piracetam has been researched along with Brain Injuries, Traumatic in 19 studies
Piracetam: A compound suggested to be both a nootropic and a neuroprotective agent.
Brain Injuries, Traumatic: A form of acquired brain injury which occurs when a sudden trauma causes damage to the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this propensity score-matched cohort analysis, levetiracetam prophylaxis was ineffective in preventing seizures as the rate of seizures was similar whether patients did or did not receive the drug." | 7.83 | Levetiracetam Prophylaxis for Post-traumatic Brain Injury Seizures is Ineffective: A Propensity Score Analysis. ( Friese, R; Gruessner, A; Joseph, B; Khalil, M; Kulvatunyou, N; Latifi, R; O'Keeffe, T; Rhee, P; Wynne, J; Zangbar, B, 2016) |
| " On the basis of currently available Level III evidence, patients treated with either levetiracetam or phenytoin have similar incidences of early seizures after TBI." | 4.93 | Should Levetiracetam or Phenytoin Be Used for Posttraumatic Seizure Prophylaxis? A Systematic Review of the Literature and Meta-analysis. ( Barker, F; Evans, LT; Fierst, TM; Hoes, K; Hymel, C; Khan, NR; Klimo, P; Mayer, R; VanLandingham, MA, 2016) |
| "In conclusion, the results of this study demonstrate no statistically significant difference in the cumulative incidence of early posttraumatic seizures within 7 days of TBI between three different levetiracetam dosing strategies." | 4.31 | Evaluation of Levetiracetam Dosing Strategies for Seizure Prophylaxis Following Traumatic Brain Injury. ( Kaleem, S; Komisarow, J; Kram, B; Lee, HJ; Ohman, K; Schultheis, J; Sigmon, J; Vatsaas, C; Yang, Z, 2023) |
| "Patients may experience a reduced incidence of clinical and electroencephalographic seizures with levetiracetam dosing >1000-mg TDD." | 4.31 | Levetiracetam dosing for seizure prophylaxis in neurocritical care patients. ( Ansari, S; Davis, GE; Findlay, MC; Hawryluk, GWJ; Hedges, A; Menacho, ST; Wolfe, BM, 2023) |
| "The primary objective of this study was to determine the effectiveness of a lower dose of levetiracetam (500 mg every 12 hours) to prevent early seizures after traumatic brain injury (TBI)." | 3.83 | Low-dose levetiracetam for seizure prophylaxis after traumatic brain injury. ( Kurita, A; Patanwala, AE; Truong, E, 2016) |
| "In this propensity score-matched cohort analysis, levetiracetam prophylaxis was ineffective in preventing seizures as the rate of seizures was similar whether patients did or did not receive the drug." | 3.83 | Levetiracetam Prophylaxis for Post-traumatic Brain Injury Seizures is Ineffective: A Propensity Score Analysis. ( Friese, R; Gruessner, A; Joseph, B; Khalil, M; Kulvatunyou, N; Latifi, R; O'Keeffe, T; Rhee, P; Wynne, J; Zangbar, B, 2016) |
| "The mean incidence of posttraumatic seizures with AED prophylaxis was 8% for early seizures and 7." | 3.01 | Use of antiepileptic drugs as prophylaxis against posttraumatic seizures in the pediatric population: a systematic review and meta-analysis. ( Al Jayyousi, O; Hazaimeh, E; Ifraitekh, AS; Jbarah, OF; Samara, QA; Sawan, S, 2023) |
| "Traumatic brain injury is a major problem worldwide." | 2.58 | A meta-analysis of the effect of different neuroprotective drugs in management of patients with traumatic brain injury. ( Abdelmonem, S; El Sayed, I; Fayed, AM; Shehata, GM; Zaki, A, 2018) |
