pirenzepine has been researched along with Gastric Ulcer in 83 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Excerpt | Relevance | Reference |
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"Fifty-five patients with endoscopically confirmed gastric ulcers received either cimetidine (28 patients) or pirenzepine (27 patients) in a randomized double-blind manner." | 9.06 | Gastric ulcer: a double-blind comparison of 100 mg pirenzepine plus antacid versus 800 mg cimetidine plus antacid. ( Arnold, J; Birchler, R; Bretholz, A; Capitaine, Y; Gonvers, JJ; Guyot, J; Ollyo, JB; Realini, S; Voirol, M, 1986) |
"163 patients with endoscopically proven benign gastric ulcers were randomly allocated to treatment with either telenzepine 3 mg nocte or ranitidine 300 mg nocte for up to 8 weeks in a prospective double-blind study." | 9.06 | [3 mg telenzepine nocte in the treatment of benign stomach ulcer disease: a double-blind comparative study with 300 mg ranitidine nocte]. ( Dammann, HG; Müller, P; Reinicke, HG; Simon, B, 1990) |
"In a double-blind, multicentre study 77 patients with benign gastric ulcer were randomly allocated to treatment with either enprostil 35 micrograms bd or pirenzepine 50 mg bd." | 9.06 | Enprostil, a prostaglandin E2 analogue, in the treatment of gastric ulcer--a multicentre comparison with pirenzepine. ( Carr-Locke, D; English, JR; Jazrawi, RP; Mountford, RA; Northfield, TC; Reed, PI; Schiller, KF; Williams, JG, 1990) |
"The purpose of the present study was to compare the effectiveness of pirenzepine and carbenoxolone in accelerating the healing of chronic gastric ulcer." | 9.05 | Comparison of pirenzepine and carbenoxolone in the treatment of chronic gastric ulcer. A double-blind endoscopic trial. ( Bianchi Porro, G; Daniotti, S; De Pretis, G; Dobrilla, G; Lazzaroni, M; Mazzacca, G; Petrillo, M; Piai, G; Sabbatini, F, 1985) |
"The gastric cytoprotective effects of vitamin A, De-Nol and sucralfate were compared with the effectiveness of pirenzepine in healing ulcer in patients with chronic gastric ulcer." | 9.05 | A comparative dynamic study of the effectiveness of gastric cytoprotection by vitamin A, De-Nol, sucralfate and ulcer healing by pirenzepine in patients with chronic gastric ulcer (a multiclinical and randomized study). ( Benedek, S; Deák, G; Jávor, T; Kenéz, P; Mózsik, G; Nagy, L; Patty, I; Simon, L; Tárnok, F, 1984) |
"37 patients with endoscopically confirmed gastric ulcers received either cimetidine (19 patients) or pirenzepine (18 patients) in a double-blind trial." | 9.05 | [Treatment of stomach ulcers with cimetidine and pirenzepine]. ( Arnold, J; Birchler, R; Bretholz, A; Capitaine, Y; Gonvers, JJ; Realini, S; Voirol, M, 1984) |
"The therapeutic effects on gastric ulcer and side-effects of 5,11-dihydro-11[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6 one-dihydrochloride (pirenzepine, LS519), a new antiulcer drug, were investigated in 15 medical institutes by a double-blind controlled clinical study, using trans-3,7-dimethyl-2,6-octadienyl-5,9,13-trimethyltetradeca-4,8,12-trienoate (gefarnate) as the standard drug." | 9.05 | Therapeutic effect of pirenzepine dihydrochloride on gastric ulcer evaluated by a double-blind controlled clinical study. Phase III study. ( Ishimori, A; Yamagata, S, 1982) |
"The effectiveness of pirenzepine in the treatment of gastric ulcer was assessed in a double-blind 6 weeks' clinical trial in comparison with placebo." | 9.04 | Pirenzepine in the treatment of gastric ulcer. A double-blind short-term clinical trial. ( Morelli, A; Narducci, F; Pelli, A; Spadacini, A, 1979) |
"Pirenzepine (PRZ) 75 mg/day for 1 week followed by 50 mg/day for 3 weeks did not show a good activity in gastric ulcer healing in comparison to carbenoxolone (CB) (300 mg/day for 1 week followed by 200 mg/day for 3 weeks)." | 9.04 | Pirenzepine and carbenozolone in gastric ulcer. Preliminary results of a multicentre double-blind controlled clinical trial. ( Barbara, L; Belsasso, E; Blasi, A; Caenazzo, E; Di Febo, G; Di Mario, F; Giorgi-Conciato, M; Marletta, F; Miglioli, M; Petrillo, M; Salvagnini, M; Scalabrin, G, 1979) |
" The pharmacokinetics of pirenzepine (Gastrozepin) was studied after single and multiple oral administration in gastric ulcer and duodenal ulcer patients." | 7.67 | Pharmacokinetics of pirenzepine in patients with gastric or duodenal ulcers. ( Bozler, G; Hayakawa, A; Kobayashi, S; Misawa, T; Nishihara, S, 1987) |
