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piracetam and HbS Disease

piracetam has been researched along with HbS Disease in 24 studies

Piracetam: A compound suggested to be both a nootropic and a neuroprotective agent.

Research Excerpts

ExcerptRelevanceReference
"To assess the effectiveness of piracetam for reducing the incidence of painful sickle cell disease crises."8.93Piracetam for reducing the incidence of painful sickle cell disease crises. ( Al Hajeri, A; Fedorowicz, Z, 2016)
"To assess the effectiveness of piracetam for reducing the incidence of painful sickle cell disease crises."8.84Piracetam for reducing the incidence of painful sickle cell disease crises. ( Al Hajeri, AA; Fedorowicz, Z; Omran, A; Tadmouri, GO, 2007)
" Since Piracetam (2-oxo-1 pyrrolidine acetamide) has been shown to have a number of clinically beneficial actions on the formed elements of the blood including disengagement of adherent diabetic and sickle erythrocytes there is a rational basis for the trial of Piracetam as an adjuvant drug in SS disease and in diabetes mellitus to improve function of the microcirculation."7.66Erythrocyte - endothelial cell adherence in sickle cell disease, diabetes mellitus, and falciparum malaria: adverse effects reversed with piracetam. ( Burek, L; Collier, BD; Diglio, CA; Fleischman, JA; Henry, RL; Nalbandian, RM; O'Donnell, FE; Reeser, FH; Williams, G, 1982)
"Piracetam is a nootropic drug that has reportedly been effective and non-toxic in sickle cell patients, but most studies were not placebo-controlled and included a small number of patients."6.71Inefficacy of piracetam in the prevention of painful crises in children and adolescents with sickle cell disease. ( Alvim, RC; Brito, AC; Franklin, HM; Oliveira, TF; Paula, MJ; Pires, MA; Rezende, PV; Viana, MB, 2005)
"To assess the effectiveness of piracetam for reducing the incidence of painful sickle cell disease crises."4.93Piracetam for reducing the incidence of painful sickle cell disease crises. ( Al Hajeri, A; Fedorowicz, Z, 2016)
"To assess the effectiveness of piracetam for reducing the incidence of painful sickle cell disease crises."4.84Piracetam for reducing the incidence of painful sickle cell disease crises. ( Al Hajeri, AA; Fedorowicz, Z; Omran, A; Tadmouri, GO, 2007)
" Since Piracetam (2-oxo-1 pyrrolidine acetamide) has been shown to have a number of clinically beneficial actions on the formed elements of the blood including disengagement of adherent diabetic and sickle erythrocytes there is a rational basis for the trial of Piracetam as an adjuvant drug in SS disease and in diabetes mellitus to improve function of the microcirculation."3.66Erythrocyte - endothelial cell adherence in sickle cell disease, diabetes mellitus, and falciparum malaria: adverse effects reversed with piracetam. ( Burek, L; Collier, BD; Diglio, CA; Fleischman, JA; Henry, RL; Nalbandian, RM; O'Donnell, FE; Reeser, FH; Williams, G, 1982)
"Piracetam is a nootropic drug that has reportedly been effective and non-toxic in sickle cell patients, but most studies were not placebo-controlled and included a small number of patients."2.71Inefficacy of piracetam in the prevention of painful crises in children and adolescents with sickle cell disease. ( Alvim, RC; Brito, AC; Franklin, HM; Oliveira, TF; Paula, MJ; Pires, MA; Rezende, PV; Viana, MB, 2005)
"Sickle cell disease is an inherited disorder of hemoglobin, resulting in abnormal red blood cells."2.58Drugs for preventing red blood cell dehydration in people with sickle cell disease. ( Ballas, SK; Nagalla, S, 2018)
"Sickle cell disease is an inherited disorder of hemoglobin, resulting in abnormal red blood cells."2.53Drugs for preventing red blood cell dehydration in people with sickle cell disease. ( Ballas, SK; Nagalla, S, 2016)
"Sickle cell disease is an inherited disorder of hemoglobin, resulting in abnormal red blood cells."2.48Drugs for preventing red blood cell dehydration in people with sickle cell disease. ( Ballas, SK; Nagalla, S, 2012)
"Sickle cell disease is an inherited disorder of haemoglobin, which results in abnormal red blood cells."2.44Drugs for preventing red blood cell dehydration in people with sickle cell disease. ( Ballas, SK; Singh, PC, 2007)
"Sickle cell disease is an inherited disorder of haemoglobin, which results in abnormal red blood cells."2.41Drugs for preventing red blood cell dehydration in people with sickle cell disease. ( De Franceschi, L; Riddington, C, 2002)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199013 (54.17)18.7374
1990's1 (4.17)18.2507
2000's6 (25.00)29.6817
2010's4 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nagalla, S3
Ballas, SK4
Al Hajeri, A1
Fedorowicz, Z2
Viana, MB2
Alvim, RC2
Riddington, C1
De Franceschi, L1
Pires, MA1
Franklin, HM1
Paula, MJ1
Brito, AC1
Oliveira, TF1
Rezende, PV1
Winblad, B1
Al Hajeri, AA1
Omran, A1
Tadmouri, GO1
Singh, PC1
Franklin, IM1
Aluoch, JR1
Nalbandian, RM3
Henry, RL3
Burek, CL1
Diglio, CA2
Goldman, AI1
Taylor, GW1
Hoffman, WH1
Fleischman, JA1
Burek, L1
Williams, G1
O'Donnell, FE1
Collier, BD1
Reeser, FH1
Asakura, T1
Ohnishi, ST1
Adachi, K1
Ozguc, M1
Hashimoto, K1
Devlin, MT1
Schwartz, E1
el-Hazmi, MA1
Warsy, AS1
al-Fawaz, I1
Opawoye, AO1
Taleb, HA1
Howsawi, Z1
Mohamed, AA1
Aly, AW1
Refai, S1
Sugathan, PS1
Rab, AS1
Ahmed, HB1
Abulaban, M1
Abdulkader, AM1
Farid, M1
de Melo, GO1
de Araujo, JT1
Nero, GS1
Murayama, M1
Costa, FF1
Zago, MA1
Bottura, C1
Salzano, FM1
Guardigni, L1
Salvi, P1
Passini, S1
Stagno, S1
Pretolani, E1
Gini, EK2
Sonnet, J2
Cornu, G1

