pirarubicin and Dysgerminoma

A 5-year-old girl presented with a painful abdominal mass. Abdominal magnetic resonance imaging (MRI) showed 3 separate masses. Tumor markers including lactate dehydrogenase (LDH), cancer antigen-125 (CA-125), beta-subunit of human chorionic gonadotropin (beta-hCG) and neuron-specific enolase (NSE) were elevated. At operation, the main tumor arose from the left ovary and was associated with torsion, whereas the other lesions were lymph node metastases. A salpingo-oophorectomy was performed. Histopathologic examination indicated that the tumor was a dysgerminoma. Immunohistochemicallly, the cells were positive for NSE and placental alkaline phosphatase (PALP) but were negative for CA-125, beta-hCG, S-100, glial fibrillary acidic protein, and vimentin. The elevated serum levels of tumor markers improved dramatically after the operation and chemotherapy.

Topics: Alkaline Phosphatase; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Bleomycin; CA-125 Antigen; CA-19-9 Antigen; Carboplatin; Child, Preschool; Chorionic Gonadotropin, beta Subunit, Human; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Dysgerminoma; Female; Humans; Isoenzymes; L-Lactate Dehydrogenase; Neoplasm Proteins; Ovarian Neoplasms; Ovariectomy; Phosphopyruvate Hydratase; Torsion Abnormality; Vinblastine