"We studied the effects of atropine and pirenzepine on acid secretion induced by electrical vagal stimulation (EVS) and on healing of gastric ulcers after mucosal excision in rats." | 7.67 | Effects of atropine and pirenzepine on healing of gastric ulcer induced by mucosal excision in rats. ( Fujiwara, M; Kitagawa, H; Sano, M, 1985) |
"Pirenzepine (Gastrozepin) is a drug recently introduced in the therapy of gastroduodenal ulcer (GDU)." | 7.66 | Inhibition of gastric mucosa carbonic anhydrase by pirenzepine in patients with gastroduodenal ulcers. ( Búzás, G; Domuta, M; Puşcaş, I; Surányi, P, 1981) |
"The effects of pirenzepine on the serum gastrin levels in the basal state and in response to a liquid test meal were investigated in nine patients with gastric ulcer." | 7.66 | Inhibition of gastrin secretion by pirenzepine (LS 519) in treatment of gastric ulcer. ( Baba, M; Itoh, T; Okuda, S; Tamura, H; Tatsuta, M; Yamamura, H, 1981) |
"Pirenzepine has been reported to inhibit gastrin secretion." | 6.68 | Effects of pirenzepine on omeprazole-induced hypergastrinemia and acid suppression in peptic ulcer patients. ( Fukino, Y; Hamada, M; Haruma, K; Inoue, M; Kajiyama, G; Kamiyasu, T; Sumii, K; Sumii, M; Tari, A, 1996) |
"The pneumonia rate in ranitidine-, pirenzepine-, and placebo-treated patients is 10 of 57, 10 of 44, and 12 of 57, respectively." | 5.08 | A randomized, double-blind trial for stress ulcer prophylaxis shows no evidence of increased pneumonia. ( Encke, A; Hanisch, EW; Naujoks, F; Windolf, J, 1998) |
"Serum gastrin levels in 44 peptic ulcer patients (26 gastric ulcer patients and 18 duodenal ulcer patients) were determined after they had been treated with omeprazole (OPZ) (20 mg/day) alone or in combination with pirenzepine (PZP) (100 mg/day)." | 5.07 | Serum gastrin levels following administration of omeprazole alone or in combination with pirenzepine. ( Arakawa, Y; Ito, K; Iwasaki, A; Kawamura, Y; Matsuo, Y; Miyazawa, K; Sakai, Y; Tashiro, Y, 1994) |
"163 patients with endoscopically proven benign gastric ulcers were randomly allocated to treatment with either telenzepine 3 mg nocte or ranitidine 300 mg nocte for up to 8 weeks in a prospective double-blind study." | 5.06 | [3 mg telenzepine nocte in the treatment of benign stomach ulcer disease: a double-blind comparative study with 300 mg ranitidine nocte]. ( Dammann, HG; Müller, P; Reinicke, HG; Simon, B, 1990) |
"In a double-blind, multicentre study 77 patients with benign gastric ulcer were randomly allocated to treatment with either enprostil 35 micrograms bd or pirenzepine 50 mg bd." | 5.06 | Enprostil, a prostaglandin E2 analogue, in the treatment of gastric ulcer--a multicentre comparison with pirenzepine. ( Carr-Locke, D; English, JR; Jazrawi, RP; Mountford, RA; Northfield, TC; Reed, PI; Schiller, KF; Williams, JG, 1990) |
"Fifty-five patients with endoscopically confirmed gastric ulcers received either cimetidine (28 patients) or pirenzepine (27 patients) in a randomized double-blind manner." | 5.06 | Gastric ulcer: a double-blind comparison of 100 mg pirenzepine plus antacid versus 800 mg cimetidine plus antacid. ( Arnold, J; Birchler, R; Bretholz, A; Capitaine, Y; Gonvers, JJ; Guyot, J; Ollyo, JB; Realini, S; Voirol, M, 1986) |
"The gastric cytoprotective effects of vitamin A, De-Nol and sucralfate were compared with the effectiveness of pirenzepine in healing ulcer in patients with chronic gastric ulcer." | 5.05 | A comparative dynamic study of the effectiveness of gastric cytoprotection by vitamin A, De-Nol, sucralfate and ulcer healing by pirenzepine in patients with chronic gastric ulcer (a multiclinical and randomized study). ( Benedek, S; Deák, G; Jávor, T; Kenéz, P; Mózsik, G; Nagy, L; Patty, I; Simon, L; Tárnok, F, 1984) |
"37 patients with endoscopically confirmed gastric ulcers received either cimetidine (19 patients) or pirenzepine (18 patients) in a double-blind trial." | 5.05 | [Treatment of stomach ulcers with cimetidine and pirenzepine]. ( Arnold, J; Birchler, R; Bretholz, A; Capitaine, Y; Gonvers, JJ; Realini, S; Voirol, M, 1984) |
"In two studies the beneficial effect of Pirenzepine in the treatment of peptic duodenal and gastric ulcers was investigated in 1686 outpatients." | 5.05 | [Treatment of ulcers with pirenzepin. Results from clinic and practice]. ( Kalk, A; Krempler, F; Sandhofer, F, 1982) |
