Page last updated: 2024-11-02

piracetam and Aging

piracetam has been researched along with Aging in 56 studies

Piracetam: A compound suggested to be both a nootropic and a neuroprotective agent.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"To study the effect of acteoside on the expression of neurotrophin-3 (NT-3) in brain tissues of subacute aging mice induced by D-galactose (D-Gal) combined with aluminum trichloride (AlCl3)."7.80[Acteoside enhances expression of neurotrophin-3 in brain tissues of subacute aging mice induced by D-galactose combined with aluminum trichloride]. ( Gao, L; He, Y; Huo, S; Peng, X; Yan, M, 2014)
" This study was designed to compare the effects of levetiracetam, an antiepileptic drug, on memory deficits associated with normal aging and AD in mouse models."7.79Effects of levetiracetam, an antiepileptic drug, on memory impairments associated with aging and Alzheimer's disease in mice. ( Devi, L; Ohno, M, 2013)
"The authors examined sodium concentrations from 97 oxcarbazepine-treated (OXC) and 451 carbamazepine-treated (CBZ) patients with epilepsy using cross-section and follow-up studies."7.73Hyponatremia from oxcarbazepine and carbamazepine. ( Dong, X; Leppik, IE; Rarick, J; White, J, 2005)
"Extensive research of the recent years has demonstrated that piracetam is effective in the treatment of cognitive decline in aging and dementia."4.80Piracetam: novelty in a unique mode of action. ( Eckert, A; Eckert, GP; Müller, WE, 1999)
"Many of the neurochemical changes associated with aging brain, particularly lower choline acetyltransferase and higher monoamine oxidase, occur with greater severity in senile dementia, Alzheimer's type (SDAT)."4.76Chemotherapy of cognitive disorders in geriatric subjects. ( Gershon, S; Goodnick, P, 1984)
"To study the effect of acteoside on the expression of neurotrophin-3 (NT-3) in brain tissues of subacute aging mice induced by D-galactose (D-Gal) combined with aluminum trichloride (AlCl3)."3.80[Acteoside enhances expression of neurotrophin-3 in brain tissues of subacute aging mice induced by D-galactose combined with aluminum trichloride]. ( Gao, L; He, Y; Huo, S; Peng, X; Yan, M, 2014)
" This study was designed to compare the effects of levetiracetam, an antiepileptic drug, on memory deficits associated with normal aging and AD in mouse models."3.79Effects of levetiracetam, an antiepileptic drug, on memory impairments associated with aging and Alzheimer's disease in mice. ( Devi, L; Ohno, M, 2013)
" The increased risk associated with piracetam may reflect awareness of memory problems before any diagnosis of dementia has been made."3.75Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVET. ( Beckett, N; Bulpitt, C; de Vernejoul, MC; Fletcher, A; Gainsborough, N; Geneva, M; Lu, FH; Peters, R; Poulter, R; Tzekova, M; Williams, B, 2009)
"The authors examined sodium concentrations from 97 oxcarbazepine-treated (OXC) and 451 carbamazepine-treated (CBZ) patients with epilepsy using cross-section and follow-up studies."3.73Hyponatremia from oxcarbazepine and carbamazepine. ( Dong, X; Leppik, IE; Rarick, J; White, J, 2005)
