piracetam has been researched along with Drug Withdrawal Symptoms in 23 studies
Piracetam: A compound suggested to be both a nootropic and a neuroprotective agent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This case is the first report of a patient who had phenobarbital (PB) withdrawal seizures after having been seizure-free for 3 years following temporal lobe surgery." | 7.75 | Phenobarbital withdrawal seizures may occur over several weeks before remitting: human data and hypothetical mechanism. ( Bidlack, JM; Morris, HH, 2009) |
| ") were determined on anxiety induced in female NMRI mice by withdrawal from 21 days of chronic administration of chlordiazepoxide." | 7.71 | The new antiepileptic drug levetiracetam normalises chlordiazepoxide withdrawal-induced anxiety in mice. ( Gower, AJ; Klitgaard, H; Lamberty, Y, 2002) |
| "This case is the first report of a patient who had phenobarbital (PB) withdrawal seizures after having been seizure-free for 3 years following temporal lobe surgery." | 3.75 | Phenobarbital withdrawal seizures may occur over several weeks before remitting: human data and hypothetical mechanism. ( Bidlack, JM; Morris, HH, 2009) |
| ") were determined on anxiety induced in female NMRI mice by withdrawal from 21 days of chronic administration of chlordiazepoxide." | 3.71 | The new antiepileptic drug levetiracetam normalises chlordiazepoxide withdrawal-induced anxiety in mice. ( Gower, AJ; Klitgaard, H; Lamberty, Y, 2002) |
| "Diazepam was added when symptom triggered as rescue medication." | 2.75 | Levetiracetam for the treatment of alcohol withdrawal syndrome: a multicenter, prospective, randomized, placebo-controlled trial. ( Heinz, A; Hinzpeter, A; Kienast, T; Plenge, T; Preuss, UW; Richter, C; Schaefer, M; Schmidt, F, 2010) |
| " After screening eligibility for outpatient detoxification, 9 alcohol-dependent patients received levetiracetam and tiapride in a flexible dosage regimen up to 2500 and 300 mg/d, respectively, for a maximum of 7 days." | 1.37 | A combination of levetiracetam and tiapride for outpatient alcohol detoxification: a case series. ( Banas, R; Förg, A; Heimann, HM; Hein, J; Heinz, A; Müller, CA; Schäfer, M; Volkmar, K, 2011) |
| "The findings of this study provide some evidence that levetiracetam is an efficacious and safe treatment option for outpatient alcohol detoxification." | 1.36 | Efficacy and safety of levetiracetam for outpatient alcohol detoxification. ( Förg, A; Heimann, HM; Hein, J; Heinz, A; Hinzpeter, A; Müller, CA; Schäfer, M; Schneider, S; Volkmar, K, 2010) |
| "He presented with severe myoclonus, which was resistant to conventional therapy and dramatically improved after administration of 12-18 gm/die piracetam." | 1.33 | Suppression of myoclonus in SCA2 by piracetam. ( Barbieri, F; de Falco, A; De Michele, G; De Rosa, A; Filla, A; Rinaldi, C; Striano, P; Striano, S; Tucci, T, 2006) |
| "Levetiracetam (LEV) is an interesting novel antiepileptic drug with proven efficacy in both animal models and patients with partial epilepsy." | 1.31 | Development of tolerance during chronic treatment of kindled rats with the novel antiepileptic drug levetiracetam. ( Hönack, D; Löscher, W, 2000) |
| "Finally it is suggested that insomnia and the loss of REM sleep may also contribute to the onset of the condition." | 1.27 | [Changes in the circadian rhythm of urinary cyclic adenosine monophosphate during the alcoholic withdrawal syndrome and related neurobiological correlations]. ( Cedaro, P; Di Piazza, V; Geatti, O; Lattuada, L; Marchetti, E; Nardoni, A, 1985) |
