piracetam has been researched along with Epilepsy, Absence in 26 studies
Piracetam: A compound suggested to be both a nootropic and a neuroprotective agent.
Epilepsy, Absence: A seizure disorder usually occurring in childhood characterized by rhythmic electrical brain discharges of generalized onset. Clinical features include a sudden cessation of ongoing activity usually without loss of postural tone. Rhythmic blinking of the eyelids or lip smacking frequently accompanies the SEIZURES. The usual duration is 5-10 seconds, and multiple episodes may occur daily. Juvenile absence epilepsy is characterized by the juvenile onset of absence seizures and an increased incidence of myoclonus and tonic-clonic seizures. (Menkes, Textbook of Child Neurology, 5th ed, p736)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Levetiracetam was administrated at starting dose of 10 mg/kg/day up to 50-60 mg/kg/day in two doses." | 6.73 | A pilot trial of levetiracetam in eyelid myoclonia with absences (Jeavons syndrome). ( Biondi, R; Capovilla, G; Coppola, A; Di Bonaventura, C; Fontanillas, L; Giallonardo, AT; Romeo, A; Rubboli, G; Sofia, V; Striano, P; Striano, S; Viri, M; Vitale, G; Zara, F, 2008) |
| "In the GAERS model of petit mal epilepsy, levetiracetam markedly suppressed spontaneous spike-and-wave discharge (SWD) but left the underlying EEG trace normal." | 5.29 | Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy. ( Boehrer, A; Gower, AJ; Hirsch, E; Marescaux, C; Noyer, M, 1995) |
| " The point estimates of carbamazepine and lamotrigine efficacy showed their superiority with respect to all comparator antiepileptic drugs for the treatment of newly diagnosed focal epilepsy." | 4.98 | Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis. ( Crescioli, G; De Masi, S; Guerrini, R; Ilvento, L; Lucenteforte, E; McGreevy, KS; Mugelli, A; Pugi, A; Rosati, A; Virgili, G, 2018) |
| " However, zonisamide- and carbamazepine-treated animals had IT values similar to those of controls, but only zonisamide significantly decreased absence seizure development." | 3.77 | Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model. ( Citraro, R; Constanti, A; De Fazio, S; De Sarro, G; Di Paola, ED; Perrota, I; Perrotta, I; Russo, E; Scicchitano, F, 2011) |
| "The nootropic drug piracetam was investigated in various experimental models of epilepsy." | 3.72 | Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models. ( De Sarro, G; Fischer, W; Kittner, H; Regenthal, R; Russo, E, 2004) |
| "Levetiracetam was administrated at starting dose of 10 mg/kg/day up to 50-60 mg/kg/day in two doses." | 2.73 | A pilot trial of levetiracetam in eyelid myoclonia with absences (Jeavons syndrome). ( Biondi, R; Capovilla, G; Coppola, A; Di Bonaventura, C; Fontanillas, L; Giallonardo, AT; Romeo, A; Rubboli, G; Sofia, V; Striano, P; Striano, S; Viri, M; Vitale, G; Zara, F, 2008) |
| "Levetiracetam was well tolerated; no patient reported side-effects." | 2.71 | Clinical experience with levetiracetam in idiopathic generalized epilepsy according to different syndrome subtypes. ( Di Bonaventura, C; Egeo, G; Fattouch, J; Giallonardo, AT; Manfredi, M; Mari, F; Prencipe, M; Vaudano, AE, 2005) |
| "Onset of absence seizures in the first year of life is very rare." | 1.39 | Early-onset absence epilepsy aggravated by valproic acid: a video-EEG report. ( Belcastro, V; Caraballo, RH; Romeo, A; Striano, P, 2013) |
| "We included 6 patients: n = 2 childhood absence epilepsy, n = 3 juvenile absence epilepsy and n = 1 epilepsy with myoclonic absences." | 1.37 | Aggravation of absence seizure related to levetiracetam. ( Auvin, S; Berquin, P; Chhun, S; Chiron, C; Delanoë, C; Ponchel, E, 2011) |
