pirenzepine has been researched along with Adipocere in 9 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have previously shown a decrease in [(3)H]pirenzepine binding to M1/M4 muscarinic receptors in the anterior cingulate cortex in schizophrenia but not in major depression or bipolar disorder." | 3.73 | M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders. ( Huang, XF; Katsifis, A; Yu, Y; Zavitsanou, K, 2005) |
| "Olanzapine is a relatively new antipsychotic drug used in the United States for the treatment of schizophrenia." | 3.71 | Tissue distribution of olanzapine in a postmortem case. ( Felo, JA; Jenkins, AJ; Merrick, TC, 2001) |
| "Schizophrenia is widely acknowledged as being a syndrome, consisting of an undefined number of diseases probably with differing pathologies." | 1.35 | Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia. ( Cowie, TF; Dean, B; Kanellakis, S; Pantelis, C; Scarr, E; Sundram, S, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (88.89) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zavitsanou, K | 1 |
| Katsifis, A | 1 |
| Yu, Y | 1 |
| Huang, XF | 1 |
| Matsumoto, I | 1 |
| Inoue, Y | 1 |
| Iwazaki, T | 1 |
| Pavey, G | 1 |
| Dean, B | 2 |
| Teaktong, T | 1 |
| Piggott, MA | 2 |
| Mckeith, IG | 1 |
| Perry, RH | 1 |
| Ballard, CG | 1 |
| Perry, EK | 1 |
| Tsang, SW | 2 |
| Lai, MK | 2 |
| Kirvell, S | 1 |
| Francis, PT | 1 |
| Esiri, MM | 1 |
| Hope, T | 1 |
| Chen, CP | 2 |
| Wong, PT | 2 |
| Pomakian, J | 1 |
| Marshall, GA | 1 |
| Vinters, HV | 1 |
| Cummings, JL | 1 |
| Warren, NM | 1 |
| Greally, E | 1 |
| Lake, M | 1 |
| Lees, AJ | 1 |
| Burn, DJ | 1 |
| Scarr, E | 1 |
| Cowie, TF | 1 |
| Kanellakis, S | 1 |
| Sundram, S | 1 |
| Pantelis, C | 1 |
| Merrick, TC | 1 |
| Felo, JA | 1 |
| Jenkins, AJ | 1 |
| Burke, RE | 1 |
| Greenbaum, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Muscarinic M1 Receptor Availability and Cognition in Schizophrenia[NCT05105542] | Phase 2 | 18 participants (Anticipated) | Interventional | 2021-04-20 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for pirenzepine and Adipocere
| Article | Year |
|---|---|
M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders.
Topics: Adult; Age of Onset; Analysis of Variance; Autoradiography; Brain Mapping; Case-Control Studies; Dos | 2005 |
5-HT2A and muscarinic receptors in schizophrenia: a postmortem study.
Topics: Aged; Aged, 80 and over; Autoradiography; Brain; Case-Control Studies; Female; Humans; Ketanserin; M | 2005 |
Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Autoradiography; Binding, Competitive; Case-Control S | 2005 |
Impaired coupling of muscarinic M1 receptors to G-proteins in the neocortex is associated with severity of dementia in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Brain Chemistry; Choline O-Acetylt | 2006 |
Disrupted muscarinic M1 receptor signaling correlates with loss of protein kinase C activity and glutamatergic deficit in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Brain Chemistry; Case-Control Studies; Dizocilpin | 2007 |
Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy.
Topics: Aged; Aged, 80 and over; Autoradiography; Azetidines; Basal Ganglia; Dopamine Plasma Membrane Transp | 2007 |
Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Cohort Studies; Down-Regulation; Female; Human | 2009 |
Tissue distribution of olanzapine in a postmortem case.
Topics: Adult; Antipsychotic Agents; Autopsy; Benzodiazepines; Drug Overdose; Forensic Anthropology; Gas Chr | 2001 |
Effect of postmortem factors on muscarinic receptor subtypes in rat brain.
Topics: Animals; Brain; Freezing; Kinetics; Male; Pirenzepine; Postmortem Changes; Quinuclidinyl Benzilate; | 1987 |