pirenzepine has been researched along with Muscle Contraction in 153 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Reserpine treatment of rats (0." | 5.28 | Reserpine-induced post-receptor reduction in muscarinic-mediated airway smooth muscle contraction. ( Blaxall, HS; Cunningham, J; Gardier, RW; Killian, LN, 1991) |
| " By using an ex vivo model of OP-induced muscle weakness, we studied the effects of the M1/M4 mAChR antagonist pirenzepine and the M2/M4 mAChR antagonist methoctramine on the force of mouse diaphragm muscle contraction." | 4.12 | Balanced modulation of neuromuscular synaptic transmission via M1 and M2 muscarinic receptors during inhibition of cholinesterases. ( Lenina, OA; Petrov, KA, 2022) |
| "According to tests, carbachol, in concentrations ranging between 10(-8) M to 10(-4) M, in a dosage-dependent way induces gastric fundus smooth muscle contraction." | 3.77 | Role of M1 receptor in regulation of gastric fundus smooth muscle contraction. ( Gajdus, M; Glaza, I; Olkowska, J; Szadujkis-Szadurska, K; Szadujkis-Szadurski, L; Szadujkis-Szadurski, R, 2011) |
| "Bethanechol induced smooth muscle contractions via muscarinic receptor subtype M3." | 3.74 | Corticotropin-releasing factor inhibition of sheep fetal colonic contractility: mechanisms to prevent meconium passage in utero. ( Ahanya, SA; Lakshmanan, J; Liu, G; Mazdak, M; Oyachi, N; Ross, MG, 2007) |
| "The effects of subtype-selective muscarinic receptor antagonists on electrically evoked release of acetylcholine and muscle contraction were compared in circular muscle preparations of the guinea-pig ileum." | 3.69 | Prejunctional M1 and postjunctional M3 muscarinic receptors in the circular muscle of the guinea-pig ileum. ( Dietrich, C; Kilbinger, H, 1995) |
| "Carbachol did not cause contraction but instead caused relaxation of colonic strips from M(2)/M(3)R-KO mice." | 1.37 | Muscarinic receptor subtypes involved in regulation of colonic motility in mice: functional studies using muscarinic receptor-deficient mice. ( Kitazawa, T; Komori, S; Kondo, T; Nakajima, M; Teraoka, H; Unno, T; Yamada, M, 2011) |
| "Cadmium (Cd) toxicity was produced in male rats to study the role of cholinoceptors in Cd-induced endothelial dysfunction." | 1.32 | Involvement of cholinoceptors in cadmium-induced endothelial dysfunction. ( Alkan, Z; Bilgen, I; Cirrik, S; Edremitlioğlu, M; Oner, G, 2003) |
| " The dose-response curves were shifted to the right by muscarinic antagonists in the following order of affinity: darifenacin (M(3))>methocramine (M(2)) >pirenzepine (M(1))." | 1.32 | Mechanisms mediating cholinergic antral circular smooth muscle contraction in rats. ( Ouyang, A; Tandon, T; Wrzos, HF, 2004) |
| " Oxotremorine generated dose-response curves that were similar in both the circular and longitudinal vectors and intermediate to those previously reported for carbachol and aceclidine." | 1.29 | The effect of muscarinic agonists and selective receptor subtype antagonists on the contractile response of the isolated rhesus monkey ciliary muscle. ( Gabelt, BT; Kaufman, PL; Poyer, JF, 1994) |
| "Atropine was used as a nonselective antagonist." | 1.29 | Functional characterization of muscarinic receptors in murine airways. ( Garssen, J; Gierveld, CM; Nijkamp, FP; Van der Vliet, H; Van Loveren, H, 1993) |
| " The in vivo dose-response effects of "selective" muscarinic antagonists on changes in lung resistance (RL) and heart rate (HR) in response to electrical stimulation of the vagus nerves were obtained in four groups of newborns." | 1.29 | Cardiopulmonary actions of muscarinic receptor subtypes in the newborn dog. ( Anderson, JW; Brundage, KL; Fisher, JT, 1996) |
| " Telenzepine (3 x 10(-8)-10(-5) M) concentration-dependently shifted to the right the dose-response curves of bethanechol, acetylcholine and McN-A343, and partially depressed the electrically-evoked twitch responses." | 1.28 | Antimuscarinic activity of telenzepine on isolated human urinary bladder: no role for M1-muscarinic receptors. ( Bertaccini, G; Monica, B; Poli, E; Pozzoli, C; Zappia, L, 1992) |
| "Amiloride (AM) is a well known potassium sparing diuretic." | 1.28 | Differential antagonism by amiloride and pirenzepine of the muscarinic receptors of rat tracheal smooth muscle. ( Santacana, GE; Silva, WI, 1990) |
| "Pirenzepine was further used to examine whether gall-bladder motor responses to synthetic sulphated cholecystokinin octapeptide (CCK-8) are sensitive to pirenzepine." | 1.28 | In-vitro effect of pirenzepine on motility of canine gall-bladder. ( Madrid, JA; Pozo, MJ; Salido, GM; Salido, MD, 1990) |
| "Reserpine treatment of rats (0." | 1.28 | Reserpine-induced post-receptor reduction in muscarinic-mediated airway smooth muscle contraction. ( Blaxall, HS; Cunningham, J; Gardier, RW; Killian, LN, 1991) |
| " All the antagonists shifted the methacholine dose-response curve to the right in a parallel and concentration-dependent fashion, yielding Schild plots with slopes not significantly different from unity." | 1.28 | Characterization of the muscarinic receptor subtype involved in phosphoinositide metabolism in bovine tracheal smooth muscle. ( Elzinga, CR; Meurs, H; Roffel, AF; Zaagsma, J, 1990) |
| "Like atropine, BTM-1086 was a potent, nonselective, competitive muscarinic antagonist with no detectable antispasmodic activity in urinary bladder or ileal muscle." | 1.28 | In vitro and in vivo antimuscarinic effects of (-)cis 2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5 benzothiazepin-4-(5H)one HCl (BTM-1086) in guinea pig peripheral tissues. ( Jackson, KN; Kachur, JF; Lowe, VC; Noronha-Blob, L; Sturm, BL, 1990) |
