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pirenzepine and Asthma, Bronchial

pirenzepine has been researched along with Asthma, Bronchial in 11 studies

Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.

Research Excerpts

ExcerptRelevanceReference
"The effect of a single intravenous dose of pirenzepine on ventilatory indices of 22 asthmatics was studied."9.07[Effect of pirenzepine, a selective M1 muscarinic receptor antagonist, on the bronchial tree patency in patients with bronchial asthma]. ( Chyrek-Borowska, S; Rutkowski, R; Siergiejko, Z, 1991)
"The effect of a single intravenous dose of pirenzepine on ventilatory indices of 22 asthmatics was studied."5.07[Effect of pirenzepine, a selective M1 muscarinic receptor antagonist, on the bronchial tree patency in patients with bronchial asthma]. ( Chyrek-Borowska, S; Rutkowski, R; Siergiejko, Z, 1991)
"The effect of two anticholinergic drugs, Ipratropium bromide, nonselective muscarinic receptor antagonist and Pirenzepine, a selective M1 receptor blocker on bronchospasm induced by metacholine and histamine was investigated."3.68[The effect of muscarinic receptor blockers on non-specific bronchial reactivity in patients with bronchial asthma]. ( Siergiejko, Z, 1992)
" To determine if postsynaptic muscarinic M-1 receptors mediate airway constriction, the action was compared of pirenzepine, that antagonizes selectively muscarinic M-1 receptors, and atropine, that blocks both muscarinic M-1 and M-2 receptors, on bronchial responses to methacholine inhalation in seven asthmatic patients."3.67Muscarinic M-1 receptors mediate the bronchial hyperresponsiveness during methacholine inhalation. ( Cazzola, M; D'Amato, G; De Novellis, V; Marmo, E; Matera, MG, 1989)
"Pirenzepine is a M1 receptor antagonist and effective in vagally-induced bronchoconstriction."1.29Comparison of the bronchodilator efficacy of nebulized pirenzepine and ipratropium bromide in patients with airway obstructive lung disease. ( Celikel, T; Ceyhan, B; Kandemir, B; Simsir, S, 1993)
" Dose-response lines in response to the two agonists, expressed as percent maximal contraction, did not differ among the groups."1.28Muscarinic-receptor functioning in tracheas from normal and ovalbumin-sensitive guinea pigs. ( Biggs, DF; Yang, ZJ, 1991)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19901 (9.09)18.7374
1990's10 (90.91)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Krasnowska, M1
Jankowska, R1
Jagiełło, E1
ten Berge, RE1
Santing, RE1
Hamstra, JJ1
Roffel, AF1
Zaagsma, J1
Cazzola, M2
Matera, MG2
Liccardi, G1
Sacerdoti, G1
D'Amato, G2
Rossi, F1
Ceyhan, B1
Celikel, T1
Simsir, S1
Kandemir, B1
Brown, ES1
Khan, DA1
Suppes, T1
Bond, GR1
Thompson, JD1
Siergiejko, Z2
Shioya, T1
Kagaya, M1
Onodera, A1
Miura, S1
Miura, K1
Miura, M1
Rutkowski, R1
Chyrek-Borowska, S1
Yang, ZJ1
Biggs, DF1
De Novellis, V1
Marmo, E1

Trials

3 trials available for pirenzepine and Asthma, Bronchial

ArticleYear
[The effect of inhaling pirenzepine--selective M1 receptor antagonist and ipratropium bromide on lung ventilation in patients with bronchial asthma].
    Pneumonologia i alergologia polska, 1994, Volume: 62, Issue:11-12

    Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Bronchoconstriction; Drug Administration Sche

1994
Effect of telenzepine, an M1-selective muscarinic receptor antagonist, in patients with nocturnal asthma.
    Pulmonary pharmacology, 1994, Volume: 7, Issue:2

    Topics: Administration, Oral; Adult; Airway Obstruction; Asthma; Dose-Response Relationship, Drug; Double-Bl

1994
[Effect of pirenzepine, a selective M1 muscarinic receptor antagonist, on the bronchial tree patency in patients with bronchial asthma].
    Pneumonologia i alergologia polska, 1991, Volume: 59, Issue:3-4

    Topics: Adult; Airway Obstruction; Asthma; Bronchi; Bronchodilator Agents; Dose-Response Relationship, Drug;

1991

Other Studies

8 other studies available for pirenzepine and Asthma, Bronchial

ArticleYear
Dysfunction of muscarinic M2 receptors after the early allergic reaction: possible contribution to bronchial hyperresponsiveness in allergic guinea-pigs.
    British journal of pharmacology, 1995, Volume: 114, Issue:4

    Topics: Administration, Inhalation; Allergens; Animals; Asthma; Benzodiazepinones; Bronchial Hyperreactivity

1995
Comparison of the bronchodilator efficacy of nebulized pirenzepine and ipratropium bromide in patients with airway obstructive lung disease.
    International journal of clinical pharmacology, therapy, and toxicology, 1993, Volume: 31, Issue:10

    Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Asthma; Female; Forced Expiratory Volume

1993
Treatment of corticosteroid-induced mood changes with olanzapine.
    The American journal of psychiatry, 1999, Volume: 156, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Antipsychotic Agents; Asthma; Benzodiazepines; Depressive Disorder;

1999
Olanzapine pediatric overdose.
    Annals of emergency medicine, 1999, Volume: 34, Issue:2

    Topics: Anti-Allergic Agents; Antipsychotic Agents; Asthma; Benzodiazepines; Cetirizine; Child; Drug Overdos

1999
[The effect of muscarinic receptor blockers on non-specific bronchial reactivity in patients with bronchial asthma].
    Pneumonologia i alergologia polska, 1992, Volume: 60, Issue:11-12

    Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Choline; Female; Histamine; Humans; Ipr

1992
[The bronchodilating effect of pirenzepine].
    Arerugi = [Allergy], 1991, Volume: 40, Issue:10

    Topics: Acetylcholine; Adult; Aged; Animals; Asthma; Bronchodilator Agents; Dogs; Dose-Response Relationship

1991
Muscarinic-receptor functioning in tracheas from normal and ovalbumin-sensitive guinea pigs.
    Canadian journal of physiology and pharmacology, 1991, Volume: 69, Issue:6

    Topics: Aerosols; Animals; Asthma; Bethanidine; Electric Stimulation; Female; Gallamine Triethiodide; Guinea

1991
Muscarinic M-1 receptors mediate the bronchial hyperresponsiveness during methacholine inhalation.
    International journal of clinical pharmacology research, 1989, Volume: 9, Issue:1

    Topics: Administration, Inhalation; Adolescent; Adult; Airway Obstruction; Asthma; Bronchi; Bronchial Spasm;

1989