| "This review discusses seizures associated with traumatic brain injury in children, including seizure incidence, relationship to severity of injury, potential detrimental effects of seizures, potential benefits of AED, adverse effects of AED, new developments in preventing epileptogenesis, and suggested recommendations for patient management." | 2.53 | Anti-epileptic drugs in pediatric traumatic brain injury. ( Litofsky, NS; Tanaka, T, 2016) |
| " However, LEV was associated with a lower adverse drug reaction rate (RR = 0." | 2.53 | The safety and efficacy of levetiracetam versus phenytoin for seizure prophylaxis after traumatic brain injury: A systematic review and meta-analysis. ( Li, J; Qi, L; Shao, WZ; Shen, J; Sun, YZ; Tang, LJ; Xu, JC; Zhai, XF; Zheng, JY, 2016) |
| "Phenytoin has been the only recommended antiepileptic drug (AED) for seizure prophylaxis; however, several shortcomings have affected its use." | 2.53 | Levetiracetam Versus Phenytoin for Seizure Prophylaxis Following Traumatic Brain Injury: A Systematic Review and Meta-Analysis. ( Wang, X; Xu, X; Yang, Y; Zheng, F, 2016) |
| "Levetiracetam appears to be a safe and effective medication for PTS prophylaxis in combat casualties." | 1.91 | Use of Levetiracetam for Post-Traumatic Seizure Prophylaxis in Combat-Related Traumatic Brain Injury. ( Atwood, R; Bradley, M; Elster, E; Walker, P; Walper, D, 2023) |
| "Overall, 3." | 1.48 | Early Seizure Prophylaxis in Traumatic Brain Injuries Revisited: A Prospective Observational Study. ( Benjamin, E; Demetriades, D; Hong, Q; Inaba, K; Khor, D; Wu, J; Xiao, S, 2018) |
| "Levetiracetam (LEV) is an antiepileptic agent targeting novel pathways." | 1.43 | Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy. ( Bramlett, HM; Browning, M; Dietrich, WD; Dixon, CE; Hayes, RL; Kochanek, PM; Mondello, S; Poloyac, SM; Povlishock, JT; Schmid, KE; Shear, DA; Tortella, FC; Wang, KK, 2016) |
| "Seizures were induced at two weeks after FPI by KA in another group (FPI-LS)." | 1.43 | Levetiracetam prophylaxis ameliorates seizure epileptogenesis after fluid percussion injury. ( Chen, YH; Chiang, YH; Chou, YC; Hoffer, BJ; Huang, EY; Kuo, TT; Ma, HI; Tsai, JJ; Wu, PJ, 2016) |
| "Posttraumatic seizure, one of the secondary injury sequelae, contributes to further damage to the injured brain." | 1.43 | Continuous electroencephalography in pediatric traumatic brain injury: Seizure characteristics and outcomes. ( Reuter-Rice, K; Vaewpanich, J, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 14 (73.68) | 24.3611 |
| 2020's | 5 (26.32) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, BC | 1 |
| Chiu, HY | 1 |
| Luh, HT | 1 |
| Lin, CJ | 1 |
| Hsieh, SH | 1 |
| Chen, TJ | 1 |
| Wu, CR | 1 |
| Chen, PY | 1 |
| Ohman, K | 1 |
| Kram, B | 1 |
| Schultheis, J | 1 |
| Sigmon, J | 1 |
| Kaleem, S | 1 |
| Yang, Z | 1 |
| Lee, HJ | 1 |
| Vatsaas, C | 1 |
| Komisarow, J | 1 |
| Samara, QA | 1 |
| Ifraitekh, AS | 1 |
| Al Jayyousi, O | 1 |
| Sawan, S | 1 |
| Hazaimeh, E | 1 |
| Jbarah, OF | 1 |
| Hedges, A | 1 |
| Findlay, MC | 1 |
| Davis, GE | 1 |
| Wolfe, BM | 1 |
| Hawryluk, GWJ | 1 |
| Menacho, ST | 1 |
| Ansari, S | 1 |
| Atwood, R | 1 |
| Walker, P | 1 |
| Walper, D | 1 |
| Elster, E | 1 |
