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pirenzepine and Cognition Disorders

pirenzepine has been researched along with Cognition Disorders in 34 studies

Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.

Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Research Excerpts

ExcerptRelevanceReference
"A pilot study was conducted to examine if donepezil could enhance cognitive function in patients with schizophrenia."9.10An open-labeled trial of adjunctive donepezil for cognitive impairments in patients with schizophrenia. ( Buchanan, RW; Gold, J; Summerfelt, A; Tek, C, 2003)
"To examine the effects of risperidone and olanzapine on cognitive functioning in elderly patients with schizophrenia or schizoaffective disorder."9.10Comparative effects of risperidone and olanzapine on cognition in elderly patients with schizophrenia or schizoaffective disorder. ( Gharabawi, G; Harvey, PD; Mao, L; Napolitano, JA, 2003)
"Olanzapine demonstrated superior antipsychotic efficacy compared with haloperidol in the treatment of acute phase schizophrenia, and in the treatment of some patients with first-episode or treatment-resistant schizophrenia."8.81Olanzapine: an updated review of its use in the management of schizophrenia. ( Bhana, N; Foster, RH; Olney, R; Plosker, GL, 2001)
"Risperidone-treated subjects with a greater degree of acute mood change were both 3."6.69The course of depressive symptoms in predicting relapse in schizophrenia: a double-blind, randomized comparison of olanzapine and risperidone. ( Andersen, SW; Tollefson, GD; Tran, PV, 1999)
"A pilot study was conducted to examine if donepezil could enhance cognitive function in patients with schizophrenia."5.10An open-labeled trial of adjunctive donepezil for cognitive impairments in patients with schizophrenia. ( Buchanan, RW; Gold, J; Summerfelt, A; Tek, C, 2003)
"The effects of risperidone and olanzapine on cognitive functioning in patients with schizophrenia were compared in a randomized, double-blind trial."5.10Changes in cognitive functioning with risperidone and olanzapine treatment: a large-scale, double-blind, randomized study. ( Green, MF; Harvey, PD; McGurk, SR; Meltzer, HY, 2003)
"To examine the effects of risperidone and olanzapine on cognitive functioning in elderly patients with schizophrenia or schizoaffective disorder."5.10Comparative effects of risperidone and olanzapine on cognition in elderly patients with schizophrenia or schizoaffective disorder. ( Gharabawi, G; Harvey, PD; Mao, L; Napolitano, JA, 2003)
"Olanzapine demonstrated superior antipsychotic efficacy compared with haloperidol in the treatment of acute phase schizophrenia, and in the treatment of some patients with first-episode or treatment-resistant schizophrenia."4.81Olanzapine: an updated review of its use in the management of schizophrenia. ( Bhana, N; Foster, RH; Olney, R; Plosker, GL, 2001)
"P50 suppression of 13 patients with schizophrenia receiving clinically effective doses of clozapine, olanzapine, or risperidone (classified as atypical antipsychotic medications) was compared to that of 13 patients receiving conventional antipsychotic medications."3.70Normal P50 suppression in schizophrenia patients treated with atypical antipsychotic medications. ( Braff, DL; Cadenhead, KS; Clementz, BA; Geyer, MA; Light, GA, 2000)