" Elevated plus-maze and passive-avoidance apparatus served as the exteroceptive behavioral models, and diazepam-, scopolamine-, and aging-induced amnesia served as the interoceptive behavioral models."3.72Ascorbic Acid: a promising memory-enhancer in mice. ( Dhingra, D; Parle, M, 2003)
"The purpose of this analysis was to compare treatment-emergent adverse events (TEAE) related to use of levetiracetam (LEV) reported by young and elderly patients with anxiety and cognitive disorders, and young epilepsy patients."3.72Tolerability of levetiracetam in elderly patients with CNS disorders. ( Cramer, JA; Edrich, P; Krämer, G; Leppik, IE; Rue, KD, 2003)
"In order to test the hypothesis that piracetam improves cognitive functions by restoring biochemical deficits of the aging brain, we investigated the effects of piracetam treatment (300 mg/kg daily for 6 weeks) on the active avoidance performance of young and aged rats."3.70Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain. ( Bartsch, R; Müller, WE; Rostock, A; Scheuer, K, 1999)
"Levetiracetam is an effective antiepileptic drug in elderly individuals with cognitive impairment."2.75Levetiracetam: a practical option for seizure management in elderly patients with cognitive impairment. ( Hepler, M; Irwin, D; Jenssen, S; Lippa, CF; Pillai, J; Rosso, A, 2010)
"Epilepsy is one of the most common neurological conditions in the elderly, and the incidence of de novo geriatric epilepsy is rising."2.49[Epilepsy in the elderly]. ( Lossius, MI; Markhus, R; Nakken, KO; Sætre, E, 2013)
" Individualization of dosage and avoidance of unnecessary polypharmacy are essential for safe utilization of anti-epileptic drugs."2.44[Epilepsy in the elderly]. ( Yoshino, A, 2007)
"3."1.33Piracetam improves mitochondrial dysfunction following oxidative stress. ( Eckert, A; Hauptmann, S; Keil, U; Müller, WE; Scherping, I; Schuessel, K, 2006)
" Furthermore, the pharmacodynamic action of diuretics was not significantly altered in the elderly."1.30Renal handling of drugs in the healthy elderly. Creatinine clearance underestimates renal function and pharmacokinetics remain virtually unchanged. ( Bischoff, I; Block, S; Fliser, D; Hanses, A; Joest, M; Mutschler, E; Ritz, E, 1999)
"Piracetam was without effect on the performance of young animals but dose-dependently decreased the choice reaction times (two levers) in aged animals without affecting the other two parameters."1.29Effects of piracetam on indices of cognitive function in a delayed alternation task in young and aged rats. ( Hubert, I; Lenègre, A; Milinkevitch, D; Porsolt, RD; Roux, S, 1994)
"Memory deficits were induced by the muscarinic cholinoceptor antagonist scopolamine (in young and old rats and mice), by the alpha 2-adrenoceptor agonist clonidine, by electroconvulsive shock, and by hypoxy."1.29Effects of cytidine diphosphate choline on rats with memory deficits. ( Getova, D; Kehayov, RA; Lazarova, MB; Mosharrof, AH; Petkov, VD; Petkov, VV; Vaglenova, J, 1993)
"Rats treated with piracetam (500 mg/kg, p."1.28Effect of piracetam administration on 3H-N-methylscopolamine binding in cerebral cortex of young and old rats. ( Marinho, MM; Sousa, FC; Viana, GS, 1992)

