Page last updated: 2024-11-02

pirenzepine and Borderline Personality Disorder

pirenzepine has been researched along with Borderline Personality Disorder in 3 studies

Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.

Borderline Personality Disorder: A personality disorder marked by a pattern of instability of interpersonal relationships, self-image, and affects, and marked impulsivity beginning by early adulthood and present in a variety of contexts. (DSM-IV)

Research Excerpts

ExcerptRelevanceReference
"Patients suffering from BPD and dysthymia were included in an 8-week, open-label study of olanzapine monotherapy."9.09Olanzapine safety and efficacy in patients with borderline personality disorder and comorbid dysthymia. ( Berry, SA; Camlin, KL; Jesberger, JA; Schulz, SC, 1999)
"The intent of this study was to compare the efficacy and safety of olanzapine versus placebo in the treatment of women meeting criteria for borderline personality disorder (BPD)."9.09Olanzapine treatment of female borderline personality disorder patients: a double-blind, placebo-controlled pilot study. ( Frankenburg, FR; Zanarini, MC, 2001)
"Patients suffering from BPD and dysthymia were included in an 8-week, open-label study of olanzapine monotherapy."5.09Olanzapine safety and efficacy in patients with borderline personality disorder and comorbid dysthymia. ( Berry, SA; Camlin, KL; Jesberger, JA; Schulz, SC, 1999)
"The intent of this study was to compare the efficacy and safety of olanzapine versus placebo in the treatment of women meeting criteria for borderline personality disorder (BPD)."5.09Olanzapine treatment of female borderline personality disorder patients: a double-blind, placebo-controlled pilot study. ( Frankenburg, FR; Zanarini, MC, 2001)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schulz, SC1
Camlin, KL1
Berry, SA1
Jesberger, JA1
Hough, DW1
Zanarini, MC1
Frankenburg, FR1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-Blind and Placebo Controlled Assessment of Depakote ER in Borderline Personality Disorder[NCT00222482]15 participants Interventional2003-03-31Completed
A Double-Blind, Placebo-Controlled Study of Brexpiprazole in the Treatment of Borderline Personality Disorder.[NCT03418675]Phase 280 participants (Actual)Interventional2018-11-26Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Hamilton Anxiety Rating Scale (HAM-A)

A clinician-administered assessment of anxiety that will be assessed at all study visits (Visit 1-Visit 8). Changes in scores from baseline to final visit will be assessed. Higher scores (up to 56) indicate higher levels of anxiety, with 0 being no symptoms of anxiety. (NCT03418675)
Timeframe: assessed at Visits 1 to 8, change in scores from Visit 1 to Visit 8 (baseline to Week 12) is reported

Interventionchange in score on a scale (Mean)
Placebo-2.41
Rexulti-4.88

Hamilton Depression Rating Scale (HAM-D)

A clinician-administered assessment of depression that will be assessed at all study visits (Visits 1-8). Higher total scores indicate higher levels of depression (up to 52), while a score of 0 would indicate no depressive symptoms. (NCT03418675)
Timeframe: Assessed at Visits 1 to 8, change in scores from Visit 1 to Visit 8 (baseline to week 12) is reported

Interventionchange in score on a scale (Mean)
Placebo-2.09
Rexulti-3.81

Barratt Impulsiveness Scale (BIS)

A self-report assessment of impulsivity that will be assessed at baseline and visit 8. The BIS is composed of 30 items describing common impulsive or non-impulsive (for reverse scored items) behaviors and preferences. Items are scored on a 4-point scale: (Rarely/Never = 1, Occasionally = 2, Often = 3, Almost Always/Always = 4). These scores are summed to produce an overall impulsivity score ranging from 30 (not impulsive) to 120 (extremely impulsive). (NCT03418675)
Timeframe: Baseline (Visit 1), Week 12 (Visit 8)

,
Interventionscore on a scale (Mean)
Visit 1Visit 8
Placebo76.5368.13
Rexulti72.2770.5

Borderline Evaluation of Severity Over Time (BEST)

