Page last updated: 2024-11-02

pirenzepine and Obsessive-Compulsive Disorder

pirenzepine has been researched along with Obsessive-Compulsive Disorder in 31 studies

Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.

Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.

Research Excerpts

ExcerptRelevanceReference
"The aim of the present study was to investigate the effect of adjunctive olanzapine in patients with obsessive-compulsive disorder (OCD) refractory to paroxetine."9.10Olanzapine augmentation of paroxetine-refractory obsessive-compulsive disorder. ( Cedro, C; D'Amico, G; D'Arrigo, C; Di Rosa, AE; La Torre, D; Muscatello, MR; Pandolfo, G; Spina, E; Zoccali, R, 2003)
"4 years) with DSM-IV schizophrenia or related disorders (N = 113) who were treated with olanzapine or risperidone."9.10Obsessive-compulsive symptoms during treatment with olanzapine and risperidone: a prospective study of 113 patients with recent-onset schizophrenia or related disorders. ( Beuk, N; de Haan, L; Dingemans, P; Hoogenboom, B; Linszen, D, 2002)
"A series of 10 patients with DSM-IV obsessive-compulsive disorder showing significant residual symptoms following an adequate SSRI trial (12 weeks) were given open-label olanzapine augmentation for a minimum of an additional 8 weeks."9.09Olanzapine addition in obsessive-compulsive disorder refractory to selective serotonin reuptake inhibitors: an open-label case series. ( Epperson, CN; McDougle, CJ; Potenza, MN; Weiss, EL, 1999)
"Adding the atypical neuroleptic risperidone to a serotonin reuptake inhibitor (SRI) has benefited patients with treatment-refractory obsessive-compulsive disorder (OCD)."9.09Olanzapine augmentation for treatment-resistant obsessive-compulsive disorder. ( Elliott, MA; Koran, LM; Ringold, AL, 2000)
"This study evaluates the clinical response to olanzapine used in association with selective serotonin reuptake inhibitors (SSRIs) or clomipramine in treatment-resistant obsessive-compulsive disorder (OCD)."9.09Olanzapine augmentation of serotonin uptake inhibitors in obsessive-compulsive disorder: an open study. ( Francobandiera, G, 2001)
"The aim was to describe the short-term (6 months) effects of olanzapine on behavioral and motor clinical manifestations in a group of 11 patients with Huntington disease."7.71Short-term effects of olanzapine in Huntington disease. ( Brusa, L; Cannella, M; Porcellini, A; Ruggieri, S; Simonelli, M; Squitieri, F, 2001)
" The aim of this study was to investigate the efficacy and tolerability of olanzapine addition to fluvoxamine-refractory OCD patients and to assess if a comorbid chronic tic disorder or a concomitant schizotypal personality disorder was associated with response."7.70Olanzapine augmentation of fluvoxamine-refractory obsessive-compulsive disorder (OCD): a 12-week open trial. ( Bellino, S; Bogetto, F; Vaschetto, P; Ziero, S, 2000)
"The aim of the present study was to investigate the effect of adjunctive olanzapine in patients with obsessive-compulsive disorder (OCD) refractory to paroxetine."5.10Olanzapine augmentation of paroxetine-refractory obsessive-compulsive disorder. ( Cedro, C; D'Amico, G; D'Arrigo, C; Di Rosa, AE; La Torre, D; Muscatello, MR; Pandolfo, G; Spina, E; Zoccali, R, 2003)
"4 years) with DSM-IV schizophrenia or related disorders (N = 113) who were treated with olanzapine or risperidone."5.10Obsessive-compulsive symptoms during treatment with olanzapine and risperidone: a prospective study of 113 patients with recent-onset schizophrenia or related disorders. ( Beuk, N; de Haan, L; Dingemans, P; Hoogenboom, B; Linszen, D, 2002)
"A series of 10 patients with DSM-IV obsessive-compulsive disorder showing significant residual symptoms following an adequate SSRI trial (12 weeks) were given open-label olanzapine augmentation for a minimum of an additional 8 weeks."5.09Olanzapine addition in obsessive-compulsive disorder refractory to selective serotonin reuptake inhibitors: an open-label case series. ( Epperson, CN; McDougle, CJ; Potenza, MN; Weiss, EL, 1999)
"Adding the atypical neuroleptic risperidone to a serotonin reuptake inhibitor (SRI) has benefited patients with treatment-refractory obsessive-compulsive disorder (OCD)."5.09Olanzapine augmentation for treatment-resistant obsessive-compulsive disorder. ( Elliott, MA; Koran, LM; Ringold, AL, 2000)