| "The enhanced seizure susceptibility after a single dose of ethanol was abolished by piracetam and MGO." | 1.27 | Influence of nootropic drugs on drinking behaviour in ethanol-preferring mice and ethanol-induced increase of seizure susceptibility. ( Andreas, K; Dienel, A; Schmidt, J, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (39.13) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sawagashira, R | 1 |
| Narita, H | 1 |
| Hashimoto, N | 1 |
| Kurita, T | 1 |
| Nakagawa, S | 1 |
| Saitoh, T | 1 |
| Kusumi, I | 1 |
| Youland, KM | 1 |
| Miller, RF | 1 |
| Mahoney, LJ | 1 |
| Borgert, AJ | 1 |
| Gundrum, JD | 1 |
| Bidlack, JM | 1 |
| Morris, HH | 1 |
| Azar, NJ | 1 |
| Lagrange, AH | 1 |
| Wang, L | 1 |
| Song, Y | 1 |
| Abou-Khalil, BW | 1 |
| Müller, CA | 2 |
| Schäfer, M | 2 |
| Schneider, S | 1 |
| Heimann, HM | 2 |
| Hinzpeter, A | 3 |
| Volkmar, K | 2 |
| Förg, A | 2 |
| Heinz, A | 4 |
| Hein, J | 2 |
| Richter, C | 2 |
| Schmidt, F | 1 |
| Kienast, T | 2 |
| Preuss, UW | 1 |
| Plenge, T | 1 |
| Schaefer, M | 2 |
| Zalewska-Kaszubska, J | 1 |
| Bajer, B | 1 |
| Czarnecka, E | 1 |
| Dyr, W | 1 |
| Gorska, D | 1 |
| Banas, R | 1 |
| De Rosa, A | 1 |
| Striano, P | 1 |
| Barbieri, F | 1 |
| de Falco, A | 1 |
| Rinaldi, C | 1 |
| Tucci, T | 1 |
| Striano, S | 1 |
| Filla, A | 1 |
| De Michele, G | 1 |
| Krebs, M | 1 |
| Leopold, K | 1 |
| Serby, M | 1 |
| Segarnick, DJ | 1 |
| Cordasco, DM | 1 |
| Rotrosen, J | 1 |
| Entin, GM | 1 |
| Zed, PJ | 1 |
| Loewen, PS | 1 |
| Robinson, G | 1 |
| Brandão, F | 1 |
| Ribeiro-da-Silva, A | 1 |
| Cadete-Leite, A | 1 |
| Löscher, W | 1 |
| Hönack, D | 1 |
| Lamberty, Y | 1 |
| Gower, AJ | 1 |
| Klitgaard, H | 1 |
| Dencker, SJ | 1 |
| Wilhelmson, G | 1 |
| Carlsson, E | 1 |
| Bereen, FJ | 1 |
| Godard, JP | 1 |
| Goerens, C | 1 |
| Grelier, C | 1 |
| Rosenstock, J | 1 |
| Prack, G | 1 |
| May, B | 1 |
| Sluchevskiĭ, FI | 1 |
| Tikhomirov, SM | 1 |
| Bakharev, VD | 1 |
| Nardoni, A | 1 |
| Di Piazza, V | 1 |
| Marchetti, E | 1 |
| Geatti, O | 1 |
| Cedaro, P | 1 |
| Lattuada, L | 1 |
| Tacconi, MT | 1 |
| Wurtman, RJ | 1 |
| Dienel, A | 1 |
| Andreas, K | 1 |
| Schmidt, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Levetiracetam in the Inpatient Treatment of Alcohol Withdrawal Syndrome [Sicherheit Und Wirksamkeit Von Levetiracetam (Keppra) für Die Behandlung Des stationären Alkoholentzugsyndroms][NCT00146471] | Phase 3 | 120 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| Placebo-Controlled Crossover Trial of Levetiracetam on Ethanol Intake[NCT01168687] | 46 participants (Actual) | Interventional | 2008-11-30 | Completed | |||
| Efficacy and Safety of Levetiracetam in Prevention of Alcohol Relapse in Recently Detoxified Alcohol Dependent Patients[NCT00758277] | Phase 3 | 201 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary outcome of this study is to determine the effect of levetiracetam on alcohol consumption as measured by change in # of drinks during each treatment period. (NCT01168687)
Timeframe: During each 14 day treatment period
| Intervention | number of drinks per treatment period (Mean) |
|---|---|
| All Subjects (n = 46) Placebo | 41.2 |
| All Subjects (n = 46) Levetiracetam | 45.4 |
1 review available for piracetam and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Medication-induced headache: overview and systematic review of therapeutic approaches.
