pirenzepine has been researched along with Aging in 40 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The changes in extracellular acetylcholine levels were investigated by microdialysis in the cortex and hippocampus of aging rats after administration of metrifonate (80 mg/kg), rivastigmine (0." | 3.71 | Effect of subchronic administration of metrifonate, rivastigmine and donepezil on brain acetylcholine in aged F344 rats. ( Bellucci, A; Casamenti, F; Costagli, C; Pepeu, G; Scali, C; Schmidt, B, 2002) |
| "Olanzapine treated subjects showed reduced day 4 deficit (compared with day 1), with no significant difference from placebo beyond 6 h post dose." | 2.69 | A comparison of the effects of olanzapine, haloperidol and placebo on cognitive and psychomotor functions in healthy elderly volunteers. ( Beuzen, JN; Taylor, N; Wesnes, K; Wood, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (20.00) | 18.7374 |
| 1990's | 20 (50.00) | 18.2507 |
| 2000's | 10 (25.00) | 29.6817 |
| 2010's | 2 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zefirov, TL | 1 |
| Ziyatdinova, NI | 1 |
| Zefirov, AL | 1 |
| du Bois, TM | 1 |
| Newell, KA | 1 |
| Han, M | 1 |
| Deng, C | 1 |
| Huang, XF | 1 |
| Nieves-Martinez, E | 1 |
| Haynes, K | 1 |
| Childers, SR | 1 |
| Sonntag, WE | 1 |
| Nicolle, MM | 1 |
| Scali, C | 2 |
| Casamenti, F | 2 |
| Bellucci, A | 1 |
| Costagli, C | 1 |
| Schmidt, B | 1 |
| Pepeu, G | 2 |
| Santafé, MM | 1 |
| Salon, I | 1 |
| Garcia, N | 1 |
| Lanuza, MA | 1 |
| Uchitel, OD | 1 |
| Tomàs, J | 1 |
| Hernandez, CM | 1 |
| Høifødt, H | 1 |
| Terry, AV | 1 |
| Tezuka, A | 1 |
| Ishihata, A | 1 |
| Aita, T | 1 |
| Katano, Y | 1 |
| Rossi, MA | 1 |
| Mash, DC | 1 |
| deToledo-Morrell, L | 1 |
| Lopes, GS | 1 |
| Smaili, SS | 1 |
| Neto, AC | 1 |
| Vladimirova, I | 1 |
| Jurkiewicz, A | 1 |
| Jurkiewicz, NH | 1 |
| Amenta, F | 3 |
| Liu, A | 2 |
| Giannella, M | 1 |
| Pigini, M | 1 |
| Tayebati, SK | 2 |
| Zaccheo, D | 3 |
| Murakawa, T | 1 |
| Ogasawara, E | 1 |
| Takahashi, S | 1 |
| Sugihara, K | 1 |
| Muraoka, M | 1 |
| Hirota, K | 1 |
| Hashimoto, H | 1 |
| Asai, M | 1 |
| Matsuki, A | 1 |
| Zeng, YC | 1 |
| Quirion, R | 2 |
| Wilson, A | 1 |
| Rowe, W | 1 |
| Aubert, I | 1 |
| Richard, J | 1 |
| Doods, H | 1 |
| Parent, A | 1 |
| White, N | 1 |
| Meaney, MJ | 2 |
| Bielarczyk, H | 1 |
| Tomsig, JL | 1 |
| Suszkiw, JB | 1 |
| Wills-Karp, M | 1 |
| Poller, U | 2 |
| Nedelka, G | 1 |
| Radke, J | 2 |
| Pönicke, K | 1 |
| Brodde, OE | 2 |
| Vannucchi, MG | 2 |
| Kopf, SR | 1 |
| Konschak, U | 1 |
| Becker, K | 1 |
| Rüter, F | 1 |
| Jakubetz, J | 1 |
| Zerkowski, HR | 1 |
| Sweet, RA | 1 |
| Pollock, BG | 1 |
| Beuzen, JN | 1 |
| Taylor, N | 1 |
| Wesnes, K | 1 |
| Wood, A | 1 |
| Madhusoodanan, S | 1 |
| Suresh, P | 1 |
| Brenner, R | 1 |
| Pillai, R | 1 |
| Weiss, C | 1 |
| Preston, AR | 1 |
| Oh, MM | 1 |
| Schwarz, RD | 2 |
| Welty, D | 1 |
| Disterhoft, JF | 1 |
| El-Assouad, D | 1 |
