pirenzepine has been researched along with Glioma in 3 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The specific binding of both the non-classical antagonist [3H] pirenzepine ( [3H]PZ) and the classical antagonist [3H](-)quinuclidinyl benzilate ( [3H](-)QNB) was determined in parallel assays of the mouse neuroblastoma x rat glioma hybrid cell line (NG 108-15)." | 7.67 | High-affinity [3H]pirenzepine binding to putative M1 muscarinic sites in the neuroblastoma x glioma hybrid cell line (NG 108-15). ( Akiyama, K; Roeske, WR; Watson, M; Yamamura, HI, 1984) |
| "The specific binding of both the non-classical antagonist [3H] pirenzepine ( [3H]PZ) and the classical antagonist [3H](-)quinuclidinyl benzilate ( [3H](-)QNB) was determined in parallel assays of the mouse neuroblastoma x rat glioma hybrid cell line (NG 108-15)." | 3.67 | High-affinity [3H]pirenzepine binding to putative M1 muscarinic sites in the neuroblastoma x glioma hybrid cell line (NG 108-15). ( Akiyama, K; Roeske, WR; Watson, M; Yamamura, HI, 1984) |
| " Continuous depolarization of a subclone of the neuroblastoma-glioma NG108-15 hybrid cells with potassium chloride increased by 45-75% the number of cholinergic muscarinic receptors, monitored with 3H-QNB, whereas a short incubation with KCl for 10 min or 6 hr had no effect." | 3.67 | Neuronal membrane depolarization and the control of cholinergic muscarinic receptors: selective effect on different neuronal cell types. ( Levy, R; Simantov, R, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akiyama, K | 1 |
| Watson, M | 1 |
| Roeske, WR | 1 |
| Yamamura, HI | 1 |
| Lazareno, S | 1 |
| Buckley, NJ | 1 |
| Roberts, FF | 1 |
| Simantov, R | 1 |
| Levy, R | 1 |
3 other studies available for pirenzepine and Glioma
| Article | Year |
|---|---|
High-affinity [3H]pirenzepine binding to putative M1 muscarinic sites in the neuroblastoma x glioma hybrid cell line (NG 108-15).
Topics: Animals; Atropine; Benzodiazepinones; Binding, Competitive; Cell Line; Glioma; Hybrid Cells; Mice; N | 1984 |
Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells.
Topics: Animals; Chickens; Glioma; Guanylyl Imidodiphosphate; In Vitro Techniques; Kinetics; Lung; Male; Myo | 1990 |
Neuronal membrane depolarization and the control of cholinergic muscarinic receptors: selective effect on different neuronal cell types.
Topics: Animals; Glioma; Membrane Potentials; Neuroblastoma; Neurons; Pirenzepine; Potassium Chloride; Quinu | 1989 |