Page last updated: 2024-11-02

piracetam and Alcohol Problem

piracetam has been researched along with Alcohol Problem in 3 studies

Piracetam: A compound suggested to be both a nootropic and a neuroprotective agent.

Research Excerpts

ExcerptRelevanceReference
"Zonisamide is a structurally related anticonvulsant that is a promising agent for the treatment of AD and may have greater tolerability than topiramate."2.80Zonisamide, topiramate, and levetiracetam: efficacy and neuropsychological effects in alcohol use disorders. ( Ciraulo, DA; Colaneri, L; Devine, E; Knapp, CM; Oscar-Berman, M; Putnam, M; Richambault, C; Richardson, MA; Sarid-Segal, O; Streeter, CC; Surprise, C; Waters, M, 2015)
"Piracetam (Pir) is a nootropic drug derived from c-aminobutyric acid and can manage cognition impairments in multiple neurological disorders."1.46Piracetam inhibits ethanol (EtOH)-induced memory deficit by mediating multiple pathways. ( Feng, J; Wang, J; Xu, F; Yang, Y, 2017)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yang, Y1
Feng, J1
Xu, F1
Wang, J1
Knapp, CM1
Ciraulo, DA1
Sarid-Segal, O1
Richardson, MA1
Devine, E1
Streeter, CC1
Oscar-Berman, M1
Surprise, C1
Colaneri, L1
Putnam, M1
Waters, M1
Richambault, C1
Devine, EG1
Ryan, ML1
Falk, DE1
Fertig, JB1
Litten, RZ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-Blind, Placebo-Controlled, Parallel Group Design Trial of; Levetiracetam, Zonisamide, Topiramate, and Placebo Control for the Treatment of Alcohol Dependent Subjects.[NCT00862563]Phase 285 participants (Actual)Interventional2009-05-31Terminated (stopped due to Recruitment goals could not be met before ending of funding for this project.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

AB-Neurotoxicity Scale.

Total Scores AB-Neurotoxicity Scale Week 12. This scale provides subject ratings of anticonvulsant neurotoxic effects. Scores may range 0 to 72, with possibility of an additional 30 points being for complaints not listed in the list of complaints provides. Total scores, therefore, may be as high as 102, with higher scores indicating greater severity of problems. Actual mean scores are shown. Means for the analysis are least means squares values obtained from a two-way repeated measures mixed models analysis, with Week (time) as the the within subject factor and treatment as the between group factor. Baseline values were used as covariates. (NCT00862563)
Timeframe: Week 12

InterventionScale Scores (Mean)
Zonisamide7.1
Levetiracetam11.3
Topiramate15.4
Sugar Pill5.8

Controlled Word Association Test (COWAT)- Letter Fluency

Number of words generated that start with a set of 3 letters. The COWAT provides a measure of verbal fluency. Actual means for COWAT results are shown. (NCT00862563)
Timeframe: Baseline & Week 12

,,,
InterventionNumber of Words Produced (Mean)
BaselineWeek 12
Levetiracetam46.245.4
Sugar Pill47.450.5
Topiramate43.428.1
Zonisamide46.532.5

COWAT-Category

Number of words produced by subjects over 60 seconds for a semantic category (Animals). The COAWAT-Category sub-test provides a measure of verbal fluency. Mean value shown are actual means for the number of words produced. (NCT00862563)
Timeframe: Baseline, Week12

,,,
InterventionNumber of Words Produced (Mean)
BaselineWeek 12
Levetiracetam20.921.2
Sugar Pill21.620.8
Topiramate21.917.0
Zonisamide22.617.4

Mean Percent Days Heavy Drinking

Mean weekly values for each treatment group for percent days heavy drinking. Heavy drinking was defined as 4 or more drinks per day for women and 5 or more drinks per day for men. (NCT00862563)
Timeframe: Weeks 10, 11, 12

