Page last updated: 2024-11-02

pirenzepine and Neoplasms

pirenzepine has been researched along with Neoplasms in 5 studies

Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"This open-label pilot study explored the antiemetic activity of olanzapine, an atypical antipsychotic, in patients with advanced cancer requiring opioid analgesics for pain."7.71A pilot exploration of the antiemetic activity of olanzapine for the relief of nausea in patients with advanced cancer and pain. ( Cooper, M; Donaghy, K; Dugan, W; Holtsclaw, E; Kirsh, KL; Lundberg, J; Passik, SD; Theobald, D, 2002)
"Olanzapine, which has been used anecdotally for chronic nausea in advanced cancer patients, might be a useful treatment for the prevention of delayed emesis in chemotherapy patients."5.32A retrospective chart review of the use of olanzapine for the prevention of delayed emesis in cancer patients. ( Beaver, M; Brown, J; Comparet, J; Dickerson, P; Gray, D; Kirsh, KL; Passik, SD; Theobald, DE; Trowbridge, R, 2003)
"This open-label pilot study explored the antiemetic activity of olanzapine, an atypical antipsychotic, in patients with advanced cancer requiring opioid analgesics for pain."3.71A pilot exploration of the antiemetic activity of olanzapine for the relief of nausea in patients with advanced cancer and pain. ( Cooper, M; Donaghy, K; Dugan, W; Holtsclaw, E; Kirsh, KL; Lundberg, J; Passik, SD; Theobald, D, 2002)
"Advanced cancer patients are polysymptomatic and often receive multiple medications for symptom relief."2.41Management of symptoms associated with advanced cancer: olanzapine and mirtazapine. A World Health Organization project. ( Davis, MP; Khawam, E; Lagman, R; Pozuelo, L, 2002)
"Olanzapine, which has been used anecdotally for chronic nausea in advanced cancer patients, might be a useful treatment for the prevention of delayed emesis in chemotherapy patients."1.32A retrospective chart review of the use of olanzapine for the prevention of delayed emesis in cancer patients. ( Beaver, M; Brown, J; Comparet, J; Dickerson, P; Gray, D; Kirsh, KL; Passik, SD; Theobald, DE; Trowbridge, R, 2003)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's4 (80.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Davis, MP1
Khawam, E1
Pozuelo, L1
Lagman, R1
Passik, SD2
Kirsh, KL2
Theobald, DE1
Dickerson, P1
Trowbridge, R1
Gray, D1
Beaver, M1
Comparet, J1
Brown, J1
Carrillo, JA1
Benítez, J1
Khojainova, N1
Santiago-Palma, J1
Kornick, C1
Breitbart, W1
Gonzales, GR1
Lundberg, J1
Theobald, D1
Donaghy, K1
Holtsclaw, E1
Cooper, M1
Dugan, W1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Olanzapine as First Line Treatment for Prevention of Nausea and Vomiting Induced by Chemotherapy of Lung Cancer: a Multicenter, Double-blind and Randomized Trial[NCT03571126]Phase 4156 participants (Anticipated)Interventional2019-05-09Recruiting
Aprepitant- and Olanzapine- Containing Regimens for Prevention of Acute and Delayed Nausea and Vomiting Associated With High Dose Melphalan and BEAM in Autologous Stem Cell Transplant Patients[NCT02939287]Phase 3429 participants (Actual)Interventional2017-09-23Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for pirenzepine and Neoplasms

ArticleYear
Management of symptoms associated with advanced cancer: olanzapine and mirtazapine. A World Health Organization project.
    Expert review of anticancer therapy, 2002, Volume: 2, Issue:4

    Topics: Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Drug Interactions; Humans; Mianserin;

2002

Trials

1 trial available for pirenzepine and Neoplasms

ArticleYear
Olanzapine in the management of cancer pain.
    Journal of pain and symptom management, 2002, Volume: 23, Issue:4

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Benzodiazepines; Female; Humans; Male; Middle Aged; N

2002

Other Studies

3 other studies available for pirenzepine and Neoplasms

ArticleYear
A retrospective chart review of the use of olanzapine for the prevention of delayed emesis in cancer patients.
    Journal of pain and symptom management, 2003, Volume: 25, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antiemetics; Antineoplastic Agents; Benzodiazepines; Female; Humans;

2003
Are antipsychotic drugs potentially chemopreventive agents for cancer?
    European journal of clinical pharmacology, 1999, Volume: 55, Issue:6

    Topics: Adult; Antineoplastic Agents; Antipsychotic Agents; Benzodiazepines; Caffeine; Carcinogens; Chemopre

1999
A pilot exploration of the antiemetic activity of olanzapine for the relief of nausea in patients with advanced cancer and pain.
    Journal of pain and symptom management, 2002, Volume: 23, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiemetics; Benzodiazepines; Dyskinesia, Drug-Induced;

2002