"The therapeutic effects on gastric ulcer and side-effects of 5,11-dihydro-11[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6 one-dihydrochloride (pirenzepine, LS519), a new antiulcer drug, were investigated in 15 medical institutes by a double-blind controlled clinical study, using trans-3,7-dimethyl-2,6-octadienyl-5,9,13-trimethyltetradeca-4,8,12-trienoate (gefarnate) as the standard drug." | 5.05 | Therapeutic effect of pirenzepine dihydrochloride on gastric ulcer evaluated by a double-blind controlled clinical study. Phase III study. ( Ishimori, A; Yamagata, S, 1982) |
"The purpose of the present study was to compare the effectiveness of pirenzepine and carbenoxolone in accelerating the healing of chronic gastric ulcer." | 5.05 | Comparison of pirenzepine and carbenoxolone in the treatment of chronic gastric ulcer. A double-blind endoscopic trial. ( Bianchi Porro, G; Daniotti, S; De Pretis, G; Dobrilla, G; Lazzaroni, M; Mazzacca, G; Petrillo, M; Piai, G; Sabbatini, F, 1985) |
"Pirenzepine (PRZ) 75 mg/day for 1 week followed by 50 mg/day for 3 weeks did not show a good activity in gastric ulcer healing in comparison to carbenoxolone (CB) (300 mg/day for 1 week followed by 200 mg/day for 3 weeks)." | 5.04 | Pirenzepine and carbenozolone in gastric ulcer. Preliminary results of a multicentre double-blind controlled clinical trial. ( Barbara, L; Belsasso, E; Blasi, A; Caenazzo, E; Di Febo, G; Di Mario, F; Giorgi-Conciato, M; Marletta, F; Miglioli, M; Petrillo, M; Salvagnini, M; Scalabrin, G, 1979) |
"The effectiveness of pirenzepine in the treatment of gastric ulcer was assessed in a double-blind 6 weeks' clinical trial in comparison with placebo." | 5.04 | Pirenzepine in the treatment of gastric ulcer. A double-blind short-term clinical trial. ( Morelli, A; Narducci, F; Pelli, A; Spadacini, A, 1979) |
"Pirenzepine (PRZ, 75 mg/day for 10 days followed by 50 mg/day for 20 days) was compared with placebo (PL) in the treatment of endoscopically confirmed active gastroduodenitis or duodenal ulcer and with carbenoxolone (CB, 300 mg/day followed by 200 mg/day) in the treatment of gastric ulcer in a 30-day double-blind clinical trial." | 5.04 | Pirenzepine in the treatment of benign gastroduodenal diseases. A double-blind controlled clinical trial. ( Cifani, G; D'Anchino, M; Di Tommaso, B; Gasbarrini, G; Giorgi-Conciato, M; Pesa, O; Sollecito, A, 1979) |
"The healing rate of duodenal ulcers may be accelerated by secretory inhibitors such as histamine H2-receptor antagonists and pirenzepine, by antacids, by protective drugs such as sucralfate and colloidal bismuth, and by antidepressant drugs such as trimipramine." | 4.77 | Therapeutic approach to ulcer healing. ( Blum, AL, 1985) |
"A randomized, prospective, interventional trial was performed comparing pirenzepine (muscarinic type I receptor antagonist) and ephedrine (nonspecific sympathomimetic) in the prevention of gastric ulcerogenesis after CCT in the rat." | 3.70 | Autonomic regulation of gastric ulcerogenesis after cervical cord transection in the rat. ( Strain, GM; Waldrop, RD, 1998) |
" The compound had no activity against cysteamine-induced duodenal ulcers and lost its cytoprotective activity in adrenalectomised rats." | 3.68 | BAY P 1455, a thiazolylaminobenzimidazole derivative with gastroprotective properties in the rat. ( Bruno, M; Grassi, A; Ippen, J; Thomas, G, 1991) |
" The pharmacokinetics of pirenzepine (Gastrozepin) was studied after single and multiple oral administration in gastric ulcer and duodenal ulcer patients." | 3.67 | Pharmacokinetics of pirenzepine in patients with gastric or duodenal ulcers. ( Bozler, G; Hayakawa, A; Kobayashi, S; Misawa, T; Nishihara, S, 1987) |
"We studied the effects of atropine and pirenzepine on acid secretion induced by electrical vagal stimulation (EVS) and on healing of gastric ulcers after mucosal excision in rats." | 3.67 | Effects of atropine and pirenzepine on healing of gastric ulcer induced by mucosal excision in rats. ( Fujiwara, M; Kitagawa, H; Sano, M, 1985) |
"The effects of pirenzepine on the serum gastrin levels in the basal state and in response to a liquid test meal were investigated in nine patients with gastric ulcer." | 3.66 | Inhibition of gastrin secretion by pirenzepine (LS 519) in treatment of gastric ulcer. ( Baba, M; Itoh, T; Okuda, S; Tamura, H; Tatsuta, M; Yamamura, H, 1981) |
"Pirenzepine (Gastrozepin) is a drug recently introduced in the therapy of gastroduodenal ulcer (GDU)." | 3.66 | Inhibition of gastric mucosa carbonic anhydrase by pirenzepine in patients with gastroduodenal ulcers. ( Búzás, G; Domuta, M; Puşcaş, I; Surányi, P, 1981) |