| "Valproic acid is an effective anti-epileptic medication often used for long-term control of seizure disorders that has been implicated in hematological toxicities, including rare reports of myelodysplasia and acute leukemia." | 1.35 | Translocation-positive acute myeloid leukemia associated with valproic acid therapy. ( Ben-Ezra, J; Massey, GV; Riley, RS; Russell, EC; Williams, DC, 2008) |
| "Levetiracetam was titrated up to an optimal dosage for every individual patient, depending on efficacy and tolerability, and reflecting clinical practice." | 1.33 | Clinical experience with levetiracetam in childhood epilepsy: an add-on and mono-therapy trial. ( Buyse, G; Ceulemans, B; Lagae, L, 2005) |
| "In the GAERS model of petit mal epilepsy, levetiracetam markedly suppressed spontaneous spike-and-wave discharge (SWD) but left the underlying EEG trace normal." | 1.29 | Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy. ( Boehrer, A; Gower, AJ; Hirsch, E; Marescaux, C; Noyer, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 13 (50.00) | 29.6817 |
| 2010's | 12 (46.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rosati, A | 1 |
| Ilvento, L | 1 |
| Lucenteforte, E | 1 |
| Pugi, A | 1 |
| Crescioli, G | 1 |
| McGreevy, KS | 1 |
| Virgili, G | 1 |
| Mugelli, A | 1 |
| De Masi, S | 1 |
| Guerrini, R | 1 |
| Belcastro, V | 1 |
| Caraballo, RH | 1 |
| Romeo, A | 2 |
| Striano, P | 2 |
| Parissis, D | 1 |
| Ioannidis, P | 1 |
| Karacostas, D | 1 |
| Paschen, I | 1 |
| Walter, U | 1 |
| Kamm, C | 1 |
| Rösche, J | 1 |
| Verrotti, A | 1 |
| Cerminara, C | 2 |
| Domizio, S | 1 |
| Mohn, A | 1 |
| Franzoni, E | 1 |
| Coppola, G | 2 |
| Zamponi, N | 1 |
| Parisi, P | 1 |
| Iannetti, P | 1 |
| Curatolo, P | 1 |
| Yang, Z | 1 |
| Liu, X | 1 |
| Qin, J | 1 |
| Zhang, Y | 1 |
| Bao, X | 1 |
| Xiong, H | 1 |
| Rosenfeld, WE | 1 |
| Benbadis, S | 1 |
| Edrich, P | 1 |
| Tassinari, CA | 1 |
| Hirsch, E | 2 |
| Russo, E | 3 |
| Citraro, R | 2 |
| Scicchitano, F | 2 |
| De Fazio, S | 2 |
| Di Paola, ED | 2 |
| Constanti, A | 2 |
| De Sarro, G | 3 |
| Tokuda, S | 1 |
| Sofue, N | 1 |
| Ohno, Y | 1 |
| Sasa, M | 2 |
| Serikawa, T | 2 |
| Fattore, C | 1 |
| Boniver, C | 1 |
| Capovilla, G | 2 |
| Citterio, A | 1 |
| Costa, P | 1 |
| Darra, F | 1 |
| Vecchi, M | 1 |
| Perucca, E | 1 |
| Perrotta, I | 1 |
| Perrota, I | 1 |
| Auvin, S | 1 |
| Chhun, S | 1 |
| Berquin, P | 1 |
| Ponchel, E | 1 |
| Delanoë, C | 1 |
| Chiron, C | 1 |
| Vrielynck, P | 1 |
| Rostomashvili, N | 1 |
| Degroote, E | 1 |
| Ghariani, S | 1 |
| van Rijckevorsel, K | 1 |
| Farooque, P | 1 |
| Goraya, J | 1 |
| Valencia, I | 1 |
| Carvalho, KS | 1 |
| Hardison, HH | 1 |
| Legido, A | 1 |
| Khurana, DS | 1 |
| Karlov, VA | 1 |
| Freĭdkova, NV | 1 |
| Rusanova, LV | 1 |
| French, JA | 1 |
| Kanner, AM | 1 |
| Bautista, J | 1 |
| Abou-Khalil, B | 1 |
| Browne, T | 1 |
| Harden, CL | 1 |
| Theodore, WH | 1 |
| Bazil, C | 1 |
| Stern, J | 1 |
| Schachter, SC | 1 |
| Bergen, D | 1 |
| Hirtz, D | 1 |
| Montouris, GD | 1 |
| Nespeca, M | 1 |
| Gidal, B | 1 |
| Marks, WJ | 1 |
| Turk, WR | 1 |
| Fischer, JH | 1 |
| Bourgeois, B | 1 |
| Wilner, A | 1 |
| Faught, RE | 1 |
| Sachdeo, RC | 1 |
| Beydoun, A | 1 |
| Glauser, TA | 1 |
| Fischer, W | 1 |
| Kittner, H | 1 |
| Regenthal, R | 1 |
| Bouwman, BM | 1 |
| van Rijn, CM | 1 |
| Lagae, L | 1 |
| Buyse, G | 1 |
| Ceulemans, B | 1 |
| Ji-qun, C | 1 |
| Ishihara, K | 1 |
| Nagayama, T | 1 |
| Di Bonaventura, C | 2 |
| Fattouch, J | 1 |
| Mari, F | 1 |
| Egeo, G | 1 |
| Vaudano, AE | 1 |
| Prencipe, M | 1 |
| Manfredi, M | 1 |
| Giallonardo, AT | 2 |
| D'Arcangelo, G | 1 |
| D'Antuono, M | 1 |
