pirarubicin and Endodermal-Sinus-Tumor

Six patients (aged 3-36 mo) with vaginal tumors (rhabdomyosarcoma and endodermal sinus tumor [EST]; n = 3 each) received intraarterial chemotherapy (IAC) and intravenous chemotherapy. Patients underwent internal iliac artery infusion with cisplatin, pirarubicin, and vindesine. Intravenous chemotherapy with vindesine, ifosfamide, and etoposide was administered after 3 weeks. Vaginal tumors disappeared in all patients after 2 or 3 cycles of alternating therapy. Two patients underwent resection of pelvic metastases. Intravenous consolidation chemotherapy was applied. Four patients were disease-free at a median follow-up of 5.8 years. One patient had pelvic recurrence treated with "salvage" therapy with IAC and surgery and was disease-free for 2.5 years.

Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy; Child, Preschool; China; Cisplatin; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Endodermal Sinus Tumor; Etoposide; Female; Humans; Ifosfamide; Iliac Artery; Infant; Infusions, Intra-Arterial; Infusions, Intravenous; Metastasectomy; Neoadjuvant Therapy; Pelvic Neoplasms; Retrospective Studies; Rhabdomyosarcoma, Embryonal; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Vaginal Neoplasms; Vindesine