| Zhang, X | 1 |
| Tian, JY | 1 |
| Svensson, AL | 1 |
| Gong, ZH | 1 |
| Meyerson, B | 1 |
| Nordberg, A | 1 |
| Su, N | 1 |
| Narayanan, N | 1 |
| Goldman-Rakic, PS | 1 |
| Imperato, A | 1 |
| Scrocco, MG | 1 |
| Ghirardi, O | 1 |
| Ramacci, MT | 1 |
| Angelucci, L | 1 |
| Kostic, V | 1 |
| Przedborski, S | 1 |
| Jackson-Lewis, V | 1 |
| Cadet, JL | 1 |
| Burke, RE | 1 |
| Pietrzak, ER | 1 |
| Wilce, PA | 1 |
| Shanley, BC | 1 |
| Bernabei, AA | 1 |
| Spencer, CJ | 1 |
| Pugsley, TA | 1 |
| Wagster, MV | 1 |
| Whitehouse, PJ | 1 |
| Walker, LC | 1 |
| Kellar, KJ | 1 |
| Price, DL | 1 |
| Araujo, DM | 1 |
| Lapchak, PA | 1 |
| Collier, B | 1 |
| Shaw, C | 1 |
| Prusky, G | 1 |
| van Huizen, F | 1 |
| Cynader, M | 1 |
| Nastuk, MA | 1 |
| Graybiel, AM | 1 |
| Sirviö, J | 2 |
| Hervonen, A | 2 |
| Riekkinen, PJ | 2 |
| Valjakka, A | 1 |
| Watson, M | 1 |
| Roeske, WR | 1 |
| Yamamura, HI | 1 |
| Surichamorn, W | 1 |
| Kim, ON | 1 |
| Lee, NH | 1 |
| Lai, WS | 1 |
| el-Fakahany, EE | 1 |
| Smith, CJ | 1 |
| Perry, EK | 1 |
| Perry, RH | 1 |
| Candy, JM | 1 |
| Johnson, M | 1 |
| Bonham, JR | 1 |
| Dick, DJ | 1 |
| Fairbairn, A | 1 |
| Blessed, G | 1 |
| Birdsall, NJ | 1 |
| Norman, AB | 1 |
| Blaker, SN | 1 |
| Thal, L | 1 |
| Creese, I | 1 |
2 reviews available for pirenzepine and Aging
| Article | Year |
|---|---|
New atypical antipsychotics. Experience and utility in the elderly.
Topics: Aged; Aging; Antipsychotic Agents; Benzodiazepines; Clozapine; Humans; Imidazoles; Indoles; Olanzapi | 1998 |
Pre- and postsynaptic markers of cholinergic neurons in the cerebral cortex of rats of different ages.
Topics: Acetylcholinesterase; Age Factors; Aging; Animals; Binding Sites; Cerebral Cortex; Choline O-Acetylt | 1988 |
2 trials available for pirenzepine and Aging
| Article | Year |
|---|---|
[Does aging influence effect of pirenzepine alone or combination of pirenzepine and famotidine on gastric secretion during anesthesia and surgery?].
Topics: Adolescent; Adult; Aged; Aging; Depression, Chemical; Elective Surgical Procedures; Famotidine; Fema | 1995 |
A comparison of the effects of olanzapine, haloperidol and placebo on cognitive and psychomotor functions in healthy elderly volunteers.
Topics: Aged; Aged, 80 and over; Aging; Antipsychotic Agents; Attention; Benzodiazepines; Cognition; Cross-O | 1999 |
36 other studies available for pirenzepine and Aging
| Article | Year |
|---|---|
Age-related peculiarities of inotropic response of rat myocardium to selective block of M1-cholinoreceptors.
Topics: Age Factors; Aging; Animals; Carbachol; Cholinergic Agonists; Cholinergic Antagonists; Depression, C | 2013 |
Perinatal PCP treatment alters the developmental expression of prefrontal and hippocampal muscarinic receptors.
Topics: Aging; Animals; Animals, Newborn; Excitatory Amino Acid Antagonists; Female; Hippocampus; Muscarinic | 2009 |
Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats.