"Pirenzepine has been reported to inhibit gastrin secretion." | 2.68 | Effects of pirenzepine on omeprazole-induced hypergastrinemia and acid suppression in peptic ulcer patients. ( Fukino, Y; Hamada, M; Haruma, K; Inoue, M; Kajiyama, G; Kamiyasu, T; Sumii, K; Sumii, M; Tari, A, 1996) |
"A total of 120 patients suffering from brain tumors was included in this study." | 2.66 | [Report of experience with stomach-protective therapy in high-dosage corticosteroid treatment of patients with brain tumors]. ( Hirschl, M, 1988) |
"Pirenzepine is a new anticholinergic agent which selectively binds to gastric mucosal muscarinic receptors." | 2.36 | The efficacy and selectivity of pirenzepine. Review and commentary. ( Reilly, PA; Texter, EC, 1982) |
" Omeprazole, which suppresses acid very effectively, may be problematic in the critically ill, limited by its oral dosage form, acid-labile properties, and potential drug interactions." | 1.28 | Controlling gastric pH: the impact of newer agents on the critically ill patient. ( Earnest, DL, 1990) |
"But pirenzepine has also been found to have a cytoprotective effect on gastric mucosa in rats." | 1.27 | Cytoprotective effect of pirenzepine and palm wine on rats gastric mucosa. ( Ezeamuzie, IC; Ibu, JO; Ngeribara, CO; Obuforoibo, AA, 1986) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 55 (66.27) | 18.7374 |
1990's | 27 (32.53) | 18.2507 |
2000's | 1 (1.20) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Lattanzi, A | 1 |
Del Soldato, P | 2 |
Simon, B | 2 |
Müller, P | 2 |
Dammann, HG | 2 |
Giorgi-Conciato, M | 3 |
Daniotti, S | 2 |
Ferrari, PA | 1 |
Gaetani, M | 1 |
Petrin, G | 1 |
Sala, P | 1 |
Valentini, P | 1 |
Klincewicz, H | 2 |
Hasik, J | 2 |
Hryniewiecki, L | 1 |
Grigor'ev, IIa | 1 |
Zhivodereov, VM | 1 |
Khar'kovskiĭ, NN | 1 |
Patty, I | 1 |
Tárnok, F | 1 |
Simon, L | 1 |
Jávor, T | 1 |
Deák, G | 1 |
Benedek, S | 1 |
Kenéz, P | 1 |
Nagy, L | 1 |
Mózsik, G | 1 |
Brühlmann, W | 1 |
von Büren, U | 1 |
Zollikofer, C | 1 |
Müller-Lissner, S | 1 |
Blum, A | 1 |
Bernardini, C | 2 |
Martinotti, E | 2 |
Del Tacca, M | 2 |
Soldani, G | 2 |
Bertelli, A | 2 |
Gonvers, JJ | 2 |
Realini, S | 2 |
Bretholz, A | 2 |
Voirol, M | 2 |
Arnold, J | 2 |
Birchler, R | 2 |
Capitaine, Y | 2 |
Kukes, VG | 1 |
Blinkov, Il | 1 |
Chekhmakina, OV | 1 |
Krivorotova, SP | 1 |
Karpenko, EV | 1 |
Pellegrini, M | 1 |
Hopkins, S | 1 |
Varin, L | 2 |
Foschi, D | 1 |
De Rosa, M | 1 |
Nakamura, K | 1 |
Sunaga, H | 1 |
Texter, EC | 1 |
Reilly, PA | 1 |
Krempler, F | 1 |
Sandhofer, F | 1 |
Kalk, A | 1 |
Gibiński, K | 1 |
Nowak, A | 1 |
Marlicz, K | 1 |
Gabryelewicz, A | 1 |
Kosidło, S | 1 |
Mattes, P | 1 |
Peros, G | 1 |
Belohlavek, D | 1 |
Merkle, N | 1 |
Kilian, J | 1 |
Puşcaş, I | 1 |
Búzás, G | 1 |
Surányi, P | 1 |
Domuta, M | 1 |
Tatsuta, M | 1 |
Itoh, T | 1 |
Okuda, S | 1 |
Tamura, H | 1 |
Baba, M | 1 |
Yamamura, H | 1 |
Berndt, H | 1 |
Otto, R | 1 |
Cerlek, S | 1 |
Papa, B | 1 |
Katicić, M | 1 |
Colić-Cvrlje, V | 1 |
Mielenz, H | 2 |
Mittelstaedt, A | 1 |
Zilly, A | 1 |
Verhoeven, A | 1 |
Ishimori, A | 2 |
Yamagata, S | 1 |
Nikolaeva, NN | 1 |
Grishchenko, EG | 1 |
Nikolaeva, LV | 1 |
Grigor'ev, PIa | 1 |
Iakovenko, AV | 1 |
Vasil'ev, IV | 1 |
Takase, H | 1 |
Yamamoto, K | 1 |
Hirano, H | 1 |
Saito, Y | 1 |
Yamashita, A | 1 |
Behrens, R | 1 |
Hofbeck, M | 1 |
Singer, H | 1 |
Scharf, J | 1 |
Rupprecht, T | 1 |
Iwasaki, A | 1 |
Miyazawa, K | 1 |
Kawamura, Y | 1 |
Sakai, Y | 1 |
Tashiro, Y | 1 |
Ito, K | 1 |
Arakawa, Y | 1 |
Matsuo, Y | 1 |
Kosaka, N | 1 |
Tanaka, H | 1 |
Tomaru, A | 1 |
Ishii, A | 1 |
Shuto, K | 1 |
Takakura, K | 2 |
Harada, J | 2 |
Mizogami, M | 2 |
Goto, Y | 2 |
Urakawa, T | 1 |
Nagahata, Y | 1 |
Kawakita, N | 1 |
Tari, A | 1 |
Hamada, M | 1 |
Kamiyasu, T | 1 |
Fukino, Y | 1 |
Sumii, M | 1 |
Haruma, K | 1 |
Sumii, K | 1 |
Inoue, M | 1 |
Kajiyama, G | 1 |
Zaĭtseva, EI | 1 |
Titova, OV | 1 |
Melekhova, LS | 1 |
Makarenko, TG | 1 |
Sosina, TE | 1 |
Karateev, AE | 1 |
Murav'ev, IuV | 1 |
Nasonova, VA | 1 |
Waldrop, RD | 1 |
Strain, GM | 1 |
Hanisch, EW | 1 |
Encke, A | 1 |
Naujoks, F | 1 |
Windolf, J | 1 |
Vakhrushev, IaM | 1 |
Muravtseva, OV | 1 |
Barbara, L | 1 |
Belsasso, E | 1 |
Blasi, A | 1 |
Caenazzo, E | 1 |
Di Febo, G | 1 |
Di Mario, F | 1 |
Marletta, F | 1 |
Miglioli, M | 1 |
Petrillo, M | 2 |
Salvagnini, M | 1 |
Scalabrin, G | 1 |
Gasbarrini, G | 1 |
D'Anchino, M | 1 |