| Tancredi, V | 1 |
| Avoli, M | 1 |
| Williams, DC | 1 |
| Massey, GV | 1 |
| Russell, EC | 1 |
| Riley, RS | 1 |
| Ben-Ezra, J | 1 |
| Marrosu, F | 1 |
| Bortolato, M | 1 |
| Frau, R | 1 |
| Orrù, M | 1 |
| Puligheddu, M | 1 |
| Fà, M | 1 |
| Muroni, A | 1 |
| Tuveri, A | 1 |
| Mereu, G | 1 |
| Sofia, V | 1 |
| Rubboli, G | 1 |
| Coppola, A | 1 |
| Vitale, G | 1 |
| Fontanillas, L | 1 |
| Biondi, R | 1 |
| Viri, M | 1 |
| Zara, F | 1 |
| Striano, S | 1 |
| Gower, AJ | 1 |
| Boehrer, A | 1 |
| Noyer, M | 1 |
| Marescaux, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-blind, Multicenter, Randomized, Placebo-controlled Study to Evaluate the Efficacy and Safety of Levetiracetam (LEV) (Oral Tablets of 500 mg b.i.d.) at a Dose of 3000 mg/Day as Adjunctive Treatment in Adolescents (≥ 12 Years) and Adults (≤ 65 Year[NCT00150774] | Phase 3 | 116 participants | Interventional | 2001-11-30 | Completed | ||
| A Double-blind, Multicenter, Randomized, Placebo-controlled Study to Evaluate the Efficacy and Safety of Adjunctive Treatment With 3000 mg/Day (Pediatric Target Dose of 60 mg/kg/Day) Oral Levetiracetam (LEV) (166, 250, and 500mg Tablets), in Adult and Ped[NCT00160550] | Phase 3 | 154 participants | Interventional | 2001-09-30 | Completed | ||
| Levetiracetam Treatment of Neonatal Seizures: A Multi-Centre Randomized Blinded Controlled Study of the Efficacy of Oral Levetiracetam as First Line Treatment for Neonatal Seizures in China[NCT02550028] | Phase 1/Phase 2 | 60 participants (Actual) | Interventional | 2015-09-01 | Terminated (stopped due to The study was concluded as planned upon reaching its predetermined endpoint, which included the completion of data collection and achievement of the necessary sample size for statistical significance.) | ||
| Phase 3: Metabolism of Lamotrigine During Treatment With Oral Contraceptives[NCT00266149] | Phase 3 | 10 participants | Interventional | 2003-06-30 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for piracetam and Epilepsy, Absence
| Article | Year |
|---|---|
Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Carbamazepine; Ch | 2018 |
Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.
Topics: Acetates; Adolescent; Adult; Age Factors; Amines; Antipsychotic Agents; Carbamazepine; Child; Clinic | 2004 |
5 trials available for piracetam and Epilepsy, Absence
| Article | Year |
|---|---|
Levetiracetam in absence epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Double-Blind Method; Electrocardiography; Elec | 2008 |
Levetiracetam as add-on therapy for idiopathic generalized epilepsy syndromes with onset during adolescence: analysis of two randomized, double-blind, placebo-controlled studies.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Double-Blin | 2009 |
Levetiracetam as add-on therapy for idiopathic generalized epilepsy syndromes with onset during adolescence: analysis of two randomized, double-blind, placebo-controlled studies.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Double-Blin | 2009 |
Levetiracetam as add-on therapy for idiopathic generalized epilepsy syndromes with onset during adolescence: analysis of two randomized, double-blind, placebo-controlled studies.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Double-Blin | 2009 |
Levetiracetam as add-on therapy for idiopathic generalized epilepsy syndromes with onset during adolescence: analysis of two randomized, double-blind, placebo-controlled studies.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Double-Blin | 2009 |
A multicenter, randomized, placebo-controlled trial of levetiracetam in children and adolescents with newly diagnosed absence epilepsy.