Research

Studies (56)

TimeframeStudies, this research(%)All Research%
pre-199019 (33.93)18.7374
1990's19 (33.93)18.2507
2000's7 (12.50)29.6817
2010's11 (19.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, P1
Sun, H1
Liu, D1
Jiao, Z1
Yue, S1
He, X1
Xia, W1
Ji, J1
Xiang, L1
Devi, L1
Ohno, M1
Nakken, KO1
Sætre, E1
Markhus, R1
Lossius, MI1
Spiegel, AM1
Koh, MT2
Vogt, NM1
Rapp, PR1
Gallagher, M2
Gao, L1
Peng, X1
Huo, S1
He, Y1
Yan, M1
Robitsek, J1
Ratner, MH1
Stewart, T1
Eichenbaum, H1
Farb, DH1
Stockburger, C1
Miano, D1
Baeumlisberger, M1
Pallas, T1
Arrey, TN1
Karas, M1
Friedland, K1
Müller, WE8
Lippa, CF1
Rosso, A1
Hepler, M1
Jenssen, S1
Pillai, J1
Irwin, D1
Peters, R1
Beckett, N1
Geneva, M1
Tzekova, M1
Lu, FH1
Poulter, R1
Gainsborough, N1
Williams, B1
de Vernejoul, MC1
Fletcher, A1
Bulpitt, C1
Haberman, RP1
Foti, S1
McCown, TJ1
Sharma, K1
Bhatnagar, M1
Kulkarni, SK1
Boido, D1
Farisello, P1
Cesca, F1
Ferrea, E1
Valtorta, F1
Benfenati, F1
Baldelli, P1
Parle, M1
Dhingra, D1
Cramer, JA1
Leppik, IE2
Rue, KD1
Edrich, P1
Krämer, G1
Dedeurwaerdere, S1
Boon, P1
De Smedt, T1
Claeys, P1
Raedt, R1
Bosman, T1
Van Hese, P1
Van Maele, G1
Vonck, K1
Keil, U1
Scherping, I1
Hauptmann, S1
Schuessel, K1
Eckert, A2
Dong, X1
White, J1
Rarick, J1
Yoshino, A1
Wittenborn, JR1
Goodnick, P1
Gershon, S1
Jänicke, B2
Wrobel, D1
Jamieson, DD1
Taylor, KM1
Platt, D2
Oswald, WD1
Matejcek, M1
Lukaschek, K1
Dennler, HJ1
Oswald, B1
Bartus, RT1
Dean, RL1
Sherman, KA1
Friedman, E1
Beer, B1
Roux, S1
Hubert, I1
Lenègre, A1
Milinkevitch, D1
Porsolt, RD1
Petkov, VD3
Kehayov, RA1
Mosharrof, AH1
Petkov, VV3
Getova, D1
Lazarova, MB1
Vaglenova, J1
Cohen, SA1
Salimov, R1
Salimova, N1
Shvets, L1
Shvets, N1
Nagy, IZ1
Koch, S1
Scheuer, K2
Rostock, A2
Bartsch, R2
Israël, L1
Myslinski, M1
Dubos, G1
Mélac, M1
Ryzhavskiĭ, BIa1
Cheprakova, VA1
Tsekatunov, DA1
Dormehl, IC1
Jordaan, B1
Oliver, DW1
Croft, S1
Eckert, GP1
Fliser, D1
Bischoff, I1
Hanses, A1
Block, S1
Joest, M1
Ritz, E1
Mutschler, E1
Clemens, JA1
Fuller, RW1
Dorn, M1
Viana, GS1
Marinho, MM1
Sousa, FC1
Mondadori, C2
Buerki, H2
Borkowski, J2
Radeke, E1
Ducret, T2
Glatt, A1
Stancheva, SL1
Hadjiivanova, CI1
Coper, H1
Heiss, WD1
Szelies, B1
Kessler, J1
Herholz, K1
Belcheva, S1
Stoyanova, V1
Wustmann, C1
Blaschke, M1
Rudolph, E1
Fischer, HD1
Schmidt, J1
Yamamoto, M1
Iwai, A1
Kawabata, S1
Ozawa, Y1
Shimizu, M1
Pilch, H2
Classen, W1
Schadé, A1
Giurgea, G1
Pavlovskaia, NI1
Vorob'eva, TV1
Zelenin, VA1
Amin, MM1
Khan, P1
Lehmann, HE1
Mirmiran, J1
Mühlberg, W1
Rieck, W1
Poschel, BP1
Ho, PM1
Ninteman, FW1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Network-Level Mechanisms for Preclinical Alzheimer's Disease Development[NCT03461861]Phase 226 participants (Actual)Interventional2019-04-11Completed
Bridging Cognitive Aging in Rodents to Man Using fMRI in Amnestic MCI[NCT01044758]Phase 296 participants (Actual)Interventional2009-12-31Completed
Brain Changes in Pediatric Obstructive Sleep Apnea[NCT05368077]70 participants (Anticipated)Interventional2022-05-14Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Functional Connectivity Strengths of Neural Networks

The seed-based functional connectivity strengths of the hippocampus network and the default mode network will be employed to measure the changes between AGB101 and Placebo perturbation. The functional connectivity strengths will be measured with the median of the Pearson cross-correlation coefficients over entire brain regions. (NCT03461861)
Timeframe: 2 weeks after treatment between AGB101 and Placebo

InterventionPearson coefficient (Median)
AGB101 220 mg0.233
Placebo0.318

Rey Auditory Verbal Learning Test (AVLT), Delayed Recall Scaled Integer. The Higher is the Better

Rey Auditory Verbal Learning Test (AVLT), delayed recall Scaled integer will be employed to measure the episodic memory changes before and after AGB101 treatment. The AVLT score will be recorded as a standard score. The theoretical range: min 50, max 155, the higher the better. The higher the number is, the better the memory. It is an integer number. (NCT03461861)
Timeframe: Placebo vs AGB101 2 weeks after treatment paired t-test

Interventionscore on a scale (Mean)
AGB101 220 mg108
Placebo105

Behavioral Performance as Assessed in the Functional Magnetic Resonance Imaging (fMRI) Memory Task

Mnemonic similarity task which assesses long term memory function. Scale ranges from 0-100 with higher scores indicating better memory performance. (NCT01044758)
Timeframe: 2 weeks

Interventionpercent correct recalled (Mean)
aMCI_62.538
aMCI_62.5 Placebo33
aMCI_12533
aMCI_125 Placebo28
aMCI_25034
aMCI_250 Placebo31
Age Matched Control44