Di Tommaso, B | 1 |
Pesa, O | 1 |
Sollecito, A | 1 |
Cifani, G | 1 |
Oselladore, D | 1 |
Chierichetti, SM | 1 |
Norberto, L | 1 |
Vibelli, C | 1 |
Morelli, A | 1 |
Pelli, A | 1 |
Narducci, F | 1 |
Spadacini, A | 1 |
Kojima, Y | 1 |
Ishihara, K | 1 |
Ohara, S | 1 |
Saigenji, K | 1 |
Hotta, K | 1 |
Kawamura, T | 1 |
Koizumi, F | 1 |
Natsvlishvili, NA | 1 |
Samonina, GE | 1 |
Ashmarin, IP | 1 |
Sigman, HH | 1 |
Poleski, MH | 1 |
Gillich, A | 1 |
Grassi, A | 1 |
Ippen, J | 1 |
Bruno, M | 1 |
Thomas, G | 1 |
Earnest, DL | 1 |
Kromer, W | 2 |
Gönne, S | 1 |
Riedel, R | 2 |
Postius, S | 1 |
Kawakami, H | 1 |
Miyata, K | 1 |
Kamato, T | 1 |
Nishida, A | 1 |
Honda, K | 1 |
Reed, PI | 1 |
Jazrawi, RP | 1 |
Northfield, TC | 1 |
Carr-Locke, D | 1 |
Mountford, RA | 1 |
Williams, JG | 1 |
Schiller, KF | 1 |
English, JR | 1 |
Reinicke, HG | 1 |
Ibáñez Delgado, F | 1 |
Torreblanca López, J | 1 |
López-Campos, JL | 2 |
Moreno Onorato, FJ | 1 |
Pekhlivanov, D | 1 |
Rankov, R | 1 |
Pekhlivanov, N | 1 |
Lambev, I | 1 |
Minkova, N | 1 |
Albrecht, R | 1 |
Nowak, W | 1 |
Kitagawa, H | 4 |
Takeda, F | 3 |
Kohei, H | 3 |
Rainsford, KD | 1 |
Madrid, JA | 1 |
Salido, GM | 1 |
Muñoz-Arrebola, P | 1 |
Martínez de Victoria, E | 1 |
Blum, AL | 1 |
Laggner, AN | 1 |
Lenz, K | 1 |
Morikawa, K | 1 |
Aratani, T | 1 |
Mizutani, F | 1 |
Kato, H | 1 |
Ito, Y | 1 |
Stockbrügger, RW | 1 |
Cronstedt, J | 1 |
Dotevall, G | 1 |
Hellner, L | 1 |
Hoffmann, P | 1 |
Hradsky, M | 1 |
Jaup, BH | 1 |
Seeberg, S | 1 |
Zheng, W | 1 |
Yong, DG | 1 |
Geng, BQ | 1 |
Gu, GG | 1 |
Martí-Cabrera, M | 1 |
Esplugues, JV | 1 |
Martí-Bonmati, L | 1 |
Sarria, B | 1 |
Vento, A | 1 |
Martí-Bonmati, E | 1 |
Gil, L | 1 |
Esplugues, J | 1 |
Ibáñez, F | 1 |
Torreblanca, J | 1 |
Moreno, FJ | 1 |
Bohnenkamp, W | 1 |
Eltze, M | 1 |
Heintze, K | 1 |
Prinz, W | 1 |
Hirschl, M | 1 |
Hayashi, T | 1 |
Kinekawa, F | 1 |
Giachetti, A | 1 |
Brambilla, A | 1 |
Ibu, JO | 1 |
Obuforoibo, AA | 1 |
Ezeamuzie, IC | 1 |
Ngeribara, CO | 1 |
Ollyo, JB | 1 |
Guyot, J | 1 |
Takano, KI | 1 |
Sugiyama, S | 1 |
Nakazawa, S | 1 |
Ozawa, T | 1 |
Hayakawa, A | 1 |
Misawa, T | 1 |
Nishihara, S | 1 |
Kobayashi, S | 1 |
Bozler, G | 1 |
Stockbrügger, R | 1 |
Sano, M | 1 |
Fujiwara, M | 1 |
Polloni, A | 1 |
Marchi, S | 1 |
Bellini, M | 1 |
Savalli, E | 1 |
Cecconi, N | 1 |
Vanacore, R | 1 |
Grassi, B | 1 |
Cameron, AD | 1 |
Bianchi Porro, G | 1 |
Lazzaroni, M | 1 |
Mazzacca, G | 1 |
Sabbatini, F | 1 |
Piai, G | 1 |
Dobrilla, G | 1 |
De Pretis, G | 1 |
Hoffenberg, P | 1 |
Maggiolo, P | 1 |
Ossa, P | 1 |
Gallo, G | 1 |
Klinger, J | 1 |
4 reviews available for pirenzepine and Gastric Ulcer
Article | Year |
---|---|
[Acid anti-secretion therapy in gastric and duodenal ulcer].
Topics: Antacids; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Duodenal Ulcer; Furans; Gastric Juice; G | 1981 |
[Gastrozepin--a new anti-ulcer agent (a review of the literature and the authors' own data)].
Topics: Animals; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Drug Evaluation; Drug Synergism; Duodenal | 1984 |
The efficacy and selectivity of pirenzepine. Review and commentary.
Topics: Anti-Ulcer Agents; Benzodiazepinones; Duodenal Ulcer; Endoscopy; Humans; Pirenzepine; Stomach Ulcer | 1982 |
Therapeutic approach to ulcer healing.
Topics: Aluminum; Antacids; Anti-Ulcer Agents; Antidepressive Agents; Benzodiazepinones; Bismuth; Colloids; | 1985 |
32 trials available for pirenzepine and Gastric Ulcer
Article | Year |
---|---|
[Antisecretory and mucosa-protecting drugs in the acute care of peptic ulcer. Review of action principles, healing rates and side effects of approved ulcer drugs and drugs under clinical trial].
Topics: Acute Disease; Aluminum; Antacids; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Clinical Trials | 1984 |
Efficacy and safety of pirenzepine in peptic ulcer and in non ulcerous gastroduodenal diseases. A multicentre controlled clinical trial.
Topics: Adult; Benzodiazepinones; Carbenoxolone; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Duode | 1982 |
[Double-blind study on therapy with new drugs in stomach and duodenal ulcers].
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Double-Blind Method; Duodenal Ulcer; Duodenoscopy; Fema | 1983 |
A comparative dynamic study of the effectiveness of gastric cytoprotection by vitamin A, De-Nol, sucralfate and ulcer healing by pirenzepine in patients with chronic gastric ulcer (a multiclinical and randomized study).
