pirenzepine has been researched along with Curling Ulcer in 140 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Curling Ulcer: Acute stress DUODENAL ULCER, usually observed in patients with extensive third-degree burns.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of cimetidine and pirenzepine on the maintenance of healing in duodenal ulceration has been compared in a multi-centre, controlled study." | 9.06 | Comparison of cimetidine and pirenzepine in the healing and maintenance of remission in duodenal ulcer. ( Gent, AE; Hellier, MD, 1990) |
| "A multicenter, double-blind, randomized controlled study was conducted in 314 duodenal ulcer patients to compare the efficacy and safety of the antimuscarinics telenzepine and pirenzepine in the treatment of duodenal ulcer." | 9.06 | [Single evening administration of a new antimuscarinic agent telenzepine in therapy of acute duodenal ulcer. Results of a randomized double-blind comparative study versus pirenzepine]. ( Dammann, HG; Dreyer, M; Merk-Härtelt, B; Müller, P; Simon, B; Wolf, N, 1989) |
| "Three different doses of the M1-selective antimuscarinic compound telenzepine were investigated in the treatment of acute duodenal ulcer in a randomized, double-blind dose-range finding study." | 9.06 | [Dose finding study of telenzepine (1.5 vs. 3 vs 5 mg once daily) in acute treatment of duodenal ulcer. A double-blind, randomized, multicenter parallel group comparison]. ( Hüttemann, W; Schneider, A, 1989) |
| "Effects of orally-administered pirenzepine and propantheline bromide on food-stimulated gastric acid secretion, serum gastrin concentration, salivary flow and heart rate were compared in 10 duodenal ulcer patients in a placebo-controlled, double-blind study." | 9.06 | Comparison of two antimuscarinic drugs, pirenzepine and propantheline, on gastric acid secretion, serum gastrin concentration, salivary flow and heart rate in patients with duodenal ulcer disease. ( Barnett, CC; Feldman, M; Richardson, CT; Walsh, JH, 1987) |
| "The efficacy of pirenzepin--of anticholinergic effect--and the H2-receptor blocking cimetidine has been studied in duodenal ulcer with random, double blind fashion." | 9.06 | [Pirenzepine and cimetidine in the treatment of duodenal ulcer]. ( Papp, J; Schandl, L; Szathmári, M; Tulassay, Z, 1988) |
| "A double-blind controlled trial was undertaken to compare the relative effectiveness of pirenzepine (Gastrozepin; Boehringer Ingelheim) and cimetidine (Tagamet; SK & F) in healing endoscopically proven duodenal ulcers." | 9.06 | Pirenzepine and cimetidine for duodenal ulcers. A comparative randomised double-blind controlled study. ( Bhoola, RL; Manion, GL; Simjee, AE; Spitaels, JM, 1988) |
| "In a randomized, endoscopically controlled double-blind trial the effectiveness of a twice daily dose of the prostaglandin E2-analogue enprostil was compared with pirenzepine given to 97 ambulatory patients with duodenal ulcers." | 9.06 | [Enprostil in the acute treatment of duodenal ulcer: direct comparative study with pirenzepin]. ( Beckenbach, HP; Daake, H; Dammann, HG; Hüttemann, R; Kalek, S; Kühn, V; Müller, P; Rohner, HG; Simon, B, 1986) |
| " The effect of pirenzepine, an antimuscarinic compound, on basal acid and pepsin secretion and on the kinetic characteristics (Vmax and ED50) of pentagastrin-stimulated gastric secretion was investigated in 11 duodenal ulcer male patients." | 9.06 | Effect of pirenzepine on basal gastric acid and pepsin secretion and on secretion stimulated with graded doses of pentagastrin in duodenal ulcer patients. ( Meneghelli, UG; Troncon, LE, 1988) |
| "Eighty-four patients with healed duodenal ulcers were treated for 1 year with pirenzepine, 50 mg twice daily, or placebo in this double-blind, randomized, multicenter trial." | 9.06 | Prevention of duodenal ulcer recurrence by pirenzepine 50 mg twice daily. ( Brassine, A; Pelckmans, P; Pen, J; Rutgeerts, P; Van der Veken, J; Van Maercke, Y; Vantrappen, G, 1987) |
| "In a double-blind, randomised trial two drug regimens were compared in a group of 129 patients with uncomplicated duodenal ulcers, 64 receiving cimetidine (800 mg) and pirenzepine (50 mg) at bed-time, 65 receiving cimetidine (800 mg) and a placebo at bed-time." | 9.06 | [Treatment of uncomplicated duodenal ulcer using cimetidine alone and in combination with pirenzepine. A comparative study]. ( Höbel, W; Huchzermeyer, H; Prex, E, 1987) |
| "A double-blind, controlled study with either 50 mg of pirenzepine or a placebo once a day was performed in 128 patients to determine the effect of pirenzepine against relapses of duodenal ulcer, the healing of the subjects' former ulcers having been confirmed endoscopically." | 9.06 | A study on the prevention of duodenal ulcer recurrence with pirenzepine. ( Fukumoto, S; Kawai, K; Kohli, Y, 1987) |
| "Sixty-seven patients with endoscopically proven duodenal ulceration were entered into a double-blind study and randomized to treatment with pirenzepine (PZ) (Gastrozepin; Boehringer Ingelheim) 50 mg twice daily or cimetidine (CM) (Tagamet; Smith Kline & French Laboratories) 400 mg twice daily, given 30 minutes before breakfast and supper." | 9.06 | Comparison of pirenzepine with cimetidine in duodenal ulcer disease. A short-term and maintenance study. ( Bank, L; Gilinsky, NH; Girdwood, AH; Kalvaria, I; Lucke, W; Marks, IN; O'Keefe, SJ; Wright, JP, 1986) |
| "A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer." | 9.06 | Controlled double-blind study of the therapeutic effect of pirenzepine dihydrochloride in duodenal ulcer. Phase III study. ( Ishimori, A; Yamagata, S, 1986) |
| "The aim of this study was to compare the effects of pirenzepine with those of atropine a non-selective antimuscarinic agent, on gastroduodenal motor patterns in duodenal ulcer patients." | 9.06 | Effects of pirenzepine and atropine on gastroduodenal motor patterns in duodenal ulcer patients. ( Arnulfo, C; Dato, D; Di Somma, C; Imbimbo, BP; Mortola, G; Reboa, G; Rezzo, R; Serafini, P, 1986) |
| "Intragastric pH was monitored during 24 hours in eight volunteers with duodenal ulcer disease in remission, while on placebo, cimetidine 400 mg bd, pirenzepine 50 mg bd, cimetidine 400 mg bd + pirenzepine 50 mg bd, cimetidine 200 mg bd + pirenzepine 25 mg bd." | 9.06 | Effect of cimetidine and pirenzepine in combination on 24 hour intragastric acidity in subjects with previous duodenal ulceration. ( Deakin, M; Ramage, JK; Williams, JG, 1986) |
| "The effects of pirenzepine and ranitidine alone and combined, on gastric acid secretion and gastrin release stimulated by liquid peptone meal were evaluated in 12 duodenal ulcer patients." | 9.06 | Inhibition of food stimulated acid secretion by association of pirenzepine and ranitidine in duodenal ulcer patients. ( Bianchi Porro, G; Imbimbo, BP; Lazzaroni, M; Parente, F; Sangaletti, O, 1986) |
| "The therapeutic efficacy of ranitidine, pirenzepine, cimetidine and placebo in the 28 day treatment of duodenal ulcer was evaluated through an open randomized study performed in 120 patients." | 9.05 | Comparison between ranitidine, cimetidine, pirenzepine and placebo in the short term treatment of duodenal ulcer. ( Cheli, R; Giacosa, A; Molinari, F; Parodi, MC, 1982) |
| "Pirenzepine, a new antimuscarinic drug which selectively binds to gastric mucosal muscarinic receptors, has been found to be as effective as cimetidine in promoting the healing of duodenal ulcer." | 9.05 | Long-term treatment and follow-up studies with pirenzepine in duodenal ulcer: a double-blind study. ( Barberani, F; Della Spoletina, A; Fatale, GP; Rossi, P; Valentini, P, 1983) |
| "The purpose of this single blind controlled multicentre trial was to compare the relative effectiveness of pirenzepine and cimetidine in healing endoscopically proven duodenal ulcers." | 9.05 | Treatment of duodenal ulcer with pirenzepine and cimetidine. ( Brandstätter, G; Brunner, H; Dittrich, H; Hentschel, E; Kern, H; Kratochvil, P; Löffelmann, K; Schütze, K; Tragl, KH; Zeiler, H, 1984) |
| "Both pirenzepine and cimetidine have been shown to be beneficial in the healing of duodenal ulcers." | 9.05 | Comparative effects of pirenzepine and cimetidine, alone and in combination, on 24-hour gastric acidity in duodenal ulcer disease. ( Mahachai, V; Reilly, P; Thomson, AB, 1984) |
| "The effectiveness of pirenzepine in the prevention of duodenal ulcer relapses was assessed by means of a double-blind controlled trial versus cimetidine." | 9.05 | Long-term management of duodenal ulcer with pirenzepine and cimetidine: a double-blind controlled clinical trial. ( Cacioli, D; Galeone, M; Giorgi-Conciato, M; Moise, G; Stock, F; Toti, GL, 1983) |
| "The effects of repeated oral doses of pirenzepine (100 mg daily for 7 days) and antacid (Maalox, 105 ml daily for 7 days) on the test-meal-stimulated release of pancreatic polypeptide (PP) were evaluated in 7 duodenal ulcer outpatients by means of a randomized cross-over study, with a wash-out period of one week between pirenzepine and antacid administration." | 9.05 | Possible role of pirenzepine on the release of pancreatic polypeptide in duodenal ulcer patients: preliminary results of a randomized cross-over study. ( Bonvicini, F; Caletti, G; Gasbarrini, G; Giorgi-Conciato, M; Severi, D; Tovoli, S, 1983) |
| "The effect of pirenzepine and cimetidine on healing, symptoms and relapse rate of duodenal ulcer was studied in a placebo-controlled double-blind trial." | 9.05 | Treatment and relapse prophylaxis of duodenal ulcer with pirenzepine and cimetidine. ( Birchler, R; Blum, AL; Eichenberger, PM; Giger, M; Gonvers, JJ; Mattle, W; Müller-Lissner, SA; Pelloni, S, 1982) |
| "Thirty-eight of forty patients satisfactorily concluded a double-blind, placebo-controlled trial to study the effects of pirenzepine (100 mg/day) on duodenal ulcers." | 9.05 | Pirenzepine in duodenal ulcer. A six week, double-blind study. ( Daniotti, S; Do, D; Martelli, S, 1982) |
| "Sixty out-patients with duodenal ulcers that were healed at the end of a 4-week treatment with pirenzepine, cimetidine or placebo were admitted to a double-blind placebo-controlled trial to study the effectiveness of pirenzepine (100 mg/daily) in preventing recurrence of ulcers." | 9.05 | Long-term treatment of duodenal ulcer with pirenzepine. A double-blind, placebo-controlled trial. ( Bianchi Porro, G; D'Imperio, N; Dal Monte, PR; Daniotti, S; Giuliani-Piccari, G; Petrillo, M, 1982) |