| "Atropine was 70-100 times more potent than pirenzepine and 8-25 times more potent than hexahydrosiladifenidol." | 1.27 | Muscarinic receptors on nerves and muscles in opossum esophagus muscularis mucosa. ( Bowker, P; Daniel, EE; Jury, J, 1987) |
| "Pirenzepine affinity was also low in the perfused rabbit ear artery preparation." | 1.27 | Vascular muscarinic receptors: pharmacological characterization in the bovine coronary artery. ( Duckles, SP, 1988) |
| " The shifts caused by atropine and pirenzepine in the dose-response curves for ACh were not parallel after in vitro treatment of the muscle with DFP." | 1.27 | Contractile responses of tracheal smooth muscle in organophosphate-treated swine: 2. Effects of antagonists. ( Dwyer, TM; Farley, JM; Murali Mohan, P; Yang, CM, 1988) |
| "Pirenzepine is an antisecretory anticholinergic type drug that has recently been shown to be relatively free of usual anticholinergic side effects on esophageal smooth muscle." | 1.27 | Pirenzepine and propantheline effects on esophageal pressure responses to bethanechol. ( Castell, DO; Castell, JA; Dalton, CB; Hassan, M, 1986) |
| "Pirenzepine was 102- to 178-fold less potent than atropine when compared at the inhibitory concentration of antagonist that produced 25, 50, and 75% inhibition (IC25, IC50, and IC75, respectively), indicating that the muscarinic receptor at the nerve-smooth muscle junction is a muscarinic receptor with low affinity for pirenzepine (M2 subtype)." | 1.27 | A muscarinic receptor subtype modulates vagally stimulated bronchial contraction. ( Baumgartener-Folkerts, C; Bloom, JW; Halonen, M; Palmer, JD; Yamamura, HI, 1988) |
| "Pilocarpine was used as a selective agonist and gallamine as a selective antagonist of these autoreceptors." | 1.27 | Prejunctional inhibitory muscarinic receptors on cholinergic nerves in human and guinea pig airways. ( Barnes, PJ; Minette, PA, 1988) |
| "2." | 1.27 | Selective antagonism by pirenzepine and N-methyl-scopolamine on muscarinic receptor subtypes of the rat vas deferens. ( Cuevas, N; Miranda, HF; Silva, WI; Wolstenholme, WW, 1988) |
| "Atropine was about 2 orders of magnitude more potent than PZ in inhibiting the CCh-induced biochemical and pharmacological responses and [3H] QNB binding, indicating the preponderance of M2 receptors in this smooth muscle." | 1.27 | M2 muscarinic receptor subtype is associated with inositol trisphosphate accumulation, myosin light chain phosphorylation and contraction in sphincter smooth muscle of rabbit iris. ( Abdel-Latif, AA; Akhtar, RA; Honkanen, RE; Howe, PH, 1987) |
| "Telenzepine was found to be 4-10 times more potent than pirenzepine with respect to depressing both gastric acid secretion and smooth muscle or myocardial responses." | 1.27 | Pharmacological evidence for selective inhibition of gastric acid secretion by telenzepine, a new antimuscarinic drug. ( Eltze, M; Gönne, S; Riedel, R; Schlotke, B; Schudt, C; Simon, WA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (28.76) | 18.7374 |
| 1990's | 77 (50.33) | 18.2507 |
| 2000's | 23 (15.03) | 29.6817 |
| 2010's | 8 (5.23) | 24.3611 |
| 2020's | 1 (0.65) | 2.80 |
| Authors | Studies |
|---|---|
| Carroll, FI | 1 |
| Abraham, P | 1 |
| Parham, K | 1 |
| Griffith, RC | 1 |
| Ahmad, A | 1 |
| Richard, MM | 1 |
| Padilla, FN | 1 |
| Witkin, JM | 1 |
| Chiang, PK | 2 |
| Minarini, A | 2 |
| Bolognesi, ML | 1 |
| Budriesi, R | 2 |
| Canossa, M | 1 |
| Chiarini, A | 2 |
| Spampinato, S | 2 |
| Melchiorre, C | 2 |
| Hegde, SS | 1 |
| Choppin, A | 1 |
| Bonhaus, D | 1 |
| Briaud, S | 1 |
| Loeb, M | 1 |
| Moy, TM | 1 |
| Loury, D | 1 |
| Eglen, RM | 3 |
| Xu, R | 1 |
| Sim, MK | 1 |
| Go, ML | 1 |
| Lenina, OA | 1 |
| Petrov, KA | 1 |
| Sahin, L | 1 |
| Cevik, OS | 1 |
| Koyuncu, DD | 1 |
| Buyukafsar, K | 1 |
| Bornia, EC | 1 |
| Bando, E | 1 |
| Machinski, M | 1 |
| Pereira, MW | 1 |
| Alves-Do-Prado, W | 2 |
| Semenov, I | 1 |
| Wang, B | 1 |
| Herlihy, JT | 1 |
| Brenner, R | 1 |
| Gajdus, M | 1 |
| Szadujkis-Szadurska, K | 1 |
| Szadujkis-Szadurski, L | 1 |
| Glaza, I | 1 |
| Szadujkis-Szadurski, R | 1 |
| Olkowska, J | 1 |
| Kondo, T | 1 |
| Nakajima, M | 1 |
| Teraoka, H | 1 |
| Unno, T | 2 |
| Komori, S | 2 |
| Yamada, M | 2 |
| Kitazawa, T | 2 |
| Moro, C | 1 |
| Uchiyama, J | 1 |
| Chess-Williams, R | 2 |
| Shahab, N | 1 |
| Kajioka, S | 1 |
| Seki, N | 1 |
| Naito, S | 1 |
| Andersson, M | 1 |
| Aronsson, P | 2 |
| Doufish, D | 1 |
| Lampert, A | 1 |
| Tobin, G | 4 |
| Brown, SM | 1 |
| Koarai, A | 1 |
| Sturton, RG | 1 |
| Nicholson, AG | 1 |
| Barnes, PJ | 3 |
| Donnelly, LE | 1 |
| Romański, KW | 1 |
| Bilgen, I | 1 |
| Oner, G | 1 |
| Edremitlioğlu, M | 1 |
| Alkan, Z | 1 |
| Cirrik, S | 1 |
| Jankovic, SM | 2 |
| Protic, BA | 2 |
| Jankovic, SV | 2 |
| Wrzos, HF | 1 |
| Tandon, T | 1 |
| Ouyang, A | 1 |
| Marti, M | 1 |
| Mevissen, M | 2 |
| Althaus, H | 1 |
| Steiner, A | 2 |
| Ng, YK | 1 |
| de Groat, WC | 1 |
| Wu, HY | 1 |
| Hashiba, K | 1 |
| Cao, J | 1 |
| Wess, J | 3 |
| Taneike, T | 1 |
| Stevens, LA | 1 |
| Chapple, CR | 1 |
| Chávez, J | 1 |
| Segura, P | 1 |
| Vargas, MH | 1 |
| Arreola, JL | 1 |
| Flores-Soto, E | 1 |
| Montaño, LM | 1 |
| Giglio, D | 2 |
| Eriksson, L | 1 |
| Pfeiffer, JB | 1 |
| Portier, CJ | 1 |
| Meylan, M | 1 |
| Lakshmanan, J | 1 |
| Oyachi, N | 1 |
| Ahanya, SA | 1 |
| Liu, G | 1 |
| Mazdak, M | 1 |
| Ross, MG | 1 |
| Del Tacca, M | 1 |
| Soldani, G | 1 |
| Bernardini, C | 1 |
| Martinotti, E | 1 |
| Maggi, CA | 1 |
| Meli, A | 1 |
| Birdsall, NJ | 1 |
| Ojewole, JA | 2 |
| Jaup, BH | 1 |
| Abrahamsson, H | 1 |
| Virtanen, R | 1 |
| Iisalo, E | 1 |