Reviews

9 reviews available for piracetam and HbS Disease

ArticleYear
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
    The Cochrane database of systematic reviews, 2018, 10-19, Volume: 10

    Topics: Acetamides; Anemia, Sickle Cell; Antisickling Agents; Clinical Trials, Phase II as Topic; Clinical T

2018
Piracetam for reducing the incidence of painful sickle cell disease crises.
    The Cochrane database of systematic reviews, 2016, Feb-12, Volume: 2

    Topics: Adolescent; Anemia, Sickle Cell; Antisickling Agents; Child; Child, Preschool; Humans; Pain; Piracet

2016
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
    The Cochrane database of systematic reviews, 2016, Mar-04, Volume: 3

    Topics: Acetamides; Anemia, Sickle Cell; Antisickling Agents; Clinical Trials, Phase II as Topic; Clinical T

2016
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
    The Cochrane database of systematic reviews, 2012, Jul-11, Issue:7

    Topics: Acetamides; Anemia, Sickle Cell; Antisickling Agents; Clinical Trials, Phase II as Topic; Clinical T

2012
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
    The Cochrane database of systematic reviews, 2002, Issue:4

    Topics: Anemia, Sickle Cell; Antisickling Agents; Dehydration; Erythrocytes; Humans; Piracetam; Randomized C

2002
Piracetam: a review of pharmacological properties and clinical uses.
    CNS drug reviews, 2005,Summer, Volume: 11, Issue:2

    Topics: Anemia, Sickle Cell; Animals; Cerebrovascular Circulation; Cognition Disorders; Drug Evaluation; Dys

2005
Piracetam for reducing the incidence of painful sickle cell disease crises.
    The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2

    Topics: Adolescent; Anemia, Sickle Cell; Antisickling Agents; Child; Child, Preschool; Humans; Pain; Piracet

2007
Drugs for preventing red blood cell dehydration in people with sickle cell disease.
    The Cochrane database of systematic reviews, 2007, Oct-17, Issue:4

    Topics: Anemia, Sickle Cell; Antisickling Agents; Dehydration; Erythrocytes; Humans; Piracetam; Randomized C

2007
The treatment of sickle cell disease. A historical and chronological literature review of the therapies applied since 1910.
    Tropical and geographical medicine, 1984, Volume: 36, Issue:4

    Topics: Anemia, Sickle Cell; Antisickling Agents; Azepines; Clinical Trials as Topic; Cyanates; Deamino Argi

1984

Trials

4 trials available for piracetam and HbS Disease

ArticleYear
Painful crises in children with sickle cell disease are not prevented by piracetam.
    Acta haematologica, 2009, Volume: 121, Issue:1