| "One hundred and thirty one patients with duodenal ulcer were treated, in a multicentre controlled trial, with pirenzepine (50 mg three times a day for 4 weeks) or with a placebo, using the same schedule." | 9.05 | Pirenzepine in the treatment of duodenal ulcer. An endoscopically controlled trial. ( , 1982) |
| "Long term pirenzepine treatment of duodenal ulcer patients was carried out." | 9.05 | Long term treatment of duodenal ulcer with pirenzepine. ( Cheli, R; Giacosa, A; Molinari, F, 1982) |
| "Twenty-eight patients with healed duodenal ulcer completed a 12-month double-blind trial to compare the effects of pirenzepine (25 mg twice daily) and placebo on the prevention of duodenal ulcer relapse." | 9.05 | Maintenance treatment of recurrent duodenal ulceration with pirenzepine. ( Bianchi Porro, G; Petrillo, M, 1980) |
| "The effect of pirenzepine and cimetidine on healing, symptoms, and relapse rate of duodenal ulcer was studied in a placebo controlled double blind trial." | 9.05 | [Treatment and prevention of recurrence of duodenal ulcer with pirenzepin and cimetidine]. ( Birchler, R; Blum, AL; Eichenberger, PM; Giger, M; Gonvers, JJ; Mattle, W; Müller-Lissner, SA; Pelloni, S, 1982) |
| "Sixty patients with endoscopically proven healed duodenal ulcers were treated for a year with either pirenzepine (Gastrozepin; Boehringer Ingelheim) 100 mg daily, cimetidine 400 mg at night, or placebo, The monthly relapse rate (patients per month) in the first 3 months (pirenzepine 2,3, cimetidine 2,3, placebo 3,0) and in the next 9 months (pirenzepine 0,33, cimetidine 0,44, placebo 0,56) is lower for pirenzepine and cimetidine than for placebo." | 9.05 | Pirenzepine, cimetidine and placebo in the long-term treatment of duodenal ulceration. A comparative study. ( Khan, F; Manion, GL; Moshal, MG; Spitaels, JM, 1982) |
| "90 patients with active duodenal ulcer were admitted to a double-blind trial to compare the effects of pirenzepine (150 mg/daily), cimetidine (1 g/daily) and placebo on the healing of duodenal ulcer." | 9.05 | Pirenzepine versus cimetidine in duodenal ulcer. A double-blind, placebo-controlled, short-term clinical trial. ( Bianchi Porro, G; D'Imperio, N; Dal Monte, PR; Daniotti, S; Petrillo, M; Piccari, GG, 1982) |
| "The therapeutic efficacy of pirenzepine (PIR) and cimetidine (CIM) in duodenal ulcer and their effects on the intragastric milieu have been studied in a double-blind multicentre trial." | 9.05 | Pirenzepine versus cimetidine in duodenal ulcer treatment. A clinical and microbiological study. ( Cronstedt, J; Dotevall, G; Hellner, L; Hoffmann, P; Hradsky, M; Jaup, BH; Seeberg, S; Stockbrügger, RW, 1985) |
| "Recurrence rates of chronic duodenal ulcer after initial therapy with pirenzepine or cimetidine were investigated in a prospective, randomized trial with a total of 80 patients." | 9.05 | [Recurrence of chronic duodenal ulcer following initial therapy with pirenzepine or cimetidine]. ( Dufek, W; Hentschel, E; Schütze, K, 1985) |
| "Eighty-four patients with endoscopically-proved active duodenal ulcer were admitted to a multicentre double-blind trial with either pirenzepine tablets (25 mg three times per day for 1 week followed by 25 mg two times per day for 3 weeks) or placebo." | 9.04 | Pirenzepine in duodenal ulcer. A multicentre double-blind controlled clinical trial, First of two parts. ( Barbara, L; Belsasso, E; Bianchi Porro, G; Blasi, A; Caenazzo, E; Chierichetti, SM; Di Febo, G; Di Mario, F; Farini, R; Giorgi-Conciato, M; Grossi, E; Mangiameli, A; Miglioli, M; Naccarato, R; Petrillo, M, 1979) |
| "Ninety-six patients with endoscopically proved active duodenal ulcers were admitted to a multicentre double-blind trial with either pirenzepine (100 mg/day, 25 mg in the morning and midday and 50 mg at bed time) or placebo for 4 weeks." | 9.04 | Pirenzepine in duodenal ulcer. A multicentre double-blind controlled clinical trial. Second of two parts. ( Barbara, L; Belsasso, E; Bianchi Porro, G; Blasi, A; Caenazzo, E; Di Febo, G; Di Mario, F; Farini, R; Giorgi-Conciato, M; Mangiameli, A; Miglioli, M; Naccarato, R; Petrillo, M, 1979) |
| "The effectiveness and safety of pirenzepine (PRZ) at 150 mg daily in the treatment of active duodenal ulcer was studied in an open pilot clinical trial followed by a double-blind trial against placebo." | 9.04 | Pirenzepine in the treatment of duodenal ulcer. ( D'Imperio, N; Dal Monte, PR; Giuliani Piccari, G; Lepore, AM; Sarti, F, 1979) |
| "The effectiveness of pirenzepine in the treatment of duodenal ulcer was assessed in a double-blind clinical trial in comparison with placebo." | 9.04 | A double-blind, short-term clinical trial of pirenzepine in duodenal ulcer. ( Morelli, A; Narducci, F; Pelli, MA; Spadacini, A, 1979) |
| "Fifty-five patients with active duodenal ulcer have completed, up to today, a one-month double-blind trial to compare the effects of pirenzepine (150 mg daily), cimetidine (1 g daily) and placebo on the healing of duodenal ulcer." | 9.04 | Pirenzepine versus cimetidine in the treatment of duodenal ulcer. ( Bianchi Porro, G; D'Imperio, N; Dal Monte, PR; Giuliani Piccari, G; Lazzaroni, M; Petrillo, M, 1979) |
| " pirenzepine infusion both on basal and pentagastrin and insulin-stimulated secretion was studied in 19 healthy and duodenal ulcer subjects." | 9.04 | Inhibition of pentagastrin and insulin-stimulated gastric secretion by pirenzepine in healthy and duodenal ulcer subjects. ( Bianchi Porro, G; Grossi, M; Petrillo, M; Prada, A, 1979) |
| "The effect of pirenzepine--a selective antimuscarinic compound--on plasma catecholamine, serum gastrin and somatostatin concentrations was studied in duodenal ulcer patients." | 7.67 | Pirenzepine depresses plasma noradrenaline in duodenal ulcer patients. ( Farnebo, LO; Graffner, H; Holst, J; Järhult, J, 1984) |
| "Overnight gastric secretion was studied in 32 patients with acute duodenal ulcers before treatment and whilst taking cimetidine 400 mg b." | 7.67 | Pharmacological response to cimetidine and healing of duodenal ulceration: effects of high-dose cimetidine and combination of cimetidine with pirenzepine. ( Colin-Jones, DG; Deakin, M; Williams, JG, 1988) |
| " The pharmacokinetics of pirenzepine (Gastrozepin) was studied after single and multiple oral administration in gastric ulcer and duodenal ulcer patients." | 7.67 | Pharmacokinetics of pirenzepine in patients with gastric or duodenal ulcers. ( Bozler, G; Hayakawa, A; Kobayashi, S; Misawa, T; Nishihara, S, 1987) |
| "Twenty-three endoscopically healed duodenal ulcer patients entered a long-term treatment with pirenzepine for 1 year (two 25-mg tablets at breakfast and two tablets at bedtime)." | 7.66 | Long-term treatment of duodenal ulcer with pirenzepine; gastric pH values and incidence of relapses: an open pilot study. ( Accadia, L; Federici, T; Gabbrielli, A; Gabbrielli, L; Giorgi-Conciato, M, 1983) |
| "A total of 60 patients with endoscopically diagnosed duodenal ulcer were treated with pirenzepine or cimetidine for 8-10 weeks until endoscopic healing of the ulcer." | 7.66 | Pirenzepine in long-term therapy for duodenal ulcer. ( Bresci, G; Capria, A; Del Tacca, M; Geloni, M; Polloni, A; Rindi, G, 1983) |
| "Pirenzepine (Gastrozepin) is a drug recently introduced in the therapy of gastroduodenal ulcer (GDU)." | 7.66 | Inhibition of gastric mucosa carbonic anhydrase by pirenzepine in patients with gastroduodenal ulcers. ( Búzás, G; Domuta, M; Puşcaş, I; Surányi, P, 1981) |
| "In 8 outpatients with duodenal ulcer the effect of a single dose of 50 mg pirenzepine is compared to a 3-7 days treatment with 2x50 mg." | 7.66 | [Acid secretion and serum gastrin during acute and chronic treatment with pirenzepine in duodenal ulcer (author's transl)]. ( Fritsch, WP; Hanrath, R; Müller, JE; Scholten, T; Strohmeyer, G, 1981) |
| "Ten patients with endoscopically proven duodenal ulcers participated in a double-blind, placebo-controlled, cross-over trial to investigate the effect of pirenzepine on nocturnal gastric acid secretion." | 7.66 | Inhibition by pirenzepine of nocturnal gastric acid secretion in duodenal ulcer patients. ( Barbara, L; Borghi, E; Corinaldesi, R; Daniotti, S; Miglioli, M; Stanghellini, V, 1981) |
| "The effects of atropine and pirenzepine on sham-feeding stimulated gastric secretion and serum gastrin and pancreatic polypeptide levels have been studied in 12 patients with duodenal ulcer." | 7.66 | Effects of pirenzepine and atropine on gastric secretory and plasma hormonal responses to sham-feeding in patients with duodenal ulcer. ( Dobrzańska, M; Konturek, SJ; Kopp, B; Kwiecień, N; Obtulowicz, W; Olesky, J; Swierczek, J, 1980) |
| "Pirenzepine has been reported to inhibit gastrin secretion." | 6.68 | Effects of pirenzepine on omeprazole-induced hypergastrinemia and acid suppression in peptic ulcer patients. ( Fukino, Y; Hamada, M; Haruma, K; Inoue, M; Kajiyama, G; Kamiyasu, T; Sumii, K; Sumii, M; Tari, A, 1996) |
| "Seasonal accumulation of duodenal ulcer recurrences suggests that maintenance therapy could be limited to the more risky periods." | 6.66 | Seasonal prevention of duodenal ulcer recurrences with pirenzepine. ( Butruk, E; Gabryelewicz, A; Gibiński, K; Habior, A; Hasik, J; Klinoewicz, H; Kosidło, S; Marlioz, K; Nowak, A; Starzyńska, T, 1987) |
| "Pirenzepine is an antimuscarinic drug highly selective for M1 receptors, which proved to be effective in the treatment of peptic ulcer." | 6.66 | [Pharmacologic treatment of duodenal ulcer. Short and long-term results with pirenzepine in ambulatory patients]. ( Barberani, F; Carpinelli, D; D'Ambrosio, C; Della Spoletina, A; Fiorini, MA; Nicolao, V; Schiaroli, G; Valentini, P, 1986) |
| "Serum gastrin levels in 44 peptic ulcer patients (26 gastric ulcer patients and 18 duodenal ulcer patients) were determined after they had been treated with omeprazole (OPZ) (20 mg/day) alone or in combination with pirenzepine (PZP) (100 mg/day)." | 5.07 | Serum gastrin levels following administration of omeprazole alone or in combination with pirenzepine. ( Arakawa, Y; Ito, K; Iwasaki, A; Kawamura, Y; Matsuo, Y; Miyazawa, K; Sakai, Y; Tashiro, Y, 1994) |