| Stacher, G | 1 |
| Havlik, E | 1 |
| Bergmann, H | 1 |
| Schmierer, G | 1 |
| Winklehner, S | 1 |
| ten Berge, RE | 1 |
| Roffel, AF | 5 |
| Zaagsma, J | 5 |
| Ren, LM | 1 |
| Nakane, T | 1 |
| Chiba, S | 1 |
| Masuda, Y | 1 |
| Yamahara, NS | 2 |
| Tanaka, M | 2 |
| Ryang, S | 1 |
| Kawai, T | 1 |
| Imaizumi, Y | 2 |
| Watanabe, M | 2 |
| Meurs, H | 2 |
| Elzinga, CR | 4 |
| Dietrich, C | 1 |
| Kilbinger, H | 2 |
| Boselli, C | 1 |
| Grana, E | 1 |
| Poyer, JF | 1 |
| Gabelt, BT | 1 |
| Kaufman, PL | 1 |
| Ram, JL | 1 |
| Judge, K | 1 |
| Jednak, MA | 1 |
| Dehpour, AR | 1 |
| Delfan, A | 1 |
| Mousavizadeh, K | 1 |
| Mortazavi, SR | 1 |
| Takase, H | 1 |
| Yamamoto, K | 1 |
| Hirano, H | 1 |
| Saito, Y | 1 |
| Yamashita, A | 1 |
| Kume, H | 1 |
| Mikawa, K | 1 |
| Takagi, K | 1 |
| Kotlikoff, MI | 1 |
| Thomas, EA | 3 |
| Ehlert, FJ | 6 |
| Altiere, RJ | 1 |
| Travis, DC | 1 |
| Roberts, J | 1 |
| Thompson, DC | 1 |
| Karlsson, E | 1 |
| Jolkkonen, M | 1 |
| Satyapan, N | 1 |
| Adem, A | 1 |
| Kumlin, E | 1 |
| Hellman, U | 1 |
| Wernstedt, C | 1 |
| Tachado, SD | 1 |
| Virdee, K | 1 |
| Akhtar, RA | 2 |
| Abdel-Latif, AA | 2 |
| von Schrenck, T | 1 |
| Sievers, J | 1 |
| Mirau, S | 1 |
| Raedler, A | 1 |
| Greten, H | 1 |
| Haxhiu-Poskurica, B | 1 |
| Ernsberger, P | 1 |
| Haxhiu, MA | 1 |
| Miller, MJ | 1 |
| Cattarossi, L | 1 |
| Martin, RJ | 1 |
| Mitchell, RW | 1 |
| Koenig, SM | 1 |
| Popovich, KJ | 1 |
| Kelly, E | 1 |
| Tallet, J | 1 |
| Leff, AR | 1 |
| Baker, SA | 1 |
| Shannon, HE | 1 |
| Sawyer, BD | 1 |
| Bemis, KG | 1 |
| Bymaster, FP | 2 |
| Health, I | 1 |
| Mitch, CH | 1 |
| Ward, JS | 1 |
| Shiraishi, K | 1 |
| Takayanagi, I | 1 |
| Garssen, J | 1 |
| Van Loveren, H | 1 |
| Gierveld, CM | 1 |
| Van der Vliet, H | 1 |
| Nijkamp, FP | 1 |
| Kerr, PM | 1 |
| Hillier, K | 1 |
| Wallis, RM | 1 |
| Garland, CJ | 1 |
| Sjögren, C | 1 |
| Radomirov, R | 1 |
| Pencheva, N | 1 |
| Norel, X | 1 |
| Walch, L | 1 |
| Costantino, M | 1 |
| Labat, C | 1 |
| Gorenne, I | 1 |
| Dulmet, E | 1 |
| Rossi, F | 1 |
| Brink, C | 1 |
| Fisher, JT | 1 |
| Brundage, KL | 1 |
| Anderson, JW | 1 |
| Elorriaga, M | 1 |
| Anselmi, E | 1 |
| Hernandez, JM | 1 |
| D'Ocon, P | 1 |
| Ivorra, D | 1 |
| Watson, N | 1 |
| Reddy, H | 1 |
| Nelson, DK | 1 |
| Glasbrenner, B | 1 |
| Dahmen, G | 1 |
| Riepl, RL | 1 |
| Malfertheiner, P | 1 |
| Adler, G | 1 |
| Mutoh, S | 1 |
| Latifpour, J | 1 |
| Saito, M | 1 |
| Weiss, RM | 1 |
| Ghelardini, C | 1 |
| Galeotti, N | 1 |
| Gualtieri, F | 1 |
| Novella Romanelli, M | 1 |
| Bartolini, A | 1 |
| Sawyer, GW | 3 |
| Lai, FM | 1 |
| Cobuzzi, A | 1 |
| Spinelli, W | 1 |
| Shen, A | 1 |
| Mitchelson, F | 3 |
| Inadome, A | 1 |
| Yoshida, M | 1 |
| Takahashi, W | 1 |
| Yono, M | 1 |
| Seshita, H | 1 |
| Miyamoto, Y | 1 |
| Kawano, T | 1 |
| Ueda, S | 1 |
| Tumiatti, V | 1 |
| Parkman, HP | 1 |
| Pagano, AP | 1 |
| Ryan, JP | 1 |
| Izzo, AA | 1 |
| Mascolo, N | 1 |
| Di Carlo, G | 1 |
| Capasso, F | 1 |
| Preuss, JM | 1 |
| Goldie, RG | 1 |
| Wynter-Adams, DM | 1 |
| Simon, OR | 1 |
| Gossell-Williams, MD | 1 |
| West, ME | 1 |
| Pesić, S | 1 |
| Grbović, L | 1 |
| Jovanović, A | 1 |
| Radenković, M | 1 |
| Stengel, PW | 2 |
| Gomeza, J | 1 |
| Cohen, ML | 3 |
| Lambrecht, G | 4 |
| Shen, S | 1 |
| Huang, Y | 1 |
| Bourreau, JP | 1 |
| Kwon, SC | 1 |
| Vera, PL | 1 |
| Miranda-Sousa, A | 1 |
| Nadelhaft, I | 1 |
| Delbro, DS | 1 |
| Falcone, JF | 1 |
| Bauzon, D | 1 |
| Kennedy, JS | 1 |
| Schenck, K | 1 |
| DeLapp, NW | 1 |
| Wright, TJ | 1 |
| Huddart, H | 1 |
| Poli, E | 3 |
| Monica, B | 1 |
| Zappia, L | 2 |
| Pozzoli, C | 1 |
| Bertaccini, G | 4 |
| Yu, M | 1 |
| Robinson, NE | 2 |
| Wang, Z | 1 |
| Derksen, FJ | 1 |
| Parekh, AB | 1 |
| Brading, AF | 1 |
| Mahesh, VK | 1 |
| Nunan, LM | 1 |
| Halonen, M | 2 |
| Yamamura, HI | 2 |
| Palmer, JD | 2 |
| Bloom, JW | 2 |
| Corrado, AP | 1 |
| Prado, WA | 1 |
| Killingsworth, CR | 1 |
| Kadlec, O | 1 |
| Hynie, S | 1 |
| Masek, K | 1 |
| Seferna, I | 1 |
| Sevcík, J | 1 |
| Janssen, LJ | 1 |
| Daniel, EE | 4 |
| Choo, LK | 2 |
| Darroch, SA | 1 |
| Gardner, A | 1 |
| Vong, YM | 1 |
| Jaiswal, N | 1 |
| Mutschler, E | 3 |
| Tacke, R | 2 |
| Malik, KU | 1 |
| Noronha-Blob, L | 2 |
| Prosser, JC | 1 |
| Sturm, BL | 2 |
| Lowe, VC | 2 |
| Enna, SJ | 1 |
| Angeli, P | 1 |
| Brasili, L | 1 |
| Cingolani, ML | 1 |
| Marucci, G | 1 |
| Pigini, P | 1 |
| Tonnini, MC | 1 |
| Shioya, T | 1 |
| Kagaya, M | 1 |
| Onodera, A | 1 |
| Miura, S | 1 |
| Miura, K | 1 |
| Miura, M | 1 |
| Itabashi, S | 1 |
| Aikawa, T | 1 |
| Sekizawa, K | 1 |
| Ohrui, T | 1 |
| Sasaki, H | 1 |
| Takishima, T | 1 |
| Durant, PA | 1 |
| Shankley, NP | 2 |
| Welsh, NJ | 1 |
| Black, JW | 2 |
| Rivera, L | 1 |
| Prieto, D | 1 |
| Hernández, M | 1 |
| Benedito, S | 1 |
| García-Sacristán, A | 1 |
| Santacana, GE | 1 |
| Silva, WI | 2 |
| Pozo, MJ | 2 |
| Salido, MD | 1 |
| Madrid, JA | 2 |
| Salido, GM | 2 |
| Barocelli, E | 1 |
| Morini, G | 1 |
| Ballabeni, V | 1 |
| Lavezzo, A | 1 |
| Impicciatore, M | 1 |
| Gardier, RW | 1 |
| Blaxall, HS | 1 |
| Killian, LN | 1 |
| Cunningham, J | 1 |
| Doods, H | 1 |
| Entzeroth, M | 1 |
| Mayer, N | 1 |
| Jackson, KN | 1 |
| Kachur, JF | 2 |
| Brichant, JF | 1 |
| Warner, DO | 1 |
| Gunst, SJ | 2 |
| Rehder, K | 1 |
| Eltze, M | 2 |
| Yegen, BC | 1 |
| Tankurt, E | 1 |
| Gürmen, N | 1 |
| Bayram, M | 1 |
| Oktay, S | 1 |
| Ulusoy, NB | 1 |
| Adami, M | 1 |
| Coruzzi, G | 2 |
| Fox, JE | 1 |
| Jury, J | 2 |
| Bowker, P | 1 |
| Duckles, SP | 1 |
| Murali Mohan, P | 1 |
| Yang, CM | 1 |
| Dwyer, TM | 1 |
| Farley, JM | 1 |
| Nowak, TV | 1 |
| Harrington, B | 1 |