A self rated scale used to measure severity and change. The first 12 items of the scale are on a scale from 1-5, with 5 meaning that the item caused extreme distress, severe difficulties in relationships, and/or kept them from getting things done. The lowest rating (1) means it caused little or no problems. Items 13-15 (positive behaviors) are rated according to frequency. Completed at every visit. (NCT03418675)
Timeframe: Assessed at Visits 1 to 8, change in scores from Visit 1 to Visit 8 (baseline to week 12) is reported

,
Interventionscore on a scale (Mean)
Visit 1Visit 8
Placebo40.9029.15
Rexulti40.5423.15

Columbia Suicide Severity Rating Scale (CSSRS)

"A self-report scale measuring suicidality. Subjects will complete the scale at all visits. Subjects are asked about suicidal thoughts. If answers are no, rater can proceed to suicidal behavior section where subject is asked about any non-suicidal self injurious behavior. If yes, subject is asked about intensity of ideations. In the event of serious threat to themselves, the subject will be escorted to the emergency room. Total score indicates severity of suicidal ideation and behavior, with lower scores representing lower levels of suicidality and higher scores representing higher levels of suicidality. A score of 0 would reflect no suicidality present, whereas a maximum score of 5 would reflect active suicidal ideation with intent to act." (NCT03418675)
Timeframe: Baseline (Visit 1), Week 12 (Visit 8)

,
Interventionscore on a scale (Mean)
Visit 1Visit 8
Placebo1.150.23
Rexulti0.730.08

MINI International Neuropsychiatric Interview

A short-structured interview that assesses comorbid psychiatric disorders according to the DSM 5 criteria. This assessment will be done during the baseline visit. (NCT03418675)
Timeframe: Baseline (Week 1)

,
InterventionParticipants (Count of Participants)
Major Depressive Episode (Current)Major Depressive Episode (Past)Manic Episode (Current)Manic Episode (Past)Hypomanic Episode (Current)Bipolar I Disorder (Current)Bipolar I Disorder (Past)Bipolar II Disorder (Current)Bipolar II Disorder (Past)Panic Disorder (Current)Panic Disorder (Lifetime)Agoraphobia (Current)Social Anxiety Disorder (Current)Obsessive Compulsive Disorder (Current)Post Traumatic Stress Disorder (Current)Alcohol Use Disorder (Past 12 months)Substance Use Disorder (Past 12 months)Any Psychotic Disorder (Current)Any Psychotic Disorder (Lifetime)Major Depressive Disorder with Psychotic Features (Current)Major Depressive Disorder with Psychotic Features (Past)Anorexia Nervosa (current)Bulimia Nervosa (Current)Binge Eating Disorder (Current)Generalized Anxiety Disorder (Current)Antisocial Personality Disorder (Lifetime)ADHD Combined Type (Current)ADHD Inattentive Type (Current)ADHD Hyperactive Type (Current)Tourette's Syndrome (Lifetime)Persistent Motor Tic Disorder (Lifetime)Provisional Vocal Tic Disorder (Lifetime)Provisional Tic Disorder (Lifetime)Specific PhobiaBody Dysmorphic Disorder (Current)
Placebo16122110000611763913110000042108201010043
Rexulti1818230000161099312880100144154411110012

Quality of Life Inventory (QOLI)

A self-report assessment of patient perceived quality of life that will be assessed at baseline and visit 8. Higher scores indicate a higher quality of life, whereas lower scores indicate a lower quality of life. Participants are asked to rate the importance of each domain on a 3-point scale ranging from 1=not important to 3=very important, and to rate how satisfied they are with that domain on a 6-point scale, ranging from -3=very dissatisfied to +3=very satisfied. In scoring, importance ratings are multiplied by satisfaction ratings to produce weighted satisfaction scores for each of the 16 domains. Weighted satisfaction scores are summed and divided by the number of domains that were rated as important or very important to produce a raw score, which is then converted to a t-score, which provides a proxy measurement for perceived quality of life. T-scores range from very low perceived quality of life (0-36) to high perceived quality of life (58-77). (NCT03418675)
Timeframe: Baseline (Week 1), Week 12 (Visit 8)

,
Interventionscore on a scale (Mean)
Visit 1Visit 8
Placebo28.8930.75
Rexulti28.7035.71