| "We randomized 785 patients with healed duodenal ulcer to receive: (1) no treatment; (2) mealtime antacids with an acid-neutralizing capacity of 80 mmol/day; (3) an antidepressant, trimipramine 25 mg; (4) an anticholinergic, pirenzepine 50 mg; (5) cimetidine 200 mg; (6) cimetidine 400 mg; (7) ranitidine 150 mg; or (8) sucralfate 1 g twice a day." | 5.07 | Maintenance therapy for duodenal ulcer: a randomized controlled comparison of seven forms of treatment. ( Hui, WM; Lai, CL; Lam, SK; Lok, AS; Ng, MM, 1992) |
| "The effect of cimetidine and pirenzepine on the maintenance of healing in duodenal ulceration has been compared in a multi-centre, controlled study." | 5.06 | Comparison of cimetidine and pirenzepine in the healing and maintenance of remission in duodenal ulcer. ( Gent, AE; Hellier, MD, 1990) |
| "A multicenter, double-blind, randomized controlled study was conducted in 314 duodenal ulcer patients to compare the efficacy and safety of the antimuscarinics telenzepine and pirenzepine in the treatment of duodenal ulcer." | 5.06 | [Single evening administration of a new antimuscarinic agent telenzepine in therapy of acute duodenal ulcer. Results of a randomized double-blind comparative study versus pirenzepine]. ( Dammann, HG; Dreyer, M; Merk-Härtelt, B; Müller, P; Simon, B; Wolf, N, 1989) |
| "Three different doses of the M1-selective antimuscarinic compound telenzepine were investigated in the treatment of acute duodenal ulcer in a randomized, double-blind dose-range finding study." | 5.06 | [Dose finding study of telenzepine (1.5 vs. 3 vs 5 mg once daily) in acute treatment of duodenal ulcer. A double-blind, randomized, multicenter parallel group comparison]. ( Hüttemann, W; Schneider, A, 1989) |
| "The effect of administering low doses of famotidine or ranitidine alone or in combination with an M1-receptor-selective antagonist, pirenzepine, on night intragastric acidity was evaluated in 16 active duodenal ulcer patients to verify 1) whether anticholinergics and H2-antagonists have a synergic effect on inhibition of night gastric acidity, and 2) whether patients with vagal hypertone are more sensitive to anticholinergics than the remainder of the duodenal ulcer population." | 5.06 | Do anticholinergics interact with histamine H2 receptor antagonists on night intragastric acidity in active duodenal ulcer patients? ( Clausi, GG; Farinelli, M; Farroni, F; Fiorucci, S; Morelli, A; Pelli, MA; Santucci, L, 1988) |
| "Effects of orally-administered pirenzepine and propantheline bromide on food-stimulated gastric acid secretion, serum gastrin concentration, salivary flow and heart rate were compared in 10 duodenal ulcer patients in a placebo-controlled, double-blind study." | 5.06 | Comparison of two antimuscarinic drugs, pirenzepine and propantheline, on gastric acid secretion, serum gastrin concentration, salivary flow and heart rate in patients with duodenal ulcer disease. ( Barnett, CC; Feldman, M; Richardson, CT; Walsh, JH, 1987) |
| "The efficacy of pirenzepin--of anticholinergic effect--and the H2-receptor blocking cimetidine has been studied in duodenal ulcer with random, double blind fashion." | 5.06 | [Pirenzepine and cimetidine in the treatment of duodenal ulcer]. ( Papp, J; Schandl, L; Szathmári, M; Tulassay, Z, 1988) |
| "A double-blind controlled trial was undertaken to compare the relative effectiveness of pirenzepine (Gastrozepin; Boehringer Ingelheim) and cimetidine (Tagamet; SK & F) in healing endoscopically proven duodenal ulcers." | 5.06 | Pirenzepine and cimetidine for duodenal ulcers. A comparative randomised double-blind controlled study. ( Bhoola, RL; Manion, GL; Simjee, AE; Spitaels, JM, 1988) |
| "In a randomized, endoscopically controlled double-blind trial the effectiveness of a twice daily dose of the prostaglandin E2-analogue enprostil was compared with pirenzepine given to 97 ambulatory patients with duodenal ulcers." | 5.06 | [Enprostil in the acute treatment of duodenal ulcer: direct comparative study with pirenzepin]. ( Beckenbach, HP; Daake, H; Dammann, HG; Hüttemann, R; Kalek, S; Kühn, V; Müller, P; Rohner, HG; Simon, B, 1986) |
| " The effect of pirenzepine, an antimuscarinic compound, on basal acid and pepsin secretion and on the kinetic characteristics (Vmax and ED50) of pentagastrin-stimulated gastric secretion was investigated in 11 duodenal ulcer male patients." | 5.06 | Effect of pirenzepine on basal gastric acid and pepsin secretion and on secretion stimulated with graded doses of pentagastrin in duodenal ulcer patients. ( Meneghelli, UG; Troncon, LE, 1988) |
| "The ulcer healing effect of the combination of pirenzepine and cimetidine was compared to the cimetidine monotherapy in 60 duodenal ulcer patients, in whom previous cimetidine monotherapy (at the dose of 1000 mg/day for 4 weeks) had not produced any healing effect." | 5.06 | [Combined antisecretory therapy in patients with duodenal ulcer]. ( Papp, J; Szathmári, M; Tulassay, Z, 1988) |
| "Eighty-four patients with healed duodenal ulcers were treated for 1 year with pirenzepine, 50 mg twice daily, or placebo in this double-blind, randomized, multicenter trial." | 5.06 | Prevention of duodenal ulcer recurrence by pirenzepine 50 mg twice daily. ( Brassine, A; Pelckmans, P; Pen, J; Rutgeerts, P; Van der Veken, J; Van Maercke, Y; Vantrappen, G, 1987) |
| "In a double-blind, randomised trial two drug regimens were compared in a group of 129 patients with uncomplicated duodenal ulcers, 64 receiving cimetidine (800 mg) and pirenzepine (50 mg) at bed-time, 65 receiving cimetidine (800 mg) and a placebo at bed-time." | 5.06 | [Treatment of uncomplicated duodenal ulcer using cimetidine alone and in combination with pirenzepine. A comparative study]. ( Höbel, W; Huchzermeyer, H; Prex, E, 1987) |
| "A double-blind, controlled study with either 50 mg of pirenzepine or a placebo once a day was performed in 128 patients to determine the effect of pirenzepine against relapses of duodenal ulcer, the healing of the subjects' former ulcers having been confirmed endoscopically." | 5.06 | A study on the prevention of duodenal ulcer recurrence with pirenzepine. ( Fukumoto, S; Kawai, K; Kohli, Y, 1987) |
| "The purpose of this study was to determine if pirenzepine and cimetidine given together was superior to cimetidine alone in inducing healing of refractory duodenal ulcers which remained unhealed after treatment with cimetidine or ranitidine for at least eight weeks." | 5.06 | Combined anti-muscarinic and H2 receptor blockade in the healing of refractory duodenal ulcer. A double blind study. ( Bardhan, KD; Bose, K; Crowe, J; Hinchliffe, RF; McCarthy, C; Thompson, M; Thompson, MH; Thomson, TJ; Walters, J; Weir, DG, 1987) |
| "Sixty-seven patients with endoscopically proven duodenal ulceration were entered into a double-blind study and randomized to treatment with pirenzepine (PZ) (Gastrozepin; Boehringer Ingelheim) 50 mg twice daily or cimetidine (CM) (Tagamet; Smith Kline & French Laboratories) 400 mg twice daily, given 30 minutes before breakfast and supper." | 5.06 | Comparison of pirenzepine with cimetidine in duodenal ulcer disease. A short-term and maintenance study. ( Bank, L; Gilinsky, NH; Girdwood, AH; Kalvaria, I; Lucke, W; Marks, IN; O'Keefe, SJ; Wright, JP, 1986) |
| "A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer." | 5.06 | Controlled double-blind study of the therapeutic effect of pirenzepine dihydrochloride in duodenal ulcer. Phase III study. ( Ishimori, A; Yamagata, S, 1986) |
| "The aim of this study was to compare the effects of pirenzepine with those of atropine a non-selective antimuscarinic agent, on gastroduodenal motor patterns in duodenal ulcer patients." | 5.06 | Effects of pirenzepine and atropine on gastroduodenal motor patterns in duodenal ulcer patients. ( Arnulfo, C; Dato, D; Di Somma, C; Imbimbo, BP; Mortola, G; Reboa, G; Rezzo, R; Serafini, P, 1986) |
| "Intragastric pH was monitored during 24 hours in eight volunteers with duodenal ulcer disease in remission, while on placebo, cimetidine 400 mg bd, pirenzepine 50 mg bd, cimetidine 400 mg bd + pirenzepine 50 mg bd, cimetidine 200 mg bd + pirenzepine 25 mg bd." | 5.06 | Effect of cimetidine and pirenzepine in combination on 24 hour intragastric acidity in subjects with previous duodenal ulceration. ( Deakin, M; Ramage, JK; Williams, JG, 1986) |
| "The effects of pirenzepine and ranitidine alone and combined, on gastric acid secretion and gastrin release stimulated by liquid peptone meal were evaluated in 12 duodenal ulcer patients." | 5.06 | Inhibition of food stimulated acid secretion by association of pirenzepine and ranitidine in duodenal ulcer patients. ( Bianchi Porro, G; Imbimbo, BP; Lazzaroni, M; Parente, F; Sangaletti, O, 1986) |
| "The therapeutic efficacy of ranitidine, pirenzepine, cimetidine and placebo in the 28 day treatment of duodenal ulcer was evaluated through an open randomized study performed in 120 patients." | 5.05 | Comparison between ranitidine, cimetidine, pirenzepine and placebo in the short term treatment of duodenal ulcer. ( Cheli, R; Giacosa, A; Molinari, F; Parodi, MC, 1982) |
| "Pirenzepine, a new antimuscarinic drug which selectively binds to gastric mucosal muscarinic receptors, has been found to be as effective as cimetidine in promoting the healing of duodenal ulcer." | 5.05 | Long-term treatment and follow-up studies with pirenzepine in duodenal ulcer: a double-blind study. ( Barberani, F; Della Spoletina, A; Fatale, GP; Rossi, P; Valentini, P, 1983) |
| "The purpose of this single blind controlled multicentre trial was to compare the relative effectiveness of pirenzepine and cimetidine in healing endoscopically proven duodenal ulcers." | 5.05 | Treatment of duodenal ulcer with pirenzepine and cimetidine. ( Brandstätter, G; Brunner, H; Dittrich, H; Hentschel, E; Kern, H; Kratochvil, P; Löffelmann, K; Schütze, K; Tragl, KH; Zeiler, H, 1984) |
| "Both pirenzepine and cimetidine have been shown to be beneficial in the healing of duodenal ulcers." | 5.05 | Comparative effects of pirenzepine and cimetidine, alone and in combination, on 24-hour gastric acidity in duodenal ulcer disease. ( Mahachai, V; Reilly, P; Thomson, AB, 1984) |