| Kalbfleisch, JH | 1 |
| Eltz, M | 1 |
| Gmelin, G | 1 |
| Strohmann, C | 1 |
| Stropp, JQ | 1 |
| Flavahan, NA | 2 |
| Feifel, R | 1 |
| Smejkal, RM | 1 |
| Abalis, I | 1 |
| Pankaskie, MC | 1 |
| Michel, AD | 1 |
| Cornett, CM | 1 |
| Kunysz, EA | 1 |
| Whiting, RL | 1 |
| Marrion, NV | 1 |
| Smart, TG | 1 |
| Marsh, SJ | 1 |
| Brown, DA | 1 |
| Gilbert, RJ | 1 |
| Dodds, WJ | 1 |
| Hassan, M | 1 |
| Dalton, CB | 1 |
| Castell, JA | 1 |
| Castell, DO | 1 |
| Micheletti, R | 1 |
| Montagna, E | 1 |
| Giachetti, A | 1 |
| Ringer, MJ | 1 |
| Hyman, PE | 1 |
| Kao, HW | 1 |
| Hsu, CT | 1 |
| Tomomasa, T | 1 |
| Snape, WJ | 1 |
| Allbee, WE | 1 |
| Gaginella, TS | 1 |
| Grandordy, BM | 1 |
| Cuss, FM | 1 |
| Sampson, AS | 1 |
| Palmer, JB | 1 |
| Allescher, HD | 1 |
| Berezin, I | 1 |
| Baumgartener-Folkerts, C | 1 |
| Kawashima, K | 1 |
| Fujimoto, K | 1 |
| Suzuki, T | 1 |
| Oohata, H | 1 |
| Ito, Y | 1 |
| Yoshitomi, T | 1 |
| Ujiie, H | 1 |
| Hongo, M | 1 |
| Satake, K | 1 |
| Okuno, Y | 1 |
| Goto, Y | 1 |
| Lin, YF | 1 |
| Minette, PA | 1 |
| Miranda, HF | 1 |
| Wolstenholme, WW | 1 |
| Cuevas, N | 1 |
| Honkanen, RE | 1 |
| Howe, PH | 1 |
| Ishii, K | 1 |
| Kato, R | 1 |
| O'Rourke, ST | 2 |
| Vanhoutte, PM | 2 |
| Grider, JR | 1 |
| Bitar, KN | 1 |
| Makhlouf, GM | 1 |
| Cartellà, A | 1 |
| Potenzoni, D | 1 |
| Nafziger, M | 1 |
| Gönne, S | 1 |
| Riedel, R | 1 |
| Schlotke, B | 1 |
| Schudt, C | 1 |
| Simon, WA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Aprepitant- and Olanzapine- Containing Regimens for Prevention of Acute and Delayed Nausea and Vomiting Associated With High Dose Melphalan and BEAM in Autologous Stem Cell Transplant Patients[NCT02939287] | Phase 3 | 429 participants (Actual) | Interventional | 2017-09-23 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for pirenzepine and Muscle Contraction
| Article | Year |
|---|---|
Effects of oral pirenzepine on gastric emptying and antral motor activity in healthy man.
Topics: Adult; Benzodiazepinones; Gastric Emptying; Gastrointestinal Motility; Humans; Male; Muscle Contract | 1982 |
M1 muscarinic mechanisms regulate intestinal-phase gallbladder physiology in humans.
Topics: Adult; Bilirubin; Ceruletide; Cholecystokinin; Cross-Over Studies; Double-Blind Method; Duodenum; Ga | 1996 |
Inhibition of cholecystokinin-induced gallbladder contraction by atropine and pirenzepine in man.
Topics: Adult; Atropine; Gallbladder; Humans; Male; Muscle Contraction; Muscle, Smooth; Pirenzepine; Recepto | 1990 |
150 other studies available for pirenzepine and Muscle Contraction
| Article | Year |
|---|---|
6-Methyl-6-azabicyclo[3.2.1]octan-3 alpha-ol 2,2-diphenylpropionate (azaprophen), a highly potent antimuscarinic agent.
Topics: Acetylcholine; alpha-Amylases; Animals; Behavior, Animal; Carbachol; Cell Line; Chemical Phenomena; | 1987 |
Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed b
Topics: Animals; Atrial Function; Benzodiazepines; Cells, Cultured; Cerebral Cortex; Drug Design; Female; Gu | 1994 |
Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo.
Topics: Adenylyl Cyclases; Animals; CHO Cells; Cricetinae; Dioxolanes; Enzyme Activation; Female; Humans; Mu | 1997 |
Synthesis and pharmacological characterization of O-alkynyloximes of tropinone and N-methylpiperidinone as muscarinic agonists.
Topics: Animals; Aorta; Binding, Competitive; Drug Design; Escape Reaction; In Vitro Techniques; Male; Maze | 1998 |
Balanced modulation of neuromuscular synaptic transmission via M1 and M2 muscarinic receptors during inhibition of cholinesterases.
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterases; Diamines; Diaphragm; Disea | 2022 |
Role of rho-kinase (ROCK) in tonic but not phasic contraction in the frog stomach smooth muscle.
Topics: Amides; Animals; Atropine; Carbachol; Gastric Mucosa; Muscle Contraction; Muscle, Smooth; Nifedipine | 2018 |
Presynaptic M1, M2, and A1 receptors play roles in tetanic fade induced by pancuronium or cisatracurium.
Topics: Animals; Atracurium; Diamines; Electric Stimulation; Hexamethonium; In Vitro Techniques; Male; Musca | 2009 |
BK channel β1 subunits regulate airway contraction secondary to M2 muscarinic acetylcholine receptor mediated depolarization.
Topics: Animals; Calcium Channels, L-Type; Excitation Contraction Coupling; In Vitro Techniques; Indoles; La | 2011 |
Role of M1 receptor in regulation of gastric fundus smooth muscle contraction.
Topics: Animals; Atropine; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Gastric Fundus | 2011 |
Muscarinic receptor subtypes involved in regulation of colonic motility in mice: functional studies using muscarinic receptor-deficient mice.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Biomechanical Phenome | 2011 |
Urothelial/lamina propria spontaneous activity and the role of M3 muscarinic receptors in mediating rate responses to stretch and carbachol.
Topics: Animals; Atropine; Benzhydryl Compounds; Benzofurans; Carbachol; Cresols; Diamines; Mandelic Acids; | 2011 |
Functional role of muscarinic receptor subtypes in calcium sensitization and their contribution to rho-kinase and protein kinase C pathways in contraction of human detrusor smooth muscle.
Topics: Amides; Calcium; Carbachol; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Maleimides; Mus | 2012 |
Muscarinic receptor subtypes involved in urothelium-derived relaxatory effects in the inflamed rat urinary bladder.
Topics: Animals; Carbachol; Cyclophosphamide; Cystitis; Dose-Response Relationship, Drug; Enzyme Inhibitors; | 2012 |
A role for M(2) and M(3) muscarinic receptors in the contraction of rat and human small airways.