Topics: Amitriptyline; Analgesics; Anti-Inflammatory Agents; Chronic Disease; Ergolines; Headache; Humans; M | 1999 |
4 trials available for piracetam and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Levetiracetam for the treatment of alcohol withdrawal syndrome: a multicenter, prospective, randomized, placebo-controlled trial.
Topics: Adult; Alcoholism; Anticonvulsants; Diazepam; Double-Blind Method; Female; Humans; Levetiracetam; Ma | 2010 |
Levetiracetam for the treatment of alcohol withdrawal syndrome: an open-label pilot trial.
Topics: Adult; Alcoholism; Dose-Response Relationship, Drug; Female; Humans; Levetiracetam; Male; Middle Age | 2006 |
Levetiracetam for the treatment of alcohol withdrawal syndrome: an open-label pilot trial.
Topics: Adult; Alcoholism; Dose-Response Relationship, Drug; Female; Humans; Levetiracetam; Male; Middle Age | 2006 |
Levetiracetam for the treatment of alcohol withdrawal syndrome: an open-label pilot trial.
Topics: Adult; Alcoholism; Dose-Response Relationship, Drug; Female; Humans; Levetiracetam; Male; Middle Age | 2006 |
Levetiracetam for the treatment of alcohol withdrawal syndrome: an open-label pilot trial.
Topics: Adult; Alcoholism; Dose-Response Relationship, Drug; Female; Humans; Levetiracetam; Male; Middle Age | 2006 |
Levetiracetam for the treatment of alcohol withdrawal syndrome: an open-label pilot trial.
Topics: Adult; Alcoholism; Dose-Response Relationship, Drug; Female; Humans; Levetiracetam; Male; Middle Age | 2006 |
Levetiracetam for the treatment of alcohol withdrawal syndrome: an open-label pilot trial.
Topics: Adult; Alcoholism; Dose-Response Relationship, Drug; Female; Humans; Levetiracetam; Male; Middle Age | 2006 |
Levetiracetam for the treatment of alcohol withdrawal syndrome: an open-label pilot trial.
Topics: Adult; Alcoholism; Dose-Response Relationship, Drug; Female; Humans; Levetiracetam; Male; Middle Age | 2006 |
Levetiracetam for the treatment of alcohol withdrawal syndrome: an open-label pilot trial.
Topics: Adult; Alcoholism; Dose-Response Relationship, Drug; Female; Humans; Levetiracetam; Male; Middle Age | 2006 |
Levetiracetam for the treatment of alcohol withdrawal syndrome: an open-label pilot trial.
Topics: Adult; Alcoholism; Dose-Response Relationship, Drug; Female; Humans; Levetiracetam; Male; Middle Age | 2006 |
Piracetam and chlormethiazole in acute alcohol withdrawal: a controlled clinical trial.
Topics: Adult; Alcoholism; Chlormethiazole; Clinical Trials as Topic; Humans; Libido; Male; Middle Aged; Pir | 1978 |
[Neuropeptides in the treatment of alcoholism and alcoholic psychoses].
Topics: Administration, Intranasal; Adrenocorticotropic Hormone; Adult; Alcohol Amnestic Disorder; Alcoholis | 1986 |
18 other studies available for piracetam and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Transient lesions of the splenium of the corpus callosum following rapid withdrawal of levetiracetam.