Topics: Adolescent; Adult; Aged; Aluminum; Antacids; Anti-Ulcer Agents; Benzodiazepinones; Bismuth; Clinical | 1984 |
[Gastric secretory inhibitors improve the visibility of gastric mucosal detail in barium studies of the stomach: a controlled clinical trial (author's transl)].
Topics: Benzodiazepinones; Cimetidine; Depression, Chemical; Gastric Emptying; Gastric Juice; Guanidines; Hu | 1981 |
[Treatment of stomach ulcers with cimetidine and pirenzepine].
Topics: Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Female; Humans; Male; Middle Aged; Pirenzepine; St | 1984 |
[Treatment of ulcers with pirenzepin. Results from clinic and practice].
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Carbenoxolone; Chemical Phenomena; Chemistry; Cimetidin | 1982 |
[Multicenter controlled clinical studies on the effectiveness of pirenzepin in the treatment of peptic ulcer].
Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Duodenal Ul | 1982 |
Pirenzepin in gastric and duodenal ulcer: a double-blind trial.
Topics: Aged; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Female; Huma | 1981 |
[Results of a controlled comparative study between cimetidine and pirenzepin in 60 patients with ulcera ventriculi or duodeni].
Topics: Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Guanidin | 1981 |
Therapeutic effect of pirenzepine dihydrochloride on gastric ulcer evaluated by a double-blind controlled clinical study. Phase III study.
Topics: Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method; Fe | 1982 |
Frequency of stress lesions of the upper gastrointestinal tract in paediatric patients after cardiac surgery: effects of prophylaxis.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Famotidine; Female; Heart Defects, Congenit | 1994 |
Serum gastrin levels following administration of omeprazole alone or in combination with pirenzepine.
Topics: Drug Therapy, Combination; Duodenal Ulcer; Gastrins; Humans; Omeprazole; Peptic Ulcer; Pirenzepine; | 1994 |
Prophylactic effects of pirenzepine (M1-blocker) on intraoperative stress ulcer: comparison with an H2-blocker.
Topics: Adult; Gastric Juice; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Intraoperative Care; Intra | 1994 |
Effect of pirenzepine on postoperative gastric secretion.
Topics: Adult; Aged; Female; Gastric Acid; Gastric Acidity Determination; Gastric Mucosa; Humans; Male; Midd | 1993 |
Effects of pirenzepine on omeprazole-induced hypergastrinemia and acid suppression in peptic ulcer patients.
Topics: Adult; Aged; Anti-Ulcer Agents; Drug Therapy, Combination; Duodenal Ulcer; Female; Gastric Acid; Gas | 1996 |
[The endoscopic assessment of the effect of ranitidine and pirenzepine on the manifestations of the gastropathy induced by nonsteroidal anti-inflammatory preparations].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Female; Gastroscopy; Histamine H2 | 1997 |
A randomized, double-blind trial for stress ulcer prophylaxis shows no evidence of increased pneumonia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Double-Blind Method; Female; Histamin | 1998 |
Pirenzepine and carbenozolone in gastric ulcer. Preliminary results of a multicentre double-blind controlled clinical trial.
Topics: Anti-Ulcer Agents; Benzodiazepinones; Carbenoxolone; Clinical Trials as Topic; Double-Blind Method; | 1979 |
Pirenzepine in the treatment of benign gastroduodenal diseases. A double-blind controlled clinical trial.
Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blin | 1979 |
Pirenzepine (LS 519) in severe duodenal ulcer and in gastric ulcer. A double-blind clinical trial.
Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Carbenoxolone; Clinical Trials as Top | 1979 |
Pirenzepine in the treatment of gastric ulcer. A double-blind short-term clinical trial.
Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blin | 1979 |
Effect of drug therapy on the relapse of peptic ulcers. 1st communication: the effect of acute therapy.
Topics: Cimetidine; Double-Blind Method; Humans; Peptic Ulcer; Pirenzepine; Recurrence; Stomach Ulcer | 1992 |
[Comparison of the M1-blocker with the H2-blocker regarding their effects on gastric pH and viscosity under general anesthesia].
Topics: Adult; Anesthesia, General; Female; Gastric Juice; Humans; Hydrogen-Ion Concentration; Male; Middle | 1991 |
Enprostil, a prostaglandin E2 analogue, in the treatment of gastric ulcer--a multicentre comparison with pirenzepine.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Enprostil; Female; Humans; Male; Middle Aged; Multicen | 1990 |
[3 mg telenzepine nocte in the treatment of benign stomach ulcer disease: a double-blind comparative study with 300 mg ranitidine nocte].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Drug Administration Schedule; Femal | 1990 |
The intragastric milieu during gastric ulcer treatment with pirenzepine 50 mg b.i.d. or cimetidine 400 mg b.i.d.
Topics: Adult; Aged; Bacteria; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Female; Fungi; Gas | 1988 |
[Report of experience with stomach-protective therapy in high-dosage corticosteroid treatment of patients with brain tumors].
Topics: Administration, Oral; Anti-Ulcer Agents; Brain Edema; Brain Neoplasms; Dexamethasone; Dose-Response | 1988 |
Gastric ulcer: a double-blind comparison of 100 mg pirenzepine plus antacid versus 800 mg cimetidine plus antacid.
Topics: Antacids; Anti-Ulcer Agents; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Adminis | 1986 |
Use of antisecretory drugs for gastroprotection during antiblastic chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Benzodiazepinones; Cyclophosphamide; Do | 1985 |
Comparison of pirenzepine and carbenoxolone in the treatment of chronic gastric ulcer. A double-blind endoscopic trial.
Topics: Anti-Ulcer Agents; Benzodiazepinones; Carbenoxolone; Chronic Disease; Clinical Trials as Topic; Doub | 1985 |
[Comparative treatment of gastric ulcer with pirenzepin, cimetidine and placebo].
Topics: Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Double-Blin | 1985 |
47 other studies available for pirenzepine and Gastric Ulcer
Article | Year |
---|---|
[Cytoprotective properties of pirenzepine, PGE2 and cimetidine in the rat].