Brain Activity in the Dentate Gyrus / CA3 Subregion of the Hippocampus Measured With Blood Oxygenation Level Dependent (BOLD) Functional MRI

Measurement of average brain activity in the dentate gyrus / CA3 subregion of the hippocampus measured with BOLD functional MRI in patients with mild cognitive impairment on placebo and on drug compared to average brain activity in this brain area in control subjects. (NCT01044758)
Timeframe: 2 weeks

Interventionmean beta coefficient (Mean)
aMCI_62.5-0.1203
aMCI_62.5 Placebo0.4353
aMCI_125-0.2238
aMCI_125 Placebo0.8814
aMCI_2500.3928
aMCI_250 Placebo0.4825
Age Matched Control-.02507

Reviews

7 reviews available for piracetam and Aging

ArticleYear
[Epilepsy in the elderly].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2013, Mar-05, Volume: 133, Issue:5

    Topics: Age Factors; Aged; Aging; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Humans; Isoxa

2013
[Epilepsy in the elderly].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2007, Volume: 27, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Amines; Anticonvulsants; Cerebrovascular Disorders; Comorbidity; Cyc

2007
Pharmacotherapy for age-related behavioral deficiencies.
    The Journal of nervous and mental disease, 1981, Volume: 169, Issue:3

    Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Brain; Central

1981
Chemotherapy of cognitive disorders in geriatric subjects.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:5

    Topics: Adrenocorticotropic Hormone; Aged; Aging; Alzheimer Disease; Arecoline; Brain Chemistry; Choline; Co

1984
On the possible role of nootropica in geriatric prevention and therapy.
    Annals of the New York Academy of Sciences, 1996, Jun-15, Volume: 786

    Topics: Aging; Free Radical Scavengers; Humans; Nootropic Agents; Piracetam; Proline; Selegiline

1996
Piracetam: novelty in a unique mode of action.
    Pharmacopsychiatry, 1999, Volume: 32 Suppl 1

    Topics: Aged; Aging; Animals; Blood Cells; Brain; Brain Diseases; Cell Membrane; Cerebrovascular Circulation

1999
Chemical manipulation of some aspects of aging.
    Advances in experimental medicine and biology, 1978, Volume: 97

    Topics: Aging; Animals; Ergolines; Estrus; Female; Humans; Longevity; Male; Monoamine Oxidase Inhibitors; Pi

1978

Trials

6 trials available for piracetam and Aging

ArticleYear
Levetiracetam: a practical option for seizure management in elderly patients with cognitive impairment.
    American journal of Alzheimer's disease and other dementias, 2010, Volume: 25, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Cognition; Cognition Disorders; Disease-Free Surviv

2010
[On the meaning of psychometrically operationalized therapeutic effects in the treatment of brain insufficiency phenomena caused by old age demonstrated by the "Nürnberger-Alters-Inventar" (author's transl)].
    Arzneimittel-Forschung, 1982, Volume: 32, Issue:5

    Topics: Activities of Daily Living; Aged; Aging; Cognition; Dihydroergotoxine; Electroencephalography; Human

1982
[Combined therapies in family practice and hospitals. A controlled clinical study of a population of 162 patients with criteria of age-related memory disorders].
    Presse medicale (Paris, France : 1983), 1997, Sep-06, Volume: 26, Issue:25

    Topics: Aged; Aging; Ambulatory Care; Cognitive Behavioral Therapy; Combined Modality Therapy; Double-Blind

1997
SPECT monitoring of improved cerebral blood flow during long-term treatment of elderly patients with nootropic drugs.
    Clinical nuclear medicine, 1999, Volume: 24, Issue:1

    Topics: Administration, Oral; Aged; Aging; Brain; Cerebellum; Cerebrovascular Circulation; Cognition; Cross-

1999
[Piracetam in premature biological aging. Double-blind study after preselection by drugs].
    Fortschritte der Medizin, 1978, Aug-10, Volume: 96, Issue:30

    Topics: Aged; Aging; Double-Blind Method; Humans; Hypoxia, Brain; Piracetam; Placebos; Progeria; Pyrrolidino

1978
Early organiform impairment test (OFIT). A new performance test for assessment of early cognitive impairment.
    Progress in neuro-psychopharmacology & biological psychiatry, 1985, Volume: 9, Issue:5-6

