piracetam has been researched along with Craniocerebral Trauma in 6 studies
Piracetam: A compound suggested to be both a nootropic and a neuroprotective agent.
Craniocerebral Trauma: Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Antiepileptic drugs (AED) such as phenytoin are often used in clinical practice with the hopes of preventing post-traumatic epilepsy." | 4.91 | Pharmacological treatments for preventing epilepsy following traumatic head injury. ( Abel, H; Campbell, LA; Pohlmann-Eden, B; Thompson, K, 2015) |
| "Levetiracetam was safe and well tolerated in this population." | 2.78 | Results of phase II levetiracetam trial following acute head injury in children at risk for posttraumatic epilepsy. ( Atabaki, SM; He, J; Klein, P; McCarter, R; McGavin, CL; Pearl, PL; Sandoval, F; Trzcinski, S; Tsuchida, T; van den Anker, J; Yu, Y, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pearl, PL | 1 |
| McCarter, R | 1 |
| McGavin, CL | 1 |
| Yu, Y | 1 |
| Sandoval, F | 1 |
| Trzcinski, S | 1 |
| Atabaki, SM | 1 |
| Tsuchida, T | 1 |
| van den Anker, J | 1 |
| He, J | 1 |
| Klein, P | 1 |
| Thompson, K | 1 |
| Pohlmann-Eden, B | 1 |
| Campbell, LA | 1 |
| Abel, H | 1 |
| Zarubina, IV | 2 |
| Shabanov, PD | 1 |
| Calliauw, L | 1 |
| Marchau, M | 1 |
| Cicerchia, G | 1 |
| Santucci, R | 1 |
| Palmieri, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot: Levetiracetam to Prevent Post-Traumatic Epilepsy[NCT01463033] | Phase 2 | 126 participants (Actual) | Interventional | 2005-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
occurrence of PTE (Post-Traumatic Epilepsy) (NCT01463033)
Timeframe: 2 years
| Intervention | participants (Number) |
|---|---|
| Levetiracetam | 6 |
| Observational | 8 |
The 66 subjects with acute head injury with a high risk for developing post-traumatic epilepsy that received levetiracetam 55 mg/kg/day in a b.i.d. were monitored for adverse events through the 30 day treatment period. (NCT01463033)
Timeframe: 30 day treatment period
| Intervention | Events (Number) | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Headache | Fatigue | Drowsiness | Memory Impairment | Amnesia | Pain | Irritability | Dizziness | Anorexia | Emotional lability | Insomnia | Cognitive changes | Ataxia | Depression | Hostility | Vertigo | Nausea | Cough | Nervousness | Paraesthesia | Weight gain | Hallucinations | Other | Diplopia | Suicidality | Psychosis | |
| Participants | 28 | 28 | 20 | 9 | 8 | 15 | 10 | 10 | 6 | 7 | 5 | 7 | 6 | 7 | 3 | 1 | 2 | 2 | 5 | 3 | 1 | 5 | 2 | 3 | 3 | 3 |
1 review available for piracetam and Craniocerebral Trauma
| Article | Year |
|---|---|
Pharmacological treatments for preventing epilepsy following traumatic head injury.
Topics: Adult; Anticonvulsants; Carbamazepine; Cause of Death; Child; Craniocerebral Trauma; Epilepsy; Human | 2015 |
3 trials available for piracetam and Craniocerebral Trauma
| Article | Year |
|---|---|
Results of phase II levetiracetam trial following acute head injury in children at risk for posttraumatic epilepsy.
Topics: Adolescent; Anticonvulsants; Brain Injuries; Child; Craniocerebral Trauma; Epilepsy, Post-Traumatic; | 2013 |
Clinical trial of piracetam in disorders of consciousness due to head injury.
Topics: Adult; Animals; Blood-Brain Barrier; Clinical Trials as Topic; Coma; Consciousness; Craniocerebral T | 1975 |
[Use of piracetam in the treatment of cranial injuries. Observations on 903 cases].
Topics: Adolescent; Adult; Aged; Brain Concussion; Child; Child, Preschool; Clinical Trials as Topic; Consci | 1985 |
2 other studies available for piracetam and Craniocerebral Trauma
| Article | Year |
|---|---|
Drug correction of behavioral reactions and metabolic disorders in rats with craniocerebral trauma.
Topics: Animals; Antioxidants; Benzimidazoles; Body Weight; Brain; Brain Injuries; Carbon Tetrachloride Pois | 2003 |
The significance of individual resistance to hypoxia for correction of the consequences of craniocerebral trauma.
Topics: Animals; Antioxidants; Behavior, Animal; Benzimidazoles; Body Temperature; Body Weight; Brain Edema; | 2005 |