Topics: Animals; Carbachol; Cholinergic Agonists; Humans; In Vitro Techniques; Lung; Muscarinic Antagonists; | 2013 |
The rebound excitation triggered by anticholinergic drugs from ovine pyloric antrum, small bowel and gallbladder.
Topics: Animals; Atropine; Electrodes, Implanted; Electromyography; Fasting; Gallbladder; Gastrointestinal M | 2003 |
Involvement of cholinoceptors in cadmium-induced endothelial dysfunction.
Topics: Acetylcholine; Administration, Oral; Animals; Aorta, Thoracic; Atropine; Cadmium; Calcimycin; Dose-R | 2003 |
Contractile effect of acetylcholine on isolated ampullar segment of Fallopian tubes.
Topics: Acetylcholine; Adult; Aged; Diamines; Fallopian Tubes; Female; Follicular Phase; Humans; Lidocaine; | 2004 |
Contractile effect of acetylcholine on isolated isthmic segment of fallopian tubes.
Topics: Acetylcholine; Adult; Aged; Atropine; Diamines; Dose-Response Relationship, Drug; Fallopian Tubes; F | 2004 |
Mechanisms mediating cholinergic antral circular smooth muscle contraction in rats.
Topics: Anesthetics, Local; Animals; Benzofurans; Bethanechol; Calcium; Calcium Channel Blockers; Cholinergi | 2004 |
In vitro effects of bethanechol on equine gastrointestinal contractility and functional characterization of involved muscarinic receptor subtypes.
Topics: Animals; Area Under Curve; Bethanechol; Cecum; Dose-Response Relationship, Drug; Duodenum; Female; G | 2005 |
Muscarinic regulation of neonatal rat bladder spontaneous contractions.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2006 |
Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice.
Topics: Animals; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Electric Stimulation; En | 2007 |
Human idiopathic and neurogenic overactive bladders and the role of M2 muscarinic receptors in contraction.
Topics: Adult; Aged; Benzofurans; Carbachol; Diamines; Dose-Response Relationship, Drug; Female; Humans; In | 2007 |
Paradoxical effect of salbutamol in a model of acute organophosphates intoxication in guinea pigs: role of substance P release.
Topics: Albuterol; Animals; Calcium; Cholinesterase Inhibitors; Colforsin; Diamines; Guinea Pigs; Lung; Male | 2007 |
In vitro characterization of parasympathetic and sympathetic responses in cyclophosphamide-induced cystitis in the rat.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cyclopho | 2007 |
In vitro effects of bethanechol on specimens of intestinal smooth muscle obtained from the duodenum and jejunum of healthy dairy cows.
Topics: Animals; Bethanechol; Cattle; Dairying; Dose-Response Relationship, Drug; Duodenum; Female; In Vitro | 2007 |
Corticotropin-releasing factor inhibition of sheep fetal colonic contractility: mechanisms to prevent meconium passage in utero.
Topics: Animals; Bethanechol; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fetus | 2007 |
Comparative study of pA2 values of pirenzepine and atropine for guinea-pig gastric fundus and gastric smooth muscle.
Topics: Animals; Atropine; Benzodiazepinones; Bethanechol; Bethanechol Compounds; Female; Gastric Fundus; Ga | 1984 |
Eserine-induced hypertone of guinea pig distal colon in vivo: a new pharmacological procedure for testing smooth muscle relaxants.
Topics: Animals; Atropine; Benzodiazepinones; Colon; Dicyclomine; Dose-Response Relationship, Drug; Guinea P | 1984 |
The relation of receptor-binding studies to receptor function.
Topics: Acetylcholine; Aminobutyrates; Benzodiazepinones; Binding Sites; Humans; Ileum; In Vitro Techniques; | 1984 |
Anticholinergic action of pirenzepine (Gastrozepin) on isolated gastrointestinal tract smooth muscles.
Topics: Acetylcholine; Animals; Benzodiazepinones; Chickens; Colon; Female; Guinea Pigs; Ileum; In Vitro Tec | 1983 |
Effects of pirenzepine (Gastrozepin) on skeletal muscle contractility.
Topics: Animals; Anti-Ulcer Agents; Benzodiazepinones; Bufonidae; Cats; Dose-Response Relationship, Drug; Fe | 1983 |
Effect of pirenzepine compared with atropine and L-hyoscyamine on esophageal peristaltic activity in humans.
Topics: Adult; Atropine; Benzodiazepinones; Deglutition; Double-Blind Method; Esophagus; Female; Gastrointes | 1982 |
Conditional involvement of muscarinic M1 receptors in vagally mediated contraction of guinea-pig bronchi.
Topics: Adrenergic beta-Antagonists; Animals; Benzodiazepinones; Bronchoconstriction; Electric Stimulation; | 1995 |
Muscarinic receptor subtypes mediating vasodilation and vasoconstriction in isolated, perfused simian coronary arteries.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Corona | 1993 |
Characterization of muscarinic receptors mediating relaxation and contraction in the rat iris dilator muscle.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Alkaloids; Anim | 1995 |
No evidence for a role of muscarinic M2 receptors in functional antagonism in bovine trachea.
Topics: Animals; Bronchoconstrictor Agents; Cattle; Dose-Response Relationship, Drug; Gallamine Triethiodide | 1995 |
Prejunctional M1 and postjunctional M3 muscarinic receptors in the circular muscle of the guinea-pig ileum.
Topics: Acetylcholine; Animals; Choline; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic A | 1995 |
Mode of antagonism of methoctramine, AF-DX 116 and hexahydrosiladifenidol in guinea-pig left atrium and ileum: comparison of Schild and resultant analysis.
Topics: Animals; Diamines; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Agonists; Muscarinic An | 1995 |
The effect of muscarinic agonists and selective receptor subtype antagonists on the contractile response of the isolated rhesus monkey ciliary muscle.
Topics: Animals; Carbachol; Ciliary Body; Dose-Response Relationship, Drug; In Vitro Techniques; Macaca mula | 1994 |
Antagonists of cholinergic and serotonergic responses of Aplysia buccal muscle.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Aplysia; Atropine; Cholinergic Antag | 1994 |
Pertussis toxin-sensitive muscarinic relaxation in the rat iris dilator muscle.
Topics: Acetylcholine; Alkaloids; Animals; Atropine; Diamines; Dose-Response Relationship, Drug; Furans; GTP | 1995 |
Effects of atropine, pirenzepine, clonidine, and morphine on biphasic response of rat gastric fundus to field stimulation.
Topics: Animals; Atropine; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Gastric Fundus | 1994 |
Pharmacological profile of gastric mucosal protection by marmin and nobiletin from a traditional herbal medicine, Aurantii fructus immaturus.
Topics: Acetylcholine; Animals; Anti-Ulcer Agents; Coumarins; Drugs, Chinese Herbal; Electric Stimulation; F | 1994 |
Role of G proteins and KCa channels in the muscarinic and beta-adrenergic regulation of airway smooth muscle.
Topics: Adenylate Cyclase Toxin; Animals; Calcium; Cholera Toxin; GTP-Binding Proteins; Guinea Pigs; Male; M | 1995 |
Pertussis toxin blocks M2 muscarinic receptor-mediated effects on contraction and cyclic AMP in the guinea pig ileum, but not M3-mediated contractions and phosphoinositide hydrolysis.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Animals; Cyclic AMP; Guanosine Triphosphate; | 1994 |
Pharmacological characterization of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries.
Topics: Acetylcholine; Animals; Endothelium, Vascular; Heart Atria; Ileum; Lung; Male; Muscarinic Antagonist | 1994 |
Cholinergic contraction of the guinea pig lung strip is mediated by muscarinic M2-like receptors.