Topics: Aging; Animals; Attention; Autoradiography; Cognition Disorders; Corpus Striatum; Food Deprivation; | 2012 |
Effect of subchronic administration of metrifonate, rivastigmine and donepezil on brain acetylcholine in aged F344 rats.
Topics: Acetylcholine; Aging; Animals; Body Weight; Brain; Carbamates; Cerebral Cortex; Cholinesterase Inhib | 2002 |
Modulation of ACh release by presynaptic muscarinic autoreceptors in the neuromuscular junction of the newborn and adult rat.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Autoreceptors; Calcium Channel Blockers; Calcium Ch | 2003 |
Spontaneously hypertensive rats: further evaluation of age-related memory performance and cholinergic marker expression.
Topics: Aging; Animals; Binding Sites; Biomarkers; Brain; Bridged Bicyclo Compounds, Heterocyclic; Disease M | 2003 |
Aging-related alterations in the contractile responses to acetylcholine, muscarinic cholinoceptors and cholinesterase activities in jejunum and colon of the male Fischer 344 rats.
Topics: Acetylcholine; Aging; Animals; Atropine; Cholinesterases; Colon; Diamines; Dose-Response Relationshi | 2004 |
Spatial memory in aged rats is related to PKCgamma-dependent G-protein coupling of the M1 receptor.
Topics: Age Factors; Aging; Analysis of Variance; Animals; Behavior, Animal; Binding, Competitive; Carbachol | 2005 |
Aging-induced decrease of cholinergic response and calcium sensitivity on rat jejunum contractions.
Topics: Adrenergic Agonists; Aging; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Sig | 2007 |
Age-related changes in the density of muscarinic cholinergic M1 and M2 receptor subtypes in pyramidal neurons of the rat hippocampus.
Topics: Aging; Animals; Autoradiography; Hippocampus; Male; Parasympatholytics; Pirenzepine; Pyramidal Cells | 1995 |
Muscarinic cholinergic receptors in the hippocampus of aged rats: influence of choline alphoscerate treatment.
Topics: Aging; Animals; Autoradiography; Glycerylphosphorylcholine; Hippocampus; Male; Osmolar Concentration | 1994 |
Facilitation of acetylcholine release and cognitive performance by an M(2)-muscarinic receptor antagonist in aged memory-impaired.
Topics: Acetylcholine; Aging; Animals; Cognition; Dibenzazepines; Male; Maze Learning; Memory Disorders; Mus | 1995 |
Perinatal low-level lead exposure and the septo-hippocampal cholinergic system: selective reduction of muscarinic receptors and cholineacetyltransferase in the rat septum.
Topics: Aging; Animals; Brain; Choline O-Acetyltransferase; Embryonic and Fetal Development; Female; Glutama | 1994 |
Age-related changes in pulmonary muscarinic receptor binding properties.
Topics: Aging; Animals; Binding, Competitive; Guinea Pigs; Lung; Male; Muscarine; Parasympathomimetics; Pipe | 1993 |
Age-dependent changes in cardiac muscarinic receptor function in healthy volunteers.
Topics: Adult; Aging; Atropine; Baroreflex; Blood Pressure; Heart; Heart Rate; Humans; Male; Middle Aged; Mu | 1997 |
Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats.
Topics: Acetylcholine; Aging; Animals; Cerebral Cortex; Male; Memory; Parasympatholytics; Pirenzepine; Rats; | 1997 |
Cardiac muscarinic receptors decrease with age. In vitro and in vivo studies.
Topics: Acetylcholine; Adenylyl Cyclases; Adult; Aged; Aging; Child; Dose-Response Relationship, Drug; Heart | 1998 |
Experience with the atypical antipsychotics--risperidone and olanzapine in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Antipsychotic Agents; Benzodiazepines; Comorbidity; Female; Geriatri | 1999 |
The M1 muscarinic agonist CI-1017 facilitates trace eyeblink conditioning in aging rabbits and increases the excitability of CA1 pyramidal neurons.
Topics: Acoustic Stimulation; Action Potentials; Aging; Animals; Blinking; Bridged Bicyclo Compounds, Hetero | 2000 |
Muscarinic cholinergic receptor subtypes in the hippocampus of aged rats.
