pirarubicin and Leukemia-Lymphoma--Adult-T-Cell

Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Doxorubicin; Drug Administration Schedule; Female; Granulocyte Colony-Stimulating Factor; Humans; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Middle Aged; Pilot Projects; Recombinant Proteins

In the present report, we describe a case of adult T cell leukemia/lymphoma (ATLL), a 58-year-old woman, successfully treated with interferon (IFN)-alpha following autologous peripheral blood stem cell transplantation (auto-PBSCT). The patient remains in remission with full performance status for more than 12 months. Auto-PBSCT reduced the abdominal lymphoma mass and IFN-alpha eliminated residual tumor cells, possibly through the induction of specific T-cell subsets expressing CD3, CD8 on their surfaces and either IFN-gamma or tumor necrosis factor (TNF)-alpha in cytoplasm. We have treated a total of 4 ATLL patients with auto-PBSCT, including the case presented herein. All other patients treated with auto-PBSCT were not followed by adjuvant chemotherapy or cytokine therapy and relapsed within 3 months after auto-PBSCT. This evidence suggests that the therapeutic success of the present case was attributable to the administration of IFN-alpha immunotherapy following auto-PBSCT.

Topics: Abdominal Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Combined Modality Therapy; Doxorubicin; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Human T-lymphotropic virus 1; Humans; Immunologic Factors; Interferon-alpha; Killer Cells, Natural; Leukemia-Lymphoma, Adult T-Cell; Middle Aged; Nitrosourea Compounds; Remission Induction; T-Lymphocytes, Cytotoxic; Transplantation, Autologous; Vincristine

Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Female; Humans; Infant; Leukemia-Lymphoma, Adult T-Cell; Neoplasms, Second Primary; Neuroblastoma