Topics: Adult; Aged; Animals; Cattle; Diamines; Female; Gallamine Triethiodide; Guinea Pigs; Humans; In Vitr | 1993 |
Protein toxins that bind to muscarinic acetylcholine receptors.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain; Consensus Sequence; Elapid Venoms; Elapid | 1994 |
M3 muscarinic receptors mediate an increase in both inositol trisphosphate production and cyclic AMP formation in dog iris sphincter smooth muscle.
Topics: Adenylyl Cyclases; Animals; Calcium; Calcium Channel Blockers; Carbachol; Cyclic AMP; Dogs; Inositol | 1994 |
Characterization of muscarinic receptors on guinea pig gallbladder smooth muscle.
Topics: Animals; Autoradiography; Carbachol; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Con | 1993 |
Development of cholinergic innervation and muscarinic receptor subtypes in piglet trachea.
Topics: Administration, Topical; Animals; Animals, Newborn; Electric Stimulation; GTP-Binding Proteins; Meth | 1993 |
Pertussis toxin augments beta-adrenergic relaxation of muscarinic contraction in canine trachealis.
Topics: Acetylcholine; Analysis of Variance; Animals; Dogs; Dose-Response Relationship, Drug; Drug Interacti | 1993 |
Functional role for the M2 muscarinic receptor in smooth muscle of guinea pig ileum.
Topics: Animals; Cyclic AMP; Diphenylacetic Acids; Guinea Pigs; Hydrolysis; In Vitro Techniques; Male; Muscl | 1993 |
Muscarinic M1 receptor agonist actions of muscarinic receptor agonists in rabbit vas deferens.
Topics: Animals; Atropine; Carbachol; Dose-Response Relationship, Drug; Hippocampus; Male; Muscarinic Antago | 1993 |
Subtype of muscarinic receptors mediating relaxation and contraction in the rat iris dilator smooth muscle.
Topics: Alkaloids; Animals; Atropine; Carbachol; Furans; In Vitro Techniques; Iris; Male; Muscle Contraction | 1993 |
Functional characterization of muscarinic receptors in murine airways.
Topics: Administration, Inhalation; Airway Resistance; Animals; Atropine; Bronchi; Electric Stimulation; In | 1993 |
Characterization of muscarinic receptors mediating contractions of circular and longitudinal muscle of human isolated colon.
Topics: Alkaloids; Atropine; Carbachol; Carcinoma; Colon; Colonic Neoplasms; Dose-Response Relationship, Dru | 1995 |
In vivo and in vitro effects of muscarinic receptor antagonists on contractions and release of [3H]acetylcholine in the rabbit urinary bladder.
Topics: Acetylcholine; Animals; Carbachol; Diamines; Female; Gallamine Triethiodide; Muscarinic Antagonists; | 1995 |
Two types of functionally different GABAA receptors mediate GABA modulation of cholinergic transmission in cat terminal ileum.
Topics: Animals; Atropine; Bicuculline; Cats; Dose-Response Relationship, Drug; Electric Stimulation; GABA A | 1995 |
Involvement of the M2 muscarinic receptor in contractions of the guinea pig trachea, guinea pig esophagus, and rat fundus.
Topics: Adrenergic beta-Agonists; Animals; Colforsin; Cyclic AMP; Esophagus; Gastric Fundus; Guinea Pigs; Hi | 1996 |
M1 and M3 muscarinic receptors in human pulmonary arteries.
Topics: Acetylcholine; Cholinergic Agonists; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Humans; In Vitro | 1996 |
Cardiopulmonary actions of muscarinic receptor subtypes in the newborn dog.
Topics: Airway Resistance; Analysis of Variance; Animals; Animals, Newborn; Bronchoconstriction; Dogs; Dose- | 1996 |
The sources of Ca2+ for muscarinic receptor-induced contraction in the rat ileum.
Topics: Acetylcholine; Animals; Calcium; Calcium Channel Blockers; Female; Ileum; In Vitro Techniques; Musca | 1996 |
Pharmacological characterization of the muscarinic receptors mediating contraction of canine saphenous vein.
Topics: Animals; Dioxolanes; Dogs; Female; In Vitro Techniques; Muscarinic Agonists; Muscle Contraction; Mus | 1995 |
Evidence for the presence of regional differences in the subtype specificity of muscarinic receptors in rabbit lower urinary tract.
Topics: Animals; Atropine; Carbachol; Diamines; Female; Muscarinic Antagonists; Muscle Contraction; Muscle, | 1997 |
Antinociception induced by SM 32 depends on a central cholinergic mechanism.
Topics: Analgesics; Animals; Cholinergic Agents; Cholinergic Fibers; Dicyclomine; GABA Antagonists; Guinea P | 1997 |
Contractile roles of the M2 and M3 muscarinic receptors in the guinea pig colon.
Topics: Animals; Colforsin; Colon; Cyclic AMP; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; M | 1998 |
Characterization of muscarinic receptors mediating the contraction of the urinary detrusor muscle in cynomolgus monkeys and guinea pigs.
Topics: Animals; Carbachol; Diamines; Female; Guinea Pigs; Macaca fascicularis; Male; Muscarinic Agonists; M | 1998 |
Muscarinic M2 receptor-mediated contraction in the guinea pig Taenia caeci: possible involvement of protein kinase C.
Topics: Animals; Cecum; Colforsin; Diphenylacetic Acids; Female; Guinea Pigs; Histamine; In Vitro Techniques | 1998 |
Prejunctional muscarinic receptors modulating acetylcholine release in rabbit detrusor smooth muscles.
Topics: Acetylcholine; Animals; Chromatography, High Pressure Liquid; Culture Techniques; Diamines; Female; | 1998 |
Muscarinic M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon: evidence for M2/M3 receptor interactions.
Topics: Animals; Colon; Diphenylacetic Acids; Guinea Pigs; Hydrolysis; In Vitro Techniques; Male; Models, Bi | 1999 |
The design of novel methoctramine-related tetraamines as muscarinic receptor subtype selective antagonists.
Topics: Animals; Atrial Function; Benzodiazepines; Benzodiazepinones; Diamines; Drug Design; Guinea Pigs; He | 1995 |
Subtypes of muscarinic receptors regulating gallbladder cholinergic contractions.
Topics: Acetylcholine; Animals; Atropine; Diamines; Electric Stimulation; Gallbladder; Guinea Pigs; Hexameth | 1999 |
Ascending neural pathways in the isolated guinea-pig ileum: effect of muscarinic M1, M2 and M3 cholinergic antagonists.
Topics: Acetylcholine; Afferent Pathways; Anal Canal; Animals; Diamines; Electric Stimulation; Guinea Pigs; | 1999 |
Muscarinic cholinoceptor subtypes mediating tracheal smooth muscle contraction and inositol phosphate generation in guinea pig and rat.
Topics: Animals; Atropine; Diamines; Guinea Pigs; In Vitro Techniques; Inositol Phosphates; Male; Muscarinic | 1999 |
Isolation of a muscarinic alkaloid with ocular hypotensive action from Trophis racemosa.
Topics: Acetylcholine; Alkaloids; Animals; Antihypertensive Agents; Atropine; Carbachol; Dogs; Female; Galla | 1999 |
Acetylcholine-induced contractions in the porcine internal mammary artery: possible role of muscarinic receptors.
Topics: Acetylcholine; Animals; Diamines; Endothelium, Vascular; In Vitro Techniques; Mammary Arteries; Musc | 1999 |
M(2) and M(4) receptor knockout mice: muscarinic receptor function in cardiac and smooth muscle in vitro.
Topics: Adenosine; Animals; Carbachol; Heart Rate; In Vitro Techniques; Male; Mice; Mice, Knockout; Muscle C | 2000 |
Functional role of muscarinic M(2) receptors in alpha,beta-methylene ATP induced, neurogenic contractions in guinea-pig ileum.