| "The effectiveness of pirenzepine in the prevention of duodenal ulcer relapses was assessed by means of a double-blind controlled trial versus cimetidine." | 5.05 | Long-term management of duodenal ulcer with pirenzepine and cimetidine: a double-blind controlled clinical trial. ( Cacioli, D; Galeone, M; Giorgi-Conciato, M; Moise, G; Stock, F; Toti, GL, 1983) |
| "Antisecretory effect of single oral therapeutic doses of pirenzepine (25 mg and 50 mg) and cimetidine (200 mg and 400 mg) was studied in 12 patients with duodenal ulcer." | 5.05 | Antisecretory activity of pirenzepine versus cimetidine in man: a controlled study. ( Citone, G; Montesani, C; Procacciante, F; Ribotta, G, 1984) |
| "The effects of repeated oral doses of pirenzepine (100 mg daily for 7 days) and antacid (Maalox, 105 ml daily for 7 days) on the test-meal-stimulated release of pancreatic polypeptide (PP) were evaluated in 7 duodenal ulcer outpatients by means of a randomized cross-over study, with a wash-out period of one week between pirenzepine and antacid administration." | 5.05 | Possible role of pirenzepine on the release of pancreatic polypeptide in duodenal ulcer patients: preliminary results of a randomized cross-over study. ( Bonvicini, F; Caletti, G; Gasbarrini, G; Giorgi-Conciato, M; Severi, D; Tovoli, S, 1983) |
| "The effect of pirenzepine and cimetidine on healing, symptoms and relapse rate of duodenal ulcer was studied in a placebo-controlled double-blind trial." | 5.05 | Treatment and relapse prophylaxis of duodenal ulcer with pirenzepine and cimetidine. ( Birchler, R; Blum, AL; Eichenberger, PM; Giger, M; Gonvers, JJ; Mattle, W; Müller-Lissner, SA; Pelloni, S, 1982) |
| "Thirty-eight of forty patients satisfactorily concluded a double-blind, placebo-controlled trial to study the effects of pirenzepine (100 mg/day) on duodenal ulcers." | 5.05 | Pirenzepine in duodenal ulcer. A six week, double-blind study. ( Daniotti, S; Do, D; Martelli, S, 1982) |
| "Sixty out-patients with duodenal ulcers that were healed at the end of a 4-week treatment with pirenzepine, cimetidine or placebo were admitted to a double-blind placebo-controlled trial to study the effectiveness of pirenzepine (100 mg/daily) in preventing recurrence of ulcers." | 5.05 | Long-term treatment of duodenal ulcer with pirenzepine. A double-blind, placebo-controlled trial. ( Bianchi Porro, G; D'Imperio, N; Dal Monte, PR; Daniotti, S; Giuliani-Piccari, G; Petrillo, M, 1982) |
| "In two studies the beneficial effect of Pirenzepine in the treatment of peptic duodenal and gastric ulcers was investigated in 1686 outpatients." | 5.05 | [Treatment of ulcers with pirenzepin. Results from clinic and practice]. ( Kalk, A; Krempler, F; Sandhofer, F, 1982) |
| "One hundred and thirty one patients with duodenal ulcer were treated, in a multicentre controlled trial, with pirenzepine (50 mg three times a day for 4 weeks) or with a placebo, using the same schedule." | 5.05 | Pirenzepine in the treatment of duodenal ulcer. An endoscopically controlled trial. ( , 1982) |
| "Long term pirenzepine treatment of duodenal ulcer patients was carried out." | 5.05 | Long term treatment of duodenal ulcer with pirenzepine. ( Cheli, R; Giacosa, A; Molinari, F, 1982) |
| "Twenty-eight patients with healed duodenal ulcer completed a 12-month double-blind trial to compare the effects of pirenzepine (25 mg twice daily) and placebo on the prevention of duodenal ulcer relapse." | 5.05 | Maintenance treatment of recurrent duodenal ulceration with pirenzepine. ( Bianchi Porro, G; Petrillo, M, 1980) |
| "The effect of pirenzepine and cimetidine on healing, symptoms, and relapse rate of duodenal ulcer was studied in a placebo controlled double blind trial." | 5.05 | [Treatment and prevention of recurrence of duodenal ulcer with pirenzepin and cimetidine]. ( Birchler, R; Blum, AL; Eichenberger, PM; Giger, M; Gonvers, JJ; Mattle, W; Müller-Lissner, SA; Pelloni, S, 1982) |
| "Sixty patients with endoscopically proven healed duodenal ulcers were treated for a year with either pirenzepine (Gastrozepin; Boehringer Ingelheim) 100 mg daily, cimetidine 400 mg at night, or placebo, The monthly relapse rate (patients per month) in the first 3 months (pirenzepine 2,3, cimetidine 2,3, placebo 3,0) and in the next 9 months (pirenzepine 0,33, cimetidine 0,44, placebo 0,56) is lower for pirenzepine and cimetidine than for placebo." | 5.05 | Pirenzepine, cimetidine and placebo in the long-term treatment of duodenal ulceration. A comparative study. ( Khan, F; Manion, GL; Moshal, MG; Spitaels, JM, 1982) |
| "90 patients with active duodenal ulcer were admitted to a double-blind trial to compare the effects of pirenzepine (150 mg/daily), cimetidine (1 g/daily) and placebo on the healing of duodenal ulcer." | 5.05 | Pirenzepine versus cimetidine in duodenal ulcer. A double-blind, placebo-controlled, short-term clinical trial. ( Bianchi Porro, G; D'Imperio, N; Dal Monte, PR; Daniotti, S; Petrillo, M; Piccari, GG, 1982) |
| "The therapeutic efficacy of pirenzepine (PIR) and cimetidine (CIM) in duodenal ulcer and their effects on the intragastric milieu have been studied in a double-blind multicentre trial." | 5.05 | Pirenzepine versus cimetidine in duodenal ulcer treatment. A clinical and microbiological study. ( Cronstedt, J; Dotevall, G; Hellner, L; Hoffmann, P; Hradsky, M; Jaup, BH; Seeberg, S; Stockbrügger, RW, 1985) |
| "Recurrence rates of chronic duodenal ulcer after initial therapy with pirenzepine or cimetidine were investigated in a prospective, randomized trial with a total of 80 patients." | 5.05 | [Recurrence of chronic duodenal ulcer following initial therapy with pirenzepine or cimetidine]. ( Dufek, W; Hentschel, E; Schütze, K, 1985) |
| "Eighty-four patients with endoscopically-proved active duodenal ulcer were admitted to a multicentre double-blind trial with either pirenzepine tablets (25 mg three times per day for 1 week followed by 25 mg two times per day for 3 weeks) or placebo." | 5.04 | Pirenzepine in duodenal ulcer. A multicentre double-blind controlled clinical trial, First of two parts. ( Barbara, L; Belsasso, E; Bianchi Porro, G; Blasi, A; Caenazzo, E; Chierichetti, SM; Di Febo, G; Di Mario, F; Farini, R; Giorgi-Conciato, M; Grossi, E; Mangiameli, A; Miglioli, M; Naccarato, R; Petrillo, M, 1979) |
| "Ninety-six patients with endoscopically proved active duodenal ulcers were admitted to a multicentre double-blind trial with either pirenzepine (100 mg/day, 25 mg in the morning and midday and 50 mg at bed time) or placebo for 4 weeks." | 5.04 | Pirenzepine in duodenal ulcer. A multicentre double-blind controlled clinical trial. Second of two parts. ( Barbara, L; Belsasso, E; Bianchi Porro, G; Blasi, A; Caenazzo, E; Di Febo, G; Di Mario, F; Farini, R; Giorgi-Conciato, M; Mangiameli, A; Miglioli, M; Naccarato, R; Petrillo, M, 1979) |
| "Pirenzepine (PRZ, 75 mg/day for 10 days followed by 50 mg/day for 20 days) was compared with placebo (PL) in the treatment of endoscopically confirmed active gastroduodenitis or duodenal ulcer and with carbenoxolone (CB, 300 mg/day followed by 200 mg/day) in the treatment of gastric ulcer in a 30-day double-blind clinical trial." | 5.04 | Pirenzepine in the treatment of benign gastroduodenal diseases. A double-blind controlled clinical trial. ( Cifani, G; D'Anchino, M; Di Tommaso, B; Gasbarrini, G; Giorgi-Conciato, M; Pesa, O; Sollecito, A, 1979) |
| "The effectiveness and safety of pirenzepine (PRZ) at 150 mg daily in the treatment of active duodenal ulcer was studied in an open pilot clinical trial followed by a double-blind trial against placebo." | 5.04 | Pirenzepine in the treatment of duodenal ulcer. ( D'Imperio, N; Dal Monte, PR; Giuliani Piccari, G; Lepore, AM; Sarti, F, 1979) |
| "The effectiveness of pirenzepine in the treatment of duodenal ulcer was assessed in a double-blind clinical trial in comparison with placebo." | 5.04 | A double-blind, short-term clinical trial of pirenzepine in duodenal ulcer. ( Morelli, A; Narducci, F; Pelli, MA; Spadacini, A, 1979) |
| "Fifty-five patients with active duodenal ulcer have completed, up to today, a one-month double-blind trial to compare the effects of pirenzepine (150 mg daily), cimetidine (1 g daily) and placebo on the healing of duodenal ulcer." | 5.04 | Pirenzepine versus cimetidine in the treatment of duodenal ulcer. ( Bianchi Porro, G; D'Imperio, N; Dal Monte, PR; Giuliani Piccari, G; Lazzaroni, M; Petrillo, M, 1979) |
| " pirenzepine infusion both on basal and pentagastrin and insulin-stimulated secretion was studied in 19 healthy and duodenal ulcer subjects." | 5.04 | Inhibition of pentagastrin and insulin-stimulated gastric secretion by pirenzepine in healthy and duodenal ulcer subjects. ( Bianchi Porro, G; Grossi, M; Petrillo, M; Prada, A, 1979) |
| "The healing rate of duodenal ulcers may be accelerated by secretory inhibitors such as histamine H2-receptor antagonists and pirenzepine, by antacids, by protective drugs such as sucralfate and colloidal bismuth, and by antidepressant drugs such as trimipramine." | 4.77 | Therapeutic approach to ulcer healing. ( Blum, AL, 1985) |
| " The compound had no activity against cysteamine-induced duodenal ulcers and lost its cytoprotective activity in adrenalectomised rats." | 3.68 | BAY P 1455, a thiazolylaminobenzimidazole derivative with gastroprotective properties in the rat. ( Bruno, M; Grassi, A; Ippen, J; Thomas, G, 1991) |
| "The effect of pirenzepine--a selective antimuscarinic compound--on plasma catecholamine, serum gastrin and somatostatin concentrations was studied in duodenal ulcer patients." | 3.67 | Pirenzepine depresses plasma noradrenaline in duodenal ulcer patients. ( Farnebo, LO; Graffner, H; Holst, J; Järhult, J, 1984) |
| "The anti-ulcer and antisecretory properties of 3-(dibenz[b,e] oxepin - 11(6H)-ylidene)-N,N- dimethylpropylamine hydrochloride (doxepin) were investigated in a series of acute experiments in rats with gastric and duodenal ulcer." | 3.67 | Anti-ulcer and secretion-inhibitory properties of the tricyclic derivative doxepin in rats and dogs. ( Fleissig, W; Leitold, M; Merk, A, 1984) |
| "Overnight gastric secretion was studied in 32 patients with acute duodenal ulcers before treatment and whilst taking cimetidine 400 mg b." | 3.67 | Pharmacological response to cimetidine and healing of duodenal ulceration: effects of high-dose cimetidine and combination of cimetidine with pirenzepine. ( Colin-Jones, DG; Deakin, M; Williams, JG, 1988) |