"This study evaluates the clinical response to olanzapine used in association with selective serotonin reuptake inhibitors (SSRIs) or clomipramine in treatment-resistant obsessive-compulsive disorder (OCD)."5.09Olanzapine augmentation of serotonin uptake inhibitors in obsessive-compulsive disorder: an open study. ( Francobandiera, G, 2001)
"The aim was to describe the short-term (6 months) effects of olanzapine on behavioral and motor clinical manifestations in a group of 11 patients with Huntington disease."3.71Short-term effects of olanzapine in Huntington disease. ( Brusa, L; Cannella, M; Porcellini, A; Ruggieri, S; Simonelli, M; Squitieri, F, 2001)
" We present three cases in which olanzapine caused a significant exacerbation of obsessive-compulsive symptoms in schizophrenia (two cases) and obsessive-compulsive disorder (one case)."3.70Olanzapine and obsessive-compulsive symptoms. ( Gournellis, R; Lykouras, L; Malliori, M; Rabavilas, A; Zervas, IM, 2000)
" The aim of this study was to investigate the efficacy and tolerability of olanzapine addition to fluvoxamine-refractory OCD patients and to assess if a comorbid chronic tic disorder or a concomitant schizotypal personality disorder was associated with response."3.70Olanzapine augmentation of fluvoxamine-refractory obsessive-compulsive disorder (OCD): a 12-week open trial. ( Bellino, S; Bogetto, F; Vaschetto, P; Ziero, S, 2000)
"Olanzapine is a recently introduced atypical neuroleptic agent for which little information is available on its use in children."2.69Open-label olanzapine treatment in five preadolescent children. ( King, BH; Krishnamoorthy, J, 1998)
"Olanzapine is a serotonin-dopamine-receptor antagonist indicated for use in the treatment of schizophrenia and other psychotic disorders."2.40Olanzapine: a serotonin-dopamine-receptor antagonist for antipsychotic therapy. ( Bever, KA; Perry, PJ, 1998)
"In this open case series, the dose-response relationship of atypical antipsychotic augmentation in the treatment of obsessive compulsive disorder (OCD), and the dose-severity relationship in atypical anti psychotic-induced OC symptoms were examined."1.31Serotonin and dopamine antagonism in obsessive-compulsive disorder: effect of atypical antipsychotic drugs. ( Lapierre, Y; Ramasubbu, R; Ravindran, A, 2000)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (29.03)18.2507
2000's22 (70.97)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mahendran, R1
Bajaj, V1
Comyn, DJ1
Crocq, MA1
Leclercq, P1
Guillon, MS1
Bailey, PE1
Safranko, I1
Poyurovsky, M2
Kurs, R1
Weizman, A2
D'Amico, G1
Cedro, C1
Muscatello, MR1
Pandolfo, G1
Di Rosa, AE1
Zoccali, R1
La Torre, D1
D'Arrigo, C1
Spina, E1
Baker, RW1
Ames, D1
Umbricht, DS1
Chengappa, KN1
Schooler, NR1
Bever, KA1
Perry, PJ1
Morrison, D1
Clark, D1
Goldfarb, E1
McCoy, L1
al-Mulhim, A1
Atwal, S1
Coupland, NJ1
Krishnamoorthy, J1
King, BH1
Potenza, MN2
Wasylink, S1
Longhurst, JG1
Epperson, CN2
McDougle, CJ2
Mottard, JP1
de la Sablonnière, JF1
Weiss, EL1
Marazziti, D2
Pallanti, S2
Ohaeri, JU1
Degner, D1
Bleich, S1
Kornhuber, J1
Rüther, E1
Dorfman-Etrog, P1
Hermesh, H1
Munitz, H1
Tollefson, GD1
Koran, LM2
Ringold, AL1
Elliott, MA1
Lykouras, L1
Zervas, IM1
Gournellis, R1
Malliori, M1
Rabavilas, A1
Bogetto, F1
Bellino, S1
Vaschetto, P1
Ziero, S1
Ramasubbu, R1
Ravindran, A1
Lapierre, Y1
Squitieri, F1
Cannella, M1
Porcellini, A1
Brusa, L1
Simonelli, M1
Ruggieri, S1
Seger, A1
Lamberti, JS1
Marusic, A1
Farmer, A1
Harel, Z1
Hallett, J1
Riggs, S1
Vaz, R1
Kiessling, L1
Grant, JE1
Francobandiera, G1
de Haan, L2
Beuk, N1
Hoogenboom, B1
Dingemans, P1
Linszen, D1
Hollander, E1
Bienstock, CA1
Rasmussen, SA1
Ravizza, L1
Benkelfat, C1
Saxena, S1
Greenberg, BD1
Sasson, Y1
Zohar, J1
Jonkers, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Treatment Efficacy of Combination Atypical Antipsychotics With Sertraline in Patients With Schizophrenia[NCT04076371]1,640 participants (Actual)Interventional2012-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for pirenzepine and Obsessive-Compulsive Disorder