Topics: Animals; Benzodiazepinones; Cimetidine; Dinoprostone; Female; Gastric Mucosa; Guanidines; Histamine | 1981 |
Gastric cytoprotection by pirenzepine: role of endogenous catecholamines.
Topics: Animals; Anti-Ulcer Agents; Benzodiazepinones; Ethanol; Gastric Mucosa; Male; Norepinephrine; Pirenz | 1984 |
[Use of gastrozepin in erosive-ulcerative diseases of the stomach and duodenum].
Topics: Anti-Ulcer Agents; Benzodiazepinones; Duodenal Ulcer; Female; Humans; Male; Pirenzepine; Stomach Ulc | 1984 |
Gastric cytoprotection by pirenzepine is not mediated by catecholamines.
Topics: Animals; Anti-Ulcer Agents; Atropine; Benzodiazepinones; Disease Models, Animal; Gastric Mucosa; Mal | 1984 |
Pharmacology: pirenzepine.
Topics: Benzodiazepinones; Humans; Pirenzepine; Stomach Ulcer | 1983 |
Further evidences on gastric cytoprotection exerted by pirenzepine.
Topics: Animals; Anti-Ulcer Agents; Benzodiazepinones; Dinoprostone; Ethanol; Gastric Mucosa; Indomethacin; | 1984 |
[Combined effect of FM-100 and several anti-ulcer agents on ulcer induced by ligation of the pylorus in rats].
Topics: Aluminum; Animals; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Drug Therapy, Combination; Gast | 1983 |
[Pathogenesis, diagnosis and therapy of ulcer disease. Therapy. 3: Pharmacologic basis and therapy with pirenzepine].
Topics: Acetylcholine; Animals; Benzodiazepinones; Gastric Acid; Gastric Mucosa; Gastrins; Histamine; Humans | 1983 |
[Effects of pirenzepin on the course of acute gastric stress lesions (author's transl)].
Topics: Benzodiazepinones; Double-Blind Method; Humans; Peptic Ulcer Hemorrhage; Piperazines; Pirenzepine; S | 1980 |
Inhibition of gastric mucosa carbonic anhydrase by pirenzepine in patients with gastroduodenal ulcers.
Topics: Animals; Benzodiazepinones; Carbonic Anhydrase Inhibitors; Cattle; Duodenal Ulcer; Gastric Mucosa; H | 1981 |
Inhibition of gastrin secretion by pirenzepine (LS 519) in treatment of gastric ulcer.
Topics: Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Depression, Chemical; Female; Gastrins; Humans; M | 1981 |
[Treatment of stomach ulcer (review)].
Topics: Aluminum; Antacids; Benzodiazepinones; Bismuth; Carbenoxolone; Cimetidine; Feeding Behavior; Gastrec | 1982 |
[Experience in the use of gastrotsepin in the treatment of stomach and duodenal ulcer].
Topics: Adolescent; Adult; Duodenal Ulcer; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; P | 1995 |
[Gastrotsepin in the therapy and prevention of peptic ulcer exacerbations associated with Helicobacter pylori bacteriosis].
Topics: Drug Evaluation; Drug Therapy, Combination; Duodenal Ulcer; Helicobacter Infections; Helicobacter py | 1995 |
Pharmacological profile of gastric mucosal protection by marmin and nobiletin from a traditional herbal medicine, Aurantii fructus immaturus.
Topics: Acetylcholine; Animals; Anti-Ulcer Agents; Coumarins; Drugs, Chinese Herbal; Electric Stimulation; F | 1994 |
Effects of KW-5805, a new antiulcer agent, on experimental gastric and duodenal ulcers, gastric mucosal lesions by necrotizing agents and gastric acid secretion.
Topics: Animals; Anti-Ulcer Agents; Benzoxepins; Cimetidine; Depression, Chemical; Duodenal Ulcer; Ethanol; | 1994 |
[New data on clinical response to therapeutic effects of gastrozepin].
Topics: Anti-Ulcer Agents; Duodenal Ulcer; Evaluation Studies as Topic; Humans; Peptic Ulcer; Pirenzepine; S | 1996 |
Autonomic regulation of gastric ulcerogenesis after cervical cord transection in the rat.
Topics: Analysis of Variance; Animals; Anti-Ulcer Agents; Ephedrine; Evaluation Studies as Topic; Male; Musc | 1998 |
[The gastric mucigenous function in the treatment of patients with ulcer with various antisecretory preparations].
Topics: Adult; Anti-Ulcer Agents; Duodenal Ulcer; Enzyme Inhibitors; Famotidine; Female; Gastric Acidity Det | 2002 |
Effects of the M1 muscarinic receptor antagonist pirenzepine on gastric mucus glycoprotein in rats with or without ethanol-induced gastric damage.
Topics: Animals; Carbohydrates; Ethanol; Gastric Mucosa; Glycoproteins; Male; Mucins; Muscarinic Antagonists | 1992 |
[Comparison of the inhibitory effects of a psychostimulant of the sydnonimine series on the development of stress and ethanol induced lesions in the rat gastric mucosa].
Topics: Animals; Antidepressive Agents; Atropine; Cold Temperature; Ethanol; Gastric Mucosa; Immobilization; | 1991 |
Effects of pirenzepine on acute mucosal erosions, gastric acid and mucosal blood flow in the spinal rat stomach.
Topics: Animals; Antacids; Gastric Acid; Gastric Mucosa; Male; Pirenzepine; Rats; Rats, Inbred Strains; Regi | 1991 |
BAY P 1455, a thiazolylaminobenzimidazole derivative with gastroprotective properties in the rat.
Topics: Adrenalectomy; Animals; Anti-Ulcer Agents; Benzimidazoles; Cimetidine; Corticosterone; Cysteamine; D | 1991 |
Controlling gastric pH: the impact of newer agents on the critically ill patient.