,,,
InterventionPercentage of Days/Week (Mean)
Week 10Week 11Week 12
Levetiracetam49.647.944.5
Sugar Pill65.761.760.9
Topiramate32.129.521.0
Zonisamide38.436.634.3

Percent Days Drinking

Mean percent days drinking for Weeks 10, 11, 12. A drinking day is considered to be a day in which 1 or more drinks have been consumed. Means are model generated least means squares values obtained from a two-way repeated measures analysis from data obtained from Weeks 1 through 12, with Week as the within subject factor and treatment group as the between group factor. (NCT00862563)
Timeframe: Weeks 10, 11, 12

,,,
InterventionPercentage of Days/ Week (Mean)
Week 10Week 11Week 12
Levetiracetam72.268.973.1
Sugar Pill83.687.278.2
Topiramate51.843.851.4
Zonisamide61.662.161.3

The Primary Efficacy Measure is the Mean Number of Drinks Consumed Per Day Over the Period From Treatment Weeks 10 Through 12 When All Study Medications Should be at Their Maximum Steady Levels Based on Their Known Pharmacokinetic Properties.

Mean standard drinks consumed per day for each treatment week, weeks 10 thru 12. Actual mean values obtained are shown. Analyses are based on model generated least squares means for a two -way repeated measures mixed models analysis for data obtained for weeks 1 through 12, with baseline values used as covariates. Week (time) was used as the within subject factor and treatment group was the between group factor. (NCT00862563)
Timeframe: Weeks 10, 11, 12

,,,
InterventionStandard Drinks per day (Mean)
Week 10Week 11Week 12
Levetiracetam4.64.34.3
Sugar Pill6.36.86.0
Topiramate3.22.72.5
Zonisamide3.83.42.5

Wechsler Memory Scale-3rd Ed. Spatial Span

WMS Spatial Span test measures working memory for a spatial sequence of numbers. This assesses visual working memory. Age adjusted scaled scores are presented. Score may range between 1 and 19, with lower scores indicating greater impairment in performance. (NCT00862563)
Timeframe: Baseline, Week 12

,,,
Interventionunits on a scale (Mean)
BaselineWeek 12
Levetiracetam10.510.9
Sugar Pill10.810.4
Topiramate12.08.4
Zonisamide10.87.9

Wechsler Memory Scales (WMS)-3d Ed Digit Span-Age Adjusted Total

WMS Digit Span is a measure of working memory. Subjects respond by repeating lists of number sequences presented by the test administrator. Age adjusted scores are presented below. Scores may range between 1 and 19, with lower scores indicating poorer performance on the task. (NCT00862563)
Timeframe: Baseline, Week 12

,,,
Interventionunits on a scale (Mean)
BaselineWeek 12
Levetiracetam11.912.2
Sugar Pill12.613.0
Topiramate12.17.7
Zonisamide11.810.0

Trials

2 trials available for piracetam and Alcohol Problem

ArticleYear
Zonisamide, topiramate, and levetiracetam: efficacy and neuropsychological effects in alcohol use disorders.
    Journal of clinical psychopharmacology, 2015, Volume: 35, Issue:1

    Topics: Adult; Aged; Alcohol Drinking; Alcohol-Related Disorders; Anticonvulsants; Cognition Disorders; Doub

2015
An exploratory evaluation of Take Control: A novel computer-delivered behavioral platform for placebo-controlled pharmacotherapy trials for alcohol use disorder.
    Contemporary clinical trials, 2016, Volume: 50

    Topics: Adult; Alcohol-Related Disorders; Antidiuretic Hormone Receptor Antagonists; Behavior Therapy; Combi

2016

Other Studies

1 other study available for piracetam and Alcohol Problem

ArticleYear
Piracetam inhibits ethanol (EtOH)-induced memory deficit by mediating multiple pathways.
    Brain research, 2017, Dec-01, Volume: 1676

    Topics: Alcohol-Related Disorders; Animals; Apoptosis; Cell Line; Cell Survival; Dose-Response Relationship,

2017