Topics: Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Double-Blind Method; Drug Resista | 2011 |
Clinical experience with levetiracetam in idiopathic generalized epilepsy according to different syndrome subtypes.
Topics: Anticonvulsants; Electroencephalography; Epilepsy, Absence; Female; Humans; Levetiracetam; Male; Myo | 2005 |
A pilot trial of levetiracetam in eyelid myoclonia with absences (Jeavons syndrome).
Topics: Adolescent; Adult; Anticonvulsants; Child; Comorbidity; Drug Therapy, Combination; Epilepsies, Myocl | 2008 |
19 other studies available for piracetam and Epilepsy, Absence
| Article | Year |
|---|---|
Early-onset absence epilepsy aggravated by valproic acid: a video-EEG report.
Topics: Age of Onset; Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy, Absence; Humans; | 2013 |
Levetiracetam as alternative treatment in Jeavons syndrome.
Topics: Adult; Anticonvulsants; Epilepsy, Absence; Female; Humans; Levetiracetam; Myoclonus; Piracetam | 2014 |
Case report: absence-status as late reexacerbation of genetic epilepsy of adolescence.
Topics: Adolescent; Age of Onset; Anticonvulsants; Electroencephalography; Epilepsy, Absence; Humans; Leveti | 2016 |
Partial seizures and atypical absence seizures as a single ictal event in a patient with Lennox-Gastaut syndrome.
Topics: Adolescent; Epilepsy; Epilepsy, Absence; Humans; Intellectual Disability; Levetiracetam; Male; Pirac | 2008 |
Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy.
Topics: Age Factors; Analysis of Variance; Animals; Anticonvulsants; Chromatography, High Pressure Liquid; D | 2010 |
Inhibitory effects of levetiracetam on absence seizures in a novel absence-like epilepsy animal model, Groggy rat.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Levetir | 2010 |
Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Depression; Dose-Response Relationship, Drug; Electr | 2011 |
Aggravation of absence seizure related to levetiracetam.
Topics: Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy, Absence; Female; France; | 2011 |
Perioral myoclonia with absences and myoclonic status aggravated by oxcarbazepine.
Topics: Anticonvulsants; Brain; Carbamazepine; Child; Electroencephalography; Epilepsies, Myoclonic; Epileps | 2011 |
Early-onset childhood absence epilepsy: is it a distinct entity?
Topics: Age Factors; Age of Onset; Anticonvulsants; Child; Child Development; Child, Preschool; Cohort Studi | 2011 |
[Complex therapy of idiopathic forms of epilepsy with small doses of valproates and levetiracetam].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy, Absence; | 2012 |
Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models.
Topics: Action Potentials; Animals; Anticonvulsants; Brain; Cobalt; Disease Models, Animal; Drug Combination | 2004 |
Effects of levetiracetam on spike and wave discharges in WAG/Rij rats.
Topics: Animals; Anticonvulsants; Electroencephalography; Epilepsy, Absence; Levetiracetam; Male; Piracetam; | 2004 |
Clinical experience with levetiracetam in childhood epilepsy: an add-on and mono-therapy trial.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cohort Studies; Dose-Response Relationship, Dr | 2005 |
Long-lasting antiepileptic effects of levetiracetam against epileptic seizures in the spontaneously epileptic rat (SER): differentiation of levetiracetam from conventional antiepileptic drugs.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Dose-Response R | 2005 |
Neocortical hyperexcitability in a genetic model of absence seizures and its reduction by levetiracetam.
Topics: 4-Aminopyridine; Age Factors; Animals; Anticonvulsants; Disease Models, Animal; Electric Stimulation | 2006 |
Translocation-positive acute myeloid leukemia associated with valproic acid therapy.
Topics: Acute Disease; Anticonvulsants; Cell Differentiation; Cell Division; Child, Preschool; Chromosomes, | 2008 |
Levetiracetam attenuates spontaneous spike-and-wave discharges in DBA/2J mice.
Topics: Animals; Anticonvulsants; Electroencephalography; Epilepsy, Absence; Ethosuximide; Injections, Intra | 2007 |
Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Epilepsies | 1995 |