Self Report Version of Zanarini Scale

A self-report scale assessing Borderline Personality severity that will be assessed at all visits.This scale is assessing severity and change in BPD symptoms. This is a 9-item scale measuring severity of different aspects of Borderline Personality Disorder, with each item rated on a 0-4 scale, 0=no symptoms, 4=severe symptoms. Total scores range from 0-36. (NCT03418675)
Timeframe: Baseline (Visit 1), Week 1 (Visit 2), Week 2 (Visit 3), Week 4 (Visit 4), Week 6 (Visit 5), Week 8 (Visit 6), Week 10 (Visit 7), Week 12 (Visit 8)

,
Interventionscore on a scale (Mean)
Visit 1Visit 2Visit 3Visit 4Visit 5Visit 6Visit 7Visit 8
Placebo18.212.810.710.79.79.68.79.3
Rexulti17.610.97.98.07.06.66.05.8

Sheehan Disability Scale (SDS)

Subjects will complete the SDS at all visits. The change in scores from baseline to study completion will be assessed. The scale itself assesses the level of disability from borderline personality disorder (or target disorder) with higher scores indicating a more debilitating disorder. Scores range from 0-30. (NCT03418675)
Timeframe: Baseline (Visit 1), Week 1 (Visit 2), Week 2 (Visit 3), Week 4 (Visit 4), Week 6 (Visit 5), Week 8 (Visit 6), Week 10 (Visit 7), Week 12 (Visit 8)

,
Interventionscore on a scale (Mean)
Visit 1Visit 2Visit 3Visit 4Visit 5Visit 6Visit 7Visit 8
Placebo17.313.311.512.411.711.212.012.7
Rexulti15.810.77.87.87.07.96.97.7

Symptom Checklist-90 Revised

An instrument that helps evaluate a broad range of psychological problems and symptoms of Borderline Personality Disorder psychopathology. This will be assessed at baseline and visit 8.The 115 items are rated by using a 5-step Likert scale (0=not at all, 4=very strong) and provide a global picture of borderline psychopathology. Global scores of borderline psychopathology are calculated by summing 12 items and range from 0-48. Higher scores indicate more severe symptoms of Borderline Personality Disorder. (NCT03418675)
Timeframe: Baseline, Visit 8 (Week 12)

,
Interventionscore on a scale (Mean)
Visit 1Visit 8
Placebo26.1720.25
Rexulti25.4214.21

Zanarini Rating Scale for Borderline Personality Disorder

A clinician-administered scale assessing Borderline Personality Scale severity at all study visits. Scores range from 0-36. Higher scores represent worse Borderline Personality Disorder severity, and lower scores represent milder Borderline Personality Disorder severity. (NCT03418675)
Timeframe: Baseline (Visit 1), Week 1 (Visit 2), Week 2 (Visit 3), Week 4 (Visit 4), Week 6 (Visit 5), Week 8 (Visit 6), Week 10 (Visit 7), Week 12 (Visit 8)

,
Interventionscore on a scale (Mean)
Visit 1Visit 2Visit 3Visit 4Visit 5Visit 6Visit 7Visit 8
Placebo14.97.64.764.25.758.4
Rexulti14.96.75.34.44.54.943.1

Trials

2 trials available for pirenzepine and Borderline Personality Disorder

ArticleYear
Olanzapine safety and efficacy in patients with borderline personality disorder and comorbid dysthymia.
    Biological psychiatry, 1999, Nov-15, Volume: 46, Issue:10

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Borderline Personality Disorder; Brief Psychiatric Rat

1999
Olanzapine treatment of female borderline personality disorder patients: a double-blind, placebo-controlled pilot study.
    The Journal of clinical psychiatry, 2001, Volume: 62, Issue:11

    Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Borderline Personality Disorder; Double-Bl

2001

Other Studies

1 other study available for pirenzepine and Borderline Personality Disorder

ArticleYear
Low-dose olanzapine for self-mutilation behavior in patients with borderline personality disorder.
    The Journal of clinical psychiatry, 2001, Volume: 62, Issue:4

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Borderline Personality Disorder; Comorbidity; Dose-Res

2001