pirenzepine has been researched along with Acromegaly in 5 studies
Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Acromegaly: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to ascertain if pirenzepine (Pz), an antimuscarinic drug, could inhibit GH secretion in acromegaly, 8 patients were submitted to 3 successive treatment courses of 9 days each: Pz, bromocriptine (BRC) and Pz plus BRC." | 7.68 | Effects of pirenzepine, bromocriptine and their association on basal and GHRH- and TRH-induced GH secretion in acromegaly. ( Fiszlejder, L; Guitelman, A; Oneto, A; Penacini, O; Ratz, S; Storani, M, 1991) |
| "In order to ascertain if pirenzepine (Pz), an antimuscarinic drug, could inhibit GH secretion in acromegaly, 8 patients were submitted to 3 successive treatment courses of 9 days each: Pz, bromocriptine (BRC) and Pz plus BRC." | 3.68 | Effects of pirenzepine, bromocriptine and their association on basal and GHRH- and TRH-induced GH secretion in acromegaly. ( Fiszlejder, L; Guitelman, A; Oneto, A; Penacini, O; Ratz, S; Storani, M, 1991) |
| "pirenzepine was unable to modify the basal GH levels whilst it showed a variable inhibitory effect on the GH response to GHRH." | 1.27 | Cholinergic involvement in the growth hormone releasing hormone-induced growth hormone release: studies in normal and acromegalic subjects. ( Camanni, F; Demislis, K; Ghigo, E; Locatelli, V; Massara, F; Mazza, E; Molinatti, GM; Müller, EE; Tangolo, D, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Attanasio, R | 1 |
| Cozzi, R | 1 |
| Oppizzi, G | 1 |
| Dallabonzana, D | 1 |
| Chiodini, I | 1 |
| Benini, Z | 1 |
| Orlandi, P | 1 |
| Liuzzi, A | 1 |
| Chiodini, PG | 1 |
| Fiszlejder, L | 2 |
| Penacini, O | 2 |
| Ratz, S | 2 |
| Oneto, A | 2 |
| Storani, M | 2 |
| Rizzo, L | 1 |
| Guitelman, A | 2 |
| Jordan, V | 1 |
| Dieguez, C | 1 |
| Valcavi, R | 1 |
| Artioli, C | 1 |
| Portioli, I | 1 |
| Rodriguez-Arnao, MD | 1 |
| Gomez-Pan, A | 1 |
| Hall, R | 1 |
| Scanlon, MF | 1 |
| Massara, F | 1 |
| Ghigo, E | 1 |
| Demislis, K | 1 |
| Tangolo, D | 1 |
| Mazza, E | 1 |
| Locatelli, V | 1 |
| Müller, EE | 1 |
| Molinatti, GM | 1 |
| Camanni, F | 1 |
1 trial available for pirenzepine and Acromegaly
| Article | Year |
|---|---|
Lack of effect of muscarinic cholinergic blockade on the GH responses to GRF 1-29 and TRH in acromegalic subjects.
Topics: Acromegaly; Adult; Aged; Benzodiazepinones; Female; Growth Hormone; Growth Hormone-Releasing Hormone | 1986 |
4 other studies available for pirenzepine and Acromegaly
| Article | Year |
|---|---|
Persistence of somatostatinergic tone in acromegaly.
Topics: Acromegaly; Adult; Aged; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Male; Mid | 1995 |
Cholinergic modulation of GH secretion in acromegalic patients before and after pituitary surgery.
Topics: Acromegaly; Adult; Cholinergic Fibers; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Hum | 1992 |
Effects of pirenzepine, bromocriptine and their association on basal and GHRH- and TRH-induced GH secretion in acromegaly.
Topics: Acromegaly; Adult; Bromocriptine; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; | 1991 |
Cholinergic involvement in the growth hormone releasing hormone-induced growth hormone release: studies in normal and acromegalic subjects.
Topics: Acromegaly; Adult; Aged; Atropine; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; | 1986 |