pirenzepine has been researched along with Hypotension, Orthostatic in 4 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Hypotension, Orthostatic: A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The newer atypical agents have a lower risk of EPS, but are associated in varying degrees with sedation, cardiovascular effects, anticholinergic effects, weight gain, sexual dysfunction, hepatic effects, lowered seizure threshold (primarily clozapine), and agranulocytosis (clozapine only)." | 4.80 | Adverse effects of the atypical antipsychotics. Collaborative Working Group on Clinical Trial Evaluations. ( , 1998) |
| "Olanzapine is an "atypical" antipsychotic agent with a high affinity for serotonin 5HT2A/C, 5HT3, 5HT6, and dopamine D1, D2, D3, D4 receptors." | 2.68 | Olanzapine: interaction study with imipramine. ( Callaghan, JT; Cerimele, BJ; Hoyes-Beehler, PJ; Kassahun, KJ; Kondraske, GV; Nyhart, EH, 1997) |
| "Pirenzepine was not effective." | 1.33 | Effects of AF-DX116 and other muscarinic receptor antagonists on orthostatic hypotension in autonomic imbalanced (SART-stressed) rats. ( Funakami, Y; Hata, T; Itoh, E, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hata, T | 1 |
| Funakami, Y | 1 |
| Itoh, E | 1 |
| Callaghan, JT | 1 |
| Cerimele, BJ | 1 |
| Kassahun, KJ | 1 |
| Nyhart, EH | 1 |
| Hoyes-Beehler, PJ | 1 |
| Kondraske, GV | 1 |
1 review available for pirenzepine and Hypotension, Orthostatic
| Article | Year |
|---|---|
Adverse effects of the atypical antipsychotics. Collaborative Working Group on Clinical Trial Evaluations.
Topics: Agranulocytosis; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Central Nervous Syst | 1998 |
2 trials available for pirenzepine and Hypotension, Orthostatic
| Article | Year |
|---|---|
Olanzapine for schizophrenia.
Topics: Antipsychotic Agents; Benzodiazepines; Constipation; Costs and Cost Analysis; Dizziness; Dose-Respon | 1997 |
Olanzapine: interaction study with imipramine.
Topics: Adrenergic Uptake Inhibitors; Adult; Analysis of Variance; Antipsychotic Agents; Benzodiazepines; Cr | 1997 |
1 other study available for pirenzepine and Hypotension, Orthostatic
| Article | Year |
|---|---|
Effects of AF-DX116 and other muscarinic receptor antagonists on orthostatic hypotension in autonomic imbalanced (SART-stressed) rats.
Topics: Animals; Atropine; Atropine Derivatives; Blood Pressure; Cold Temperature; Diamines; Heart Rate; Hyp | 2005 |