| Bradley, M | 1 |
| Khor, D | 1 |
| Wu, J | 1 |
| Hong, Q | 1 |
| Benjamin, E | 1 |
| Xiao, S | 1 |
| Inaba, K | 1 |
| Demetriades, D | 1 |
| Wilson, CD | 1 |
| Burks, JD | 1 |
| Rodgers, RB | 1 |
| Evans, RM | 1 |
| Bakare, AA | 1 |
| Safavi-Abbasi, S | 1 |
| Bakr, A | 1 |
| Belli, A | 1 |
| Patanwala, AE | 1 |
| Kurita, A | 1 |
| Truong, E | 1 |
| Browning, M | 1 |
| Shear, DA | 1 |
| Bramlett, HM | 1 |
| Dixon, CE | 1 |
| Mondello, S | 1 |
| Schmid, KE | 1 |
| Poloyac, SM | 1 |
| Dietrich, WD | 1 |
| Hayes, RL | 1 |
| Wang, KK | 1 |
| Povlishock, JT | 1 |
| Tortella, FC | 1 |
| Kochanek, PM | 1 |
| Chen, YH | 1 |
| Huang, EY | 1 |
| Kuo, TT | 1 |
| Hoffer, BJ | 1 |
| Wu, PJ | 1 |
| Ma, HI | 1 |
| Tsai, JJ | 1 |
| Chou, YC | 1 |
| Chiang, YH | 1 |
| Tanaka, T | 1 |
| Litofsky, NS | 1 |
| Xu, JC | 1 |
| Shen, J | 1 |
| Shao, WZ | 1 |
| Tang, LJ | 1 |
| Sun, YZ | 1 |
| Zhai, XF | 1 |
| Qi, L | 1 |
| Li, J | 1 |
| Zheng, JY | 1 |
| Zangbar, B | 1 |
| Khalil, M | 1 |
| Gruessner, A | 1 |
| Joseph, B | 1 |
| Friese, R | 1 |
| Kulvatunyou, N | 1 |
| Wynne, J | 1 |
| Latifi, R | 1 |
| Rhee, P | 1 |
| O'Keeffe, T | 1 |
| Yang, Y | 1 |
| Zheng, F | 1 |
| Xu, X | 1 |
| Wang, X | 1 |
| Vaewpanich, J | 1 |
| Reuter-Rice, K | 1 |
| El Sayed, I | 1 |
| Zaki, A | 1 |
| Fayed, AM | 1 |
| Shehata, GM | 1 |
| Abdelmonem, S | 1 |
| Khan, NR | 1 |
| VanLandingham, MA | 1 |
| Fierst, TM | 1 |
| Hymel, C | 1 |
| Hoes, K | 1 |
| Evans, LT | 1 |
| Mayer, R | 1 |
| Barker, F | 1 |
| Klimo, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pharmacokinetic Analysis of Levetiracetam Prophylaxis in Critically Ill Patients With Severe Traumatic Brain Injury[NCT04836481] | 20 participants (Anticipated) | Observational | 2021-01-01 | Recruiting | |||
| The Impact and Outcomes of Combined Cerebrolysin and Amantadine Sulfate Administration on Management of Patients With Traumatic Brain Injury in the ICU[NCT06052787] | Phase 3 | 150 participants (Anticipated) | Interventional | 2023-09-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for piracetam and Brain Injuries, Traumatic
| Article | Year |
|---|---|
Comparative efficacy of prophylactic anticonvulsant drugs following traumatic brain injury: A systematic review and network meta-analysis of randomized controlled trials.
Topics: Anticonvulsants; Brain Injuries, Traumatic; Carbamazepine; Child; Humans; Levetiracetam; Network Met | 2022 |
Use of antiepileptic drugs as prophylaxis against posttraumatic seizures in the pediatric population: a systematic review and meta-analysis.
Topics: Adult; Anticonvulsants; Brain Injuries, Traumatic; Child; Humans; Levetiracetam; Phenytoin; Piraceta | 2023 |
Early and Late Posttraumatic Epilepsy in the Setting of Traumatic Brain Injury: A Meta-analysis and Review of Antiepileptic Management.
Topics: Anticonvulsants; Brain Injuries, Traumatic; Epilepsy, Post-Traumatic; Humans; Levetiracetam; Phenyto | 2018 |
A systematic review of levetiracetam versus phenytoin in the prevention of late post-traumatic seizures and survey of UK neurosurgical prescribing practice of antiepileptic medication in acute traumatic brain injury.
Topics: Adult; Anticonvulsants; Brain Injuries, Traumatic; Cohort Studies; Epilepsy, Post-Traumatic; Female; | 2018 |
Anti-epileptic drugs in pediatric traumatic brain injury.
