pirenzepine has been researched along with Asthma in 11 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of a single intravenous dose of pirenzepine on ventilatory indices of 22 asthmatics was studied." | 9.07 | [Effect of pirenzepine, a selective M1 muscarinic receptor antagonist, on the bronchial tree patency in patients with bronchial asthma]. ( Chyrek-Borowska, S; Rutkowski, R; Siergiejko, Z, 1991) |
| "The effect of a single intravenous dose of pirenzepine on ventilatory indices of 22 asthmatics was studied." | 5.07 | [Effect of pirenzepine, a selective M1 muscarinic receptor antagonist, on the bronchial tree patency in patients with bronchial asthma]. ( Chyrek-Borowska, S; Rutkowski, R; Siergiejko, Z, 1991) |
| "The effect of two anticholinergic drugs, Ipratropium bromide, nonselective muscarinic receptor antagonist and Pirenzepine, a selective M1 receptor blocker on bronchospasm induced by metacholine and histamine was investigated." | 3.68 | [The effect of muscarinic receptor blockers on non-specific bronchial reactivity in patients with bronchial asthma]. ( Siergiejko, Z, 1992) |
| " To determine if postsynaptic muscarinic M-1 receptors mediate airway constriction, the action was compared of pirenzepine, that antagonizes selectively muscarinic M-1 receptors, and atropine, that blocks both muscarinic M-1 and M-2 receptors, on bronchial responses to methacholine inhalation in seven asthmatic patients." | 3.67 | Muscarinic M-1 receptors mediate the bronchial hyperresponsiveness during methacholine inhalation. ( Cazzola, M; D'Amato, G; De Novellis, V; Marmo, E; Matera, MG, 1989) |
| "Pirenzepine is a M1 receptor antagonist and effective in vagally-induced bronchoconstriction." | 1.29 | Comparison of the bronchodilator efficacy of nebulized pirenzepine and ipratropium bromide in patients with airway obstructive lung disease. ( Celikel, T; Ceyhan, B; Kandemir, B; Simsir, S, 1993) |
| " Dose-response lines in response to the two agonists, expressed as percent maximal contraction, did not differ among the groups." | 1.28 | Muscarinic-receptor functioning in tracheas from normal and ovalbumin-sensitive guinea pigs. ( Biggs, DF; Yang, ZJ, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 10 (90.91) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krasnowska, M | 1 |
| Jankowska, R | 1 |
| Jagiełło, E | 1 |
| ten Berge, RE | 1 |
| Santing, RE | 1 |
| Hamstra, JJ | 1 |
| Roffel, AF | 1 |
| Zaagsma, J | 1 |
| Cazzola, M | 2 |
| Matera, MG | 2 |
| Liccardi, G | 1 |
| Sacerdoti, G | 1 |
| D'Amato, G | 2 |
| Rossi, F | 1 |
| Ceyhan, B | 1 |
| Celikel, T | 1 |
| Simsir, S | 1 |
| Kandemir, B | 1 |
| Brown, ES | 1 |
| Khan, DA | 1 |
| Suppes, T | 1 |
| Bond, GR | 1 |
| Thompson, JD | 1 |
| Siergiejko, Z | 2 |
| Shioya, T | 1 |
| Kagaya, M | 1 |
| Onodera, A | 1 |
| Miura, S | 1 |
| Miura, K | 1 |
| Miura, M | 1 |
| Rutkowski, R | 1 |
| Chyrek-Borowska, S | 1 |
| Yang, ZJ | 1 |
| Biggs, DF | 1 |
| De Novellis, V | 1 |
| Marmo, E | 1 |
3 trials available for pirenzepine and Asthma
| Article | Year |
|---|---|
[The effect of inhaling pirenzepine--selective M1 receptor antagonist and ipratropium bromide on lung ventilation in patients with bronchial asthma].
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Bronchoconstriction; Drug Administration Sche | 1994 |
Effect of telenzepine, an M1-selective muscarinic receptor antagonist, in patients with nocturnal asthma.
Topics: Administration, Oral; Adult; Airway Obstruction; Asthma; Dose-Response Relationship, Drug; Double-Bl | 1994 |
[Effect of pirenzepine, a selective M1 muscarinic receptor antagonist, on the bronchial tree patency in patients with bronchial asthma].
Topics: Adult; Airway Obstruction; Asthma; Bronchi; Bronchodilator Agents; Dose-Response Relationship, Drug; | 1991 |
8 other studies available for pirenzepine and Asthma
| Article | Year |
|---|---|
Dysfunction of muscarinic M2 receptors after the early allergic reaction: possible contribution to bronchial hyperresponsiveness in allergic guinea-pigs.
Topics: Administration, Inhalation; Allergens; Animals; Asthma; Benzodiazepinones; Bronchial Hyperreactivity | 1995 |
Comparison of the bronchodilator efficacy of nebulized pirenzepine and ipratropium bromide in patients with airway obstructive lung disease.
Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Asthma; Female; Forced Expiratory Volume | 1993 |
Treatment of corticosteroid-induced mood changes with olanzapine.
Topics: Adrenal Cortex Hormones; Adult; Antipsychotic Agents; Asthma; Benzodiazepines; Depressive Disorder; | 1999 |
Olanzapine pediatric overdose.
Topics: Anti-Allergic Agents; Antipsychotic Agents; Asthma; Benzodiazepines; Cetirizine; Child; Drug Overdos | 1999 |
[The effect of muscarinic receptor blockers on non-specific bronchial reactivity in patients with bronchial asthma].
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Choline; Female; Histamine; Humans; Ipr | 1992 |
[The bronchodilating effect of pirenzepine].
Topics: Acetylcholine; Adult; Aged; Animals; Asthma; Bronchodilator Agents; Dogs; Dose-Response Relationship | 1991 |
Muscarinic-receptor functioning in tracheas from normal and ovalbumin-sensitive guinea pigs.
Topics: Aerosols; Animals; Asthma; Bethanidine; Electric Stimulation; Female; Gallamine Triethiodide; Guinea | 1991 |
Muscarinic M-1 receptors mediate the bronchial hyperresponsiveness during methacholine inhalation.
Topics: Administration, Inhalation; Adolescent; Adult; Airway Obstruction; Asthma; Bronchi; Bronchial Spasm; | 1989 |