" Subjective impairment, as assessed with the subscale 'mental functioning', was significantly correlated with greater conventional neuroleptic dosage after controlling for psychopathology (P<0."2.70Relationship between neuroleptic dosage and subjective cognitive dysfunction in schizophrenic patients treated with either conventional or atypical neuroleptic medication. ( Krausz, M; Moritz, S; Naber, D; Woodward, TS, 2002)
"Risperidone-treated subjects with a greater degree of acute mood change were both 3."2.69The course of depressive symptoms in predicting relapse in schizophrenia: a double-blind, randomized comparison of olanzapine and risperidone. ( Andersen, SW; Tollefson, GD; Tran, PV, 1999)
"Risperidone has relatively consistent positive effects on working memory, executive functioning, and attention, whereas improvement in verbal learning and memory was inconsistent."2.40The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia. ( McGurk, SR; Meltzer, HY, 1999)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.94)18.7374
1990's9 (26.47)18.2507
2000's23 (67.65)29.6817
2010's1 (2.94)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nieves-Martinez, E1
Haynes, K1
Childers, SR1
Sonntag, WE1
Nicolle, MM1
Lykouras, L1
Typaldou, M1
Gournellis, R1
Vaslamatzis, G1
Christodoulou, GN1
Ondo, WG1
Levy, JK1
Vuong, KD1
Hunter, C1
Jankovic, J1
Buchanan, RW1
Summerfelt, A1
Tek, C1
Gold, J1
Broerse, A1
Crawford, TJ1
den Boer, JA1
de Haan, L1
van Amelsvoort, T1
Ichikawa, J1
Chung, YC1
Li, Z1
Dai, J1
Meltzer, HY3
Aguglia, E1
De Vanna, M1
Onor, ML1
Ferrara, D1
Harvey, PD2
Green, MF1
McGurk, SR2
Bokszanska, A1
Martin, G1
Vanstraelen, M1
Holt, G1
Bouras, N1
Taylor, D1
Napolitano, JA1
Mao, L1
Gharabawi, G1
Brunnauer, A1
Geiger, E1
Laux, G1
Wilson, MS1
Gibson, CJ1
Hamm, RJ1
Dean, B1
Teaktong, T1
Piggott, MA1
Mckeith, IG2
Perry, RH2
Ballard, CG1
Perry, EK2
Tsang, SW1
Lai, MK1
Kirvell, S1
Francis, PT1
Esiri, MM1
Hope, T1
Chen, CP1
Wong, PT1
Doods, HN1
Quirion, R1
Mihm, G1
Engel, W1
Rudolf, K1
Entzeroth, M1
Schiavi, GB1
Ladinsky, H1
Bechtel, WD1
Ensinger, HA1
Tollefson, GD3
Keks, NA1
Purdon, SE2
Breier, A2
Walker, Z1
Grace, J1
Overshot, R1
Satarasinghe, S1
Swan, A1
Katona, CL1
Andersen, SW1
Tran, PV1
Jones, BD1
Stip, E1
Labelle, A1
Addington, D1
David, SR1
Light, GA1
Geyer, MA1
Clementz, BA1
Cadenhead, KS1
Braff, DL1
Bhana, N1
Foster, RH1
Olney, R1
Plosker, GL1
Risch, SC1
McGurk, S1
Horner, MD1
Nahas, Z1
Owens, SD1
Molloy, M1
Gilliard, C1
Christie, S1
Markowitz, JS1
DeVane, CL1
Mintzer, J1
George, MS1
Stephan, KE1
Magnotta, VA1
White, T1
Arndt, S1
Flaum, M1
O'Leary, DS1
Andreasen, NC1
Moritz, S1
Woodward, TS1
Krausz, M1
Naber, D1
Kuroki, T1
Tashiro, N1
Sharma, T1
Smith, CJ1
Candy, JM1
Johnson, M1
Bonham, JR1
Dick, DJ1
Fairbairn, A1
Blessed, G1
Birdsall, NJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effectiveness of Paliperidone ER(Invega®) on Depressive Symptoms of Schizophrenia Patients: A 8-week Open-label Prospective, Non-comparative Study[NCT01399450]Phase 411 participants (Actual)Interventional2011-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for pirenzepine and Cognition Disorders

