
| Alda, M | 1 |
| Grof, P | 1 |
| Pillmann, F | 1 |
| Schlote, K | 1 |
| Broich, K | 1 |
| Marneros, A | 1 |
| Woolley, J | 1 |
| Smith, S | 1 |
| Hedges, DW | 1 |
| Jeppson, KG | 1 |
| Jiang, YX | 1 |
| Peng, JZ | 1 |
| Lim, DK | 1 |
| Hoskins, B | 1 |
| Ho, IK | 1 |
4 reviews available for pirenzepine and Seizures
| Article | Year |
|---|---|
Antipsychotic medication and seizures: a review.
Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clinical Trials as Topic; Clozapine; Dibenzothi | 2003 |
[Brain tumor].
Topics: Antipsychotic Agents; Benzodiazepines; Brain Neoplasms; Haloperidol; Humans; Hydrocephalus; Immunogl | 2003 |
Side effect profiles of new antipsychotic agents.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Clozapine; Dyskinesia, Drug-Induced; | 1996 |
The relationship of pharmacology to side effects.
Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Clozapine; D | 1997 |
11 other studies available for pirenzepine and Seizures
| Article | Year |
|---|---|
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Olanzapine-associated seizure.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Female; Humans; Huntington Disease; Olanzapine; Pirenz | 2003 |
A pentylenetetrazole-induced generalized seizure in early life enhances the efficacy of muscarinic receptor coupling to G-protein in hippocampus and neocortex of adult rat.
Topics: Animals; Autoradiography; Drug Interactions; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotri | 2005 |
Assessment of the muscarinic receptor subtypes involved in pilocarpine-induced seizures in mice.
Topics: Animals; Atropine; Cerebral Ventricles; Injections, Intraventricular; Male; Mice; Parasympatholytics | 1994 |
Seizure associated with olanzapine.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Drug Interactions; Female; Haloperido | 1999 |
Seizures caused by possible interaction between olanzapine and clomipramine.
Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzodiazepines; Clomipramine; Drug I | 2000 |
Electroencephalogram alterations during treatment with olanzapine.
Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Electroencephalography; Female; Humans; Ma | 2000 |
Lowered seizure threshold on olanzapine.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Humans; Male; Olanzapine; Paranoid Disorders; Pirenzep | 2001 |
New-onset seizure associated with quetiapine and olanzapine.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Dibenzothiazepines; Female; Humans; Olanzapine; Pirenz | 2002 |
Effect of intracerebral injection of pirenzepine on electroencephalography and convulsions in conscious rabbits.
Topics: Amygdala; Animals; Electroencephalography; Female; Hemicholinium 3; Hippocampus; Injections, Intrave | 1992 |
Trihexyphenidyl enhances physostigmine prophylaxis against soman poisoning in guinea pigs.
Topics: Animals; Body Weight; Brain; Drinking; Drug Interactions; Guinea Pigs; Kinetics; Lethal Dose 50; Mal | 1991 |