pirenzepine has been researched along with Hypertension in 9 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recent evidence has suggested that pilocarpine (ACh receptor agonist) injected peripherally may act centrally producing salivation and hypertension." | 7.74 | Central muscarinic receptor subtypes involved in pilocarpine-induced salivation, hypertension and water intake. ( Borella, TL; Colombari, DS; De Luca, LA; Menani, JV, 2008) |
| "Recent evidence has suggested that pilocarpine (ACh receptor agonist) injected peripherally may act centrally producing salivation and hypertension." | 3.74 | Central muscarinic receptor subtypes involved in pilocarpine-induced salivation, hypertension and water intake. ( Borella, TL; Colombari, DS; De Luca, LA; Menani, JV, 2008) |
| "Cadmium (Cd) toxicity was produced in male rats to study the role of cholinoceptors in Cd-induced endothelial dysfunction." | 1.32 | Involvement of cholinoceptors in cadmium-induced endothelial dysfunction. ( Alkan, Z; Bilgen, I; Cirrik, S; Edremitlioğlu, M; Oner, G, 2003) |
| " We have evaluated the consequences of HFD on heart rate (HR) and blood pressure (BP) circadian cycles and methylscopolamine dose-response curves." | 1.30 | Impaired atrial M(2)-cholinoceptor function in obesity-related hypertension. ( Berlan, M; Galitzky, J; Merial, C; Montastruc, JL; Pelat, M; Senard, JM; Verwaerde, P, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Menegatti, R | 1 |
| Carvalho, FS | 1 |
| Lião, LM | 1 |
| Villavicencio, B | 1 |
| Verli, H | 1 |
| Mourão, AA | 1 |
| Xavier, CH | 1 |
| Castro, CH | 1 |
| Pedrino, GR | 1 |
| Franco, OL | 1 |
| Oliveira-Silva, I | 1 |
| Ashpole, NM | 1 |
| Silva, ON | 1 |
| Costa, EA | 1 |
| Fajemiroye, JO | 1 |
| Borella, TL | 1 |
| De Luca, LA | 1 |
| Colombari, DS | 1 |
| Menani, JV | 1 |
| Hernandez, CM | 1 |
| Høifødt, H | 1 |
| Terry, AV | 1 |
| Bilgen, I | 1 |
| Oner, G | 1 |
| Edremitlioğlu, M | 1 |
| Alkan, Z | 1 |
| Cirrik, S | 1 |
| Bruning, TA | 1 |
| Chang, PC | 1 |
| Hendriks, MG | 2 |
| Vermeij, P | 1 |
| Pfaffendorf, M | 2 |
| van Zwieten, PA | 2 |
| Sim, MK | 1 |
| Manjeet, S | 1 |
| Gattu, M | 1 |
| Pauly, JR | 1 |
| Urbanawiz, S | 1 |
| Buccafusco, JJ | 1 |
| Pelat, M | 1 |
| Verwaerde, P | 1 |
| Merial, C | 1 |
| Galitzky, J | 1 |
| Berlan, M | 1 |
| Montastruc, JL | 1 |
| Senard, JM | 1 |
1 trial available for pirenzepine and Hypertension
| Article | Year |
|---|---|
In vivo characterization of muscarinic receptor subtypes that mediate vasodilatation in patients with essential hypertension.
Topics: Atropine; Forearm; Humans; Hypertension; Male; Methacholine Chloride; Middle Aged; Nitroprusside; Pa | 1995 |
8 other studies available for pirenzepine and Hypertension
| Article | Year |
|---|---|
Novel choline analog 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol produces sympathoinhibition, hypotension, and antihypertensive effects.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Atropine; Blood Pressure; Heart Rate; Hypertensio | 2019 |
Central muscarinic receptor subtypes involved in pilocarpine-induced salivation, hypertension and water intake.
Topics: Animals; Blood Pressure; Diamines; Drinking Behavior; Heart Rate; Hypertension; Injections, Intraven | 2008 |
Spontaneously hypertensive rats: further evaluation of age-related memory performance and cholinergic marker expression.
Topics: Aging; Animals; Binding Sites; Biomarkers; Brain; Bridged Bicyclo Compounds, Heterocyclic; Disease M | 2003 |
Involvement of cholinoceptors in cadmium-induced endothelial dysfunction.
Topics: Acetylcholine; Administration, Oral; Animals; Aorta, Thoracic; Atropine; Cadmium; Calcimycin; Dose-R | 2003 |
Characterization of the muscarinic receptors in the mesenteric vascular bed of spontaneously hypertensive rats.
Topics: Animals; Atropine; Benzodiazepinones; Endothelium, Vascular; Hypertension; Male; Mesenteric Artery, | 1993 |
Muscarinic receptors in the aortae of normo- and hypertensive rats: a binding study.
Topics: Acetylcholine; Animals; Aorta; Atropine; Binding, Competitive; Endothelium, Vascular; Guanylyl Imido | 1993 |
Autoradiographic comparison of muscarinic M1 and M2 binding sites in the CNS of spontaneously hypertensive and normotensive rats.
Topics: Animals; Autoradiography; Blood Pressure; Brain; Brain Chemistry; Central Nervous System; Hypertensi | 1997 |
Impaired atrial M(2)-cholinoceptor function in obesity-related hypertension.
Topics: Adenylyl Cyclases; Animals; Blood Pressure; Body Weight; Dogs; Dose-Response Relationship, Drug; Hea | 1999 |