pirenzepine has been researched along with Muscle Relaxation in 22 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "3." | 1.28 | Responsiveness and sensitivity to cholinergic agonists and antagonists in bovine isolated bronchial muscle. ( Cazzola, M; Constantino, M; De Santis, D; Matera, MG; Rossi, F, 1992) |
| " In tissues precontracted with methacholine, 11-([[2-(diethylamino)methyl]-1-piperidinyl]acetyl)5,11- dihydro-6H-pyrido[2,3-6][1,4]benzodiazepine-6-one (AF-DX 116), a selective M2 antagonist, shifted dose-response curves to both isoproterenol and forskolin significantly to the left." | 1.28 | M2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine airway smooth muscle. ( Fernandes, LB; Fryer, AD; Hirshman, CA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.64) | 18.7374 |
| 1990's | 14 (63.64) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shahab, N | 1 |
| Kajioka, S | 1 |
| Seki, N | 1 |
| Naito, S | 1 |
| Andersson, M | 1 |
| Aronsson, P | 1 |
| Doufish, D | 1 |
| Lampert, A | 1 |
| Tobin, G | 1 |
| Sohn, JT | 1 |
| Ok, SH | 1 |
| Kim, HJ | 1 |
| Moon, SH | 1 |
| Shin, IW | 1 |
| Lee, HK | 1 |
| Chung, YK | 1 |
| Hamrouni, AM | 1 |
| Gudka, N | 1 |
| Broadley, KJ | 1 |
| Kitazawa, T | 1 |
| Hashiba, K | 1 |
| Cao, J | 1 |
| Unno, T | 1 |
| Komori, S | 1 |
| Yamada, M | 1 |
| Wess, J | 1 |
| Taneike, T | 1 |
| Masuda, Y | 1 |
| Yamahara, NS | 2 |
| Tanaka, M | 2 |
| Ryang, S | 1 |
| Kawai, T | 1 |
| Imaizumi, Y | 2 |
| Watanabe, M | 2 |
| Roffel, AF | 1 |
| Meurs, H | 1 |
| Elzinga, CR | 1 |
| Zaagsma, J | 1 |
| Altiere, RJ | 1 |
| Travis, DC | 1 |
| Roberts, J | 1 |
| Thompson, DC | 1 |
| Shiraishi, K | 1 |
| Takayanagi, I | 1 |
| Radomirov, R | 1 |
| Pencheva, N | 1 |
| Norel, X | 1 |
| Walch, L | 1 |
| Costantino, M | 1 |
| Labat, C | 1 |
| Gorenne, I | 1 |
| Dulmet, E | 1 |
| Rossi, F | 2 |
| Brink, C | 1 |
| Ostrom, RS | 2 |
| Ehlert, FJ | 2 |
| Matera, MG | 1 |
| Cazzola, M | 1 |
| Constantino, M | 1 |
| De Santis, D | 1 |
| Fernandes, LB | 1 |
| Fryer, AD | 1 |
| Hirshman, CA | 1 |
| Micheletti, R | 2 |
| Giudici, L | 2 |
| Turconi, M | 1 |
| Donetti, A | 2 |
| Jaiswal, N | 1 |
| Lambrecht, G | 1 |
| Mutschler, E | 1 |
| Tacke, R | 1 |
| Malik, KU | 1 |
| Schiavone, A | 1 |
| Angelici, O | 1 |
| Duranti, P | 1 |
| Cereda, E | 1 |
| Tsukahara, T | 1 |
| Hongo, K | 1 |
| Kassell, NF | 1 |
| Ogawa, H | 1 |
| Schumacher, C | 1 |
| Steinberg, R | 1 |
| Kan, JP | 1 |
| Michaud, JC | 1 |
| Bourguignon, JJ | 1 |
| Wermuth, CG | 1 |
| Feltz, P | 1 |
| Worms, P | 1 |
| Biziere, K | 1 |
| Duckles, SP | 1 |
| Yamamura, HI | 1 |
| Lee, V | 1 |
22 other studies available for pirenzepine and Muscle Relaxation
| Article | Year |
|---|---|
Functional role of muscarinic receptor subtypes in calcium sensitization and their contribution to rho-kinase and protein kinase C pathways in contraction of human detrusor smooth muscle.