    Topics: Adult; Aged; Aging; Clinical Trials as Topic; Cognition Disorders; Double-Blind Method; Female; Huma

1985

Other Studies

43 other studies available for piracetam and Aging

ArticleYear
Protective effect of a phenolic extract containing indoline amides from Portulaca oleracea against cognitive impairment in senescent mice induced by large dose of D-galactose /NaNO
    Journal of ethnopharmacology, 2017, May-05, Volume: 203

    Topics: Aging; Amides; Animals; Antioxidants; Cognitive Dysfunction; Disease Models, Animal; Galactose; Indo

2017
Effects of levetiracetam, an antiepileptic drug, on memory impairments associated with aging and Alzheimer's disease in mice.
    Neurobiology of learning and memory, 2013, Volume: 102

    Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Conditioning, Operant; Disease Mo

2013
Hilar interneuron vulnerability distinguishes aged rats with memory impairment.
    The Journal of comparative neurology, 2013, Oct-15, Volume: 521, Issue:15

    Topics: Aging; Animals; Antigens, Nuclear; Behavior, Animal; CA3 Region, Hippocampal; Cell Count; Cognition;

2013
[Acteoside enhances expression of neurotrophin-3 in brain tissues of subacute aging mice induced by D-galactose combined with aluminum trichloride].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2014, Volume: 30, Issue:10

    Topics: Aging; Aluminum Chloride; Aluminum Compounds; Animals; Antioxidants; Blotting, Western; Brain; Chlor

2014
Combined administration of levetiracetam and valproic acid attenuates age-related hyperactivity of CA3 place cells, reduces place field area, and increases spatial information content in aged rat hippocampus.
    Hippocampus, 2015, Volume: 25, Issue:12

    Topics: Action Potentials; Aging; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Central Nervous

2015
A Mitochondrial Role of SV2a Protein in Aging and Alzheimer's Disease: Studies with Levetiracetam.
    Journal of Alzheimer's disease : JAD, 2016, Volume: 50, Issue:1

    Topics: Adenosine Triphosphate; Aging; Alzheimer Disease; Animals; Brain; Cell Line; Cognition Disorders; Fe

2016
Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVET.
    Age and ageing, 2009, Volume: 38, Issue:5

    Topics: Aged, 80 and over; Aging; Alcohol Drinking; Antihypertensive Agents; Cognition Disorders; Dementia;

2009
Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:4

    Topics: Age Factors; Aging; Animals; Anticonvulsants; CA3 Region, Hippocampal; Cognition Disorders; Disease

2010
Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:4

    Topics: Age Factors; Aging; Animals; Anticonvulsants; CA3 Region, Hippocampal; Cognition Disorders; Disease

2010
Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:4

    Topics: Age Factors; Aging; Animals; Anticonvulsants; CA3 Region, Hippocampal; Cognition Disorders; Disease

2010
Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:4

    Topics: Age Factors; Aging; Animals; Anticonvulsants; CA3 Region, Hippocampal; Cognition Disorders; Disease

2010
Effect of Convolvulus pluricaulis Choisy and Asparagus racemosus Willd on learning and memory in young and old mice: a comparative evaluation.
    Indian journal of experimental biology, 2010, Volume: 48, Issue:5

    Topics: Acetylcholine; Aging; Animals; Antioxidants; Cholinergic Agents; Convolvulus; Dose-Response Relation

2010
Cortico-hippocampal hyperexcitability in synapsin I/II/III knockout mice: age-dependency and response to the antiepileptic drug levetiracetam.
    Neuroscience, 2010, Nov-24, Volume: 171, Issue:1

    Topics: 4-Aminopyridine; Aging; Analysis of Variance; Animals; Anticonvulsants; Cerebral Cortex; Disease Mod

2010
Ascorbic Acid: a promising memory-enhancer in mice.
    Journal of pharmacological sciences, 2003, Volume: 93, Issue:2

    Topics: Aging; Amnesia; Animals; Antioxidants; Anxiety; Ascorbic Acid; Avoidance Learning; Behavior, Animal;

2003
Tolerability of levetiracetam in elderly patients with CNS disorders.
    Epilepsy research, 2003, Volume: 56, Issue:2-3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anticonvulsants; Anxiety Disorders; Central Nervo

2003
Chronic levetiracetam treatment early in life decreases epileptiform events in young GAERS, but does not prevent the expression of spike and wave discharges during adulthood.
    Seizure, 2005, Volume: 14, Issue:6