| " On a molar basis and with regard to inhibition of cysteamine-induced acid secretion, telenzepine ranked first, followed by omeprazole, cimetidine, and pirenzepine; cysteamine-induced duodenal ulcers were best inhibited by telenzepine, with pirenzepine, omeprazole and cimetidine ranking 2nd, 3rd and 4th." | 3.67 | An acid-independent antiulcer effect of M1 antimuscarinics in the rat. ( Gönne, S; Kromer, W, 1988) |
| " The pharmacokinetics of pirenzepine (Gastrozepin) was studied after single and multiple oral administration in gastric ulcer and duodenal ulcer patients." | 3.67 | Pharmacokinetics of pirenzepine in patients with gastric or duodenal ulcers. ( Bozler, G; Hayakawa, A; Kobayashi, S; Misawa, T; Nishihara, S, 1987) |
| "The oral administration of pirenzepine (PRZ), an antimuscarinic agent, has a variable effect on gastric acid secretion in patients with duodenal ulcer, and it seems to potentiate cimetidine-induced inhibition of secretion." | 3.67 | Lack of pharmacokinetic interaction between cimetidine and pirenzepine. ( Jamali, F; Mahachai, V; Reilly, PA; Thomson, AB, 1985) |
| "The effects of pirenzepine and the H2-blocker ranitidine on pepsin secretion were studied in patients with duodenal ulcer." | 3.66 | The influence of various secretory inhibitors on peptic activity. ( Gabryelewicz, A; Laszewicz, W; Sarosiek, J, 1980) |
| "Twenty-three endoscopically healed duodenal ulcer patients entered a long-term treatment with pirenzepine for 1 year (two 25-mg tablets at breakfast and two tablets at bedtime)." | 3.66 | Long-term treatment of duodenal ulcer with pirenzepine; gastric pH values and incidence of relapses: an open pilot study. ( Accadia, L; Federici, T; Gabbrielli, A; Gabbrielli, L; Giorgi-Conciato, M, 1983) |
| "A total of 60 patients with endoscopically diagnosed duodenal ulcer were treated with pirenzepine or cimetidine for 8-10 weeks until endoscopic healing of the ulcer." | 3.66 | Pirenzepine in long-term therapy for duodenal ulcer. ( Bresci, G; Capria, A; Del Tacca, M; Geloni, M; Polloni, A; Rindi, G, 1983) |
| "Pirenzepine (Gastrozepin) is a drug recently introduced in the therapy of gastroduodenal ulcer (GDU)." | 3.66 | Inhibition of gastric mucosa carbonic anhydrase by pirenzepine in patients with gastroduodenal ulcers. ( Búzás, G; Domuta, M; Puşcaş, I; Surányi, P, 1981) |
| "In 8 outpatients with duodenal ulcer the effect of a single dose of 50 mg pirenzepine is compared to a 3-7 days treatment with 2x50 mg." | 3.66 | [Acid secretion and serum gastrin during acute and chronic treatment with pirenzepine in duodenal ulcer (author's transl)]. ( Fritsch, WP; Hanrath, R; Müller, JE; Scholten, T; Strohmeyer, G, 1981) |
| "Ten patients with endoscopically proven duodenal ulcers participated in a double-blind, placebo-controlled, cross-over trial to investigate the effect of pirenzepine on nocturnal gastric acid secretion." | 3.66 | Inhibition by pirenzepine of nocturnal gastric acid secretion in duodenal ulcer patients. ( Barbara, L; Borghi, E; Corinaldesi, R; Daniotti, S; Miglioli, M; Stanghellini, V, 1981) |
| "The effects of atropine and pirenzepine on sham-feeding stimulated gastric secretion and serum gastrin and pancreatic polypeptide levels have been studied in 12 patients with duodenal ulcer." | 3.66 | Effects of pirenzepine and atropine on gastric secretory and plasma hormonal responses to sham-feeding in patients with duodenal ulcer. ( Dobrzańska, M; Konturek, SJ; Kopp, B; Kwiecień, N; Obtulowicz, W; Olesky, J; Swierczek, J, 1980) |
| "Pirenzepine has been reported to inhibit gastrin secretion." | 2.68 | Effects of pirenzepine on omeprazole-induced hypergastrinemia and acid suppression in peptic ulcer patients. ( Fukino, Y; Hamada, M; Haruma, K; Inoue, M; Kajiyama, G; Kamiyasu, T; Sumii, K; Sumii, M; Tari, A, 1996) |
| " They were obtained by the chi-square (chi 2) goodness-of-fit test, recently applied for the evaluation of dose-response curves." | 2.67 | Modern approach to the evaluation of combined effects of single-dose trials and clinical time-course studies, exemplified by combinations of pirenzepine and H2-receptor antagonists. ( Londong, W; Pöch, G, 1993) |
| "Seasonal accumulation of duodenal ulcer recurrences suggests that maintenance therapy could be limited to the more risky periods." | 2.66 | Seasonal prevention of duodenal ulcer recurrences with pirenzepine. ( Butruk, E; Gabryelewicz, A; Gibiński, K; Habior, A; Hasik, J; Klinoewicz, H; Kosidło, S; Marlioz, K; Nowak, A; Starzyńska, T, 1987) |
| "Pirenzepine is an antimuscarinic drug highly selective for M1 receptors, which proved to be effective in the treatment of peptic ulcer." | 2.66 | [Pharmacologic treatment of duodenal ulcer. Short and long-term results with pirenzepine in ambulatory patients]. ( Barberani, F; Carpinelli, D; D'Ambrosio, C; Della Spoletina, A; Fiorini, MA; Nicolao, V; Schiaroli, G; Valentini, P, 1986) |
| " Selectivity is dose limited and has so far been demonstrated only at a daily dosage of 100 mg, in 2 divided doses." | 2.36 | The efficacy and selectivity of pirenzepine. Review and commentary. ( Reilly, PA; Texter, EC, 1982) |
| "Duodenal ulcer was found to relapse more frequently in patients with total serum pepsinogen more than 109 micrograms tyr X ml-1 X 24 h-1 and in patients with maximal acid output more than 60 mmol/h (Logrank test; both p less than 0." | 1.27 | Recurrence of duodenal ulcer under continuous antisecretory treatment: an approach to the detection of predictive markers. ( Battaglia, G; Burlina, A; Di Mario, F; Farini, R; Naccarato, R; Piccoli, A; Plebani, M; Vianello, F, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 120 (85.71) | 18.7374 |
| 1990's | 19 (13.57) | 18.2507 |
| 2000's | 1 (0.71) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Battaglia, G | 3 |
| Farini, R | 4 |
| Di Mario, F | 5 |
| Piccoli, A | 2 |
| Plebani, M | 2 |
| Vianello, F | 2 |
| Burlina, A | 1 |
| Naccarato, R | 4 |
| Lattanzi, A | 1 |
| Demling, L | 1 |
| Lux, G | 1 |
| Simon, B | 3 |
| Müller, P | 3 |
| Dammann, HG | 3 |
| Morelli, A | 3 |
| Narducci, F | 2 |
| Pelli, MA | 3 |
| Farroni, F | 2 |
| Daniotti, S | 6 |
| Del Soldato, P | 3 |
| Graffner, H | 1 |
| Farnebo, LO | 1 |
| Holst, J | 1 |
| Järhult, J | 1 |
| Espinoza, M | 1 |
| Csendes, A | 1 |
| Medina, LA | 1 |
| Fuster, F | 1 |
| Braghetto, I | 1 |
| Encina, J | 1 |
| Giorgi-Conciato, M | 7 |
| Ferrari, PA | 1 |
| Gaetani, M | 1 |
| Petrin, G | 1 |
| Sala, P | 1 |
| Valentini, P | 3 |
| Gabryelewicz, A | 3 |
| Laszewicz, W | 1 |
| Sarosiek, J | 1 |
| Giacosa, A | 2 |
| Cheli, R | 2 |
| Molinari, F | 2 |
| Parodi, MC | 1 |
| Klincewicz, H | 2 |
| Hasik, J | 3 |
| Hryniewiecki, L | 1 |
| Hájková, J | 1 |
| Klabusay, L | 1 |
| Brunner, H | 2 |
| Xiao, SD | 1 |
| Pan, QY | 1 |
| Barberani, F | 2 |
| Della Spoletina, A | 2 |
| Rossi, P | 1 |
| Fatale, GP | 1 |
| Hoffenberg, P | 1 |
| Dittrich, H | 1 |
| Kratochvil, P | 1 |
| Brandstätter, G | 1 |
| Hentschel, E | 2 |
| Schütze, K | 2 |
| Tragl, KH | 1 |
| Kern, H | 1 |
| Löffelmann, K | 1 |
| Zeiler, H | 1 |
| Grigor'ev, IIa | 1 |
| Zhivodereov, VM | 1 |
| Khar'kovskiĭ, NN | 1 |
| Tytgat, GN | 1 |
| Hameeteman, W | 1 |
| van Olffen, GH | 1 |
| Mahachai, V | 3 |
| Reilly, P | 1 |
| Thomson, AB | 2 |
| Federici, T | 1 |
| Accadia, L | 1 |
| Gabbrielli, L | 1 |
| Gabbrielli, A | 1 |
| Galeone, M | 1 |
| Cacioli, D | 1 |
| Toti, GL | 1 |
| Moise, G | 1 |
| Stock, F | 1 |
| Procacciante, F | 1 |
| Citone, G | 1 |
| Montesani, C | 1 |
| Ribotta, G | 1 |
| Leitold, M | 1 |
| Fleissig, W | 1 |
| Merk, A | 1 |
| Kukes, VG | 1 |
| Blinkov, Il | 1 |
| Chekhmakina, OV | 1 |
| Krivorotova, SP | 1 |
| Karpenko, EV | 1 |
| Girola, M | 1 |
| Balducci, A | 1 |
| Gütz, HJ | 1 |
| Capria, A | 2 |
| Bresci, G | 2 |
| Polloni, A | 2 |
| Rindi, G | 2 |
| Geloni, M | 2 |
| Del Tacca, M | 1 |
| Maleev, A | 1 |
| Krŭstev, Z | 1 |
| Deredzhian, S | 1 |
| Ivanchev, T | 1 |
| Vradzhaliev, Zh | 1 |
| Gasbarrini, G | 2 |
| Tovoli, S | 1 |
| Severi, D | 1 |
| Bonvicini, F | 1 |
| Caletti, G | 1 |
| Matincheva, R | 1 |
| Mateva, L | 1 |
| Ivanov, S | 1 |
| Eichenberger, PM | 2 |
| Giger, M | 2 |
| Mattle, W | 2 |
| Pelloni, S | 2 |
| Müller-Lissner, SA | 2 |
| Gonvers, JJ | 2 |
| Birchler, R | 2 |
| Blum, AL | 3 |
| Do, D | 1 |
| Martelli, S | 1 |
| Dal Monte, PR | 5 |
| Bianchi Porro, G | 11 |
| Petrillo, M | 8 |
| Giuliani-Piccari, G | 1 |
| D'Imperio, N | 4 |
| Texter, EC | 1 |
| Reilly, PA | 2 |
| Krempler, F | 1 |
| Sandhofer, F | 1 |
| Kalk, A | 1 |
| Gibiński, K | 2 |
| Nowak, A | 2 |
| Marlicz, K | 1 |
| Kosidło, S | 2 |
| Grossi, K | 1 |
| Lazzaroni, M | 4 |
| Puşcaş, I | 1 |
| Búzás, G | 1 |
| Surányi, P | 1 |
| Domuta, M | 1 |
| Zimmermann, W | 1 |
| Frank, N | 1 |
| Philippi, M | 1 |
| Burkhard, B | 1 |
| Scholten, T | 1 |
| Fritsch, WP | 1 |
| Müller, JE | 1 |
| Hanrath, R | 1 |
| Strohmeyer, G | 1 |
| Catrambone, G | 1 |
| Ferraris, R | 1 |
| Parodi, A | 1 |
| Ruffo, A | 1 |
| Corinaldesi, R | 1 |
| Miglioli, M | 3 |
| Stanghellini, V | 1 |
| Borghi, E | 1 |
| Barbara, L | 3 |
| Londong, W | 2 |
| Londong, V | 1 |
| Prechtl, R | 1 |
| Weber, T | 1 |
| von Werder, K | 1 |
| Konturek, SJ | 1 |
| Obtulowicz, W | 1 |
| Kwiecień, N | 1 |
| Dobrzańska, M | 1 |
| Swierczek, J | 1 |
| Kopp, B | 1 |
| Olesky, J | 1 |
| Stenquist, B | 1 |
| Haglund, U | 1 |
| Lind, T | 1 |
| Olbe, L | 1 |
| Cerlek, S | 1 |
| Papa, B | 1 |
| Katicić, M | 1 |
| Colić-Cvrlje, V | 1 |
| Mielenz, H | 2 |
| Mittelstaedt, A | 1 |
| Zilly, A | 1 |
| Verhoeven, A | 1 |
| Moshal, MG | 1 |
| Spitaels, JM | 2 |
| Khan, F | 1 |
| Manion, GL | 2 |
| Piccari, GG | 1 |
| Nikolaeva, NN | 1 |
| Grishchenko, EG | 1 |
| Nikolaeva, LV | 1 |
| Grigor'ev, PIa | 1 |
| Iakovenko, AV | 1 |
| Vasil'ev, IV | 1 |
| Zverkov, IV | 2 |
| Minushkin, ON | 2 |
| Sokolov, LK | 1 |
| Maslovskiĭ, LV | 1 |
| Iwasaki, A | 1 |
| Miyazawa, K | 1 |
| Kawamura, Y | 1 |
| Sakai, Y | 1 |
| Tashiro, Y | 1 |
| Ito, K | 1 |
| Arakawa, Y | 1 |
| Matsuo, Y | 1 |
| Kosaka, N | 1 |
| Tanaka, H | 1 |
| Tomaru, A | 1 |
| Ishii, A | 1 |
| Shuto, K | 1 |
| Pöch, G | 1 |
| Niv, Y | 1 |
| Chamud, M | 1 |
| Mysh, V | 1 |
| Tari, A | 1 |
| Hamada, M | 1 |
| Kamiyasu, T | 1 |
| Fukino, Y | 1 |
| Sumii, M | 1 |
| Haruma, K | 1 |
| Sumii, K | 1 |
