piracetam and Glioma
piracetam has been researched along with Glioma in 19 studies
Piracetam: A compound suggested to be both a nootropic and a neuroprotective agent.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seizures are common in patients with gliomas, and phenytoin (PHT) is frequently used to control tumor-related seizures." | 9.14 | Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. ( Barbaro, N; Burt, M; Chakalian, L; Chang, E; Chang, S; Lamborn, KR; Lim, DA; McDermott, MW; Tarapore, P, 2009) |
| "To determine the safety and tolerability of IV and oral levetiracetam monotherapy for seizures in brain tumor patients following resection." | 8.86 | A prospective evaluation and literature review of levetiracetam use in patients with brain tumors and seizures. ( Finch, CK; Michael, LM; Sills, AK; Usery, JB, 2010) |
| "To correlate SV2A expression in surgically removed tumor and peritumoral tissue of glioma patients with epilepsy with the clinical response to levetiracetam in a prospective cohort." | 7.77 | Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma. ( Aronica, E; de Groot, M; Heimans, JJ; Reijneveld, JC, 2011) |
| "To evaluate the efficacy and safety of levetiracetam in the management of epilepsy in patients with glioma." | 7.76 | Efficacy and safety of levetiracetam in patients with glioma: a clinical prospective study. ( Buttolo, L; Cenzato, M; Padovani, A; Rosati, A; Stefini, R; Todeschini, A, 2010) |
| "In this study, patients with glioma treated with levetiracetam and phenytoin had similar seizure control." | 7.76 | Seizures in patients with glioma treated with phenytoin and levetiracetam. ( Anderson, SK; Lachance, DH; Merrell, RT; Meyer, FB, 2010) |
| "Levetiracetam (LEV) is a newer anticonvulsant with a favorable safety profile." | 6.77 | Intravenous and oral levetiracetam in patients with a suspected primary brain tumor and symptomatic seizures undergoing neurosurgery: the HELLO trial. ( Bähr, O; Franz, K; Hermisson, M; Körtvelyessy, P; Nussbaum, S; Rieger, J; Rona, S; Seifert, V; Steinbach, JP; Tatagiba, M; Weller, M, 2012) |
| "Seizures are common in patients with gliomas, and phenytoin (PHT) is frequently used to control tumor-related seizures." | 5.14 | Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. ( Barbaro, N; Burt, M; Chakalian, L; Chang, E; Chang, S; Lamborn, KR; Lim, DA; McDermott, MW; Tarapore, P, 2009) |
| "To determine the safety and tolerability of IV and oral levetiracetam monotherapy for seizures in brain tumor patients following resection." | 4.86 | A prospective evaluation and literature review of levetiracetam use in patients with brain tumors and seizures. ( Finch, CK; Michael, LM; Sills, AK; Usery, JB, 2010) |
| "We report the case of an aborted awake craniotomy for a left frontotemporoinsular glioma due to ammonia encephalopathy on a patient taking Levetiracetam, valproic acid and clobazam." | 3.81 | Ammonia encephalopathy and awake craniotomy for brain language mapping: cause of failed awake craniotomy. ( Arroyo Pérez, R; Fernández-Candil, JL; León Jorba, A; Pacreu Terradas, S; Villalba Martínez, G; Vivanco-Hidalgo, RM, 2015) |
| "To correlate SV2A expression in surgically removed tumor and peritumoral tissue of glioma patients with epilepsy with the clinical response to levetiracetam in a prospective cohort." | 3.77 | Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma. ( Aronica, E; de Groot, M; Heimans, JJ; Reijneveld, JC, 2011) |
| "To evaluate the efficacy and safety of levetiracetam in the management of epilepsy in patients with glioma." | 3.76 | Efficacy and safety of levetiracetam in patients with glioma: a clinical prospective study. ( Buttolo, L; Cenzato, M; Padovani, A; Rosati, A; Stefini, R; Todeschini, A, 2010) |
| "In this study, patients with glioma treated with levetiracetam and phenytoin had similar seizure control." | 3.76 | Seizures in patients with glioma treated with phenytoin and levetiracetam. ( Anderson, SK; Lachance, DH; Merrell, RT; Meyer, FB, 2010) |
