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piracetam and Ache

piracetam has been researched along with Ache in 20 studies

Piracetam: A compound suggested to be both a nootropic and a neuroprotective agent.

Research Excerpts

ExcerptRelevanceReference
"The purpose of this open-label study was to assess the effectiveness and tolerability of levetiracetam (LEV) in the treatment of patients with lower lumbar radiculopathy diagnosed by clinical presentation, physical examination, and electrodiagnostics."9.14Effectiveness of levetiracetam in the treatment of lumbar radiculopathy: an open-label prospective cohort study. ( Anderson, DG; Cifu, DX; Deschner, S; Hamza, MS; Snyder, JW, 2009)
"To assess the effectiveness of piracetam for reducing the incidence of painful sickle cell disease crises."8.93Piracetam for reducing the incidence of painful sickle cell disease crises. ( Al Hajeri, A; Fedorowicz, Z, 2016)
"To assess the effectiveness of piracetam for reducing the incidence of painful sickle cell disease crises."8.84Piracetam for reducing the incidence of painful sickle cell disease crises. ( Al Hajeri, AA; Fedorowicz, Z; Omran, A; Tadmouri, GO, 2007)
" Based on the experience with carbamazepine, gabapentin, and lamotrigine, these newer AEDs are being investigated for the management of neuropathic pain."8.82Oxcarbazepine, topiramate, zonisamide, and levetiracetam: potential use in neuropathic pain. ( Guay, DR, 2003)
"Levetiracetam (200-1000 nmol/paw) produced a significant dose-dependent reduction of the paw inflammatory hyperalgesia and edema induced by carrageenan."7.78The local peripheral antihyperalgesic effect of levetiracetam and its mechanism of action in an inflammatory pain model. ( Micov, AM; Stepanović-Petrović, RM; Tomić, MA; Ugrešić, ND, 2012)
"Levetiracetam, a novel antiepileptic drug, has recently been shown to have antinociceptive effects in various animal models of pain."7.76The antihyperalgesic effect of levetiracetam in an inflammatory model of pain in rats: mechanism of action. ( Micov, A; Popović, B; Stepanović-Petrović, R; Tomić, M, 2010)
"Piracetam is a nootropic drug that has reportedly been effective and non-toxic in sickle cell patients, but most studies were not placebo-controlled and included a small number of patients."6.71Inefficacy of piracetam in the prevention of painful crises in children and adolescents with sickle cell disease. ( Alvim, RC; Brito, AC; Franklin, HM; Oliveira, TF; Paula, MJ; Pires, MA; Rezende, PV; Viana, MB, 2005)
"Levetiracetam (LEV) is a novel anticonvulsant with proven antinociceptive properties."5.48Antinociceptive and pronociceptive effect of levetiracetam in tonic pain model. ( Alfaro-Rodriguez, A; Bandala, C; Bonilla-Jaime, H; Carrillo-Mora, P; Cortes-Altamirano, JL; Olmos-Hernández, A; Reyes-Long, S, 2018)
"The purpose of this open-label study was to assess the effectiveness and tolerability of levetiracetam (LEV) in the treatment of patients with lower lumbar radiculopathy diagnosed by clinical presentation, physical examination, and electrodiagnostics."5.14Effectiveness of levetiracetam in the treatment of lumbar radiculopathy: an open-label prospective cohort study. ( Anderson, DG; Cifu, DX; Deschner, S; Hamza, MS; Snyder, JW, 2009)
"To assess the effectiveness of piracetam for reducing the incidence of painful sickle cell disease crises."4.93Piracetam for reducing the incidence of painful sickle cell disease crises. ( Al Hajeri, A; Fedorowicz, Z, 2016)
"To assess the effectiveness of piracetam for reducing the incidence of painful sickle cell disease crises."4.84Piracetam for reducing the incidence of painful sickle cell disease crises. ( Al Hajeri, AA; Fedorowicz, Z; Omran, A; Tadmouri, GO, 2007)
" Based on the experience with carbamazepine, gabapentin, and lamotrigine, these newer AEDs are being investigated for the management of neuropathic pain."4.82Oxcarbazepine, topiramate, zonisamide, and levetiracetam: potential use in neuropathic pain. ( Guay, DR, 2003)