| Inoue, M | 1 |
| Kajiyama, G | 1 |
| Zaĭtseva, EI | 1 |
| Titova, OV | 1 |
| Melekhova, LS | 1 |
| Makarenko, TG | 1 |
| Sosina, TE | 1 |
| Sheptulin, AA | 1 |
| Okhlobystin, AV | 1 |
| Vakhrushev, IaM | 1 |
| Muravtseva, OV | 1 |
| Belsasso, E | 2 |
| Blasi, A | 2 |
| Caenazzo, E | 2 |
| Chierichetti, SM | 2 |
| Di Febo, G | 2 |
| Grossi, E | 1 |
| Mangiameli, A | 2 |
| D'Anchino, M | 1 |
| Di Tommaso, B | 1 |
| Pesa, O | 1 |
| Sollecito, A | 1 |
| Cifani, G | 1 |
| Oselladore, D | 1 |
| Norberto, L | 1 |
| Vibelli, C | 1 |
| Giuliani Piccari, G | 2 |
| Lepore, AM | 1 |
| Sarti, F | 1 |
| Spadacini, A | 1 |
| Prada, A | 1 |
| Grossi, M | 1 |
| Hui, WM | 1 |
| Lam, SK | 1 |
| Lok, AS | 1 |
| Ng, MM | 1 |
| Lai, CL | 1 |
| Orlovskiĭ, VF | 1 |
| Medvedev, VN | 1 |
| Parente, F | 2 |
| Grassi, A | 1 |
| Ippen, J | 1 |
| Bruno, M | 1 |
| Thomas, G | 1 |
| Kromer, W | 2 |
| Gönne, S | 2 |
| Riedel, R | 1 |
| Postius, S | 1 |
| Lodin, Z | 1 |
| Zizkovský, V | 1 |
| Tauber, O | 2 |
| Dvorák, P | 1 |
| Srajer, J | 1 |
| Lovacký, S | 2 |
| Gent, AE | 1 |
| Hellier, MD | 1 |
| Pekhlivanov, D | 1 |
| Rankov, R | 1 |
| Pekhlivanov, N | 1 |
| Lambev, I | 1 |
| Minkova, N | 1 |
| Muñoz-Arrebola, P | 2 |
| Madrid, JA | 2 |
| Salido, GM | 2 |
| Martinez de Victoria, E | 2 |
| Pavlov, SA | 1 |
| Vinogradov, VA | 1 |
| Iarygin, KN | 1 |
| Shugurov, VA | 1 |
| Bogdanov, AN | 1 |
| Ooi, S | 1 |
| Kaneko, E | 1 |
| Mysh, VG | 2 |
| Grigo'reva, IN | 1 |
| Dreyer, M | 1 |
| Wolf, N | 1 |
| Merk-Härtelt, B | 1 |
| Grigor'eva, IN | 1 |
| Hüttemann, W | 1 |
| Schneider, A | 1 |
| Savarino, V | 1 |
| Mela, GS | 1 |
| Celle, G | 1 |
| Saakian, Ag | 1 |
| Lane, MR | 1 |
| Lee, SP | 2 |
| Fiorucci, S | 1 |
| Clausi, GG | 1 |
| Farinelli, M | 1 |
| Santucci, L | 1 |
| Deakin, M | 2 |
| Colin-Jones, DG | 1 |
| Williams, JG | 2 |
| Richardson, CT | 1 |
| Barnett, CC | 1 |
| Walsh, JH | 1 |
| Feldman, M | 1 |
| Szathmári, M | 3 |
| Tulassay, Z | 3 |
| Schandl, L | 1 |
| Papp, J | 3 |
| Simjee, AE | 1 |
| Bhoola, RL | 1 |
| Nanivadekar, SA | 1 |
| Govindani, NF | 1 |
| Sawant, PD | 1 |
| Patel, HD | 1 |
| Rachmilewitz, D | 1 |
| Ligumsky, M | 1 |
| Fich, A | 1 |
| Goldin, E | 1 |
| Eliakim, A | 1 |
| Karmeli, F | 1 |
| Rohner, HG | 1 |
| Beckenbach, HP | 1 |
| Daake, H | 1 |
| Hüttemann, R | 1 |
| Kalek, S | 1 |
| Kühn, V | 1 |
| Jewell, LD | 1 |
| Yacoub, W | 1 |
| Salkie, ML | 1 |
| Sherbaniuk, R | 1 |
| Walker, K | 1 |
| Kirdeikis, P | 1 |
| Simpson, I | 1 |
| Zuk, L | 1 |
| Brunet, MK | 1 |
| Zheng, W | 1 |
| Yong, DG | 1 |
| Geng, BQ | 1 |
| Gu, GG | 1 |
| Meneghelli, UG | 1 |
| Troncon, LE | 1 |
| Rutgeerts, P | 1 |
| Vantrappen, G | 1 |
| Brassine, A | 1 |
| Van Maercke, Y | 1 |
| Pen, J | 1 |
| Pelckmans, P | 1 |
| Van der Veken, J | 1 |
| Huchzermeyer, H | 1 |
| Höbel, W | 1 |
| Prex, E | 1 |
| Kohli, Y | 1 |
| Fukumoto, S | 1 |
| Kawai, K | 1 |
| Bardhan, KD | 1 |
| Thompson, M | 1 |
| Bose, K | 1 |
| Hinchliffe, RF | 1 |
| Crowe, J | 1 |
| Weir, DG | 1 |
| McCarthy, C | 1 |
| Walters, J | 1 |
| Thomson, TJ | 1 |
| Thompson, MH | 1 |
| Masoero, G | 1 |
| Rossanino, A | 1 |
| Arossa, W | 1 |
| Marchetto, M | 1 |
| Marucci, M | 1 |
| De la Pierre, M | 1 |
| Chiverton, SG | 1 |
| Hunt, RH | 1 |
| Contractor, QQ | 1 |
| Benson, L | 1 |
| Contractor, TQ | 1 |
| Schulz, T | 1 |
| Magni, G | 1 |
| Borgherini, G | 1 |
| Donzella, G | 1 |
| Pellegrini, C | 1 |
| Marks, IN | 1 |
| Wright, JP | 1 |
| Bank, L | 1 |
| Girdwood, AH | 1 |
| Kalvaria, I | 1 |
| Gilinsky, NH | 1 |
| O'Keefe, SJ | 1 |
| Lucke, W | 1 |
| Ishimori, A | 1 |
| Yamagata, S | 1 |
| Federici, G | 1 |
| Corsini, G | 1 |
| Di Somma, C | 1 |
| Arnulfo, C | 1 |
| Mortola, G | 1 |
| Dato, D | 1 |
| Serafini, P | 1 |
| Rezzo, R | 1 |
| Imbimbo, BP | 2 |
| Reboa, G | 1 |
| Kuhn, E | 1 |
| Andĕl, M | 1 |
| Brodan, V | 1 |
| Veselková, A | 1 |
| Guslandi, M | 1 |
| Butruk, E | 1 |
| Habior, A | 1 |
| Klinoewicz, H | 1 |
| Marlioz, K | 1 |
| Starzyńska, T | 1 |
| Hayakawa, A | 1 |
| Misawa, T | 1 |
| Nishihara, S | 1 |
| Kobayashi, S | 1 |
| Bozler, G | 1 |
| Ramage, JK | 1 |
| Likov, AF | 1 |
| Guba, ES | 1 |
| Belokon', SN | 1 |
| Dzhangirov, IP | 1 |
| D'Ambrosio, C | 1 |
| Schiaroli, G | 1 |
| Fiorini, MA | 1 |
| Nicolao, V | 1 |
| Carpinelli, D | 1 |
| Mwakyusa, DH | 1 |
| Stockbrügger, R | 1 |
| Sangaletti, O | 2 |
| D'Imperio, M | 1 |
| Ferri, M | 1 |
| Fratucello, F | 1 |
| Jamali, F | 1 |
| Marchi, S | 1 |
| Bellini, M | 1 |
| Savalli, E | 1 |
| Cecconi, N | 1 |
| Vanacore, R | 1 |
| Grassi, B | 1 |
| Cameron, AD | 1 |
| Jaup, BH | 1 |
| Cronstedt, J | 1 |
| Dotevall, G | 1 |
| Hellner, L | 1 |
| Hoffmann, P | 1 |
| Hradsky, M | 1 |
| Seeberg, S | 1 |
| Stockbrügger, RW | 1 |
| Dufek, W | 1 |
7 reviews available for pirenzepine and Curling Ulcer
| Article | Year |
|---|---|
[Acid anti-secretion therapy in gastric and duodenal ulcer].
Topics: Antacids; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Duodenal Ulcer; Furans; Gastric Juice; G | 1981 |
[Gastrozepin--a new anti-ulcer agent (a review of the literature and the authors' own data)].
Topics: Animals; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Drug Evaluation; Drug Synergism; Duodenal | 1984 |
Sucralfate, bismuth compounds, substituted benzimidazoles, trimipramine and pirenzepine in the short- and long-term treatment of duodenal ulcer.
Topics: Aluminum; Animals; Antacids; Anti-Ulcer Agents; Benzimidazoles; Benzodiazepinones; Bismuth; Clinical | 1984 |
The efficacy and selectivity of pirenzepine. Review and commentary.
Topics: Anti-Ulcer Agents; Benzodiazepinones; Duodenal Ulcer; Endoscopy; Humans; Pirenzepine; Stomach Ulcer | 1982 |
'Difficult' duodenal ulcer patients: clinical and therapeutic problems.
Topics: Anti-Ulcer Agents; Drug Therapy, Combination; Duodenal Ulcer; Histamine H2 Antagonists; Humans; Omep | 1991 |
Therapeutic approach to ulcer healing.
Topics: Aluminum; Antacids; Anti-Ulcer Agents; Antidepressive Agents; Benzodiazepinones; Bismuth; Colloids; | 1985 |
Focus on duodenitis.
Topics: Cimetidine; Diagnosis, Differential; Duodenal Ulcer; Duodenitis; Endoscopy; Humans; Pirenzepine | 1986 |
83 trials available for pirenzepine and Curling Ulcer
| Article | Year |
|---|---|
[Antisecretory and mucosa-protecting drugs in the acute care of peptic ulcer. Review of action principles, healing rates and side effects of approved ulcer drugs and drugs under clinical trial].
Topics: Acute Disease; Aluminum; Antacids; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Clinical Trials | 1984 |
Seasonal prophylactic treatment with pirenzepine to prevent duodenal ulcer recurrence.
Topics: Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Humans; Pirenzepin | 1984 |
[Effect of inhibitors of acid secretion in patients with duodenal ulcer. Comparative study of cimetidine, ranitidine and pirenzepine].
Topics: Adolescent; Adult; Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Female; | 1984 |
Efficacy and safety of pirenzepine in peptic ulcer and in non ulcerous gastroduodenal diseases. A multicentre controlled clinical trial.
Topics: Adult; Benzodiazepinones; Carbenoxolone; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Duode | 1982 |
Comparison between ranitidine, cimetidine, pirenzepine and placebo in the short term treatment of duodenal ulcer.
Topics: Adolescent; Adult; Aged; Antacids; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Clinical Trials | 1982 |
[Double-blind study on therapy with new drugs in stomach and duodenal ulcers].
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Double-Blind Method; Duodenal Ulcer; Duodenoscopy; Fema | 1983 |
[Treatment of duodenal ulcer with pirenzepin].
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Duodenal Ulcer; Female; Human | 1983 |
[Pirenzepin].
Topics: Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Depression, Chemical; Duodenal Ulcer; Gastr | 1983 |
[Short-term clinical trial of pirenzepine in duodenal ulcer].
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Duodenal Ulcer; Female; Human | 1983 |
[Pirenzepine in the treatment of duodenal ulcer--a multicenter double blind study].
Topics: Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; | 1983 |
Long-term treatment and follow-up studies with pirenzepine in duodenal ulcer: a double-blind study.
Topics: Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Duod | 1983 |
[Treatment of duodenal ulcer with pirenzepin].
Topics: Adult; Antacids; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method | 1983 |
Treatment of duodenal ulcer with pirenzepine and cimetidine.
Topics: Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Female; | 1984 |
Sucralfate, bismuth compounds, substituted benzimidazoles, trimipramine and pirenzepine in the short- and long-term treatment of duodenal ulcer.
Topics: Aluminum; Animals; Antacids; Anti-Ulcer Agents; Benzimidazoles; Benzodiazepinones; Bismuth; Clinical | 1984 |
Comparative effects of pirenzepine and cimetidine, alone and in combination, on 24-hour gastric acidity in duodenal ulcer disease.
Topics: Adult; Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, C | 1984 |
Long-term management of duodenal ulcer with pirenzepine and cimetidine: a double-blind controlled clinical trial.
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method; Duodenal | 1983 |
Antisecretory activity of pirenzepine versus cimetidine in man: a controlled study.
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Depression, Chemical; Double-Blind Method; | 1984 |
Possible role of pirenzepine on the release of pancreatic polypeptide in duodenal ulcer patients: preliminary results of a randomized cross-over study.
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Duodenal Ulcer; Humans; Male; Middle Aged; Pancreatic P | 1983 |
Treatment and relapse prophylaxis of duodenal ulcer with pirenzepine and cimetidine.
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Double-Blind Meth | 1982 |
Pirenzepine in duodenal ulcer. A six week, double-blind study.
Topics: Adult; Antacids; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method | 1982 |
Long-term treatment of duodenal ulcer with pirenzepine. A double-blind, placebo-controlled trial.
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method; Duodenal | 1982 |
[Treatment of ulcers with pirenzepin. Results from clinic and practice].