    Topics: Aging; Animals; Anticonvulsants; Brain; Electrodes, Implanted; Electroencephalography; Epilepsy; Lev

2005
Piracetam improves mitochondrial dysfunction following oxidative stress.
    British journal of pharmacology, 2006, Volume: 147, Issue:2

    Topics: Adenosine Triphosphate; Aging; Animals; Antioxidants; Brain; Caspase 9; Culture Media, Serum-Free; F

2006
Hyponatremia from oxcarbazepine and carbamazepine.
    Neurology, 2005, Dec-27, Volume: 65, Issue:12

    Topics: Adult; Age Factors; Aging; Anticonvulsants; Carbamazepine; Databases, Factual; Dose-Response Relatio

2005
Changes in motor activity with age and the effects of pharmacologic treatment.
    Experimental gerontology, 1984, Volume: 19, Issue:5

    Topics: Aging; Animals; Body Weight; Dextroamphetamine; Dihydroergotoxine; Female; Meclofenoxate; Motor Acti

1984
Effects of centrophenoxine, piracetam and hydergine on rat brain lipid peroxidation.
    Experientia, 1981, Volume: 37, Issue:8

    Topics: Aging; Animals; Brain; Dihydroergotoxine; Glycolates; In Vitro Techniques; Lipid Peroxides; Male; Me

1981
[Age dependent changes in organs and the significance for drug therapy].
    Die Naturwissenschaften, 1983, Volume: 70, Issue:1

    Topics: Aged; Aging; Drug Therapy; Erythrocyte Count; Erythrocytes; Female; Humans; Kidney; Male; Middle Age

1983
Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats.
    Neurobiology of aging, 1981,Summer, Volume: 2, Issue:2

    Topics: Acetylcholine; Aging; Animals; Brain Chemistry; Choline; Male; Memory; Parasympathetic Nervous Syste

1981
Effects of piracetam on indices of cognitive function in a delayed alternation task in young and aged rats.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:3

    Topics: Aging; Animals; Cognition; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Memory, Sh

1994
Effects of cytidine diphosphate choline on rats with memory deficits.
    Arzneimittel-Forschung, 1993, Volume: 43, Issue:8

    Topics: Aging; Animals; Avoidance Learning; Clonidine; Cytidine Diphosphate Choline; Electroshock; Fetal Alc

1993
Effects of piracetam on N-methyl-D-aspartate receptor properties in the aged mouse brain.
    Pharmacology, 1993, Volume: 47, Issue:4

    Topics: Administration, Oral; Aging; Animals; Binding Sites; Brain; Dizocilpine Maleate; Female; Mice; Pirac

1993
Effect of chronic piracetam on age-related changes of cross-maze exploration in mice.
    Pharmacology, biochemistry, and behavior, 1995, Volume: 52, Issue:3

    Topics: Aging; Animals; Exploratory Behavior; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Noot

1995
Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain.
    Biochemical pharmacology, 1997, Jan-24, Volume: 53, Issue:2

    Topics: Aged; Aging; Animals; Brain; Female; Humans; Male; Membrane Fluidity; Mice; Neuroprotective Agents;

1997
[Effect of piracetam administration during lactation on morphometric parameters of neocortex and hippocampus of one month old rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1997, Volume: 124, Issue:8

    Topics: Aging; Animals; Animals, Suckling; Cerebral Cortex; Female; Hippocampus; Male; Neurons; Nootropic Ag

1997
Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain.
    Pharmacopsychiatry, 1999, Volume: 32 Suppl 1

    Topics: Age Factors; Aging; Analysis of Variance; Animals; Anisotropy; Avoidance Learning; Brain Chemistry;

1999
Renal handling of drugs in the healthy elderly. Creatinine clearance underestimates renal function and pharmacokinetics remain virtually unchanged.
    European journal of clinical pharmacology, 1999, Volume: 55, Issue:3

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Atenolol; Creatinine; Diuretics; Female; Glomerular

1999
Effect of piracetam administration on 3H-N-methylscopolamine binding in cerebral cortex of young and old rats.
    Life sciences, 1992, Volume: 50, Issue:13

    Topics: Aging; Animals; Binding, Competitive; Female; Kinetics; Male; Motor Cortex; N-Methylscopolamine; Par

1992
CGS 5649 B, a new compound, reverses age-related cognitive dysfunctions in rats.
    Behavioral and neural biology, 1992, Volume: 57, Issue:2