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Double-Blind Method; Female; Humans

2009
Inefficacy of piracetam in the prevention of painful crises in children and adolescents with sickle cell disease.
    Acta haematologica, 2005, Volume: 113, Issue:4

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Cross-Over Studies; Double-Blind Me

2005
The treatment of sickle cell disease. A historical and chronological literature review of the therapies applied since 1910.
    Tropical and geographical medicine, 1984, Volume: 36, Issue:4

    Topics: Anemia, Sickle Cell; Antisickling Agents; Azepines; Clinical Trials as Topic; Cyanates; Deamino Argi

1984
Piracetam is useful in the treatment of children with sickle cell disease.
    Acta haematologica, 1996, Volume: 96, Issue:4

    Topics: Anemia, Sickle Cell; Child; Child, Preschool; Double-Blind Method; Female; Follow-Up Studies; Hospit

1996

Other Studies

12 other studies available for piracetam and HbS Disease

ArticleYear
Piracetam and sickle-cell disease.
    Lancet (London, England), 1980, Apr-05, Volume: 1, Issue:8171

    Topics: Anemia, Sickle Cell; Erythrocytes, Abnormal; Humans; Piracetam; Pyrrolidinones

1980
Diminished adherence of sickle erythrocytes to cultured vascular endothelium by piracetam.
    American journal of hematology, 1983, Volume: 15, Issue:2

    Topics: Anemia, Sickle Cell; Animals; Cell Adhesion; Cells, Cultured; Endothelium; Erythrocytes, Abnormal; H

1983
Erythrocyte - endothelial cell adherence in sickle cell disease, diabetes mellitus, and falciparum malaria: adverse effects reversed with piracetam.
    Medical hypotheses, 1982, Volume: 8, Issue:2

    Topics: Anemia, Sickle Cell; Cell Adhesion; Diabetes Mellitus; Endothelium; Erythrocytes; Humans; Malaria; P

1982
Effect of piracetam on sickle erythrocytes and sickle hemoglobin.
    Biochimica et biophysica acta, 1981, May-29, Volume: 668, Issue:3

    Topics: Anemia, Sickle Cell; Blood Viscosity; Erythrocytes, Abnormal; Gels; Hemoglobin, Sickle; Humans; In V

1981
Piracetam in sickle-cell anaemia.
    Lancet (London, England), 1976, Nov-20, Volume: 2, Issue:7995

    Topics: Adolescent; Anemia, Sickle Cell; Child; Child, Preschool; Drug Evaluation; Humans; Piracetam; Pyrrol

1976
Piracetam and acetamide in sickle-cell disease.
    Lancet (London, England), 1977, Aug-20, Volume: 2, Issue:8034

    Topics: Acetamides; Adolescent; Adult; Anemia, Sickle Cell; Antisickling Agents; Child; Child, Preschool; Dr

1977
Sickle-cell disease: Two new therapeutic strategies.
    Lancet (London, England), 1978, Sep-09, Volume: 2, Issue:8089

    Topics: Anemia, Sickle Cell; Antisickling Agents; Drug Evaluation; Erythrocyte Membrane; Humans; Molecular C

1978
Effects of piracetam and iodoacetamide on erythrocyte sickling.
    Lancet (London, England), 1979, Dec-15, Volume: 2, Issue:8155

    Topics: Anemia, Sickle Cell; Animals; Antisickling Agents; Erythrocyte Aging; Erythrocytes, Abnormal; Humans

1979
Incidence, effects, and management of sickle cell disease in Brazil.
    The American journal of pediatric hematology/oncology, 1985,Fall, Volume: 7, Issue:3

    Topics: Anemia, Sickle Cell; Brazil; Female; Fetal Hemoglobin; Genetic Carrier Screening; Genetic Counseling

1985
[A clinical case. Sickle cell crisis in drepanocytic anemia].
    Giornale di clinica medica, 1988, Volume: 69, Issue:5

    Topics: Adult; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Steroidal; Blood Transfusion; Female; Huma

1988
Use of piracetam improves sickle cell deformability in vitro and in vivo.
    Journal of clinical pathology, 1987, Volume: 40, Issue:1

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Erythrocyte Deformability; Female;

1987
[Trial prevention of vaso-occlusive crises in homozygote sickle cell anemia using piracetam].
    Annales de la Societe belge de medecine tropicale, 1985, Volume: 65, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Drug Evaluation; Hum

1985