pirenzepine has been researched along with Nerve Degeneration in 3 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both acute and chronic administration of N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine and dizocilpine have been proposed to mimic some of the symptoms of schizophrenia." | 7.71 | Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophrenia. ( Johnson, KM; McInnis, J; Ross-Sanchez, M; Shinnick-Gallagher, P; Wang, C; Wiley, JL, 2001) |
| "Both acute and chronic administration of N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine and dizocilpine have been proposed to mimic some of the symptoms of schizophrenia." | 3.71 | Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophrenia. ( Johnson, KM; McInnis, J; Ross-Sanchez, M; Shinnick-Gallagher, P; Wang, C; Wiley, JL, 2001) |
| "These results suggest that cases of Alzheimer's disease express heterogeneities in neocortical pathology which are reflected in the laminar patterns of binding to postsynaptic receptors." | 1.28 | Laminar alterations in gamma-aminobutyric acidA, muscarinic, and beta adrenoceptors and neuron degeneration in cingulate cortex in Alzheimer's disease. ( Crino, PB; Vogt, BA; Volicer, L, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, C | 1 |
| McInnis, J | 1 |
| Ross-Sanchez, M | 1 |
| Shinnick-Gallagher, P | 1 |
| Wiley, JL | 1 |
| Johnson, KM | 1 |
| Vogt, BA | 1 |
| Crino, PB | 1 |
| Volicer, L | 1 |
| Nishino, N | 1 |
| Fujiwara, H | 1 |
| Noguchi-Kuno, SA | 1 |
| Tanaka, C | 1 |
3 other studies available for pirenzepine and Nerve Degeneration
| Article | Year |
|---|---|
Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophrenia.
Topics: Animals; Antipsychotic Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Behavior, Anima | 2001 |
Laminar alterations in gamma-aminobutyric acidA, muscarinic, and beta adrenoceptors and neuron degeneration in cingulate cortex in Alzheimer's disease.
Topics: Adrenergic beta-Antagonists; Aged; Alzheimer Disease; Gyrus Cinguli; Humans; Muscimol; Nerve Degener | 1991 |
GABAA receptor but not muscarinic receptor density was decreased in the brain of patients with Parkinson's disease.
Topics: Aged; Brain; Choline O-Acetyltransferase; Dopamine; Female; Glutamate Decarboxylase; Humans; Male; M | 1988 |