Topics: Alprostadil; Anti-Ulcer Agents; Critical Care; Gastric Acid; Histamine H2 Antagonists; Humans; Hydro | 1990 |
Direct comparison between the ulcer-healing effects of two H(+)-K(+)-ATPase inhibitors, one M1-selective antimuscarinic and one H2 receptor antagonist in the rat.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Triphosphatases; Animals; Anti-Ulcer Agents; Benz | 1990 |
Studies on the mechanism for the gastric mucosal protection by famotidine in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Famotidine; Gastric Mucosa; Male; Pirenzepine; Rats; Rats, I | 1991 |
[The effects of pirenzepine on regenerating parietal cells].
Topics: Animals; Cytoplasm; Dose-Response Relationship, Drug; Parietal Cells, Gastric; Pirenzepine; Rats; Ra | 1990 |
[Antiulcer treatment with Biotidin and Gastrozepin and its effect on the occupational fitness of drivers and machinery operators].
Topics: Adult; Automobile Driving; Bulgaria; Duodenal Ulcer; Engineering; Humans; Middle Aged; Physical Fitn | 1990 |
[Mucosa protection--an assessable value? An experimental study in rats].
Topics: Animals; Cimetidine; Female; Gastric Acidity Determination; Gastric Mucosa; Pirenzepine; Rats; Rats, | 1990 |
A simple method for estimation of gastric mucus and effects of antiulcerogenic agents on the decrease in mucus during water-immersion stress in rats.
Topics: Alcian Blue; Animals; Anti-Ulcer Agents; Atropine; Bombesin; Gastric Mucosa; Immersion; Irritants; M | 1986 |
Quantitation by computerized visual image analysis of gastric mucosal lesions induced in mice and rats by non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bethanechol; Bethanechol Compounds; Dinoprostone; | 1989 |
Circadian rhythms of food intake in gastroduodenally-ulcerated rats: effects of three anti-ulcer drugs.
Topics: Animals; Anti-Ulcer Agents; Circadian Rhythm; Duodenal Ulcer; Eating; Female; Indomethacin; Male; Pi | 1989 |
[Prevention of stress ulcer in intensive care patients].
Topics: Alprostadil; Antacids; Critical Care; Drug Therapy, Combination; Enteral Nutrition; Histamine H2 Ant | 1986 |
[Cytoprotective activity of tiquizium bromide (HSR-902) and its mechanism].
Topics: Animals; Bicarbonates; Ganglionic Blockers; Gastric Mucosa; Male; Pirenzepine; Quinolizines; Rats; R | 1987 |
[Antiulcer effects of pirenzepine in rats].
Topics: Animals; Cats; Duodenal Ulcer; Female; Gastric Acid; Gastric Juice; Gastrins; Hexosamines; Male; Pep | 1988 |
Effects of antisecretory drugs on mucosal erosions induced by intragastric distension in rats: a comparative study.
Topics: Animals; Carbenoxolone; Cimetidine; Dinoprostone; Gastric Mucosa; In Vitro Techniques; Male; Pirenze | 1988 |
[Action of the drug pirenzepine on regenerating parietal cells. Morphological and quantitative study].
Topics: Animals; Gastric Acid; Male; Parietal Cells, Gastric; Pirenzepine; Rats; Rats, Inbred Strains; Regen | 1988 |
Comparison of the gastric antisecretory and antiulcer potencies of telenzepine, pirenzepine, ranitidine and cimetidine in the rat.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Female; Gastric Acid; Parasympatholytics; Pirenzepine; Ranit | 1988 |
Effects of antimuscarinic agents and prostaglandin E2 on the gastric mucosal lesions induced by necrotizing agents and water-immersion stress in rats.
Topics: Animals; Anti-Ulcer Agents; Atropine; Cimetidine; Dinoprostone; Male; Parasympatholytics; Pirenzepin | 1986 |
Effect of pirenzepine and PGE2 on taurocholic acid-induced gastric lesions.
Topics: Animals; Anti-Ulcer Agents; Dinoprostone; Male; Pirenzepine; Prostaglandins E; Rats; Rats, Inbred St | 1986 |
Cytoprotective effect of pirenzepine and palm wine on rats gastric mucosa.
Topics: Animals; Ethanol; Female; Gastric Mucosa; Male; Pirenzepine; Rats; Rats, Inbred Strains; Stomach Ulc | 1986 |
The role of phospholipase in the genesis of gastric ulcers in rats.
Topics: Animals; Gastric Juice; Gastric Mucosa; Male; Phospholipases; Pirenzepine; Prostaglandins; Rats; Rat | 1987 |
Pharmacokinetics of pirenzepine in patients with gastric or duodenal ulcers.
Topics: Administration, Oral; Adult; Duodenal Ulcer; Female; Half-Life; Humans; Male; Middle Aged; Pirenzepi | 1987 |
[Do anticholinergic drugs still have significance in the therapy of ulcer?].
Topics: Atropine; Cimetidine; Drug Therapy, Combination; Duodenal Ulcer; Gastric Acid; Humans; Parasympathol | 1986 |
Effects of atropine and pirenzepine on healing of gastric ulcer induced by mucosal excision in rats.
Topics: Animals; Atropine; Benzodiazepinones; Electric Stimulation; Gastric Acid; Gastric Mucosa; Male; Para | 1985 |
Pirenzepine and gastroduodenal ulcers.
Topics: Benzodiazepinones; Duodenal Ulcer; Humans; Pirenzepine; Stomach Ulcer | 1985 |
Gastric cytoprotection by pirenzepine in rats: evaluating method for cytoprotective activity by antisecretory agents.
Topics: Animals; Anti-Ulcer Agents; Atropine; Benzodiazepinones; Buffers; Cimetidine; Dinoprostone; Ethanol; | 1985 |