| "Levetiracetam (LEV) is a newer anticonvulsant with a favorable safety profile." | 2.77 | Intravenous and oral levetiracetam in patients with a suspected primary brain tumor and symptomatic seizures undergoing neurosurgery: the HELLO trial. ( Bähr, O; Franz, K; Hermisson, M; Körtvelyessy, P; Nussbaum, S; Rieger, J; Rona, S; Seifert, V; Steinbach, JP; Tatagiba, M; Weller, M, 2012) |
| "In most cases, either the seizure or the medications used to treat the seizure may contribute to cognitive and psychosocial difficulties of various degrees of severity." | 2.52 | Clinical Management of Seizures in Patients With Low-Grade Glioma. ( Blakeley, J; Piotrowski, AF, 2015) |
| "Levetiracetam was very well tolerated." | 1.42 | Epilepsy in patients with gliomas: incidence and control of seizures. ( Hasegawa, Y; Iuchi, T; Kawasaki, K; Sakaida, T, 2015) |
| "Although seizures in brain tumor patients are common, the knowledge on optimal anti-seizure therapy in this patient group is limited." | 1.35 | Efficacy of anti-epileptic drugs in patients with gliomas and seizures. ( Rijsman, RM; Taphoorn, MJ; van Breemen, MS; Vecht, CJ; Walchenbach, R; Zwinkels, H, 2009) |
| "Levetiracetam was more likely to be used in children who received chemotherapy or radiation therapy (8/14, or 57%) than in those who did not receive adjuvant therapies (3/18, or 17%) (P = 0." | 1.35 | The use of antiepileptic drugs in pediatric brain tumor patients. ( Kan, L; Levy, AS; Maytal, J; Shinnar, S; Sogawa, Y, 2009) |
Research
Studies (19)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 12 (63.16) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ju, IG | 1 |
| Hong, SM | 1 |
| Yun, SW | 1 |
| Huh, E | 1 |
| Kim, DH | 1 |
| Kim, SY | 1 |
| Oh, MS | 1 |
| van der Meer, PB | 1 |
| Dirven, L | 1 |
| Fiocco, M | 1 |
| Vos, MJ | 1 |
| Kouwenhoven, MCM | 1 |
| van den Bent, MJ | 1 |
| Taphoorn, MJB | 1 |
| Koekkoek, JAF | 1 |
| Iuchi, T | 1 |
| Hasegawa, Y | 1 |
| Kawasaki, K | 1 |
| Sakaida, T | 1 |
| Villalba Martínez, G | 1 |
| Fernández-Candil, JL | 1 |
| Vivanco-Hidalgo, RM | 1 |
| Pacreu Terradas, S | 1 |
| León Jorba, A | 1 |
| Arroyo Pérez, R | 1 |
| Piotrowski, AF | 1 |
| Blakeley, J | 1 |
| Ismail, FS | 1 |
| Moinfar, Z | 1 |
| Prochnow, N | 1 |
| Dambach, H | 1 |
| Hinkerohe, D | 1 |
| Haase, CG | 1 |
| Förster, E | 1 |
| Faustmann, PM | 1 |
| Shershever, AS | 1 |
| Bentsion, DL | 1 |
| Lavrova, SA | 1 |
| Sorokova, EV | 1 |
| Lim, DA | 1 |
| Tarapore, P | 1 |
| Chang, E | 1 |
| Burt, M | 1 |
| Chakalian, L | 1 |
| Barbaro, N | 1 |
| Chang, S | 1 |
| Lamborn, KR | 1 |
| McDermott, MW | 1 |
| van Breemen, MS | 1 |
| Rijsman, RM | 1 |
| Taphoorn, MJ | 1 |
| Walchenbach, R | 1 |
| Zwinkels, H | 1 |
| Vecht, CJ | 1 |
| Sogawa, Y | 1 |
| Kan, L | 1 |
| Levy, AS | 1 |
| Maytal, J | 1 |
| Shinnar, S | 1 |
| Usery, JB | 1 |
| Michael, LM | 1 |
| Sills, AK | 1 |
| Finch, CK | 1 |
| Rosati, A | 1 |
| Buttolo, L | 1 |
| Stefini, R | 1 |
| Todeschini, A | 1 |
| Cenzato, M | 1 |
| Padovani, A | 1 |
| Merrell, RT | 1 |
| Anderson, SK | 1 |
| Meyer, FB | 1 |
| Lachance, DH | 1 |
| Engh, JA | 1 |
| de Groot, M | 2 |
| Aronica, E | 1 |
| Heimans, JJ | 2 |
| Reijneveld, JC | 2 |
| Bähr, O | 1 |
| Hermisson, M | 1 |
| Rona, S | 1 |
| Rieger, J | 1 |
| Nussbaum, S | 1 |
| Körtvelyessy, P | 1 |
| Franz, K | 1 |
| Tatagiba, M | 1 |
| Seifert, V | 1 |
| Weller, M | 1 |
| Steinbach, JP | 1 |
| Hefti, M | 1 |
| Albert, I | 1 |
| Luginbuehl, V | 1 |
| Douw, L | 1 |
| Sizoo, EM | 1 |
| Bosma, I | 1 |
| Froklage, FE | 1 |
| Postma, TJ | 1 |
| Klein, M | 1 |
| Wagner, GL | 1 |
| Wilms, EB | 1 |
| Van Donselaar, CA | 1 |
| Vecht, ChJ | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study on Glioma Patients: Understanding Their Glioma Clinical Trial Experiences[NCT05958472] | 500 participants (Anticipated) | Observational | 2024-08-31 | Not yet recruiting | |||
| Prospective Trial of Intravenous Levetiracetam in Patients With Primary Brain Tumors and at Least One Symptomatic Seizure Who Undergo Biopsy or Cytoreductive Surgery (HELLO-study)[NCT00571155] | Phase 4 | 30 participants (Anticipated) | Interventional | 2007-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
2 reviews available for piracetam and Glioma
| Article | Year |
|---|---|
Clinical Management of Seizures in Patients With Low-Grade Glioma.
