piracetam has been researched along with Alcohol Problem in 3 studies
Piracetam: A compound suggested to be both a nootropic and a neuroprotective agent.
Excerpt | Relevance | Reference |
---|---|---|
"Zonisamide is a structurally related anticonvulsant that is a promising agent for the treatment of AD and may have greater tolerability than topiramate." | 2.80 | Zonisamide, topiramate, and levetiracetam: efficacy and neuropsychological effects in alcohol use disorders. ( Ciraulo, DA; Colaneri, L; Devine, E; Knapp, CM; Oscar-Berman, M; Putnam, M; Richambault, C; Richardson, MA; Sarid-Segal, O; Streeter, CC; Surprise, C; Waters, M, 2015) |
"Piracetam (Pir) is a nootropic drug derived from c-aminobutyric acid and can manage cognition impairments in multiple neurological disorders." | 1.46 | Piracetam inhibits ethanol (EtOH)-induced memory deficit by mediating multiple pathways. ( Feng, J; Wang, J; Xu, F; Yang, Y, 2017) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 3 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Yang, Y | 1 |
Feng, J | 1 |
Xu, F | 1 |
Wang, J | 1 |
Knapp, CM | 1 |
Ciraulo, DA | 1 |
Sarid-Segal, O | 1 |
Richardson, MA | 1 |
Devine, E | 1 |
Streeter, CC | 1 |
Oscar-Berman, M | 1 |
Surprise, C | 1 |
Colaneri, L | 1 |
Putnam, M | 1 |
Waters, M | 1 |
Richambault, C | 1 |
Devine, EG | 1 |
Ryan, ML | 1 |
Falk, DE | 1 |
Fertig, JB | 1 |
Litten, RZ | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Double-Blind, Placebo-Controlled, Parallel Group Design Trial of; Levetiracetam, Zonisamide, Topiramate, and Placebo Control for the Treatment of Alcohol Dependent Subjects.[NCT00862563] | Phase 2 | 85 participants (Actual) | Interventional | 2009-05-31 | Terminated (stopped due to Recruitment goals could not be met before ending of funding for this project.) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Total Scores AB-Neurotoxicity Scale Week 12. This scale provides subject ratings of anticonvulsant neurotoxic effects. Scores may range 0 to 72, with possibility of an additional 30 points being for complaints not listed in the list of complaints provides. Total scores, therefore, may be as high as 102, with higher scores indicating greater severity of problems. Actual mean scores are shown. Means for the analysis are least means squares values obtained from a two-way repeated measures mixed models analysis, with Week (time) as the the within subject factor and treatment as the between group factor. Baseline values were used as covariates. (NCT00862563)
Timeframe: Week 12
Intervention | Scale Scores (Mean) |
---|---|
Zonisamide | 7.1 |
Levetiracetam | 11.3 |
Topiramate | 15.4 |
Sugar Pill | 5.8 |
Number of words generated that start with a set of 3 letters. The COWAT provides a measure of verbal fluency. Actual means for COWAT results are shown. (NCT00862563)
Timeframe: Baseline & Week 12
Intervention | Number of Words Produced (Mean) | |
---|---|---|
Baseline | Week 12 | |
Levetiracetam | 46.2 | 45.4 |
Sugar Pill | 47.4 | 50.5 |
Topiramate | 43.4 | 28.1 |
Zonisamide | 46.5 | 32.5 |
Number of words produced by subjects over 60 seconds for a semantic category (Animals). The COAWAT-Category sub-test provides a measure of verbal fluency. Mean value shown are actual means for the number of words produced. (NCT00862563)
Timeframe: Baseline, Week12
Intervention | Number of Words Produced (Mean) | |
---|---|---|
Baseline | Week 12 | |
Levetiracetam | 20.9 | 21.2 |
Sugar Pill | 21.6 | 20.8 |
Topiramate | 21.9 | 17.0 |
Zonisamide | 22.6 | 17.4 |