Topics: Amides; Calcium; Carbachol; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Maleimides; Mus | 2012 |
Muscarinic receptor subtypes involved in urothelium-derived relaxatory effects in the inflamed rat urinary bladder.
Topics: Animals; Carbachol; Cyclophosphamide; Cystitis; Dose-Response Relationship, Drug; Enzyme Inhibitors; | 2012 |
Inhibitory effect of fentanyl on acetylcholine-induced relaxation in rat aorta.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Aorta, Thoracic; Calcimycin; Dose-Response Relationship, | 2004 |
Investigation of the mechanism for the relaxation of rat duodenum mediated via M1 muscarinic receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bicuculline; Dose-Res | 2006 |
Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice.
Topics: Animals; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Electric Stimulation; En | 2007 |
Characterization of muscarinic receptors mediating relaxation and contraction in the rat iris dilator muscle.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Alkaloids; Anim | 1995 |
No evidence for a role of muscarinic M2 receptors in functional antagonism in bovine trachea.
Topics: Animals; Bronchoconstrictor Agents; Cattle; Dose-Response Relationship, Drug; Gallamine Triethiodide | 1995 |
Pertussis toxin-sensitive muscarinic relaxation in the rat iris dilator muscle.
Topics: Acetylcholine; Alkaloids; Animals; Atropine; Diamines; Dose-Response Relationship, Drug; Furans; GTP | 1995 |
Pharmacological characterization of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries.
Topics: Acetylcholine; Animals; Endothelium, Vascular; Heart Atria; Ileum; Lung; Male; Muscarinic Antagonist | 1994 |
Subtype of muscarinic receptors mediating relaxation and contraction in the rat iris dilator smooth muscle.
Topics: Alkaloids; Animals; Atropine; Carbachol; Furans; In Vitro Techniques; Iris; Male; Muscle Contraction | 1993 |
Two types of functionally different GABAA receptors mediate GABA modulation of cholinergic transmission in cat terminal ileum.
Topics: Animals; Atropine; Bicuculline; Cats; Dose-Response Relationship, Drug; Electric Stimulation; GABA A | 1995 |
M1 and M3 muscarinic receptors in human pulmonary arteries.
Topics: Acetylcholine; Cholinergic Agonists; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Humans; In Vitro | 1996 |
M2 muscarinic receptor inhibition of agonist-induced cyclic adenosine monophosphate accumulation and relaxation in the guinea pig ileum.
Topics: Animals; Cyclic AMP; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Male; Muscarinic Agonists; | 1997 |
Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea.
Topics: Animals; Colforsin; Diphenylacetic Acids; Guinea Pigs; Histamine; Ileum; Isoproterenol; Muscle Relax | 1999 |
Responsiveness and sensitivity to cholinergic agonists and antagonists in bovine isolated bronchial muscle.
Topics: Acetylcholine; Animals; Atropine; Bronchi; Cattle; Gallamine Triethiodide; In Vitro Techniques; Musc | 1992 |
M2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine airway smooth muscle.
Topics: Animals; Dogs; Drug Interactions; Isoproterenol; Methacholine Chloride; Muscle Relaxation; Muscle, S | 1992 |
4-DAMP analogues reveal heterogeneity of M1 muscarinic receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Duodenum; In Vitro Te | 1990 |
Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Antihy | 1991 |
Affinity profile of the novel muscarinic antagonist, guanylpirenzepine.
Topics: Animals; Atrial Function; Duodenum; Guanine; Guinea Pigs; Ileum; Male; Muscarine; Muscarinic Antagon | 1990 |
Characterization of muscarinic cholinergic receptors on the endothelium and the smooth muscle of the rabbit thoracic aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Atropine; Endothelium, Vascular; Male; Muscle Relaxation; M | 1989 |
Pharmacological characterization of the aminopyridazine SR 95639A, a selective M1 muscarinic agonist.
Topics: Animals; Behavior, Animal; Cisterna Magna; Dose-Response Relationship, Drug; Electrophysiology; Guin | 1989 |
AF-DX 116 discriminates between muscarinic M2 receptors of the heart and vasculature.
Topics: Animals; Arteries; Atrial Function; Ear; Female; Male; Muscle Relaxation; Muscle, Smooth, Vascular; | 1987 |