ArticleYear
Olanzapine: a serotonin-dopamine-receptor antagonist for antipsychotic therapy.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1998, May-15, Volume: 55, Issue:10

    Topics: Antipsychotic Agents; Benzodiazepines; Clinical Trials as Topic; Dopamine Antagonists; Humans; Obses

1998
Refractory obsessive-compulsive disorder: state-of-the-art treatment.
    The Journal of clinical psychiatry, 2002, Volume: 63 Suppl 6

    Topics: Antipsychotic Agents; Benzodiazepines; Cognitive Behavioral Therapy; Combined Modality Therapy; Drug

2002

Trials

8 trials available for pirenzepine and Obsessive-Compulsive Disorder

ArticleYear
Open-label olanzapine in obsessive-compulsive disorder refractory to antidepressant treatment.
    European psychiatry : the journal of the Association of European Psychiatrists, 2002, Volume: 17, Issue:5

    Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Dose-Response Relationship, Drug; Drug Adm

2002
Olanzapine augmentation of paroxetine-refractory obsessive-compulsive disorder.
    Progress in neuro-psychopharmacology & biological psychiatry, 2003, Volume: 27, Issue:4

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Drug Resistance; Female; Humans; Male; Middle Aged; Ob

2003
Obsessive-compulsive symptoms in schizophrenia: a comparison of olanzapine and placebo.
    Psychopharmacology bulletin, 1996, Volume: 32, Issue:1

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Female; Humans; Male; Obsessive-Compulsive Disorder; O

1996
Open-label olanzapine treatment in five preadolescent children.
    Journal of child and adolescent psychopharmacology, 1998, Volume: 8, Issue:2

    Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Benzod

1998
Olanzapine addition in obsessive-compulsive disorder refractory to selective serotonin reuptake inhibitors: an open-label case series.
    The Journal of clinical psychiatry, 1999, Volume: 60, Issue:8

    Topics: Adult; Ambulatory Care; Antipsychotic Agents; Benzodiazepines; Drug Therapy, Combination; Female; Hu

1999
Olanzapine augmentation for treatment-resistant obsessive-compulsive disorder.
    The Journal of clinical psychiatry, 2000, Volume: 61, Issue:7

    Topics: Adult; Benzodiazepines; Drug Administration Schedule; Drug Therapy, Combination; Fluoxetine; Humans;

2000
Olanzapine augmentation of serotonin uptake inhibitors in obsessive-compulsive disorder: an open study.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2001, Volume: 46, Issue:4

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clomipramine; Dose-Response Relationship, Drug; Drug A

2001
Obsessive-compulsive symptoms during treatment with olanzapine and risperidone: a prospective study of 113 patients with recent-onset schizophrenia or related disorders.
    The Journal of clinical psychiatry, 2002, Volume: 63, Issue:2

    Topics: Acute Disease; Adult; Antipsychotic Agents; Benzodiazepines; Comorbidity; Female; Humans; Longitudin

2002

Other Studies

21 other studies available for pirenzepine and Obsessive-Compulsive Disorder

ArticleYear
Emergence of compulsive symptoms with olanzapine treatment.
    The Australian and New Zealand journal of psychiatry, 2002, Volume: 36, Issue:4

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Humans; Male; Obsessive-Compulsive Di

2002
Norepinephrine in the treatment of olanzapine overdose.
    Anaesthesia, 2002, Volume: 57, Issue:10

    Topics: Adrenergic alpha-Agonists; Adult; Antipsychotic Agents; Benzodiazepines; Drug Overdose; Humans; Male

2002
Reply to Dr Mahendran. We have not found reported cases of [obsessive-compulsive] OC arising from de novo with olanzapine treatment.
    The Australian and New Zealand journal of psychiatry, 2003, Volume: 37, Issue:1

    Topics: Adult; Benzodiazepines; Clomipramine; Fluoxetine; Humans; Male; Obsessive-Compulsive Disorder; Olanz

