pirarubicin and Stomatitis

pirarubicin has been researched along with Stomatitis* in 2 studies

Other Studies

2 other study(ies) available for pirarubicin and Stomatitis

Article	Year
[A phase II study of (2''R)-4'-O-tetrahydropyranyladriamycin (THP) in patients with head and neck cancer]. Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:5 A phase II study of a new anthracycline, (2"R)-4'-O-tetrahydropyranyladriamycin (THP), was conducted in 110 patients with various head and neck cancers in a multi-institutional cooperative study. The response rate was 20.3% (PR 12) in an intravenously injected group and 52.3% (CR 8, PR 15) in an intraarterially injected group. In the former cases, the response rate according to primary sites was 19.2 to 27.3% for the maxilla, pharynx, oral cavity and larynx. In the latter cases, it was 40.9 to 64.3% for the maxilla, pharynx and oral cavity, and 100% for the external auditory meatus (CR 1, PR 1). According to histology, the response rate was 37.5 % in squamous cell carcinoma. Partial response was observed in two cases of undifferentiated carcinoma. The predominant toxicity was myelosuppression. Leukocytopenia (less than 3,000/mm3) was noted in 44 cases (41.9%). Loss of hair and stomatitis were observed in 13 (12.6%) and 12 (11.7%) respectively. However, these were mild and recovered quickly on discontinuation of THP. We concluded that THP therapy was markedly effective for various head and neck cancers. Topics: Alopecia; Doxorubicin; Drug Administration Schedule; Drug Evaluation; Head and Neck Neoplasms; Humans; Infusions, Intra-Arterial; Infusions, Parenteral; Leukopenia; Stomatitis	1986
[Effects of single administration of tetrahydropyranyladriamycin (THP) in lymphoid malignancy]. Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:7 Of 3 patients with adult ALL and 23 patients with NHL treated with intravenous administration of 10 mg/M2 of THP for 5 consecutive days, complete remission was observed in 3 patients and partial remission in 14. The antitumor spectrum of THP seemed to be similar to that of Adriamycin from evidence that THP was effective in patients with NHL of diffuse large and mixed cell type. Neither cardiotoxicity nor alopecia was noticed. Anorexia, nausea or vomiting was mild but granulocytopenia and thrombocytopenia were severe in the patients with ALL and leukemic type NHL. Further studies are required for determining cross resistance to other anthracyclines and an optimal dose schedule. Topics: Adult; Aged; Anorexia; Antibiotics, Antineoplastic; Doxorubicin; Drug Administration Schedule; Female; Humans; Leukemia, Lymphoid; Leukopenia; Lymphoma; Male; Middle Aged; Naphthacenes; Nausea; Stomatitis; Thrombocytopenia	1984

Article

Year

[A phase II study of (2''R)-4'-O-tetrahydropyranyladriamycin (THP) in patients with head and neck cancer].

Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:5

A phase II study of a new anthracycline, (2"R)-4'-O-tetrahydropyranyladriamycin (THP), was conducted in 110 patients with various head and neck cancers in a multi-institutional cooperative study. The response rate was 20.3% (PR 12) in an intravenously injected group and 52.3% (CR 8, PR 15) in an intraarterially injected group. In the former cases, the response rate according to primary sites was 19.2 to 27.3% for the maxilla, pharynx, oral cavity and larynx. In the latter cases, it was 40.9 to 64.3% for the maxilla, pharynx and oral cavity, and 100% for the external auditory meatus (CR 1, PR 1). According to histology, the response rate was 37.5 % in squamous cell carcinoma. Partial response was observed in two cases of undifferentiated carcinoma. The predominant toxicity was myelosuppression. Leukocytopenia (less than 3,000/mm3) was noted in 44 cases (41.9%). Loss of hair and stomatitis were observed in 13 (12.6%) and 12 (11.7%) respectively. However, these were mild and recovered quickly on discontinuation of THP. We concluded that THP therapy was markedly effective for various head and neck cancers.

Topics: Alopecia; Doxorubicin; Drug Administration Schedule; Drug Evaluation; Head and Neck Neoplasms; Humans; Infusions, Intra-Arterial; Infusions, Parenteral; Leukopenia; Stomatitis

1986

[Effects of single administration of tetrahydropyranyladriamycin (THP) in lymphoid malignancy].

Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:7

Of 3 patients with adult ALL and 23 patients with NHL treated with intravenous administration of 10 mg/M2 of THP for 5 consecutive days, complete remission was observed in 3 patients and partial remission in 14. The antitumor spectrum of THP seemed to be similar to that of Adriamycin from evidence that THP was effective in patients with NHL of diffuse large and mixed cell type. Neither cardiotoxicity nor alopecia was noticed. Anorexia, nausea or vomiting was mild but granulocytopenia and thrombocytopenia were severe in the patients with ALL and leukemic type NHL. Further studies are required for determining cross resistance to other anthracyclines and an optimal dose schedule.

Topics: Adult; Aged; Anorexia; Antibiotics, Antineoplastic; Doxorubicin; Drug Administration Schedule; Female; Humans; Leukemia, Lymphoid; Leukopenia; Lymphoma; Male; Middle Aged; Naphthacenes; Nausea; Stomatitis; Thrombocytopenia

1984