Page last updated: 2024-11-02

piracetam and Glioma

piracetam has been researched along with Glioma in 19 studies

Piracetam: A compound suggested to be both a nootropic and a neuroprotective agent.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"Seizures are common in patients with gliomas, and phenytoin (PHT) is frequently used to control tumor-related seizures."9.14Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. ( Barbaro, N; Burt, M; Chakalian, L; Chang, E; Chang, S; Lamborn, KR; Lim, DA; McDermott, MW; Tarapore, P, 2009)
"To determine the safety and tolerability of IV and oral levetiracetam monotherapy for seizures in brain tumor patients following resection."8.86A prospective evaluation and literature review of levetiracetam use in patients with brain tumors and seizures. ( Finch, CK; Michael, LM; Sills, AK; Usery, JB, 2010)
"To correlate SV2A expression in surgically removed tumor and peritumoral tissue of glioma patients with epilepsy with the clinical response to levetiracetam in a prospective cohort."7.77Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma. ( Aronica, E; de Groot, M; Heimans, JJ; Reijneveld, JC, 2011)
"To evaluate the efficacy and safety of levetiracetam in the management of epilepsy in patients with glioma."7.76Efficacy and safety of levetiracetam in patients with glioma: a clinical prospective study. ( Buttolo, L; Cenzato, M; Padovani, A; Rosati, A; Stefini, R; Todeschini, A, 2010)
"In this study, patients with glioma treated with levetiracetam and phenytoin had similar seizure control."7.76Seizures in patients with glioma treated with phenytoin and levetiracetam. ( Anderson, SK; Lachance, DH; Merrell, RT; Meyer, FB, 2010)
"Levetiracetam (LEV) is a newer anticonvulsant with a favorable safety profile."6.77Intravenous and oral levetiracetam in patients with a suspected primary brain tumor and symptomatic seizures undergoing neurosurgery: the HELLO trial. ( Bähr, O; Franz, K; Hermisson, M; Körtvelyessy, P; Nussbaum, S; Rieger, J; Rona, S; Seifert, V; Steinbach, JP; Tatagiba, M; Weller, M, 2012)
"Seizures are common in patients with gliomas, and phenytoin (PHT) is frequently used to control tumor-related seizures."5.14Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. ( Barbaro, N; Burt, M; Chakalian, L; Chang, E; Chang, S; Lamborn, KR; Lim, DA; McDermott, MW; Tarapore, P, 2009)
"To determine the safety and tolerability of IV and oral levetiracetam monotherapy for seizures in brain tumor patients following resection."4.86A prospective evaluation and literature review of levetiracetam use in patients with brain tumors and seizures. ( Finch, CK; Michael, LM; Sills, AK; Usery, JB, 2010)
"We report the case of an aborted awake craniotomy for a left frontotemporoinsular glioma due to ammonia encephalopathy on a patient taking Levetiracetam, valproic acid and clobazam."3.81Ammonia encephalopathy and awake craniotomy for brain language mapping: cause of failed awake craniotomy. ( Arroyo Pérez, R; Fernández-Candil, JL; León Jorba, A; Pacreu Terradas, S; Villalba Martínez, G; Vivanco-Hidalgo, RM, 2015)
"To correlate SV2A expression in surgically removed tumor and peritumoral tissue of glioma patients with epilepsy with the clinical response to levetiracetam in a prospective cohort."3.77Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma. ( Aronica, E; de Groot, M; Heimans, JJ; Reijneveld, JC, 2011)
"To evaluate the efficacy and safety of levetiracetam in the management of epilepsy in patients with glioma."3.76Efficacy and safety of levetiracetam in patients with glioma: a clinical prospective study. ( Buttolo, L; Cenzato, M; Padovani, A; Rosati, A; Stefini, R; Todeschini, A, 2010)
"In this study, patients with glioma treated with levetiracetam and phenytoin had similar seizure control."3.76Seizures in patients with glioma treated with phenytoin and levetiracetam. ( Anderson, SK; Lachance, DH; Merrell, RT; Meyer, FB, 2010)
"Levetiracetam (LEV) is a newer anticonvulsant with a favorable safety profile."2.77Intravenous and oral levetiracetam in patients with a suspected primary brain tumor and symptomatic seizures undergoing neurosurgery: the HELLO trial. ( Bähr, O; Franz, K; Hermisson, M; Körtvelyessy, P; Nussbaum, S; Rieger, J; Rona, S; Seifert, V; Steinbach, JP; Tatagiba, M; Weller, M, 2012)
"In most cases, either the seizure or the medications used to treat the seizure may contribute to cognitive and psychosocial difficulties of various degrees of severity."2.52Clinical Management of Seizures in Patients With Low-Grade Glioma. ( Blakeley, J; Piotrowski, AF, 2015)
"Levetiracetam was very well tolerated."1.42Epilepsy in patients with gliomas: incidence and control of seizures. ( Hasegawa, Y; Iuchi, T; Kawasaki, K; Sakaida, T, 2015)
"Although seizures in brain tumor patients are common, the knowledge on optimal anti-seizure therapy in this patient group is limited."1.35Efficacy of anti-epileptic drugs in patients with gliomas and seizures. ( Rijsman, RM; Taphoorn, MJ; van Breemen, MS; Vecht, CJ; Walchenbach, R; Zwinkels, H, 2009)
"Levetiracetam was more likely to be used in children who received chemotherapy or radiation therapy (8/14, or 57%) than in those who did not receive adjuvant therapies (3/18, or 17%) (P = 0."1.35The use of antiepileptic drugs in pediatric brain tumor patients. ( Kan, L; Levy, AS; Maytal, J; Shinnar, S; Sogawa, Y, 2009)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (26.32)29.6817
2010's12 (63.16)24.3611
2020's2 (10.53)2.80