" These results suggest that ceftriaxone, particularly in combinations with ibuprofen, celecoxib, paracetamol, or levetiracetam, may provide useful approach to the clinical treatment of inflammation-related pain."3.80Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents. ( Boškovic, BD; Kovacevic, JM; Micov, AM; Stepanovic-Petrovic, RM; Tomic, MA, 2014)
"Levetiracetam (LEV), a new anticonvulsant agent primarily used to treat epilepsy, has been used in pain treatment but the cellular mechanism of this action remains unclear."3.78Modulation of action potential and calcium signaling by levetiracetam in rat sensory neurons. ( Ayar, A; Ozcan, M, 2012)
"Levetiracetam (200-1000 nmol/paw) produced a significant dose-dependent reduction of the paw inflammatory hyperalgesia and edema induced by carrageenan."3.78The local peripheral antihyperalgesic effect of levetiracetam and its mechanism of action in an inflammatory pain model. ( Micov, AM; Stepanović-Petrović, RM; Tomić, MA; Ugrešić, ND, 2012)
"Levetiracetam, a novel antiepileptic drug, has recently been shown to have antinociceptive effects in various animal models of pain."3.76The antihyperalgesic effect of levetiracetam in an inflammatory model of pain in rats: mechanism of action. ( Micov, A; Popović, B; Stepanović-Petrović, R; Tomić, M, 2010)
"Piracetam is a nootropic drug that has reportedly been effective and non-toxic in sickle cell patients, but most studies were not placebo-controlled and included a small number of patients."2.71Inefficacy of piracetam in the prevention of painful crises in children and adolescents with sickle cell disease. ( Alvim, RC; Brito, AC; Franklin, HM; Oliveira, TF; Paula, MJ; Pires, MA; Rezende, PV; Viana, MB, 2005)
"Levetiracetam (LEV) is a novel anticonvulsant with proven antinociceptive properties."1.48Antinociceptive and pronociceptive effect of levetiracetam in tonic pain model. ( Alfaro-Rodriguez, A; Bandala, C; Bonilla-Jaime, H; Carrillo-Mora, P; Cortes-Altamirano, JL; Olmos-Hernández, A; Reyes-Long, S, 2018)
"Piracetam is a prototype of nootropic drugs used to improve cognitive impairment."1.39Analgesic activity of piracetam: effect on cytokine production and oxidative stress. ( Casagrande, R; Hohmann, MS; Mizokami, SS; Navarro, SA; Serafim, KG; Verri, WA, 2013)
"Levetiracetam is an AED with unique mechanisms of action that may have analgesic properties in various pain syndromes."1.33Levetiracetam as an adjunctive analgesic in neoplastic plexopathies: case series and commentary. ( Dunteman, ED, 2005)
"nefiracetam was also blocked by i."1.31Nonopioid and neuropathy-specific analgesic action of the nootropic drug nefiracetam in mice. ( Rashid, MH; Ueda, H, 2002)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.00)18.7374
1990's0 (0.00)18.2507
2000's10 (50.00)29.6817
2010's9 (45.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cortes-Altamirano, JL1
Reyes-Long, S1
Olmos-Hernández, A1
Bonilla-Jaime, H1
Carrillo-Mora, P1
Bandala, C1
Alfaro-Rodriguez, A1
Navarro, SA1
Serafim, KG1
Mizokami, SS1
Hohmann, MS1
Casagrande, R1
Verri, WA1
Stepanovic-Petrovic, RM2
Micov, AM2
Tomic, MA2
Kovacevic, JM1
Boškovic, BD1
Rémi, C1
Lorenzl, S1
Vyhnalek, B1
Rastorfer, K1
Feddersen, B1
Micov, A2
Tomić, M2
Pecikoza, U1
Ugrešić, N1
Stepanović-Petrović, R2
Al Hajeri, A1
Fedorowicz, Z2
Viana, MB2
Alvim, RC2
Hamza, MS1
Anderson, DG1
Snyder, JW1
Deschner, S1
Cifu, DX1
Popović, B1
Ozcan, M2
Ayar, A2
Ugrešić, ND1
Rashid, MH1
Ueda, H1
Ardid, D1
Lamberty, Y1
Alloui, A1
Coudore-Civiale, MA1
Klitgaard, H1
Eschalier, A1
Ilag, VL1
Guay, DR1
Dunteman, ED1
Pires, MA1
Franklin, HM1
Paula, MJ1
Brito, AC1
Oliveira, TF1
Rezende, PV1
Al Hajeri, AA1
Omran, A1
Tadmouri, GO1
Canpolat, S1
Kutlu, S1
Myslivecek, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Placebo-Controlled Crossover Trial of Levetiracetam on Ethanol Intake[NCT01168687]46 participants (Actual)Interventional2008-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Standard Alcoholic Drinks Per Treatment Period

