pirarubicin and Leukemia--Promyelocytic--Acute

Pirarubicin (THP) has shown equal or superior cytotoxicity compared to doxorubicin. One of the main anticancer actions of doxorubicin is believed to be involved in ROS (reactive oxygen species) generation. Therefore, the anticancer mechanisms of THP may involve ROS generation. The aim of this study was to clarify the mechanisms of THP-induced apoptosis through ROS generation.. We analyzed the apoptotic events induced by THP in HL-60 cells and HP100 cells, hydrogen peroxide (H. These findings can be explained by the involvement of H

Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Doxorubicin; Humans; Hydrogen Peroxide; Leukemia, Promyelocytic, Acute; Membrane Potential, Mitochondrial; Reactive Oxygen Species; Tumor Cells, Cultured