ArticleYear
Therapeutic potential of CNS-active M2 antagonists: novel structures and pharmacology.
    Life sciences, 1993, Volume: 52, Issue:5-6

    Topics: Animals; Benzodiazepinones; Brain; CHO Cells; Cognition Disorders; Cricetinae; Dibenzazepines; Drug

1993
Cognitive function in schizophrenic patients.
    The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 11

    Topics: Antipsychotic Agents; Benzodiazepines; Cerebral Cortex; Clozapine; Cognition Disorders; Dopamine; Gl

1996
Measuring outcome in schizophrenia: differences among the atypical antipsychotics. Collaborative Working Group on Clinical Trial Evaluations.
    The Journal of clinical psychiatry, 1998, Volume: 59 Suppl 12

    Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition Disorders; Cost-Benefit Analysis; Dibenz

1998
[Use of novel agents in the treatment of schizophrenia and a look to the future].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1998, Volume: 18, Issue:3

    Topics: Antipsychotic Agents; Benzodiazepines; Clinical Trials as Topic; Clozapine; Cognition Disorders; Hum

1998
Cognitive improvement in schizophrenia with novel antipsychotic medications.
    Schizophrenia research, 1999, Mar-01, Volume: 35 Suppl

    Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition Disorders; Dibenzothiazepines; Humans; O

1999
Cognitive deficit in schizophrenia and its neurochemical basis.
    The British journal of psychiatry. Supplement, 1999, Issue:37

    Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition Disorders; Glutamic Acid; Haloperidol; H

1999
The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia.
    Schizophrenia bulletin, 1999, Volume: 25, Issue:2

    Topics: Antipsychotic Agents; Attention; Benzodiazepines; Clinical Trials as Topic; Clozapine; Cognition Dis

1999
Olanzapine: an updated review of its use in the management of schizophrenia.
    Drugs, 2001, Volume: 61, Issue:1

    Topics: Adolescent; Aged; Animals; Antipsychotic Agents; Benzodiazepines; Child; Child, Preschool; Cognition

2001
[Clinical and pharmacological studies of the second generation antipsychotics].
    Fukuoka igaku zasshi = Hukuoka acta medica, 2001, Volume: 92, Issue:11

    Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition Disorders; Cytoskeletal Proteins; Dibenz

2001

Trials

11 trials available for pirenzepine and Cognition Disorders

ArticleYear
Olanzapine treatment for dopaminergic-induced hallucinations.
    Movement disorders : official journal of the Movement Disorder Society, 2002, Volume: 17, Issue:5

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Cognition Disorders; Dopamine Agonists; Double-Blind Me

2002
An open-labeled trial of adjunctive donepezil for cognitive impairments in patients with schizophrenia.
    Schizophrenia research, 2003, Jan-01, Volume: 59, Issue:1

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Cognition Disorders; Donepezil; Drug Therapy, Combinat

2003
Differential effects of olanzapine and risperidone on cognition in schizophrenia? A saccadic eye movement study.
    The Journal of neuropsychiatry and clinical neurosciences, 2002,Fall, Volume: 14, Issue:4

    Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Cognition Disorders; Female; Humans; Male;

2002
Changes in cognitive functioning with risperidone and olanzapine treatment: a large-scale, double-blind, randomized study.
    Psychopharmacology, 2003, Volume: 169, Issue:3-4

    Topics: Adolescent; Adult; Arousal; Benzodiazepines; Cognition Disorders; Diagnostic and Statistical Manual

2003
Risperidone and olanzapine in adults with intellectual disability: a clinical naturalistic study.
    International clinical psychopharmacology, 2003, Volume: 18, Issue:5

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Benzodiazepines; Cognition Disorders; Comorbidity; Di

2003
Comparative effects of risperidone and olanzapine on cognition in elderly patients with schizophrenia or schizoaffective disorder.
    International journal of geriatric psychiatry, 2003, Volume: 18, Issue:9

    Topics: Aged; Antipsychotic Agents; Benzodiazepines; Cognition Disorders; Double-Blind Method; Female; Human

2003
The course of depressive symptoms in predicting relapse in schizophrenia: a double-blind, randomized comparison of olanzapine and risperidone.
    Biological psychiatry, 1999, Aug-01, Volume: 46, Issue:3

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Cluster Analysis; Cognition Disorders; Depressive Diso

1999
Neuropsychological change in early phase schizophrenia during 12 months of treatment with olanzapine, risperidone, or haloperidol. The Canadian Collaborative Group for research in schizophrenia.
    Archives of general psychiatry, 2000, Volume: 57, Issue:3

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Benzodiazepines; Cognition Disorders; Double-Blind Me

2000
A double-blind placebo-controlled case study of the use of donepezil to improve cognition in a schizoaffective disorder patient: functional MRI correlates.
    Neurocase, 2001, Volume: 7, Issue:2

    Topics: Adult; Basal Ganglia; Benzodiazepines; Brain; Brain Mapping; Cognition Disorders; Cross-Over Studies

2001
Effects of olanzapine on cerebellar functional connectivity in schizophrenia measured by fMRI during a simple motor task.
    Psychological medicine, 2001, Volume: 31, Issue:6