2003
Olanzapine-sertraline combination in schizophrenia with obsessive-compulsive disorder.
    The Journal of clinical psychiatry, 2003, Volume: 64, Issue:5

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Comorbidity; Drug Therapy, Combination; Humans; Middle

2003
Worsening of obsessive-compulsive symptoms following treatment with olanzapine.
    The American journal of psychiatry, 1998, Volume: 155, Issue:6

    Topics: Acute Disease; Adult; Antipsychotic Agents; Benzodiazepines; Comorbidity; Humans; Male; Obsessive-Co

1998
Provocation of obsessive-compulsive behaviour and tremor by olanzapine.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1998, Volume: 43, Issue:6

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Female; Humans; Obsessive-Compulsive Disorder; Olanzap

1998
Olanzapine augmentation of fluoxetine in the treatment of refractory obsessive-compulsive disorder.
    Journal of clinical psychopharmacology, 1998, Volume: 18, Issue:5

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Drug Therapy, Combination; Female; Fluoxetine; Humans;

1998
Olanzapine-induced obsessive-compulsive disorder.
    The American journal of psychiatry, 1999, Volume: 156, Issue:5

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clomipramine; Fluoxetine; Humans; Male; Obsessive-Comp

1999
Effectiveness of olanzapine treatment for severe obsessive-compulsive disorder.
    The American journal of psychiatry, 1999, Volume: 156, Issue:11

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Drug Therapy, Combination; Female; Fluvoxamine; Humans

1999
Naturalistic study of olanzapine in treatment-resistant schizophrenia and acute mania, depression and obsessional disorder.
    East African medical journal, 2000, Volume: 77, Issue:2

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Depressive Disorde

2000
Olanzapine treatment of obsessive-compulsive disorder.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2000, Volume: 45, Issue:4

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Humans; Male; Obsessive-Compulsive Disorder; Olanzapin

2000
Beneficial effect of olanzapine in schizophrenic patients with obsessive-compulsive symptoms.
    International clinical psychopharmacology, 2000, Volume: 15, Issue:3

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Female; Humans; Male; Middle Aged; Obsessive-Compulsiv

2000
Olanzapine and obsessive-compulsive symptoms.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2000, Volume: 10, Issue:5

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Female; Humans; Male; Obsessive-Compulsive Disorder; O

2000
Olanzapine augmentation of fluvoxamine-refractory obsessive-compulsive disorder (OCD): a 12-week open trial.
    Psychiatry research, 2000, Oct-30, Volume: 96, Issue:2

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Benzodiazepines; Comorbidity; Drug Therapy, Combinati

2000
Serotonin and dopamine antagonism in obsessive-compulsive disorder: effect of atypical antipsychotic drugs.
    Pharmacopsychiatry, 2000, Volume: 33, Issue:6

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clomipramine; Dopamine Antagonists; Female; Humans; Ma

2000
Short-term effects of olanzapine in Huntington disease.
    Neuropsychiatry, neuropsychology, and behavioral neurology, 2001, Volume: 14, Issue:1

    Topics: Administration, Oral; Adult; Aged; Antipsychotic Agents; Anxiety; Benzodiazepines; Depression; Femal

2001
Priapism associated with polypharmacy.
    The Journal of clinical psychiatry, 2001, Volume: 62, Issue:2

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Drug Therapy, Combination; Fluvoxamine; Humans; Male;

2001
Antidepressant augmentation with low-dose olanzapine in obsessive-compulsive disorder.
    The British journal of psychiatry : the journal of mental science, 2000, Volume: 177

    Topics: Antipsychotic Agents; Benzodiazepines; Drug Interactions; Fluoxetine; Humans; Male; Middle Aged; Obs

2000
Antibodies against human putamen in adolescents with anorexia nervosa.
    The International journal of eating disorders, 2001, Volume: 29, Issue:4

    Topics: Adolescent; Anorexia Nervosa; Antibodies; Benzodiazepines; Body Mass Index; Caudate Nucleus; Enzyme-

2001
Successful treatment of nondelusional body dysmorphic disorder with olanzapine: a case report.
    The Journal of clinical psychiatry, 2001, Volume: 62, Issue:4

    Topics: Age of Onset; Antipsychotic Agents; Benzodiazepines; Drug Administration Schedule; Female; Humans; M

2001
Olanzapine-induced obsessive-compulsive symptoms in a patient with bipolar II disorder.
    Psychopharmacology, 2002, Volume: 162, Issue:1

    Topics: Adult; Benzodiazepines; Bipolar Disorder; Female; Humans; Obsessive-Compulsive Disorder; Olanzapine;

2002