Topics: Adenosine Triphosphate; Animals; Diphenylacetic Acids; Dose-Response Relationship, Drug; Guinea Pigs | 2000 |
Efficacy of muscarinic stimulation and mode of excitation-contraction coupling in bovine trachealis muscle.
Topics: Acetylcholine; Animals; Calcium; Cattle; Cromakalim; Diamines; Dose-Response Relationship, Drug; Dru | 2000 |
Mechanisms of acetylcholine-induced vasorelaxation in high K+-stimulated rabbit renal arteries.
Topics: Acetylcholine; Animals; Atropine; Calcium; Calcium Channel Blockers; Cations, Monovalent; Endotheliu | 2001 |
Effects of two atypical neuroleptics, olanzapine and risperidone, on the function of the urinary bladder and the external urethral sphincter in anesthetized rats.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Blood Pressure; Female; Muscle Contraction; Olanzapi | 2001 |
On the functional role of muscarinic M2 receptors in cholinergic and purinergic responses in the rat urinary bladder.
Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Animals; Carbachol; Diamines; Dose-Response Re | 2001 |
Potent antagonism of 5-HT(3) and 5-HT(6) receptors by olanzapine.
Topics: Animals; Benzodiazepines; Binding, Competitive; Clozapine; Dibenzothiazepines; Dose-Response Relatio | 2001 |
The nature of the acetylcholine and 5-hydroxytryptamine receptors in buccal smooth muscle of the pest slug Deroceras reticulatum.
Topics: Acetylcholine; Animals; Atropine; Choline; Esters; Gallamine Triethiodide; Hexamethonium; Mollusca; | 2002 |
Muscarinic receptor knockout mice: role of muscarinic acetylcholine receptors M(2), M(3), and M(4) in carbamylcholine-induced gallbladder contractility.
Topics: Animals; Anti-Arrhythmia Agents; Atropine; Carbachol; Cardiovascular Agents; Cholinesterase Inhibito | 2002 |
Antimuscarinic activity of telenzepine on isolated human urinary bladder: no role for M1-muscarinic receptors.
Topics: Adult; Aged; Electric Stimulation; Humans; In Vitro Techniques; Male; Middle Aged; Muscarinic Antago | 1992 |
Muscarinic receptor subtypes in equine tracheal smooth muscle.
Topics: Acetylcholine; Animals; Electric Stimulation; Gallamine Triethiodide; Horses; In Vitro Techniques; M | 1992 |
The M3 muscarinic receptor links to three different transduction mechanisms with different efficacies in circular muscle of guinea-pig stomach.
Topics: Animals; Carbachol; Female; Gallamine Triethiodide; Gastric Fundus; Guinea Pigs; In Vitro Techniques | 1992 |
A minority of muscarinic receptors mediate rabbit tracheal smooth muscle contraction.
Topics: Animals; Atropine; Female; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Myocardi | 1992 |
Effects of atropine, pirenzepine, imipramine and phenothiazines on the mammalian neuromuscular junction.
Topics: Acetylcholine; Animals; Atropine; Diaphragm; Electric Stimulation; Female; Imipramine; Male; Muscle | 1992 |
The role of muscarinic M1 and M2 receptors in airway constriction in the cat.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gallamine Triethiodid | 1992 |
Non-synaptic cholinergic modulation of neurogenic twitches of the guinea-pig ileum.
Topics: Acetylcholine; Action Potentials; Adenylyl Cyclases; Animals; Atropine; Calcium; Guinea Pigs; Ileum; | 1991 |
Pre- and postjunctional muscarinic receptors in canine bronchi.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bethanechol Compounds | 1990 |
Selective inhibition of responses to carbachol and McN-A-343 in the rabbit vas deferens.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bis-Trimethylammonium | 1990 |
Effect of temperature reduction on responsiveness to cholinomimetics in the taenia caeci of the guinea-pig.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Carbachol; | 1991 |
Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Antihy | 1991 |
(+/-)-Terodiline: an M1-selective muscarinic receptor antagonist. In vivo effects at muscarinic receptors mediating urinary bladder contraction, mydriasis and salivary secretion.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atrial Function; Buty | 1991 |
Pharmacological characterization of muscarinic receptor subtypes in rabbit isolated tissue preparations.
Topics: Animals; Aorta, Thoracic; Atropine; Diamines; Jejunum; Male; Muscarinic Antagonists; Muscle Contract | 1991 |
[The bronchodilating effect of pirenzepine].
Topics: Acetylcholine; Adult; Aged; Animals; Asthma; Bronchodilator Agents; Dogs; Dose-Response Relationship | 1991 |
Pre- and postjunctional muscarinic receptor subtypes in dog airways.
Topics: Acetylcholine; Animals; Atropine; Bronchi; Dogs; Dose-Response Relationship, Drug; Electric Stimulat | 1991 |
Pharmacological analysis of agonist-antagonist interactions at acetylcholine muscarinic receptors in a new urinary bladder assay.
Topics: Animals; Atropine; Atropine Derivatives; Guinea Pigs; Hemicholinium 3; In Vitro Techniques; Male; Mi | 1991 |
Distribution and function of cholinergic receptors in the sheep detrusor muscle.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Atropine; Carbachol; Cholinesterase Inhibitors; Gangli | 1991 |
Differential antagonism by amiloride and pirenzepine of the muscarinic receptors of rat tracheal smooth muscle.
Topics: Amiloride; Animals; Carrier Proteins; Dose-Response Relationship, Drug; Kinetics; Male; Muscle Contr | 1990 |
In-vitro effect of pirenzepine on motility of canine gall-bladder.
Topics: Acetylcholine; Animals; Atropine; Cholecystokinin; Dogs; Gallbladder; Isometric Contraction; Male; M | 1990 |
Effects of two new pirenzepine analogs on the contractile response of the guinea-pig oesophageal muscularis mucosae to acetylcholine, bethanechol, histamine and high potassium.
Topics: Acetylcholine; Animals; Atropine; Benzodiazepinones; Bethanechol; Bethanechol Compounds; Esophagus; | 1990 |
Reserpine-induced post-receptor reduction in muscarinic-mediated airway smooth muscle contraction.
Topics: Animals; Binding, Competitive; Bronchi; Humans; Lung; Male; Methacholine Chloride; Muscle Contractio | 1991 |
Cardioselectivity of AQ-RA 741, a novel tricyclic antimuscarinic drug.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Cats; Female; Guinea Pigs; Heart; In Vitro Techniq | 1991 |
Muscarinic M3 receptors mediate contraction of human central and peripheral airway smooth muscle.
Topics: Bronchi; Humans; In Vitro Techniques; Ipratropium; Muscle Contraction; Muscle, Smooth; Parasympathol | 1990 |
Characterization of the muscarinic receptor subtype involved in phosphoinositide metabolism in bovine tracheal smooth muscle.
Topics: Animals; Cattle; In Vitro Techniques; Inositol Phosphates; Methacholine Compounds; Muscle Contractio | 1990 |
In vitro and in vivo antimuscarinic effects of (-)cis 2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5 benzothiazepin-4-(5H)one HCl (BTM-1086) in guinea pig peripheral tissues.
Topics: Animals; Atropine; Calcium; Female; Guinea Pigs; Heart Atria; Ileum; In Vitro Techniques; Male; Musc | 1990 |
Muscarinic receptor subtypes in canine trachea.
Topics: Acetylcholine; Animals; Dogs; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, | 1990 |
Telenzepine enantiomers block muscarinic M1-receptors with opposite kinetics.
Topics: Animals; Electric Stimulation; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smoo | 1990 |
Characterization of cholinoreceptors in the rat urinary bladder by the use of agonists and antagonists of the cholinergic system.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Benzodiazep | 1985 |
Substance P: a potent inhibitor of the canine small intestine in vivo.