Topics: Adolescent; Anticonvulsants; Corpus Callosum; Female; Humans; Levetiracetam; Magnetic Resonance Imag | 2017 |
Levetiracetam as adjunctive therapy for acute alcohol withdrawal syndrome in hospitalized patients.
Topics: Adult; Alcoholism; Anticonvulsants; Benzodiazepines; Cohort Studies; Drug Therapy, Combination; Fema | 2014 |
Phenobarbital withdrawal seizures may occur over several weeks before remitting: human data and hypothetical mechanism.
Topics: Anticonvulsants; Data Collection; Female; Humans; Lamotrigine; Levetiracetam; Middle Aged; Phenobarb | 2009 |
Transient improvement after brief antiepileptic drug withdrawal in the epilepsy monitoring unit--possible relationship to AED tolerance.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Administration Schedule; Drug Resistance; Drug Tolerance | 2010 |
Efficacy and safety of levetiracetam for outpatient alcohol detoxification.
Topics: Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Ambulatory Care; Anticonvulsants; Female; Hum | 2010 |
Voluntary alcohol consumption and plasma beta-endorphin levels in alcohol preferring rats chronically treated with levetiracetam: a preliminary study.
Topics: Alcohol Drinking; Alcoholism; Animals; Anticonvulsants; beta-Endorphin; Disease Models, Animal; Dose | 2011 |
A combination of levetiracetam and tiapride for outpatient alcohol detoxification: a case series.
Topics: Adult; Aged; Alcoholism; Dopamine Antagonists; Drug Therapy, Combination; Female; Humans; Levetirace | 2011 |
Suppression of myoclonus in SCA2 by piracetam.
Topics: Adult; Ataxia; Ataxins; Dose-Response Relationship, Drug; Gait Ataxia; Humans; Infusions, Intravenou | 2006 |
Piracetam reduces alcohol withdrawal in mice without potentiating alcohol sedative effects.
Topics: Animals; Drug Synergism; Ethanol; Humans; Male; Mice; Mice, Inbred Strains; Piracetam; Pyrrolidinone | 1982 |
[Use of piracetam (nootropil) on alcoholism patients under ambulatory control of withdrawal manifestations].
Topics: Adult; Alcoholism; Ambulatory Care; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pi | 1981 |
GM1 and piracetam do not revert the alcohol-induced depletion of cholinergic fibers in the hippocampal formation of the rat.
Topics: Animals; Central Nervous System Depressants; Cholinergic Fibers; Ethanol; G(M1) Ganglioside; Hippoca | 1999 |
Development of tolerance during chronic treatment of kindled rats with the novel antiepileptic drug levetiracetam.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug T | 2000 |
The new antiepileptic drug levetiracetam normalises chlordiazepoxide withdrawal-induced anxiety in mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Chlordiazepoxide; Dose | 2002 |
Usefulness of piracetam in intensive care.
Topics: Alcoholism; Brain Diseases; Brain Injuries; Carbon Monoxide Poisoning; Cerebrovascular Disorders; Ch | 1976 |
[Therapy of drug dependence in adolescents. Clinical aspects of somatic detoxification].
Topics: Adolescent; Adult; Age Factors; Doxepin; Female; Follow-Up Studies; Humans; Male; Methadone; Piracet | 1976 |
[Changes in the circadian rhythm of urinary cyclic adenosine monophosphate during the alcoholic withdrawal syndrome and related neurobiological correlations].
Topics: Adult; Alcoholism; Circadian Rhythm; Clonidine; Cyclic AMP; Female; Humans; Piracetam; Sleep Initiat | 1985 |
Piracetam: physiological disposition and mechanism of action.
Topics: Absorption; Animals; Brain; Chromatography, Thin Layer; Ethanol; Humans; Kinetics; Learning; Piracet | 1986 |
Influence of nootropic drugs on drinking behaviour in ethanol-preferring mice and ethanol-induced increase of seizure susceptibility.
Topics: Alcohol Drinking; Alcoholism; Animals; Dihydroergotoxine; Ethanol; Male; Meglumine; Mice; Mice, Inbr | 1985 |