    Topics: Aging; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Ergoloid Mesylates; Fumarates;

1992
Age-related changes of the effects of a group of nootropic drugs on the content of rat brain biogenic monoamines.
    General pharmacology, 1991, Volume: 22, Issue:5

    Topics: Aging; Animals; Biogenic Monoamines; Brain Chemistry; Male; Piracetam; Psychotropic Drugs; Pyrrolidi

1991
Effects of age and drugs on food and fluid intake.
    Growth, development, and aging : GDA, 1991,Fall, Volume: 55, Issue:3

    Topics: Aging; Amphetamines; Animals; Behavior, Animal; Benzodiazepines; Body Weight; Diazepam; Drinking; Dr

1991
Abnormalities of energy metabolism in Alzheimer's disease studied with PET.
    Annals of the New York Academy of Sciences, 1991, Volume: 640

    Topics: Adult; Aged; Aging; Alzheimer Disease; Brain; Deoxyglucose; Energy Metabolism; Fluorodeoxyglucose F1

1991
Effects of nootropic agents on the performing of active two-way avoidance tasks in young and old rats.
    Acta physiologica et pharmacologica Bulgarica, 1990, Volume: 16, Issue:3

    Topics: Aging; Animals; Avoidance Learning; Male; Meclofenoxate; Memory; Piracetam; Psychotropic Drugs; Rats

1990
Influence of nootropic drugs on the age-dependent potassium-coupling of transmitter release.
    Biomedica biochimica acta, 1990, Volume: 49, Issue:7

    Topics: Aging; Animals; Calcium-Transporting ATPases; Dopamine; Dose-Response Relationship, Drug; Meclofenox

1990
Effects of indeloxazine hydrochloride on passive avoidance behavior of senescence-accelerated mice.
    European journal of pharmacology, 1989, Jul-18, Volume: 166, Issue:2

    Topics: Aging; Animals; Antidepressive Agents; Avoidance Learning; Cognition; Cycloheximide; Dihydroergotoxi

1989
Piracetam elevates muscarinic cholinergic receptor density in the frontal cortex of aged but not of young mice.
    Psychopharmacology, 1988, Volume: 94, Issue:1

    Topics: Aging; Animals; Atropine; Cerebral Cortex; Female; Male; Mice; Oxotremorine; Piracetam; Pyrrolidinon

1988
Chronic treatment with piracetam elevates muscarinic cholinergic receptor density in the frontal cortex of aged mice.
    Pharmacopsychiatry, 1988, Volume: 21, Issue:6

    Topics: Aging; Animals; Brain Chemistry; Cerebral Cortex; Female; In Vitro Techniques; Mice; Piracetam; Pyrr

1988
Effects of oxiracetam on learning and memory in animals: comparison with piracetam.
    Clinical neuropharmacology, 1986, Volume: 9 Suppl 3

    Topics: Aging; Animals; Avoidance Learning; Drug Administration Schedule; Electroshock; Memory; Mice; Pirace

1986
The predictive value of animal experimentation for clinical geropsychopharmacology.
    Gerontology, 1986, Volume: 32 Suppl 1

    Topics: Aging; Animals; Brain; Cats; Corpus Callosum; Evoked Potentials; Humans; Learning; Piracetam; Pyrrol

1986
[Effect of nootropil on the ultrastructure of the cerebral cortex of the aged rat].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1986, Volume: 86, Issue:7

    Topics: Aging; Animals; Capillaries; Cerebral Cortex; Microscopy, Electron; Neuroglia; Phagocytosis; Piracet

1986
The effect of age on clinical pharmacokinetics of piracetam.
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:2

    Topics: Adult; Aged; Aging; Blood Proteins; Body Weight; Erythrocytes; Female; Half-Life; Humans; Kinetics;

1985
Arousal deficit shown in aged rat's quantitative EEG and ameliorative action of pramiracetam compared to piracetam.
    Experientia, 1985, Nov-15, Volume: 41, Issue:11

    Topics: Aging; Animals; Cerebral Cortex; Electroencephalography; Hippocampus; Male; Piracetam; Pyrrolidines;

1985
Basic mechanisms of aging.
    Scandinavian journal of clinical and laboratory investigation. Supplementum, 1974, Volume: 141

    Topics: Acetylglucosaminidase; Aging; Animals; Brain; Cathepsins; Cytoplasm; Diaphragm; DNA; Glucuronidase;

1974