Authors

AuthorsStudies
Ju, IG1
Hong, SM1
Yun, SW1
Huh, E1
Kim, DH1
Kim, SY1
Oh, MS1
van der Meer, PB1
Dirven, L1
Fiocco, M1
Vos, MJ1
Kouwenhoven, MCM1
van den Bent, MJ1
Taphoorn, MJB1
Koekkoek, JAF1
Iuchi, T1
Hasegawa, Y1
Kawasaki, K1
Sakaida, T1
Villalba Martínez, G1
Fernández-Candil, JL1
Vivanco-Hidalgo, RM1
Pacreu Terradas, S1
León Jorba, A1
Arroyo Pérez, R1
Piotrowski, AF1
Blakeley, J1
Ismail, FS1
Moinfar, Z1
Prochnow, N1
Dambach, H1
Hinkerohe, D1
Haase, CG1
Förster, E1
Faustmann, PM1
Shershever, AS1
Bentsion, DL1
Lavrova, SA1
Sorokova, EV1
Lim, DA1
Tarapore, P1
Chang, E1
Burt, M1
Chakalian, L1
Barbaro, N1
Chang, S1
Lamborn, KR1
McDermott, MW1
van Breemen, MS1
Rijsman, RM1
Taphoorn, MJ1
Walchenbach, R1
Zwinkels, H1
Vecht, CJ1
Sogawa, Y1
Kan, L1
Levy, AS1
Maytal, J1
Shinnar, S1
Usery, JB1
Michael, LM1
Sills, AK1
Finch, CK1
Rosati, A1
Buttolo, L1
Stefini, R1
Todeschini, A1
Cenzato, M1
Padovani, A1
Merrell, RT1
Anderson, SK1
Meyer, FB1
Lachance, DH1
Engh, JA1
de Groot, M2
Aronica, E1
Heimans, JJ2
Reijneveld, JC2
Bähr, O1
Hermisson, M1
Rona, S1
Rieger, J1
Nussbaum, S1
Körtvelyessy, P1
Franz, K1
Tatagiba, M1
Seifert, V1
Weller, M1
Steinbach, JP1
Hefti, M1
Albert, I1
Luginbuehl, V1
Douw, L1
Sizoo, EM1
Bosma, I1
Froklage, FE1
Postma, TJ1
Klein, M1
Wagner, GL1
Wilms, EB1
Van Donselaar, CA1
Vecht, ChJ1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study on Glioma Patients: Understanding Their Glioma Clinical Trial Experiences[NCT05958472]500 participants (Anticipated)Observational2024-08-31Not yet recruiting
Prospective Trial of Intravenous Levetiracetam in Patients With Primary Brain Tumors and at Least One Symptomatic Seizure Who Undergo Biopsy or Cytoreductive Surgery (HELLO-study)[NCT00571155]Phase 430 participants (Anticipated)Interventional2007-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for piracetam and Glioma

ArticleYear
Clinical Management of Seizures in Patients With Low-Grade Glioma.
    Seminars in radiation oncology, 2015, Volume: 25, Issue:3

    Topics: Anticonvulsants; Brain Neoplasms; Glioma; Humans; Lamotrigine; Levetiracetam; Piracetam; Seizures; T

2015
A prospective evaluation and literature review of levetiracetam use in patients with brain tumors and seizures.
    Journal of neuro-oncology, 2010, Volume: 99, Issue:2

    Topics: Administration, Oral; Adult; Aged; Anticonvulsants; Brain Neoplasms; Dose-Response Relationship, Dru