The primary outcome of this study is to determine the effect of levetiracetam on alcohol consumption as measured by change in # of drinks during each treatment period. (NCT01168687)
Timeframe: During each 14 day treatment period

Interventionnumber of drinks per treatment period (Mean)
All Subjects (n = 46) Placebo41.2
All Subjects (n = 46) Levetiracetam45.4

Reviews

3 reviews available for piracetam and Ache

ArticleYear
Piracetam for reducing the incidence of painful sickle cell disease crises.
    The Cochrane database of systematic reviews, 2016, Feb-12, Volume: 2

    Topics: Adolescent; Anemia, Sickle Cell; Antisickling Agents; Child; Child, Preschool; Humans; Pain; Piracet

2016
Oxcarbazepine, topiramate, zonisamide, and levetiracetam: potential use in neuropathic pain.
    The American journal of geriatric pharmacotherapy, 2003, Volume: 1, Issue:1

    Topics: Aged; Analgesics, Non-Narcotic; Animals; Carbamazepine; Clinical Trials as Topic; Dose-Response Rela

2003
Piracetam for reducing the incidence of painful sickle cell disease crises.
    The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2

    Topics: Adolescent; Anemia, Sickle Cell; Antisickling Agents; Child; Child, Preschool; Humans; Pain; Piracet

2007

Trials

3 trials available for piracetam and Ache

ArticleYear
Painful crises in children with sickle cell disease are not prevented by piracetam.
    Acta haematologica, 2009, Volume: 121, Issue:1

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Double-Blind Method; Female; Humans

2009
Effectiveness of levetiracetam in the treatment of lumbar radiculopathy: an open-label prospective cohort study.
    PM & R : the journal of injury, function, and rehabilitation, 2009, Volume: 1, Issue:4

    Topics: Adult; Aged; Analgesics; Female; Humans; Levetiracetam; Lumbar Vertebrae; Male; Middle Aged; Pain; P

2009
Inefficacy of piracetam in the prevention of painful crises in children and adolescents with sickle cell disease.
    Acta haematologica, 2005, Volume: 113, Issue:4

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Cross-Over Studies; Double-Blind Me

2005

Other Studies

14 other studies available for piracetam and Ache

ArticleYear
Antinociceptive and pronociceptive effect of levetiracetam in tonic pain model.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:2

    Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Leve

2018
Analgesic activity of piracetam: effect on cytokine production and oxidative stress.
    Pharmacology, biochemistry, and behavior, 2013, Volume: 105

    Topics: Analgesics; Animals; Cytokines; Male; Mice; Oxidative Stress; Pain; Piracetam

2013
Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents.
    Anesthesiology, 2014, Volume: 120, Issue:3

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Ceftriaxone; Ce

2014
Continuous subcutaneous use of levetiracetam: a retrospective review of tolerability and clinical effects.
    Journal of pain & palliative care pharmacotherapy, 2014, Volume: 28, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans

2014
Levetiracetam synergises with common analgesics in producing antinociception in a mouse model of painful diabetic neuropathy.
    Pharmacological research, 2015, Volume: 97

    Topics: Acetaminophen; Analgesics; Animals; Aspirin; Diabetic Neuropathies; Dose-Response Relationship, Drug

2015
The antihyperalgesic effect of levetiracetam in an inflammatory model of pain in rats: mechanism of action.
    British journal of pharmacology, 2010, Volume: 161, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Hyperalgesia;

2010
Modulation of action potential and calcium signaling by levetiracetam in rat sensory neurons.
    Journal of receptor and signal transduction research, 2012, Volume: 32, Issue:3

    Topics: Action Potentials; Analgesics; Animals; Anticonvulsants; Calcium; Dose-Response Relationship, Drug;

2012
The local peripheral antihyperalgesic effect of levetiracetam and its mechanism of action in an inflammatory pain model.
    Anesthesia and analgesia, 2012, Volume: 115, Issue:6

    Topics: Adenosine A1 Receptor Antagonists; Adrenergic alpha-Antagonists; Anesthetics, Local; Animals; Carrag

2012
Nonopioid and neuropathy-specific analgesic action of the nootropic drug nefiracetam in mice.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1

    Topics: Analgesia; Animals; Diabetes Mellitus, Experimental; Hyperalgesia; Male; Mice; Mice, Inbred Strains;

2002
Antihyperalgesic effect of levetiracetam in neuropathic pain models in rats.
    European journal of pharmacology, 2003, Jul-18, Volume: 473, Issue:1

    Topics: Acute Disease; Analgesics; Animals; Carbamazepine; Chronic Disease; Constriction, Pathologic; Diabet

2003
Future Pain Drugs - Europe 2003. 15-16 September 2003, London, UK.
    IDrugs : the investigational drugs journal, 2003, Volume: 6, Issue:11

    Topics: Acetaminophen; Acetates; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, A

2003
Levetiracetam as an adjunctive analgesic in neoplastic plexopathies: case series and commentary.
    Journal of pain & palliative care pharmacotherapy, 2005, Volume: 19, Issue:1

    Topics: Adult; Aged; Analgesics, Opioid; Anticonvulsants; Brachial Plexus Neuropathies; Dose-Response Relati

2005
Antinociceptive efficacy of levetiracetam in a mice model for painful diabetic neuropathy.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:7

    Topics: Analgesics; Animals; Anticonvulsants; Behavior, Animal; Diabetic Neuropathies; Disease Models, Anima

2008
Proceedings: The effects of piracetam on cortical evoked responses in rats stimulated at different postnatal periods.
    Activitas nervosa superior, 1975, Volume: 17, Issue:4

    Topics: Animals; Auditory Perception; Cerebral Cortex; Evoked Potentials; Pain; Piracetam; Pyrrolidinones; R

1975