Topics: Anticonvulsants; Brain Neoplasms; Glioma; Humans; Lamotrigine; Levetiracetam; Piracetam; Seizures; T | 2015 |
A prospective evaluation and literature review of levetiracetam use in patients with brain tumors and seizures.
Topics: Administration, Oral; Adult; Aged; Anticonvulsants; Brain Neoplasms; Dose-Response Relationship, Dru | 2010 |
Trials
2 trials available for piracetam and Glioma
| Article | Year |
|---|---|
Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Neoplasms; Craniotomy; Female; Glioma; Humans | 2009 |
Intravenous and oral levetiracetam in patients with a suspected primary brain tumor and symptomatic seizures undergoing neurosurgery: the HELLO trial.
Topics: Administration, Oral; Adult; Aged; Anticonvulsants; Brain Neoplasms; Chemotherapy, Adjuvant; Electro | 2012 |
Other Studies
15 other studies available for piracetam and Glioma
| Article | Year |
|---|---|
CCL01, a novel formulation composed of
Topics: Animals; Cell Line, Tumor; Cuscuta; Cyclic AMP Response Element-Binding Protein; Extracellular Signa | 2021 |
Effectiveness of Antiseizure Medication Duotherapies in Patients With Glioma: A Multicenter Observational Cohort Study.
Topics: Anticonvulsants; Cohort Studies; Glioma; Humans; Levetiracetam; Piracetam; Retrospective Studies; Se | 2022 |
Epilepsy in patients with gliomas: incidence and control of seizures.
Topics: Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Carbamazepine; Female; Glioma; Humans; Inci | 2015 |
Ammonia encephalopathy and awake craniotomy for brain language mapping: cause of failed awake craniotomy.
Topics: Anesthesia, General; Anesthesia, Local; Anticonvulsants; Aphasia; Benzodiazepines; Brain Diseases; B | 2015 |
Dexamethasone and levetiracetam reduce hetero-cellular gap-junctional coupling between F98 glioma cells and glial cells in vitro.
Topics: Animals; Antineoplastic Agents; Astrocytes; Cell Communication; Cell Line, Tumor; Connexin 43; Conne | 2017 |
[Use of keppra during the radiotherapy in patients with brain tumors and epileptic seizures after surgical treatment].
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Brain Neoplasms; Child; Dose-Response Rela | 2008 |
Efficacy of anti-epileptic drugs in patients with gliomas and seizures.
Topics: Adult; Anticonvulsants; Brain Neoplasms; Carbamazepine; Drug Therapy, Combination; Female; Follow-Up | 2009 |
The use of antiepileptic drugs in pediatric brain tumor patients.
Topics: Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Carbamazepine; Child; Drug Interactions; Fo | 2009 |
Efficacy and safety of levetiracetam in patients with glioma: a clinical prospective study.
Topics: Adult; Aged; Anticonvulsants; Brain Neoplasms; Dose-Response Relationship, Drug; Epilepsy; Female; G | 2010 |
Seizures in patients with glioma treated with phenytoin and levetiracetam.
Topics: Adult; Aged; Anticonvulsants; Female; Glioma; Humans; Levetiracetam; Male; Middle Aged; Phenytoin; P | 2010 |
Anti-convulsants and gene expression in malignant gliomas.
Topics: Brain Neoplasms; Convulsants; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplast | 2010 |
Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma.
Topics: Adult; Aged; Blotting, Western; Brain Neoplasms; Cohort Studies; Epilepsy; False Positive Reactions; | 2011 |
Phenytoin reduces 5-aminolevulinic acid-induced protoporphyrin IX accumulation in malignant glioma cells.
Topics: Aminolevulinic Acid; Anticonvulsants; Fluorescence; Glioma; Glutathione; Humans; Levetiracetam; Memb | 2012 |
Levetiracetam improves verbal memory in high-grade glioma patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain Neoplasms; Cognition Disorders; Female; Glioma; Huma | 2013 |
Levetiracetam: preliminary experience in patients with primary brain tumours.
Topics: Brain Neoplasms; Follow-Up Studies; Glioma; Humans; Levetiracetam; Piracetam; Prospective Studies; S | 2003 |