Topics: Aging; Animals; Hippocampus; Male; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Inbred F344; Rec | 2002 |
Chronic treatments with tacrine and (-)-nicotine induce different changes of nicotinic and muscarinic acetylcholine receptors in the brain of aged rat.
Topics: Aging; Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Drug Administration S | 2002 |
Enhanced chronotropic and inotropic responses of rat myocardium to cholinergic stimulus with aging.
Topics: Acetylcholine; Acetylcholinesterase; Aging; Animals; Carbachol; Heart; Heart Rate; In Vitro Techniqu | 1992 |
Age-dependent decrease in the affinity of muscarinic M1 receptors in neocortex of rhesus monkeys.
Topics: Aging; Animals; Autoradiography; Binding, Competitive; Carbachol; Cerebral Cortex; Kinetics; Macaca | 1991 |
In vivo probing of the brain cholinergic system in the aged rat. Effects of long-term treatment with acetyl-L-carnitine.
Topics: Acetylcarnitine; Acetylcholine; Aging; Analysis of Variance; Animals; Atropine; Hippocampus; Male; P | 1991 |
Effect of unilateral perinatal hypoxic-ischemic brain injury in the rat on striatal muscarinic cholinergic receptors and high-affinity choline uptake sites: a quantitative autoradiographic study.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Binding, Competitive; Brain Ischemia; Choline; Co | 1991 |
Interaction of chronic ethanol consumption and aging on brain muscarinic cholinergic receptors.
Topics: Aging; Animals; Binding Sites; Brain; Carbachol; Ethanol; Male; Pirenzepine; Quinuclidinyl Benzilate | 1990 |
Loss of muscarinic M1 receptors with aging in the cerebral cortex of Fisher 344 rats.
Topics: Aging; Animals; Cerebral Cortex; Male; Pirenzepine; Quinuclidinyl Benzilate; Rats; Rats, Inbred F344 | 1990 |
Laminar organization and age-related loss of cholinergic receptors in temporal neocortex of rhesus monkey.
Topics: Aging; Animals; Autoradiography; Macaca mulatta; N-Methylscopolamine; Oxotremorine; Pirenzepine; Rec | 1990 |
Effects of aging on nicotinic and muscarinic autoreceptor function in the rat brain: relationship to presynaptic cholinergic markers and binding sites.
Topics: Acetylcholine; Aging; Animals; Brain; Carbachol; Cerebral Cortex; Choline O-Acetyltransferase; Corpu | 1990 |
Differential effects of quinolinic acid lesions on muscarinic acetylcholine receptors in cat visual cortex during postnatal development.
Topics: Aging; Animals; Cats; Pirenzepine; Pyridines; Quinolinic Acid; Quinolinic Acids; Receptors, Muscarin | 1989 |
Ontogeny of M1 and M2 muscarinic binding sites in the striatum of the cat: relationships to one another and to striatal compartmentalization.
Topics: Aging; Animals; Binding, Competitive; Cats; Corpus Striatum; Embryonic and Fetal Development; Gestat | 1989 |
Cholinergic binding in the hippocampus of the aging male rat.
Topics: Aging; Animals; Hippocampus; In Vitro Techniques; Male; Nicotine; Pirenzepine; Rats; Rats, Inbred St | 1988 |
Decreased muscarinic receptor density in the aged rat brain.
Topics: Aging; Animals; Brain; Kinetics; Pirenzepine; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic | 1988 |
Effects of aging on the interaction of quinuclidinyl benzilate, N-methylscopolamine, pirenzepine, and gallamine with brain muscarinic receptors.
Topics: Aging; Animals; Binding, Competitive; Cerebellum; Cerebral Cortex; Corpus Striatum; Gallamine Trieth | 1988 |
Muscarinic cholinergic receptor subtypes in hippocampus in human cognitive disorders.
Topics: Acetylcholinesterase; Aging; Choline O-Acetyltransferase; Cognition Disorders; Hippocampus; Humans; | 1988 |
Effects of aging and cholinergic deafferentation on putative muscarinic cholinergic receptor subtypes in rat cerebral cortex.
Topics: Acetylcholine; Aging; Animals; Binding, Competitive; Cerebral Cortex; Choline O-Acetyltransferase; D | 1986 |