Topics: Acetylcholine; Animals; Atropine; Benzodiazepinones; Dogs; Dose-Response Relationship, Drug; Enkepha | 1986 |
Muscarinic receptors on nerves and muscles in opossum esophagus muscularis mucosa.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Carbachol; | 1987 |
Vascular muscarinic receptors: pharmacological characterization in the bovine coronary artery.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Calcim | 1988 |
Contractile responses of tracheal smooth muscle in organophosphate-treated swine: 2. Effects of antagonists.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropi | 1988 |
Evidence for muscarinic inhibitory neurotransmission in rodent small intestine.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Atropi | 1989 |
Presynaptic muscarinic receptors mediating inhibition of neurogenic contractions in rabbit vas deferens are of the ganglionic M1-type.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Binding Sit | 1988 |
Muscarinic receptor reserve and beta-adrenergic sensitivity in tracheal smooth muscle.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Animals; Dogs; | 1989 |
Cholecystokinin induced gallbladder contraction is influenced by nicotinic and muscarinic receptors.
Topics: Animals; Atropine; Cholecystokinin; Dogs; Gallbladder; Hexamethonium; Hexamethonium Compounds; Male; | 1989 |
Stereoselectivity at muscarinic receptor subtypes: observations with the enantiomers of phenglutarimide.
Topics: Animals; Electric Stimulation; Female; Glutethimide; Guinea Pigs; Ileum; In Vitro Techniques; Male; | 1989 |
Muscarinic receptor subtype specificity of 5'-(isobutylthio)-adenosine (SIBA) and its analogs.
Topics: Acetylcholine; Animals; Antineoplastic Agents; Brain Chemistry; Chemical Phenomena; Chemistry; Deoxy | 1989 |
The interaction of hexamethonium with muscarinic receptor subtypes in vitro.
Topics: Animals; Carbachol; Diamines; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Kinetics; M | 1989 |
Muscarinic suppression of the M-current in the rat sympathetic ganglion is mediated by receptors of the M1-subtype.
Topics: Animals; Calcium; Gallamine Triethiodide; Ganglia, Spinal; Ganglia, Sympathetic; Ileum; In Vitro Tec | 1989 |
Pharmacological analysis of muscarinic receptors coupled to oxyntic cell secretion in the mouse stomach.
Topics: Animals; Atropine; Atropine Derivatives; Benzodiazepinones; Binding, Competitive; Cimetidine; Guinea | 1985 |
Effect of selective muscarinic antagonists on peristaltic contractions in opossum smooth muscle.
Topics: Animals; Atropine; Benzodiazepinones; Bethanechol; Bethanechol Compounds; Dose-Response Relationship | 1986 |
Pirenzepine and propantheline effects on esophageal pressure responses to bethanechol.
Topics: Adult; Benzodiazepinones; Bethanechol; Bethanechol Compounds; Esophagus; Female; Gastrointestinal Ag | 1986 |
AF-DX 116, a cardioselective muscarinic antagonist.
Topics: Animals; Atropine; Bethanechol; Bethanechol Compounds; Carbachol; Cats; Dimethylphenylpiperazinium I | 1987 |
[3H]QNB binding and contraction of rabbit colonic smooth muscle cells.
Topics: Animals; Atropine; Bethanechol; Bethanechol Compounds; Binding, Competitive; Cell Count; Colon; Kine | 1987 |
Antihistaminic and antimuscarinic effects of amitriptyline on guinea pig ileal electrolyte transport and muscle contractility in vitro.
Topics: Amitriptyline; Animals; Bethanechol; Bethanechol Compounds; Electrolytes; Guinea Pigs; Histamine H1 | 1988 |
Phosphatidylinositol response to cholinergic agonists in airway smooth muscle: relationship to contraction and muscarinic receptor occupancy.
Topics: Acetylcholine; Animals; Atropine; Benzodiazepinones; Carbachol; Cattle; Chlorides; Dose-Response Rel | 1986 |
Characteristics of canine lower esophageal sphincter: a new electrophysiological tool.
Topics: Animals; Carbachol; Cimetidine; Dogs; Electric Stimulation; Electrophysiology; Esophagus; Female; Hi | 1988 |
A muscarinic receptor subtype modulates vagally stimulated bronchial contraction.
Topics: Animals; Atropine; Bronchi; Electric Stimulation; Female; In Vitro Techniques; Male; Muscle Contract | 1988 |
Direct determination of acetylcholine release by radioimmunoassay and presence of presynaptic M1 muscarinic receptors in guinea pig ileum.
Topics: Acetylcholine; Animals; Atropine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; | 1988 |
Autoregulation of acetylcholine release from vagus nerve terminals through activation of muscarinic receptors in the dog trachea.
Topics: Acetylcholine; Animals; Dogs; Female; Gallamine Triethiodide; Male; Membrane Potentials; Muscle Cont | 1988 |
[Studies on the muscarine receptors in rat gastric smooth muscle].
Topics: Acetylcholine; Animals; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Pirenzepine; | 1988 |
Prejunctional inhibitory muscarinic receptors on cholinergic nerves in human and guinea pig airways.
Topics: Acetylcholine; Animals; Bronchi; Electric Stimulation; Gallamine Triethiodide; Guinea Pigs; Humans; | 1988 |
Selective antagonism by pirenzepine and N-methyl-scopolamine on muscarinic receptor subtypes of the rat vas deferens.
Topics: Animals; Male; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Pirenzep | 1988 |
M2 muscarinic receptor subtype is associated with inositol trisphosphate accumulation, myosin light chain phosphorylation and contraction in sphincter smooth muscle of rabbit iris.
Topics: Animals; Atropine; Carbachol; Female; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Ph | 1987 |
Suppression by muscarinic M2 stimulation of the contractile mechanism via histamine H1 receptors in the longitudinal muscle of guinea pig ileum.
Topics: Animals; Atropine; Calcium; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histamine; Ileum; | 1987 |
Subtypes of muscarinic receptors on adrenergic nerves and vascular smooth muscle of the canine saphenous vein.
Topics: Acetylcholine; Adrenergic Fibers; Animals; Atropine; Dogs; Electric Stimulation; Gallamine Triethiod | 1987 |
Characterization of muscarinic receptors in canine bronchial smooth muscle.
Topics: Acetylcholine; Animals; Bronchi; Dogs; Electric Stimulation; Female; In Vitro Techniques; Male; Musc | 1987 |
Identification of muscarinic M2 receptors on single muscle cells of the human and guinea pig intestine.
Topics: Acetylcholine; Animals; Atropine; Guinea Pigs; Humans; Jejunum; Muscle Contraction; Muscle, Smooth; | 1987 |
Action of pirenzepine on the human urinary bladder in vitro.
Topics: Acetylcholine; Atropine; Benzodiazepinones; Dimethylphenylpiperazinium Iodide; Electric Stimulation; | 1986 |
Two types of neuronal muscarine receptors modulating acetylcholine release from guinea-pig myenteric plexus.
Topics: Acetylcholine; Animals; Benzodiazepinones; Guinea Pigs; Ileum; In Vitro Techniques; Muscarine; Muscl | 1985 |
Action of different agonists and antagonists of the cholinergic system on the rat lower esophageal sphincter.
Topics: Animals; Benzodiazepinones; Calcium; Cold Temperature; Dimethylphenylpiperazinium Iodide; Esophagoga | 1985 |
Pharmacological evidence for selective inhibition of gastric acid secretion by telenzepine, a new antimuscarinic drug.
Topics: Aminopyrine; Animals; Benzodiazepinones; Dogs; Female; Gastric Acid; Gastric Mucosa; Guinea Pigs; In | 1985 |