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Cerebellum; Cognition Disorders; Female; Humans; Magne

2001
Relationship between neuroleptic dosage and subjective cognitive dysfunction in schizophrenic patients treated with either conventional or atypical neuroleptic medication.
    International clinical psychopharmacology, 2002, Volume: 17, Issue:1

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition Disorders; Dose-Response Relation

2002

Other Studies

14 other studies available for pirenzepine and Cognition Disorders

ArticleYear
Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats.
    Behavioural brain research, 2012, Feb-01, Volume: 227, Issue:1

    Topics: Aging; Animals; Attention; Autoradiography; Cognition Disorders; Corpus Striatum; Food Deprivation;

2012
Coexistence of Capgras and Frégoli syndromes in a single patient. Clinical, neuroimaging and neuropsychological findings.
    European psychiatry : the journal of the Association of European Psychiatrists, 2002, Volume: 17, Issue:4

    Topics: Adult; Benzodiazepines; Brain; Capgras Syndrome; Cognition Disorders; Depersonalization; Female; Hum

2002
Comparable dopamine 2 receptor occupancy.
    The American journal of psychiatry, 2002, Volume: 159, Issue:12

    Topics: Benzodiazepines; Cognition Disorders; Dopamine Antagonists; Haloperidol; Humans; Olanzapine; Pirenze

2002
Cholinergic modulation of basal and amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens.
    Brain research, 2002, Dec-20, Volume: 958, Issue:1

    Topics: Acetylcholine; Adrenergic Uptake Inhibitors; Amphetamine; Animals; Cognition Disorders; Dopamine; Ma

2002
Insight in persons with schizophrenia: effects of switching from conventional neuroleptics to atypical antipsychotics.
    Progress in neuro-psychopharmacology & biological psychiatry, 2002, Volume: 26, Issue:7-8

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition; Cognition Disorders; Female; Hal

2002
[Neuroleptics and cognition].
    Psychiatrische Praxis, 2003, Volume: 30 Suppl 2

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition Disorders; Drug Therapy, Combinat

2003
Haloperidol, but not olanzapine, impairs cognitive performance after traumatic brain injury in rats.
    American journal of physical medicine & rehabilitation, 2003, Volume: 82, Issue:11

    Topics: Analysis of Variance; Animals; Antipsychotic Agents; Benzodiazepines; Brain Injuries; Cognition Diso

2003
M1 receptor agonism, a possible treatment for cognitive deficits in schizophrenia.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:8

    Topics: Brain Chemistry; Cognition Disorders; Humans; Muscarinic Agonists; Muscarinic Antagonists; Pirenzepi

2004
Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies.
    Behavioural brain research, 2005, Jun-20, Volume: 161, Issue:2

    Topics: Aged; Aged, 80 and over; Analysis of Variance; Autoradiography; Binding, Competitive; Case-Control S

2005
Impaired coupling of muscarinic M1 receptors to G-proteins in the neocortex is associated with severity of dementia in Alzheimer's disease.
    Neurobiology of aging, 2006, Volume: 27, Issue:9

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Brain Chemistry; Choline O-Acetylt

2006
Olanzapine in dementia with Lewy bodies: a clinical study.
    International journal of geriatric psychiatry, 1999, Volume: 14, Issue:6

    Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Cognition Disorders; Contraindicatio

1999
Normal P50 suppression in schizophrenia patients treated with atypical antipsychotic medications.
    The American journal of psychiatry, 2000, Volume: 157, Issue:5

    Topics: Acoustic Stimulation; Adult; Antipsychotic Agents; Auditory Perception; Benzodiazepines; Clozapine;

2000
Atypical antipsychotics and cognition in schizophrenia.
    Archives of general psychiatry, 2002, Volume: 59, Issue:6

    Topics: Antipsychotic Agents; Benzodiazepines; Cognition; Cognition Disorders; Dose-Response Relationship, D

2002
Muscarinic cholinergic receptor subtypes in hippocampus in human cognitive disorders.
    Journal of neurochemistry, 1988, Volume: 50, Issue:3

    Topics: Acetylcholinesterase; Aging; Choline O-Acetyltransferase; Cognition Disorders; Hippocampus; Humans;

1988