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Carbenoxolone; Chemical Phenomena; Chemistry; Cimetidin | 1982 |
[Multicenter controlled clinical studies on the effectiveness of pirenzepin in the treatment of peptic ulcer].
Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Duodenal Ul | 1982 |
Pirenzepine in the treatment of duodenal ulcer. An endoscopically controlled trial.
Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Duodenal Ul | 1982 |
Smoking and duodenal ulcer.
Topics: Benzodiazepinones; Cimetidine; Duodenal Ulcer; Humans; Piperazines; Pirenzepine; Smoking | 1980 |
Interactions of cimetidine and pirenzepine on peptone-stimulated gastric acid secretion in man.
Topics: Adult; Benzodiazepinones; Cimetidine; Drug Interactions; Duodenal Ulcer; Female; Gastric Acid; Gastr | 1980 |
Long term treatment of duodenal ulcer with pirenzepine.
Topics: Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Duodenal Ulcer; Endoscopy; Female; Follow-Up Stud | 1982 |
Maintenance treatment of recurrent duodenal ulceration with pirenzepine.
Topics: Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method; Du | 1980 |
Pirenzepin in gastric and duodenal ulcer: a double-blind trial.
Topics: Aged; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Female; Huma | 1981 |
[Results of a controlled comparative study between cimetidine and pirenzepin in 60 patients with ulcera ventriculi or duodeni].
Topics: Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Guanidin | 1981 |
[Treatment and prevention of recurrence of duodenal ulcer with pirenzepin and cimetidine].
Topics: Adult; Aged; Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Female; Guanid | 1982 |
Pirenzepine, cimetidine and placebo in the long-term treatment of duodenal ulceration. A comparative study.
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; F | 1982 |
Pirenzepine versus cimetidine in duodenal ulcer. A double-blind, placebo-controlled, short-term clinical trial.
Topics: Adult; Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; | 1982 |
[Levels of gastrin and somatostatin in blood and gastroduodenal gastrin and somatostatin cells in the differentiation of treatment of patients with duodenal ulcer].
Topics: Adult; Duodenal Ulcer; Duodenum; Follow-Up Studies; Gastrins; Humans; Male; Pirenzepine; Ranitidine; | 1994 |
Serum gastrin levels following administration of omeprazole alone or in combination with pirenzepine.
Topics: Drug Therapy, Combination; Duodenal Ulcer; Gastrins; Humans; Omeprazole; Peptic Ulcer; Pirenzepine; | 1994 |
Modern approach to the evaluation of combined effects of single-dose trials and clinical time-course studies, exemplified by combinations of pirenzepine and H2-receptor antagonists.
Topics: Cimetidine; Double-Blind Method; Drug Therapy, Combination; Duodenal Ulcer; Female; Gastric Acid; Hu | 1993 |
Effects of pirenzepine on omeprazole-induced hypergastrinemia and acid suppression in peptic ulcer patients.
Topics: Adult; Aged; Anti-Ulcer Agents; Drug Therapy, Combination; Duodenal Ulcer; Female; Gastric Acid; Gas | 1996 |
Pirenzepine in duodenal ulcer. A multicentre double-blind controlled clinical trial, First of two parts.
Topics: Adult; Age Factors; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Met | 1979 |
Pirenzepine in duodenal ulcer. A multicentre double-blind controlled clinical trial. Second of two parts.
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method; Duodenal | 1979 |
Pirenzepine in the treatment of benign gastroduodenal diseases. A double-blind controlled clinical trial.
Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blin | 1979 |
Pirenzepine (LS 519) in severe duodenal ulcer and in gastric ulcer. A double-blind clinical trial.
Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Carbenoxolone; Clinical Trials as Top | 1979 |
Pirenzepine in the treatment of duodenal ulcer.
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method; Duodenal | 1979 |
A double-blind, short-term clinical trial of pirenzepine in duodenal ulcer.
Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blin | 1979 |
Pirenzepine versus cimetidine in the treatment of duodenal ulcer.
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Double-Blind Meth | 1979 |
Inhibition of pentagastrin and insulin-stimulated gastric secretion by pirenzepine in healthy and duodenal ulcer subjects.
Topics: Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method; Du | 1979 |
[The differentiated treatment of patients with duodenal peptic ulcer].
Topics: Adult; Biopsy; Drug Evaluation; Duodenal Ulcer; Gastric Acid; Gastrins; Humans; Male; Pepsinogens; P | 1992 |
Maintenance therapy for duodenal ulcer: a randomized controlled comparison of seven forms of treatment.
Topics: Adult; Antacids; Cimetidine; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Hong Kong; Hospita | 1992 |
Comparison of cimetidine and pirenzepine in the healing and maintenance of remission in duodenal ulcer.
Topics: Adult; Aged; Cimetidine; Duodenal Ulcer; Female; Humans; Male; Middle Aged; Pirenzepine; Recurrence; | 1990 |
[Receptor characteristics of the duodenal mucosa in peptic ulcer: a new approach to the individual selection of the therapy].
Topics: Adolescent; Adult; Anti-Ulcer Agents; Clinical Trials as Topic; Duodenal Ulcer; Duodenum; Enkephalin | 1989 |
[Single evening administration of a new antimuscarinic agent telenzepine in therapy of acute duodenal ulcer. Results of a randomized double-blind comparative study versus pirenzepine].
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Duodenal Ulcer; | 1989 |
[Dose finding study of telenzepine (1.5 vs. 3 vs 5 mg once daily) in acute treatment of duodenal ulcer. A double-blind, randomized, multicenter parallel group comparison].
Topics: Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Duodenal Ulcer; Female; Humans; | 1989 |
Recurrence of duodenal ulcer after medical treatment.
Topics: Adult; Aged; Anti-Ulcer Agents; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Duodenal | 1988 |
Do anticholinergics interact with histamine H2 receptor antagonists on night intragastric acidity in active duodenal ulcer patients?
Topics: Adult; Circadian Rhythm; Drug Interactions; Drug Therapy, Combination; Duodenal Ulcer; Famotidine; G | 1988 |
Comparison of two antimuscarinic drugs, pirenzepine and propantheline, on gastric acid secretion, serum gastrin concentration, salivary flow and heart rate in patients with duodenal ulcer disease.
Topics: Adult; Double-Blind Method; Duodenal Ulcer; Female; Food; Gastric Acid; Gastrins; Heart Rate; Humans | 1987 |
[Pirenzepine and cimetidine in the treatment of duodenal ulcer].
Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Female; Gast | 1988 |
Pirenzepine and cimetidine for duodenal ulcers. A comparative randomised double-blind controlled study.
Topics: Adolescent; Adult; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Female | 1988 |
A comparison of two dosage regimens of pirenzepine versus cimetidine in endoscopically diagnosed duodenal ulcer. A randomised, controlled clinical trial.
Topics: Adult; Cimetidine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Duodenal Ulcer; Femal | 1988 |
Role of endogenous gastric prostanoids in the pathogenesis and therapy of duodenal ulcer.
Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Alprostadil; Aluminum; Anti-Inflammatory Agents; Be | 1986 |
[Enprostil in the acute treatment of duodenal ulcer: direct comparative study with pirenzepin].
Topics: Acute Disease; Adult; Anti-Ulcer Agents; Benzodiazepinones; Clinical Trials as Topic; Double-Blind M | 1986 |
Effect of pirenzepine on basal gastric acid and pepsin secretion and on secretion stimulated with graded doses of pentagastrin in duodenal ulcer patients.
Topics: Adult; Clinical Trials as Topic; Duodenal Ulcer; Gastric Acid; Humans; Male; Middle Aged; Pentagastr | 1988 |
[Combined antisecretory therapy in patients with duodenal ulcer].
Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; D | 1988 |
Prevention of duodenal ulcer recurrence by pirenzepine 50 mg twice daily.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Female; Humans; Male; Mi | 1987 |
[Treatment of uncomplicated duodenal ulcer using cimetidine alone and in combination with pirenzepine. A comparative study].
Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; D | 1987 |
Combination of pirenzepine and cimetidine in the therapy of duodenal ulcer.
Topics: Cimetidine; Clinical Trials as Topic; Drug Combinations; Duodenal Ulcer; Humans; Pirenzepine; Random | 1987 |
A study on the prevention of duodenal ulcer recurrence with pirenzepine.
Topics: Adult; Aged; Clinical Trials as Topic; Duodenal Ulcer; Female; Humans; Male; Middle Aged; Pirenzepin | 1987 |
Combined anti-muscarinic and H2 receptor blockade in the healing of refractory duodenal ulcer. A double blind study.
Topics: Adult; Aged; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; D | 1987 |
Daily gastric pH in controls and in duodenal ulcer patients: basal condition and response to treatment.
Topics: Adult; Cimetidine; Circadian Rhythm; Duodenal Ulcer; Female; Gastric Acidity Determination; Humans; | 1988 |
Effect of single nocturnal dose of pirenzepine versus ranitidine in duodenal ulcer.
Topics: Adult; Drug Administration Schedule; Duodenal Ulcer; Female; Humans; Male; Middle Aged; Pirenzepine; | 1988 |
Comparison of pirenzepine with cimetidine in duodenal ulcer disease. A short-term and maintenance study.
Topics: Adult; Antacids; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Double- | 1986 |
Controlled double-blind study of the therapeutic effect of pirenzepine dihydrochloride in duodenal ulcer. Phase III study.
Topics: Benzodiazepinones; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Humans; Pirenzepin | 1986 |
Prevention of relapse with various antiulcer drugs.
Topics: Adult; Antacids; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Female; Humans; Male; Middle | 1986 |
Effects of pirenzepine and atropine on gastroduodenal motor patterns in duodenal ulcer patients.
Topics: Adult; Aged; Atropine; Clinical Trials as Topic; Duodenal Ulcer; Duodenum; Female; Gastrointestinal | 1986 |
Seasonal prevention of duodenal ulcer recurrences with pirenzepine.
Topics: Adult; Double-Blind Method; Drug Administration Schedule; Duodenal Ulcer; Female; Humans; Male; Pati | 1987 |
Effect of cimetidine and pirenzepine in combination on 24 hour intragastric acidity in subjects with previous duodenal ulceration.
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Drug Therapy, Combination; Duodenal Ulcer; | 1986 |
[Pharmacologic treatment of duodenal ulcer. Short and long-term results with pirenzepine in ambulatory patients].
Topics: Adult; Aged; Double-Blind Method; Duodenal Ulcer; Female; Follow-Up Studies; Gastric Acid; Humans; M | 1986 |
The efficacy of pirenzepine in duodenal ulcer healing.
Topics: Adolescent; Adult; Aged; Duodenal Ulcer; Female; Humans; Male; Middle Aged; Pirenzepine | 1986 |
Inhibition of food stimulated acid secretion by association of pirenzepine and ranitidine in duodenal ulcer patients.
Topics: Adult; Drug Therapy, Combination; Duodenal Ulcer; Female; Food; Gastric Acid; Gastrins; Humans; Male | 1986 |
Effect of pirenzepine and atropine on peptone meal-stimulated gastric secretion and plasma gastrin in healthy volunteers, patients with duodenal ulcer and vagotomized patients.
Topics: Adult; Atropine; Benzodiazepinones; Duodenal Ulcer; Female; Gastric Acid; Gastrins; Humans; Kinetics | 1985 |
Is maximal acid output useful in identifying relapsing duodenal ulcer patients?
Topics: Adult; Aged; Benzodiazepinones; Cimetidine; Duodenal Ulcer; Female; Follow-Up Studies; Gastric Acid; | 1985 |
Use of antisecretory drugs for gastroprotection during antiblastic chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Benzodiazepinones; Cyclophosphamide; Do | 1985 |
Treatment of duodenal ulcers using pirenzepine and cimetidine: controlled trial.
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; F | 1985 |
Pirenzepine versus cimetidine in duodenal ulcer treatment. A clinical and microbiological study.
Topics: Aged; Antacids; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Clinical Trials as Topic; Dose-Res | 1985 |
[Recurrence of chronic duodenal ulcer following initial therapy with pirenzepine or cimetidine].
Topics: Adult; Aged; Benzodiazepinones; Chronic Disease; Cimetidine; Clinical Trials as Topic; Duodenal Ulce | 1985 |
51 other studies available for pirenzepine and Curling Ulcer
| Article | Year |
|---|---|
Recurrence of duodenal ulcer under continuous antisecretory treatment: an approach to the detection of predictive markers.