Mean weekly values for each treatment group for percent days heavy drinking. Heavy drinking was defined as 4 or more drinks per day for women and 5 or more drinks per day for men. (NCT00862563)
Timeframe: Weeks 10, 11, 12
Intervention | Percentage of Days/Week (Mean) | ||
---|---|---|---|
Week 10 | Week 11 | Week 12 | |
Levetiracetam | 49.6 | 47.9 | 44.5 |
Sugar Pill | 65.7 | 61.7 | 60.9 |
Topiramate | 32.1 | 29.5 | 21.0 |
Zonisamide | 38.4 | 36.6 | 34.3 |
Mean percent days drinking for Weeks 10, 11, 12. A drinking day is considered to be a day in which 1 or more drinks have been consumed. Means are model generated least means squares values obtained from a two-way repeated measures analysis from data obtained from Weeks 1 through 12, with Week as the within subject factor and treatment group as the between group factor. (NCT00862563)
Timeframe: Weeks 10, 11, 12
Intervention | Percentage of Days/ Week (Mean) | ||
---|---|---|---|
Week 10 | Week 11 | Week 12 | |
Levetiracetam | 72.2 | 68.9 | 73.1 |
Sugar Pill | 83.6 | 87.2 | 78.2 |
Topiramate | 51.8 | 43.8 | 51.4 |
Zonisamide | 61.6 | 62.1 | 61.3 |
Mean standard drinks consumed per day for each treatment week, weeks 10 thru 12. Actual mean values obtained are shown. Analyses are based on model generated least squares means for a two -way repeated measures mixed models analysis for data obtained for weeks 1 through 12, with baseline values used as covariates. Week (time) was used as the within subject factor and treatment group was the between group factor. (NCT00862563)
Timeframe: Weeks 10, 11, 12
Intervention | Standard Drinks per day (Mean) | ||
---|---|---|---|
Week 10 | Week 11 | Week 12 | |
Levetiracetam | 4.6 | 4.3 | 4.3 |
Sugar Pill | 6.3 | 6.8 | 6.0 |
Topiramate | 3.2 | 2.7 | 2.5 |
Zonisamide | 3.8 | 3.4 | 2.5 |
WMS Spatial Span test measures working memory for a spatial sequence of numbers. This assesses visual working memory. Age adjusted scaled scores are presented. Score may range between 1 and 19, with lower scores indicating greater impairment in performance. (NCT00862563)
Timeframe: Baseline, Week 12
Intervention | units on a scale (Mean) | |
---|---|---|
Baseline | Week 12 | |
Levetiracetam | 10.5 | 10.9 |
Sugar Pill | 10.8 | 10.4 |
Topiramate | 12.0 | 8.4 |
Zonisamide | 10.8 | 7.9 |
WMS Digit Span is a measure of working memory. Subjects respond by repeating lists of number sequences presented by the test administrator. Age adjusted scores are presented below. Scores may range between 1 and 19, with lower scores indicating poorer performance on the task. (NCT00862563)
Timeframe: Baseline, Week 12
Intervention | units on a scale (Mean) | |
---|---|---|
Baseline | Week 12 | |
Levetiracetam | 11.9 | 12.2 |
Sugar Pill | 12.6 | 13.0 |
Topiramate | 12.1 | 7.7 |
Zonisamide | 11.8 | 10.0 |
2 trials available for piracetam and Alcohol Problem
Article | Year |
---|---|
Zonisamide, topiramate, and levetiracetam: efficacy and neuropsychological effects in alcohol use disorders.
Topics: Adult; Aged; Alcohol Drinking; Alcohol-Related Disorders; Anticonvulsants; Cognition Disorders; Doub | 2015 |
An exploratory evaluation of Take Control: A novel computer-delivered behavioral platform for placebo-controlled pharmacotherapy trials for alcohol use disorder.
Topics: Adult; Alcohol-Related Disorders; Antidiuretic Hormone Receptor Antagonists; Behavior Therapy; Combi | 2016 |
1 other study available for piracetam and Alcohol Problem
Article | Year |
---|---|
Piracetam inhibits ethanol (EtOH)-induced memory deficit by mediating multiple pathways.
Topics: Alcohol-Related Disorders; Animals; Apoptosis; Cell Line; Cell Survival; Dose-Response Relationship, | 2017 |