2010

Trials

2 trials available for piracetam and Glioma

ArticleYear
Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study.
    Journal of neuro-oncology, 2009, Volume: 93, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Neoplasms; Craniotomy; Female; Glioma; Humans

2009
Intravenous and oral levetiracetam in patients with a suspected primary brain tumor and symptomatic seizures undergoing neurosurgery: the HELLO trial.
    Acta neurochirurgica, 2012, Volume: 154, Issue:2

    Topics: Administration, Oral; Adult; Aged; Anticonvulsants; Brain Neoplasms; Chemotherapy, Adjuvant; Electro

2012

Other Studies

15 other studies available for piracetam and Glioma

ArticleYear
CCL01, a novel formulation composed of
    Food & function, 2021, Nov-01, Volume: 12, Issue:21

    Topics: Animals; Cell Line, Tumor; Cuscuta; Cyclic AMP Response Element-Binding Protein; Extracellular Signa

2021
Effectiveness of Antiseizure Medication Duotherapies in Patients With Glioma: A Multicenter Observational Cohort Study.
    Neurology, 2022, Sep-06, Volume: 99, Issue:10

    Topics: Anticonvulsants; Cohort Studies; Glioma; Humans; Levetiracetam; Piracetam; Retrospective Studies; Se

2022
Epilepsy in patients with gliomas: incidence and control of seizures.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2015, Volume: 22, Issue:1

    Topics: Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Carbamazepine; Female; Glioma; Humans; Inci

2015
Ammonia encephalopathy and awake craniotomy for brain language mapping: cause of failed awake craniotomy.
    Revista espanola de anestesiologia y reanimacion, 2015, Volume: 62, Issue:5

    Topics: Anesthesia, General; Anesthesia, Local; Anticonvulsants; Aphasia; Benzodiazepines; Brain Diseases; B

2015
Dexamethasone and levetiracetam reduce hetero-cellular gap-junctional coupling between F98 glioma cells and glial cells in vitro.
    Journal of neuro-oncology, 2017, Volume: 131, Issue:3

    Topics: Animals; Antineoplastic Agents; Astrocytes; Cell Communication; Cell Line, Tumor; Connexin 43; Conne

2017
[Use of keppra during the radiotherapy in patients with brain tumors and epileptic seizures after surgical treatment].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2008, Volume: 108, Issue:10

    Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Brain Neoplasms; Child; Dose-Response Rela

2008
Efficacy of anti-epileptic drugs in patients with gliomas and seizures.
    Journal of neurology, 2009, Volume: 256, Issue:9

    Topics: Adult; Anticonvulsants; Brain Neoplasms; Carbamazepine; Drug Therapy, Combination; Female; Follow-Up

2009
The use of antiepileptic drugs in pediatric brain tumor patients.
    Pediatric neurology, 2009, Volume: 41, Issue:3

    Topics: Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Carbamazepine; Child; Drug Interactions; Fo

2009
Efficacy and safety of levetiracetam in patients with glioma: a clinical prospective study.
    Archives of neurology, 2010, Volume: 67, Issue:3

    Topics: Adult; Aged; Anticonvulsants; Brain Neoplasms; Dose-Response Relationship, Drug; Epilepsy; Female; G

2010
Seizures in patients with glioma treated with phenytoin and levetiracetam.
    Journal of neurosurgery, 2010, Volume: 113, Issue:6

    Topics: Adult; Aged; Anticonvulsants; Female; Glioma; Humans; Levetiracetam; Male; Middle Aged; Phenytoin; P

2010
Anti-convulsants and gene expression in malignant gliomas.
    Neurosurgery, 2010, Volume: 67, Issue:6

    Topics: Brain Neoplasms; Convulsants; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplast

2010
Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma.
    Neurology, 2011, Aug-09, Volume: 77, Issue:6

    Topics: Adult; Aged; Blotting, Western; Brain Neoplasms; Cohort Studies; Epilepsy; False Positive Reactions;

2011
Phenytoin reduces 5-aminolevulinic acid-induced protoporphyrin IX accumulation in malignant glioma cells.
    Journal of neuro-oncology, 2012, Volume: 108, Issue:3

    Topics: Aminolevulinic Acid; Anticonvulsants; Fluorescence; Glioma; Glutathione; Humans; Levetiracetam; Memb

2012
Levetiracetam improves verbal memory in high-grade glioma patients.
    Neuro-oncology, 2013, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain Neoplasms; Cognition Disorders; Female; Glioma; Huma

2013
Levetiracetam: preliminary experience in patients with primary brain tumours.
    Seizure, 2003, Volume: 12, Issue:8

    Topics: Brain Neoplasms; Follow-Up Studies; Glioma; Humans; Levetiracetam; Piracetam; Prospective Studies; S

2003