piplartine and Squamous-Cell-Carcinoma-of-Head-and-Neck

piplartine has been researched along with Squamous-Cell-Carcinoma-of-Head-and-Neck* in 2 studies

Other Studies

2 other study(ies) available for piplartine and Squamous-Cell-Carcinoma-of-Head-and-Neck

Article	Year
Molecular Modeling and In Vitro Evaluation of Piplartine Analogs against Oral Squamous Cell Carcinoma. Molecules (Basel, Switzerland), 2023, Feb-09, Volume: 28, Issue:4 Cancer is a principal cause of death in the world, and providing a better quality of life and reducing mortality through effective pharmacological treatment remains a challenge. Among malignant tumor types, squamous cell carcinoma-esophageal cancer (EC) is usually located in the mouth, with approximately 90% located mainly on the tongue and floor of the mouth. Piplartine is an alkamide found in certain species of the genus Topics: Cell Line, Tumor; Humans; Mouth Neoplasms; Piperidones; Quality of Life; Squamous Cell Carcinoma of Head and Neck	2023
Piperlongumine inhibits head and neck squamous cell carcinoma proliferation by docking to Akt. Phytotherapy research : PTR, 2020, Volume: 34, Issue:12 Piperlongumine (PL) is a biologically active alkaloid isolated from the long pepper roots and widely used as a traditional medicine in Ayurvedic medicine. However, the mechanism of PL's effect on head and neck squamous cell carcinoma (HNSCC) is not well understood. We performed cell experiments to confirm PL's inhibitory effect on HNSCC and employing cisplatin as positive control. Next, we conducted bioinformatics to predict PL's potential targets and verified by western blotting. Molecular docking, Biacore experiment and kinase activity assays were applied to elucidate the mechanism by which PL inhibited target activity. In vivo efficacy was verified by xenotransplantation and immunohistochemistry. PL inhibited proliferation, promoted late apoptosis, arrested cell cycle and inhibited DNA replication of the HEp-2 and FaDu cell lines. Employing bioinformatics, we found that PL's target was Akt and PL attenuated Akt phosphorylation. We found from molecular docking, Biacore experiment and kinase activity assay that PL inhibited Akt activation by docking to Akt to restrain its activity. In addition, PL significantly inhibited the growth of xenograft tumors by down regulating the expression of p-Akt in vivo. This study provides new insights into the molecular functions of PL and indicate its potential as a therapeutic agent for HNSCC. Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dioxolanes; Humans; Mice; Mice, Nude; Molecular Docking Simulation; Proto-Oncogene Proteins c-akt; Squamous Cell Carcinoma of Head and Neck	2020

Article

Year

Molecular Modeling and In Vitro Evaluation of Piplartine Analogs against Oral Squamous Cell Carcinoma.

Molecules (Basel, Switzerland), 2023, Feb-09, Volume: 28, Issue:4

Cancer is a principal cause of death in the world, and providing a better quality of life and reducing mortality through effective pharmacological treatment remains a challenge. Among malignant tumor types, squamous cell carcinoma-esophageal cancer (EC) is usually located in the mouth, with approximately 90% located mainly on the tongue and floor of the mouth. Piplartine is an alkamide found in certain species of the genus

Topics: Cell Line, Tumor; Humans; Mouth Neoplasms; Piperidones; Quality of Life; Squamous Cell Carcinoma of Head and Neck

2023

Piperlongumine inhibits head and neck squamous cell carcinoma proliferation by docking to Akt.

Phytotherapy research : PTR, 2020, Volume: 34, Issue:12

Piperlongumine (PL) is a biologically active alkaloid isolated from the long pepper roots and widely used as a traditional medicine in Ayurvedic medicine. However, the mechanism of PL's effect on head and neck squamous cell carcinoma (HNSCC) is not well understood. We performed cell experiments to confirm PL's inhibitory effect on HNSCC and employing cisplatin as positive control. Next, we conducted bioinformatics to predict PL's potential targets and verified by western blotting. Molecular docking, Biacore experiment and kinase activity assays were applied to elucidate the mechanism by which PL inhibited target activity. In vivo efficacy was verified by xenotransplantation and immunohistochemistry. PL inhibited proliferation, promoted late apoptosis, arrested cell cycle and inhibited DNA replication of the HEp-2 and FaDu cell lines. Employing bioinformatics, we found that PL's target was Akt and PL attenuated Akt phosphorylation. We found from molecular docking, Biacore experiment and kinase activity assay that PL inhibited Akt activation by docking to Akt to restrain its activity. In addition, PL significantly inhibited the growth of xenograft tumors by down regulating the expression of p-Akt in vivo. This study provides new insights into the molecular functions of PL and indicate its potential as a therapeutic agent for HNSCC.

Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dioxolanes; Humans; Mice; Mice, Nude; Molecular Docking Simulation; Proto-Oncogene Proteins c-akt; Squamous Cell Carcinoma of Head and Neck

2020