Topics: Adolescent; Adult; Alcohol Drinking; Anti-Ulcer Agents; Benzodiazepinones; Blood Group Antigens; Cim | 1984 |
[Duodenal ulcer - conservative treatment, success and limitations].
Topics: Antacids; Benzodiazepinones; Carbenoxolone; Cimetidine; Duodenal Ulcer; Histamine H2 Antagonists; Hu | 1982 |
Pirenzepine depresses plasma noradrenaline in duodenal ulcer patients.
Topics: Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Dopamine; Duodenal Ulcer; Epinephrine; Female; Ga | 1984 |
The influence of various secretory inhibitors on peptic activity.
Topics: Adult; Benzodiazepinones; Dose-Response Relationship, Drug; Duodenal Ulcer; Furans; Humans; Middle A | 1980 |
Long-term treatment of duodenal ulcer with pirenzepine; gastric pH values and incidence of relapses: an open pilot study.
Topics: Adult; Aged; Anti-Ulcer Agents; Benzodiazepinones; Duodenal Ulcer; Female; Gastric Acidity Determina | 1983 |
Anti-ulcer and secretion-inhibitory properties of the tricyclic derivative doxepin in rats and dogs.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Benzodiazepinones; Carbachol; Cimetidine; Depr | 1984 |
[Use of gastrozepin in erosive-ulcerative diseases of the stomach and duodenum].
Topics: Anti-Ulcer Agents; Benzodiazepinones; Duodenal Ulcer; Female; Humans; Male; Pirenzepine; Stomach Ulc | 1984 |
[Pirenzepin versus cimetidine in duodenal ulcer: short-term controlled clinical study].
Topics: Adult; Benzodiazepinones; Cimetidine; Duodenal Ulcer; Female; Guanidines; Humans; Male; Middle Aged; | 1983 |
[Treatment of duodenal ulcer].
Topics: Aluminum; Antacids; Benzodiazepinones; Cimetidine; Duodenal Ulcer; Feeding Behavior; Gastric Acid; H | 1983 |
Pirenzepine in long-term therapy for duodenal ulcer.
Topics: Adult; Aged; Antacids; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Duodenal Ulcer; Female; Hum | 1983 |
[Serum gastrin levels before and after short-term treatment of duodenal ulcer with cimetidine and pirenzepin].
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Drug Evaluation; Duodenal Ulcer; Female; Ga | 1983 |
[Circadian changes in gastric acidity during drug therapy of duodenal ulcer].
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Bismuth; Butylscopolammonium Bromide; Cimetidine; Drug | 1983 |
Inhibition of gastric mucosa carbonic anhydrase by pirenzepine in patients with gastroduodenal ulcers.
Topics: Animals; Benzodiazepinones; Carbonic Anhydrase Inhibitors; Cattle; Duodenal Ulcer; Gastric Mucosa; H | 1981 |
[Duodenal ulcer in the aged. Diagnosis, therapy and disease course].
Topics: Acute Disease; Aged; Benzodiazepinones; Cimetidine; Duodenal Ulcer; Female; Humans; Male; Piperazine | 1981 |
[Acid secretion and serum gastrin during acute and chronic treatment with pirenzepine in duodenal ulcer (author's transl)].
Topics: Administration, Oral; Benzodiazepinones; Drug Administration Schedule; Duodenal Ulcer; Gastric Acid; | 1981 |
[Our experience in the use of gastric secretion inhibitors in surgery].
Topics: Aged; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Duodenal Ulcer; Female; Humans; Piperazines; | 1981 |
Inhibition by pirenzepine of nocturnal gastric acid secretion in duodenal ulcer patients.
Topics: Adult; Benzodiazepinones; Circadian Rhythm; Double-Blind Method; Drug Administration Schedule; Drug | 1981 |
Effects of pirenzepine and atropine on gastric secretory and plasma hormonal responses to sham-feeding in patients with duodenal ulcer.
Topics: Adult; Atropine; Benzodiazepinones; Dose-Response Relationship, Drug; Duodenal Ulcer; Eating; Gastri | 1980 |
The effect of different anticholinergics on the gastric acid response to sham feeding in man.
Topics: Adult; Benzodiazepinones; Duodenal Ulcer; Eating; Female; Gastric Acid; Humans; Male; Middle Aged; P | 1982 |
[Experience in the use of gastrotsepin in the treatment of stomach and duodenal ulcer].
Topics: Adolescent; Adult; Duodenal Ulcer; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; P | 1995 |
[Gastrotsepin in the therapy and prevention of peptic ulcer exacerbations associated with Helicobacter pylori bacteriosis].
Topics: Drug Evaluation; Drug Therapy, Combination; Duodenal Ulcer; Helicobacter Infections; Helicobacter py | 1995 |
Effects of KW-5805, a new antiulcer agent, on experimental gastric and duodenal ulcers, gastric mucosal lesions by necrotizing agents and gastric acid secretion.
Topics: Animals; Anti-Ulcer Agents; Benzoxepins; Cimetidine; Depression, Chemical; Duodenal Ulcer; Ethanol; | 1994 |
A new diagnostic test for incomplete vagotomy: experimental study in dogs.
Topics: Animals; Diagnosis, Differential; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Duoden | 1993 |
[New data on clinical response to therapeutic effects of gastrozepin].
Topics: Anti-Ulcer Agents; Duodenal Ulcer; Evaluation Studies as Topic; Humans; Peptic Ulcer; Pirenzepine; S | 1996 |
[Antisecretory effects of quamatel and gastrocepin in duodenal ulcer: comparison with intragastric pH-metry].
Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Duodenal Ulcer; Famotidine; Female; Follow-Up Studies; G | 1998 |
[The gastric mucigenous function in the treatment of patients with ulcer with various antisecretory preparations].
Topics: Adult; Anti-Ulcer Agents; Duodenal Ulcer; Enzyme Inhibitors; Famotidine; Female; Gastric Acidity Det | 2002 |
[Clinical course and treatment of duodenal ulcer in women].
Topics: Adolescent; Adult; Aged; Antacids; Anti-Bacterial Agents; Combined Modality Therapy; Duodenal Ulcer; | 1991 |
BAY P 1455, a thiazolylaminobenzimidazole derivative with gastroprotective properties in the rat.
Topics: Adrenalectomy; Animals; Anti-Ulcer Agents; Benzimidazoles; Cimetidine; Corticosterone; Cysteamine; D | 1991 |
Direct comparison between the ulcer-healing effects of two H(+)-K(+)-ATPase inhibitors, one M1-selective antimuscarinic and one H2 receptor antagonist in the rat.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Triphosphatases; Animals; Anti-Ulcer Agents; Benz | 1990 |
Plasma beta-endorphin, bombesin and pancreatic polypeptide immunoreactivity in healthy subjects and ulcer patients and changes during treatment with pirenzepine.
Topics: Adult; beta-Endorphin; Bombesin; Duodenal Ulcer; Humans; Pancreatic Polypeptide; Pirenzepine | 1991 |
[Antiulcer treatment with Biotidin and Gastrozepin and its effect on the occupational fitness of drivers and machinery operators].
Topics: Adult; Automobile Driving; Bulgaria; Duodenal Ulcer; Engineering; Humans; Middle Aged; Physical Fitn | 1990 |
Modifications of gamma-glutamyl transpeptidase activity in duodenal mucosa of rats treated with different antiulcer drugs.
Topics: Animals; Anti-Ulcer Agents; Duodenal Ulcer; Duodenum; Female; gamma-Glutamyltransferase; Indomethaci | 1989 |
Gastric acid secretion stimulated by modified sham-feeding, and the effects of histamine H2-antagonist and anti-muscarinic agent in patients with duodenal ulcer.
Topics: Adult; Cimetidine; Duodenal Ulcer; Gastric Acid; Histamine H2 Antagonists; Humans; Middle Aged; Musc | 1989 |
[A method of increasing the effectiveness of anti-ulcer therapy].
Topics: Adult; Aluminum Hydroxide; Antacids; Benzocaine; Carbonates; Combined Modality Therapy; Diet; Drug C | 1989 |
Circadian rhythms of food intake in gastroduodenally-ulcerated rats: effects of three anti-ulcer drugs.
Topics: Animals; Anti-Ulcer Agents; Circadian Rhythm; Duodenal Ulcer; Eating; Female; Indomethacin; Male; Pi | 1989 |
[The effect of almagel, gastrotsepin and food on the acidity and protease activity of the stomach and duodenum in peptic ulcer].
Topics: Aluminum Hydroxide; Anti-Ulcer Agents; Benzocaine; Drug Combinations; Drug Evaluation; Duodenal Ulce | 1989 |
Low doses of H2 antagonists and interaction with anticholinergics.
Topics: Drug Synergism; Duodenal Ulcer; Famotidine; Gastric Acidity Determination; Humans; Pirenzepine; Rani | 1989 |
[Effect of gastrozepin on the rate of gastric emptying in patients with peptic ulcer and dumping syndrome following gastric resection].
Topics: Adult; Anti-Ulcer Agents; Atropine; Benzodiazepinones; Chronic Disease; Drug Evaluation; Dumping Syn | 1985 |
Pharmacological response to cimetidine and healing of duodenal ulceration: effects of high-dose cimetidine and combination of cimetidine with pirenzepine.
Topics: Adolescent; Adult; Aged; Cimetidine; Drug Therapy, Combination; Duodenal Ulcer; Humans; Middle Aged; | 1988 |
Enprostil reduces G-cell hyperplasia and hypergastrinemia in duodenal ulcer.
Topics: Adult; Cimetidine; Duodenal Ulcer; Enprostil; Gastric Acid; Gastrins; Humans; Hydrogen-Ion Concentra | 1987 |
[Antiulcer effects of pirenzepine in rats].
Topics: Animals; Cats; Duodenal Ulcer; Female; Gastric Acid; Gastric Juice; Gastrins; Hexosamines; Male; Pep | 1988 |
An acid-independent antiulcer effect of M1 antimuscarinics in the rat.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Cysteamine; Duodenal Ulcer; Female; Gastric Acid; Omeprazole | 1988 |
Combination of pirenzepine and cimetidine in the therapy of duodenal ulcer.
Topics: Cimetidine; Drug Therapy, Combination; Duodenal Ulcer; Humans; Pirenzepine | 1988 |
Personality and duodenal ulcer response to antisecretory treatment.
Topics: Cimetidine; Duodenal Ulcer; Female; Humans; Male; Middle Aged; Personality; Personality Inventory; P | 1987 |
The metabolic effects of acute and chronic administration of gastrozepin.
Topics: Administration, Oral; Adult; Blood Glucose; Catecholamines; Cholesterol; Duodenal Ulcer; Fatty Acids | 1987 |
Pharmacokinetics of pirenzepine in patients with gastric or duodenal ulcers.
Topics: Administration, Oral; Adult; Duodenal Ulcer; Female; Half-Life; Humans; Male; Middle Aged; Pirenzepi | 1987 |
[Effect of gastrozepin on the rate of gastrointestinal tract evacuation in patients with peptic ulcer of the duodenum].
Topics: Adult; Anti-Ulcer Agents; Barium Sulfate; Benzodiazepinones; Digestive System; Duodenal Ulcer; Femal | 1986 |
[Do anticholinergic drugs still have significance in the therapy of ulcer?].
Topics: Atropine; Cimetidine; Drug Therapy, Combination; Duodenal Ulcer; Gastric Acid; Humans; Parasympathol | 1986 |
A combination of pirenzepine and cimetidine: a new approach to treatment of duodenal ulcer in "non-responders".
Topics: Adult; Anti-Ulcer Agents; Benzodiazepinones; Cimetidine; Drug Therapy, Combination; Duodenal Ulcer; | 1985 |
Lack of pharmacokinetic interaction between cimetidine and pirenzepine.
Topics: Administration, Oral; Adult; Benzodiazepinones; Chromatography, High Pressure Liquid; Cimetidine; Ci | 1985 |
Pirenzepine and gastroduodenal ulcers.
Topics: Benzodiazepinones; Duodenal Ulcer; Humans; Pirenzepine; Stomach Ulcer | 1985 |