Topics: Anticonvulsants; Brain Injuries, Traumatic; Child; Humans; Levetiracetam; Phenytoin; Piracetam; Seiz | 2016 |
The safety and efficacy of levetiracetam versus phenytoin for seizure prophylaxis after traumatic brain injury: A systematic review and meta-analysis.
Topics: Anticonvulsants; Brain Injuries, Traumatic; Humans; Levetiracetam; Phenytoin; Piracetam; Seizures | 2016 |
Levetiracetam Versus Phenytoin for Seizure Prophylaxis Following Traumatic Brain Injury: A Systematic Review and Meta-Analysis.
Topics: Anticonvulsants; Brain Injuries, Traumatic; Cohort Studies; Humans; Levetiracetam; Observational Stu | 2016 |
A meta-analysis of the effect of different neuroprotective drugs in management of patients with traumatic brain injury.
Topics: Adult; Amino Acids; Brain Injuries, Traumatic; Cognition Disorders; Cytidine Diphosphate Choline; Gl | 2018 |
Should Levetiracetam or Phenytoin Be Used for Posttraumatic Seizure Prophylaxis? A Systematic Review of the Literature and Meta-analysis.
Topics: Anticonvulsants; Brain Injuries, Traumatic; Humans; Levetiracetam; Phenytoin; Piracetam; Seizures | 2016 |
1 trial available for piracetam and Brain Injuries, Traumatic
| Article | Year |
|---|---|
[Electrophysiological correlates of efficacy of nootropic drugs in the treatment of consequences of traumatic brain injury in adolescents].
Topics: Adolescent; Alpha Rhythm; Amino Acids; Ascorbic Acid; Asthenia; Attention; Brain; Brain Injuries, Tr | 2010 |
9 other studies available for piracetam and Brain Injuries, Traumatic
| Article | Year |
|---|---|
Evaluation of Levetiracetam Dosing Strategies for Seizure Prophylaxis Following Traumatic Brain Injury.
Topics: Anticonvulsants; Brain Injuries, Traumatic; Cohort Studies; Humans; Levetiracetam; Piracetam; Retros | 2023 |
Levetiracetam dosing for seizure prophylaxis in neurocritical care patients.
Topics: Adult; Anticonvulsants; Brain Injuries, Traumatic; Female; Humans; Levetiracetam; Male; Middle Aged; | 2023 |
Use of Levetiracetam for Post-Traumatic Seizure Prophylaxis in Combat-Related Traumatic Brain Injury.
Topics: Adult; Anticonvulsants; Brain Injuries, Traumatic; Female; Humans; Levetiracetam; Male; Piracetam; R | 2023 |
Early Seizure Prophylaxis in Traumatic Brain Injuries Revisited: A Prospective Observational Study.
Topics: Adult; Anticonvulsants; Brain Injuries, Traumatic; Female; Humans; Incidence; Levetiracetam; Male; M | 2018 |
Low-dose levetiracetam for seizure prophylaxis after traumatic brain injury.
Topics: Adult; Aged; Anticonvulsants; Brain Injuries, Traumatic; Cohort Studies; Dose-Response Relationship, | 2016 |
Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.
Topics: Animals; Biomarkers; Brain Injuries, Traumatic; Disease Models, Animal; Glial Fibrillary Acidic Prot | 2016 |
Levetiracetam prophylaxis ameliorates seizure epileptogenesis after fluid percussion injury.
Topics: Animals; Anticonvulsants; Brain Injuries, Traumatic; CA1 Region, Hippocampal; Disease Models, Animal | 2016 |
Levetiracetam Prophylaxis for Post-traumatic Brain Injury Seizures is Ineffective: A Propensity Score Analysis.
Topics: Adolescent; Adult; Anticonvulsants; Brain Injuries, Traumatic; Chemoprevention; Databases, Factual; | 2016 |
Continuous electroencephalography in pediatric traumatic brain injury: Seizure characteristics and outcomes.
Topics: Adolescent; Brain; Brain Injuries, Traumatic; Child; Child, Preschool; Electroencephalography; Epile | 2016 |